Scientific Sessions

Program Overview

Symposia Sessions

• Aromatase (CYP19) Gene Expression and Function: Current State of Knowledge As a Mode-of-Action for Toxicological Effects
• Eat Well, Breathe Well: Nutritional Determinants of Susceptibility to Airborne Pollutants
• Heat Shock Proteins and the Toxicological Response
• Immunomodulation During Complementary and Alternative Medicine (CAM) Therapy: Risks and Benefits
• In Vitro Models of Human Toxicity Pathways
• Incorporating 'Omics in the Study of Reproduction and Development
• Interactomes and Their Application in Toxicology
• MicroRNAs in Biology and Toxicology
• New Insights into Skin Homeostasis and Carcinogenesis
• Pulmonary Effects of In Utero and Early Postnatal Exposure to Arsenic
• Regulation of Drug Transporters in Different Disease States and its Toxicological and Clinical Implications
• Superantigens, Cytokine Storm and Toxic Reactions

Symposia Sessions: Thematic Track

Biomarkers

• Biomarkers: New Breakthroughs in the World of Air Pollution Studies
• From Mechanisms to Biomarkers: Basic and Applied Metabolomics in Toxicology

Epigenetics

• Epigenetic Implications to Toxicology
• Gene-Environment Interactions: Epigenetic Pathways in Chronic Disease Promotion and Progression
• Genomic, Non-Genomic, and Epigenetic Mechanisms of Nuclear Hormone Receptor Action
• Mammalian Retrotranspositional Elements: Epigenetic Regulation, Species Differences, and Potential Roles As Mediators of Cellular Responses to Toxic Stress
• Transcriptional Changes in Immunotoxicology: Transcription Factors, Signal Transduction, and Epigenetics

Inflammation and Disease

• Nitrative and Oxidative Stress in Toxicology and Disease
• The Good, the Bad and the Ugly of Toxicant-Induced Pulmonary Inflammation
• The Role of Inflammation during Metabolic Liver Disease and Drug-Induced Liver Toxicity: Novel Insights
• Zinc, Inflammation and Diabetes

Nanotechnology

• Aquatic Species As Sentinels for Human Health: Comparative Toxicology of Metals, Nanoparticles, and PCB's
• Nanotoxicology and Drug Delivery

Neurodegenerative Disease

• Does Metal Toxicity Play a Role in the Etiology of Alzheimer's Disease?
• Novel Signaling Mechanisms that Regulate Dopaminergic Neuronal Survival or Death: Implications in Parkinson's Disease

Workshop Sessions

• Developing Brain: Safety Assessment for Pediatric Use of Pharmaceuticals
• Dose Selection and Design Considerations in Safety Studies for Biotherapeutics
• Drug Discovery: Current and Future State of In Vitro Screening Strategies for Safety
• Food Allergy—Basic Mechanisms and Applications to Identifying Risks Associated with Plant Incorporated Pesticides and Other Genetically Modified Crops
• From Genes to Organs: Advancements in Modeling Biological Systems
• Is Modulation of the Immune System by Perfluoroalkyl Acids a Human Health Concern?
• Low-Dose Non-Linearity: What Can Emerging Technologies Tell Us?
• Maternal Toxicity and Its Impact on Study Design and Data Interpretation
• Oxidative Stress As a Regulator of Normal Function and Mediator of Toxicant-Induced Damage with Impacts on Reproduction and Development
• Pesticide Mixtures: Experimental Evaluation and Computational Modeling
• Safety of High-Intensity Sweeteners: Bittersweet Controversy
• The Impact of Transcript Profiling in Drug Safety Assessment
• The Molecular Mechanism of Alpha, Beta: Unsaturated Carbonyl Toxicity: Getting in Touch with the Soft Side of Chemistry
• The Road to Personalized Medicine
• Toxicology of Unintentional and Intentional Disasters

Workshop Sessions: Thematic Track

Biomarkers

• Improved Safety Biomarkers for Monitoring Kidney Injury

Inflammation and Disease

• Biomarkers for Assessing the Systemic Inflammatory Response Syndrome in Toxicology Studies

Nanotechnology

• Agglomeration Versus Dispersion: How Nanoparticle Behavior Affects Exposure and Toxicity In Vitro, In Vivo, and in the Real World

Neurodegenerative Disease

• Pesticides and Parkinson's Disease: Implications of New Epidemiology and Exposure Data to Risk Assessment

Roundtables Sessions

• Characterization and Application of PBPK Models in Risk Assessment
• Devils Lie in the Details: Practices and Problems in Neuropathology—Significance of Neurotoxicology
• Leveraging Non-Clinical Disease Models for Early Perspective on Safety and Risk During Drug Discovery
• National Children's Study: Opportunities and Challenges for Toxicologists
• Phototoxicology: A Passing Fancy or Enduring Concern
• Preclinical Evaluation of Cancer Hazard and Risk of Biopharmaceuticals
• Role of Regulatory Cooperative Efforts in Food Protection
• Setting a Safe Starting Dose in Initial Clinical Trials with Biotherapeutics: Do I Use the NOAEL or the MABEL?
• Weight of Evidence Advancements in Risk Assessment: Conceptual Frameworks and Case Studies Illustrating Fundamentals of Application
• What is an Adverse Effect in the Age of 'Omics?

Roundtable Sessions: Thematic Track

Biomarkers

• Biomarkers of Cardiac Hypertrophy and Skeletal Muscle Toxicity—Successes and Challenges Related to Their Implementation in Drug Development

Inflammation and Disease

• Is There a Future for Animal Models in the Investigation of Idiosyncratic DILI in Humans?

Nanotechnology

• The Regulatory Frontier: Addressing Products of Nanotechnology
• The Use of Engineered Nanomaterials in Food and Food-Related Products: Is this a Concern for Human and Environmental Safety?

Historical Highlights Sessions

• A Quarter of a Century (1984–2009) Since the Bhopal Disaster: Lessons Learned
• Dioxin, Forty Years of Science: Are We Any Closer to Assessing Potential Risk?

Informational Sessions

• Kinase Inhibitors as Targeted Therapeutics in Inflammation and Oncology: Approaches to Predict and Manage Clinical Toxicities
• Lead: Children's Exposures and Current Regulatory Standards
• Peer Review of Toxicology, Exposure, and Risk Data: Ensuring the Best Science

Informational Sessions: Thematic Track

Biomarkers

• NIH Genes, Environment and Health Initiative: Biomarkers and Biosensors for Detecting Response to Environmental Stress
• Novel Translational Safety Biomarkers and Safety First at the FDA

Education—Career Development Sessions

• Career Opportunities and Transitions in Toxicology
• Grantsmanship Forum: Tools and Skills Needed to Navigate Toxicology Research Funding
• The Future of Environmental Health Science: Featuring NIEHS Funded Early Career Investigators
• Toxicologists: The Next Generation

Regional Interest Session

• Biofuels and the Bay: Characterizing Health and Ecosystem Impacts in the Chesapeake