Scientific Sessions

Program Overview

Symposium Sessions

• Aging As a Determinant of Xenobiotic Toxicity
• Bile Salt Transport and Liver Injury
• Faster Science for Better Decisions: Characterizing Environmental Contaminant Risk from High-Throughput Data
• Gender Divergent Xenobiotic Responses
• Genotoxic Impurities in Drugs and Drug Products: What Is the Right Way to Deal with Impurities in R&D Versus Regulatory Guidance?
• Mechanisms of Chemical-Induced Liver Cancer: Putting the Pieces Together
• Mechanistic Role of Reactive Intermediate Protein Covalent Binding in Target Organ Toxicity: Past, Present, and Future
• Neurological Responses after Exposure to Inhaled Metal Particles
• New Strategies for the Use of Genetic Toxicology Data in Human Risk Assessment
• Ovarian Toxicity: Current Concepts in Toxicology, Pathology, and Mechanisms
• Phthalate Reproductive and Developmental Toxicity and Risk Assessment
• Silica and Asbestos Immunotoxicity: Mechanisms to Fibrosis, Autoimmunity, and Modified Tumor Resistance
• The Fetal Basis of Adult Disease
• Zebrafish Models for Developmental Neurobehavioral Toxicology

Symposium Sessions: Thematic Track

Cell Signaling

• Alterations in Regulatory T Cells: Novel Pathways to Immunotoxicology
• It's Not Your Father's Aryl-Hydrocarbon Receptor: New Biological Roles for a Misunderstood Receptor
• MAP Kinase Signaling: A Common Target in Different Tissue
• TRPing the Sensor: The Role of TRP Channel Signaling in Cardiopulmonary Toxicity

Gene-Environment Interactions

• Genetics: The Link between Exposures, Gene x Environment Interaction, and Toxicity

Metabolic Disease

• Metabolic Syndrome and Increased Sensitivity to Drug-Induced Liver Injury (DILI): Nonclinical Models and Clinical Implications
• Recent Knowledge of Critical Regulators of Lipid Homeostasis in Metabolic Disease
• Signaling Mechanisms for Metabolic Dysfunction Following Low Level Arsenic Exposures: From Mouse to Man
• Zinc, Copper, and Their Metabolic Effect: Myths and Musts

Mitochondrial Basis of Disease

• Mitochondrial Toxicity in Disease and Death
• Molecular Determinants of Mitochondrial Disease

Translational Toxicology

• Anti-Drug Antibody-Mediated Toxicity in Nonclinical Toxicity Studies: Impact and Relevance to Human Safety

Workshop Sessions

• Blood-Based Genomic Profiles As Biomarkers of Exposure and Effect
• Current Thinking and Experiences Related to Developmental and Reproductive Safety Assessment of Biotherapeutics
• Determination of the Contributions of Individual Stressors in Cumulative Risk Assessments
• Heart Smart: Innovative Approaches for Improving Cardiovascular Safety through Collaboration
• Immunotoxicity and Other Safety Considerations in the Development of Therapeutic Vaccines
• Minerals and Metals: Pros and Cons of Deliberate Exposure
• Research Advances and Enduring Needs in Children's Environmental Health Protection
• The Process of Defining Risk for Environmental Chemicals Having Significant Skin Exposure and Absorption Potential
• Toxicological Challenges in Green Product Development
• Understanding Nonlinearities at the Low End of the Dose-Response Curve: Insights from Molecular Network Analysis
• Widely Varying Strategies Implemented in Discovery to Reduce the Failure Rate of Clinical Lead Candidates in Development

Workshop Sessions: Thematic Track

Cell Signaling

• ‘Omics Profiling of Cell and Tissue Interactions of Nanomaterials: Insight into Mechanisms of Action
• Systems Biology Approaches to Understanding Cell Signaling in Dermal and Ocular Toxicology

Toxicity Testing in the 21st Century

• High-Throughput Electrophysiology—21st Century Toxicity Testing Approaches with Functional Outcomes
• Opportunities to Modify Current Regulatory Testing Guidelines and Advance the Assessment of Carcinogenicity Risk in the 21st Century
• Toxicity Testing in the 21st Century for Ecotoxicology
• Toxicology in the 21st Century: Stem Cells in Drug Discovery and Development

Translational Toxicology

• Humanized Models in Toxicology and Their Application to Hazard Characterization and Risk Assessment
• Low-Dose Linearity from Interaction of Agents with Background Disease Causes: A Conversation About Statistical and Toxicological Principles
• Novel Research Approaches, Animal Models, and Clinical Examples in Translational Toxicology
• Translation of Nonclinical Models to Clinical Risk Management Strategies of Severe Infectious Diseases with Immunomodulatory Drugs

Roundtable Sessions

• Combination Toxicology Studies for Pharmaceutical Agents: Design Considerations and Impact on Clinical Development
• Inhaled Particles: From the Nose to the Brain?
• Melamine Contamination of Infant Formulas: Lessons Learned
• Overview of Current Regulatory Expectations for Oligonucleotide-Based Therapeutics: Case Studies for Different Classes of ONDs
• Safety of Vitamins and Minerals: Controversies and Perspectives
• The Evolution of the Extended One-Generation Study Design for Agricultural and Industrial Chemical Hazard Identification
• Weighing Complex Data in Risk Decisions: Concepts of Evidence-Based Toxicology
• Women's Health: Toxicology and Safety of Complementary and Alternative Medicine

Roundtable Sessions: Thematic Track

Translational Toxicology

• Can Animal Neurotoxicity Predict Human Dysfunction?
• The Ying and Yang of Immunomodulatory Biopharmaceuticals: What Have We Learned since MABEL and How Close Are We to the Clinical Dose?

Historical Highlights Session

Historical Highlights Session: Thematic Track

Translational Toxicology

• Translating Toxicology to Public Health Protection: Lessons Learned from Superfund

Informational Sessions

• Impact of Tungsten and Tungsten Alloys on Health Risk
• Life-Stage Adjustment Five Years Later—Experiences from the Cancer Risk Assessment Field
• Recent Advances in Pulmonary Surfactant Toxicological Assessment and Therapeutics
• Seeking Funding for Undergraduate Research
• The 2009 Tennessee Fly Ash Spill: An Environmental Emergency Case Study

Informational Sessions: Thematic Track

Toxicity Testing in the 21st Century

• Human Hepatocytes Derived from Embryonic Stem Cells: A New Tool for In Vitro Toxicity Testing
• The Tox21st Community and the Future of Toxicology Testing

Translational Toxicology

• Measuring Immune Responses in Monkeys for Drug Development: Opportunities and Challenges for Predicting Human Efficacy and Immunotoxicity

Education/Career Development Sessions

• Career Alternatives in Toxicology: Lessons Learned
• Science Communication in 2010: A New Decade in Toxicology and Need for Better Communication
• Where Do I Go Now? Rational Career Development Planning for Early-Career Scientists

Regional Interest Session

• POPs: What’s New and Why Should We Care?