| ToxLearn
Modules
- Introduction
- Dose-Effect and Dose-Response
- Types of Toxicity
- Factors Affecting Toxicity
Dose
Route of exposure
Time course of exposure
Characteristics of exposed organism
- Toxicokinetics and Toxicodynamics
Toxicokinetics
Absorption
Distribution/Storage
Biotransformation
Excretion
Toxicodynamics
- Toxicity Assessment – Human and Animal
Methods
Laboratory studies: in vivo, in vitro and in silico
Human observation: epidemiology and clinical investigation
Assessing acute toxicity
Definition of acute toxicity
LD50/LC50
Assessing chronic toxicity
Definition of chronic toxicity
Non-cancer effects: neurotoxicology, reproductive toxicology,
immunotoxicology, etc.
NOAEL, LOAEL, etc.
Cancer: potency factor
- Toxicity Assessment – Ecological
- Applied Toxicology
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ToxTutor was originally produced
as a basic tutorial for those using the NLM toxicology databases.
The new version with updated content is called ToxLearn to reflect
the emphasis on active learning and effective use of graphics and
the web format to address the needs of a variety of learners. The
content is directed to the level of the undergraduate student and
educated general public.
SOT is partnering with NLM in the production of ToxLearn. We expect
release of Modules 1-3 this summer.
Potential authors will provide the following information:
- An expression of interest in the project indicating which one
or more modules you are interested in authoring.
- A writing sample consisting of about 250 words, highlighting
a relevant toxicology concept, and aimed at undergraduate students.
Ideally, it would incorporate graphic images. A PowerPoint or
Web-based presentation which fulfills or complements these requirements
could also be submitted.
- Personal resume of no more than 3 pages.
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