Continuing Education Courses On-Line
SOT and the Continuing Education Committee are proud to present the release of two on-line courses as part of a new and exciting pilot program to expand educational opportunities. These on-line CE Courses were recorded during live presentation in 2009 at the SOT Annual Meeting in Baltimore, Maryland.
Each course runs approximately three and a half hours and is divided into a brief introduction followed by four, 45-minute segments that are viewed individually. Registrants will have 30-day unlimited access to the course(s) beginning on the date of purchase. The course segments are viewed via on-line streaming audio and slide presentation, and are not downloadable.
Registration Information
SOT On-Line CE Course Registration includes 30-day unlimited access beginning on the date of purchase. You will receive a confirmation receipt by e-mail once your registration is complete. This e-mail will include the start date for your 30-day access, as well as account login information, and instructions. Courses are viewed via on-line streaming of audio and slide presentations and require Internet access.
Register Translation of Safety Biomarkers in Drug Discovery and Development
Register Stress as a Confounding Factor
Fees by Member Type
| SOT Member |
$75.00 |
Non-Member |
$150.00 |
SOT Retired Member |
$55.00 |
| Postdoctoral Member |
FREE |
| Postdoctoral Non-Member* |
$45.00 |
| Graduate/Student Member |
FREE |
Graduate/Undergraduate Student Non-Member* |
$22.50 |
SOT Affiliate |
$75.00 |
*Students and Postdocs Non-Members: Please provide your institution, advisor name, and contact information, and a copy of any available identification via e-mail to sothq@toxicology.org or fax to
(703) 438-3113 to ATTN: CE On-Line. Student or Postdoc status will be verified prior to enrollment at the reduced rate, which may result in a delay in the access start date. Registrants will receive notification once enrollment has been activated.
Register Translation of Safety Biomarkers in Drug Discovery and Development
Register Stress as a Confounding Factor
If you prefer to register via mail or fax download, and submit this CE Course On-Line Registration Form. All registrations submitted by fax or hard copy will be processed on-line by SOT staff and the registrant notified of the access start date.
Mail or Fax Forms to: Society of Toxicology Continuing Education
ATTN: CE On-Line
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
FAX: (703) 438-3113
After you register, you will recive an e-mail notification confirming your enrollment, including details on how to access the course. If you did not receive verification of enrollment, please contact us.
Access a CE Course On-Line
Please click on the title of the course to access viewing or to register on-line (view registration details).
Login Translation of Safety Biomarkers in Drug Discovery and Development
Login Stress as a Confounding Factor
Student/Postdoc SOT Members
As a special promotion, these on-line CE courses are available for FREE to all Student and Postdoc members of SOT through May 31, 2010. Please take advantage of this opportunity and log in to view these courses! No registration is required.
Baltimore Attendees
Did you attend these courses live? Review them again for FREE as a refresher! These courses were presented as AM07 (morning course) and PM13 (afternoon course) in Baltimore in 2009. If you were a registrant for one of these courses at the 2009 Annual Meeting, access to that course has been automatically provided to you through May 31, 2010. No registration is required.
 Tell a Colleague
Having difficulty accessing your course? Please contact us.
Group Viewing
SOT encourages you to share these courses with your friends and colleagues by inviting them to view with you by projecting the presentation to a group. However, access to these courses is linked through the registrant’s SOT account so we strongly discourage sharing of individual account information. Certificates of attendance are available only to original purchasing registrant.
Certificates
Course certificates are available to anyone who has registered for the course through SOT. If you would like to receive a certificate of completion, please contact us.
Feedback
Would you like to provide some feedback on our on-line courses? Complete the CE Course On-Line Survey through the course viewing page and let us know what you think.
Course Descriptions
Translation of Safety Biomarkers in Drug Discovery and Development (Advanced)
AM07—Baltimore 2009
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Chairperson(s): Kay Criswell, Pfizer Global Research and Development, Groton, CT and Jennifer Colangelo, Pfizer, Inc. , Groton, CT
Sponsor: Regulatory and Safety Evaluation Specialty Section
Sponsor: Regulatory and Safety Evaluation Specialty Section
Endorsed by:
Comparative and Veterinary Specialty Section
Drug Discovery Toxicology Specialty Section
Several major areas prove problematic in translating animal data/biomarkers to humans. This course focuses on translational issues in hematology, clinical chemistry, protein and peptide assays. It concludes with a risk assessment presentation summarizing the realities of implementing the overall process in defining human relevance of safety and efficacy from preclinical data. Preclinical data gathered in laboratory animals is required by regulatory agencies to determine safety in humans prior to marketing of new products. Species-specific differences in routine and esoteric serum biomarkers make the relevance of findings in animals difficult to interpret. Knowledge in this area is beneficial to the safe conduct of clinical trials and the inclusion of relevant biomarkers as effective safety and efficacy endpoints during new product development. Research scientists, industry scientists, laboratory personnel, and pathologists interested in biomarker development, translation, execution and applications from preclinical through clinical trials may be interested. The difference between data obtained in preclinical and clinical circumstances will be covered in this course. Therefore, it may be of interest to anyone in a preclinical research setting through those engaged in clinical trials, as well as those evaluating the safety of industrial chemicals. Course objectives include identification of potential relevance or non-relevance of animal-based hematologic and clinical chemistry biomarkers to humans, identification of methods of overcoming species-specific problems in protein and peptides biomarkers, and understanding human relevance of animal data and the impact of biomarker utilization on speed and decision-making.
Translation of Safety Biomarkers: Introduction, Kay Criswell, Pfizer Global Research & Development, Groton, CT
Does Preclinical Hematology Predict Human Safety? Nancy Everds, Amgen Inc. , Seattle, WA
Translation of Clinical Chemistry Biomarkers: Pitfalls and Solutions, Denise Bounous, Bristol-Myers Squibb, Princeton, NJ
Overcoming the Problem of Species-Specific Proteins and Peptides in Assay Development, Jennifer Colangelo, Pfizer Global Research & Development, Groton, CT
Connecting the Dots to Define Human Relevance to Preclinical Data: Implementing Techniques to Enhance Speed of Delivery and Decision Making, Michael R. Bleavins, Michigan Technology & Research Institute, Ann Arbor, MI
Stress as a Confounding Factor (Basic)
PM13—Baltimore 2009
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Chairperson(s): Katie Sprugel, Amgen, Seattle, WA and Nancy Everds, Amgen, Seattle, WA
Sponsor: Toxicologic and Exploratory Pathology Specialty Section
Endorsed by:
Immunotoxicology Specialty Section
Regulatory and Safety Evaluation Specialty Section
Women in Toxicology Special Interest Group
Stress can confound the interpretation of toxicity studies. The biology of stress includes complex interrelationships between neurologic and endocrine pathways. Stressors can have effects on in-life, clinical pathology, endocrine, and immune system parameters. Effects on any of these systems may be observed during a toxicity study. The challenge in toxicology is to differentiate between primary test article-related changes and secondary changes related to stress. This differentiation is fundamental to the assessment of stress in the regulatory environment. Understanding the pathophysiology of major systems impacted by stress and the potential range of responses is key to assessing the contribution of stress to study findings. Effects of stress in animals and humans, including potential biomarkers, will be discussed. Key references for the understanding of stress-related findings will be provided.
Introduction, Katie Sprugel, Amgen Inc. , Seattle, WA
Neurohormonal Aspects of Stress, David Dorman, North Carolina State University, Raleigh, NC
Stress and Clinical Pathology, Nancy Everds, Amgen Inc. , Seattle, WA
Stress and Endocrine Organs, George Foley, Schering-Plough, Summit, NJ
Stress and the Immune System, Paul Snyder, Purdue University, West Lafayette, IN
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