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The Drug Discovery Toxicology Specialty Section provides a forum for discussion of emerging technologies, predictive toxicology, safety pharmacology, target validation and safety assessment in a Discovery research environment. Drug Discovery Toxicology is a sub-specialty created to fulfill the growing need for incorporating predictive and integrative toxicological approaches early in drug discovery and development. Early application of these approaches is the key to identifying potential liabilities and providing necessary perspective that helps reduce attrition of drug candidates at later stages of the process. The overarching goal is to provide an integrated understanding of a drug candidate’s liabilities prior to its advancement into non-clinical development and clinical evaluation. This specialty section seeks to foster discussion and provide guidance around appropriate application of technologies and approaches that may refine or compliment traditional animal-based toxicology models. It also aims to identify gaps in novel and emerging technologies that require further development and application. To find out more information about DDTSS please contact Drew Badger.

As of July 2007, we have 305 members comprised of industry, academic, government, and student participants. Prospective members can be directed to the SOT website and enroll there. Alternatively, they can select this specialty section when dues are renewed. For more information, please contact the section’s secretary/treasurer, Mark Fielden

Drew Badger: President
Allergan

Kyle Kolaja: Vice President
Roche

John Davis: Vice President Elect  
Pfizer

Secretary/Treasurer: Mark Fielden 
Roche

Councilor: Greg Stevens
Pfizer

Councilor: Brian Gemzik
Bristol-Meyers Squibb

Councilor: Jim Stevens  
Eli Lilly and Company

Student Representative/Web liaison: Kim Henderson 
UCLA, PhD Program in Molecular Toxicology

Program Committee: Bruce Carr

2007 DDTSS Scientific Sessions (xls)

Accepted Courses and Sessions for 2008 (pdf)

Student Poster Competition—2008 Annual Meeting
First ($600), second ($300) and third (Gift Certificate) place prizes will be presented at the 2008 Annual Meeting. The competition is open to current graduate students whose abstract has been accepted by SOT for presentation at the 2008 Annual Meeting.  Applicants must submit a copy of the abstract and a letter of support from their dissertation advisor via e-mail to Mark Fielden mark.fielden@roche.com.  A selected set of applicants will be invited to present their posters during a special poster judging session distinct from the regularly scheduled poster sessions. Student winners will also be eligible to participate in 2008/2009 DDTSS as the Student Representative. To participate in the DDTSS Student Award competition, membership in SOT and/or DDTSS is encouraged but not necessary.  For more information, please contact Mark Fielden. The deadline for submission is March 1, 2008.

2007 SOT Meeting Poster Winners

First Place ($600)
Pat Shaw, Michigan State University, for his abstract titled “Co-exposure of mice to travofloxacin and lipopolysaccharide leads to an altered inflammatory response in a mouse model of idiosyncratic liver injury.” 

Second Place ($300)
Andy Lickteig, University of Arizona, for his abstract titled “Drug metabolizing enzymes, efflux transporter expression, and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic steatohepatitus.”

Third Place ($100)
Sumitra Sengupta, Oregon State University, for her abstract titled “Chemical genetic approaches to unravel the molecular pathways controlling regeneration.”

ByLaws (pdf)

ByLaws (word doc)

Winter 2007

DDTSS short communication July 2007

Winter 2006

Fall 2005

As a graduate student member of the DDTSS you will have the opportunity to network with professionals in the field of toxicology and compete for poster prizes. The benefits of being involved with DDTSS are not limited to students thinking about industry careers.

Any one interested in toxicology consulting, disease and pharmaceutical research, and health related government positions are impacted by drug discovery toxicology. Your first specialty section membership is FREE and you can sign up at any time through the SOT Web site. Contact the student representative, Kim Henderson or visit Specialty Section information on the SOT Web site for more information.

Specialty Section Student Communication

More to Come!

SOT Cruise Pictures 2006

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SOT 2007 Annual Meeting in Charlotte, N.C

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Contact SOT HQ for further questions.

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