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Mark your calendar SOT Annual Meeting March 11–15, 2012.

Risk Assessment Specialty Section

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RASS Award Winners

2011 Award Winners

RASS Perry J. Gehring Best Graduate Student Abstract Award

Student: Corrie Ellison
Advisor: James R. Olson
Title: Construction and validation of a human PBPK/PD model for dermal chlorpyrifos exposure utilizing human biomarker data
Authors: Corie A. Ellison¹, James B. Knaak¹, Robin McDougall², Pamela J. Lein 3,4, Fayssal M. Farahat5, W. Kent Anger³, James R. Olson¹
Affiliation: ¹University at Buffalo, Buffalo, NY; ²University of Ontario Institute of Technology, Oshawa, Canada; ³Oregon Health & Science University, Portland, OR; 4UC Davis School of Veterinary Medicine, Davis, CA; 5Menoufia University, Shibin el Kom, Egypt

RASS Perry J. Gehring Best Postdoctoral Fellow Abstract Award

Postdoc: Ben Moeller
Advisor: Jim Swenberg
Title: Molecular Dosimetry of N2-hydroxymethyl-dG Adducts Following Formaldehyde Exposure to Non-Human Primates
Authors: Benjamin C. Moeller¹, Kun Lu², Melanie Doyle-Eisele³, Jacob McDonald³, Andrew Gigliotti³, James A. Swenberg1,2
Affiliation: ¹Curriculum in Toxicology, University of North Carolina—Chapel Hill; ²Department of Environmental Sciences and Engineering, University of North Carolina—Chapel Hill; ³Lovelace Respiratory Research Institute, Albuquerque, NM

RASS Robert J. Rubin Student Travel Award

Student: P.K. Senthilkumar
Title: Telomere dysfunction and telomerase reactivation in human skin keratinocytes: a possible new mechanism of PCB carcinogenesis
Authors: P.K. Senthilkumar, A. Klingelhutz, L.W. Robertson, and G. Ludewig
Affiliation: Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA

RASS John Doull Award

Student: Mathieu Valcke
Advisor: Kannan Krishnan
Title: Evaluation of the impact of demography on the adequacy of the human kinetic adjustment factor (HKAF)
Authors: M. Valcke1,2, K. Krishnan¹
Affiliation: ¹Santé environnementale et Santé au travail, Université de Montréal, Montréal, QC, Canada; ²Direction de la Santé environnementale et de la Toxicologie, Institut national de santé publique du Québec, Montréal, QC, Canada.

Overall Best Abstract

Case Study on Dose-Responses for Mutagenicity and Clastogenicity Induced by DNA-Reactive Chemicals

Lynn H. Pottenger¹, Martha M. Moore², Tong Zhou³, Errol Zeiger4

  1. The Dow Chemical Company, Midland, MI, United States.
  2. U.S. FDA/NCTR, Jefferson, AR, United States.
  3. U.S. FDA/CVM, Rockville, MD, United States.
  4. Errol Zeiger Consulting, Chapel Hill, NC, United States.

Session: March 7, 2011, 9:30 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Poster Session Title: Genotoxicity
Abstract Final ID: 332 Poster Board -630

Top Ten Abstracts in Order of Presentation

Mode of Action (MOA) and Dose-Response Approaches for Nuclear Receptors

Dieter Schrenk5, Robert Budinsky¹, J. Christopher Corton³, Cliff Elcombe², James Klaunig4, Doug Wolf³

  1. Dow, Midland, MI, United States.
  2. CRX Biosciences, Dundee, Scotland, United Kingdom.
  3. U.S. EPA, Research Triangle Park, NC, United States.
  4. Indiana University, Indianapolis, IN, United States.
  5. University of Kaiserslautern, Kaiserslautern, Germany.

Session: March 7, 2011, 9:30 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Poster Session Title: Receptor and Receptor-Mediated Toxicity
Abstract Final ID: 367 Poster Board -724

Case Studies on the Role of DNA Adduct Data in Cancer Risk Assessment: Context Is Key

J. Skare¹, L. H. Pottenger², L. Andrews², A. Bachman³, P. J. Boogaard4, J. Cadet5, P. Farmer6, M. Himmelstein7, A. Jarabek8, J. Kim9, E. Martin10, R. Mauthe11, R. Persaud12, J. Preston8, R. Schoeny8, J. Swenberg13, G. Williams14, F. Zhang², E. Zeiger15

  1. Procter & Gamble, Cincinnati , OH, United States.
  2. The Dow Chemical Company, Midland, MI, United States.
  3. EMBSI, Annandale, NJ, United States.
  4. Shell International, The Hague, Netherlands.
  5. CEA/Grenoble, Grenoble, France.
  6. U. Leicester, Leicester, United Kingdom.
  7. DuPont, Newark, DE, United States.
  8. U.S. EPA, RTP, NC, United States.
  9. HESI, Washington, DC, United States.
  10. AstraZeneca, Macclesfield, United Kingdom.
  11. Pfizer, Groton, CT, United States.
  12. L’Oreal, Clark, NJ, United States.
  13. UNC, Chapel Hill, NC, United States.
  14. NY Medical College, Valhalla, NY, United States.
  15. E. Zeiger Consulting, Chapel Hill, NC, United States.

Session: March 7, 2011, 1:00 PM to 4:30 PM
Location: Exhibit Hall (Convention Center)
Poster Session Title: Risk Assessment: Computational Approaches, Analyses, and Applications
Abstract Final ID: 486 Poster Board -229

Use of a PBPK/PD Model to Derive Age-Specific Interspecies (UFA) and Interindividual (UFH) Uncertainty Factors for Chlorpyrifos

Paul S. Price¹, Paul M. Hinderliter², Torka S. Poet²

  1. Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, United States.
  2. Battelle Pacific Northwest Division, Richland, WA, United States.

Session: March 7, 2011, 4:27 PM to 4:45 PM
Location: Room 202B (Convention Center)
Session Title: Advancing Assessment Approaches: Pesticides and Other Key Contaminants
Session Type: Platform Session
Abstract Final ID: 866

Modeling Vapor Uptake and Tissue Disposition in Human Lungs

Madhuri Singal¹, Bahman Asgharian², Owen T. Price², Jeffry S. Schroeter³, Julia S. Kimbell4

  1. Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ, United States.
  2. Health Effects & Medical Response, Applied Research Associates, Raleigh, NC, United States.
  3. Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, United States.
  4. Department of Otolaryngology/Head and Neck Surgery, University of North Carolina, Chapel Hill, NC, United
    States.

Session: March 9, 2011, 1:00 PM to 4:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Risk Assessment: Models and Approaches for Inhaled Agents
Session Type: Poster Session
Abstract Final ID: 2289 Poster Board -435

Dose-Response of Naphthalene—Induced Genotoxicity and Glutathione Detoxification in Human TK6 Lymphoblasts

Leslie Recio¹, Kim Shepard¹, Carol Swartz¹, Gregory Kedderis²

  1. ILS, Research Triangle Park, NC, United States.
  2. Consultant, Chapel Hill, NC, United States.

Session: March 8, 2011, 1:00 PM to 4:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Mutagenecity
Session Type: Poster Session
Abstract Final ID: 1421 Poster Board -319

Molecular Dosimetry and Half Life of N2-hydroxymethyl-dG Adduct in Rats Exposed to Formaldehyde

Kun Lu ¹, Benjamin Moeller², Melanie Doyle-Eisele³, Jacob McDonald³,James A. Swenberg1,2

  1. Environmental Sciences and Engineering , University of North Carolina, Chapel Hill, NC, United States.
  2. Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, United States.
  3. Lovelace Respiratory Research Institute, Albuquerque, NM, United States.

Session: March 8, 2011, 1:00 PM to 4:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Biomarkers of Environmental Exposures
Session Type: Poster Session
Abstract Final ID: 1690 Poster Board -934

Corn Oil as a Causative Factor for Proliferative Lesions of the Forestomach in B6C3F1 Mice Exposed by Gavage

Laura M. Plunkett¹, Tom Starr², Judith A. MacGregor³, Ann M. Jonyas4

  1. Integrative Biostrategies LLC, Houston, TX, United States.
  2. TBS Associates, Raleigh, NC, United States.
  3. Toxicology Consulting Services, Arnold, MD, United States.
  4. Amvac Chemical Corporation, Newport Beach, CA, United States

Session: March 9, 2011, 9:00 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Risk Assessment: Conceptual Constructs and Current Controversies
Session Type: Poster Session
Abstract Final ID: 1964 Poster Board -438

Arsenic Risk Assessment Following Removal of Constraining Factors—Reference Population and Median Exposure Metric

Steven H. Lamm1,2, Shayhan Robbins¹, Jun Lu³, Chao Zhou, RusanChen4, Manning Feinleib5

  1. Epidemiology, Consultants in Epidemiology and Occupational Health (CEOH), Washington, DC, United States.
  2. Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
  3. Mathematics, American University, Washington, DC, United States.
  4. Center for New Design in Learning and Scholarship, Georgetown University, Washington, DC, United States.
  5. Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Session: March 9, 2011, 9:00 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Risk Assessment: Conceptual Constructs and Current Controversies
Session Type: Poster Session
Abstract Final ID: 1939 Poster Board -413

Estimating Toxicity-Related Biological Pathway Altering Doses for High Throughput Chemical Risk Assessments

Richard Judson¹, David J. Dix¹, Kavlock J. Robert¹, R. Woodrow Setzer¹, Elaine A. Cohen Hubal¹, Matthew T. Martin¹

  1. U.S. EPA, Research Triangle Park, NC, United States.

Session: March 9, 2011, 10:24 AM to 10:45 AM
Session Location: Room 147 (Convention Center)
Session Title: QSAR Approaches and Predictive Pathways
Session Type: Platform Session
Abstract Final ID: 1813

Sub-chronic naphthalene inhalation causes a decrease in p53 codon 271 CAT mutant fraction in the nasalrespiratory epithelium of male rats

Fanxue Meng¹, Yiying Wang¹, Meagan B. Myers¹, Brian A. Wong²,Elizabeth A. Gross², Harvey J. Clewell³, Darol E. Dodd², Barbara L. Parsons¹

  1. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, United States.
  2. Division of Toxicology and Preclinical Studies, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, United States.
  3. Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, United States.

Session: March 9, 2011, 9:00 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Session Title: Risk Assessment: Conceptual Constructs and Current Controversies
Session Type: Poster Session
Abstract Final ID: 1953 Poster Board -427

Best Published Paper Demonstrating an Application of Risk Assessment

Pouillot R, Delignette-Muller ML. 2010. Evaluating variability and uncertainty separately in microbial quantitative risk assessment using two R packages. International Journal of Food Microbiology 142(3):330–40.

Top Ten Publications

Andersen ME, Clewell HJ 3rd, Bermudez E, Dodd DE, Willson GA, Campbell JL, Thomas RS. 2010. Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. Toxicological Sciences 118(2):716–31.

Aylward LL, Kirman CR, Blount BC, Hays SM. 2010. Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)—application of steady-state PBPK model solutions. Regulatory Toxicology and Pharmacology 58(1):33–44.

Kumar A, Xagoraraki I. 2010. Human health risk assessment of pharmaceuticals in water: an uncertainty analysis for meprobamate, carbamazepine, and phenytoin. Regulatory Toxicology Pharmacology 57(2–3):146–56.

Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicological Sciences 116(2):441–51.

Magee B, Samuelian J, Haines K, Chappel M, Penn I, Chin D, Anders D, Hinz J. 2010. Screening-level population risk assessment of nasal tumors in the US due to naphthalene exposure. Regulatory Toxicology and Pharmacology 57(2–3):168–80.

Mörk AK, Johanson G. 2010. Chemical-specific adjustment factors for intraspecies variability of acetone toxicokinetics using a probabilistic approach. Toxicological Sciences 116(1):336–48.

Simon T, Aylward LL, Kirman CR, Rowlands JC, Budinsky RA. 2010. Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Toxicological Sciences 112(2):490–506.

Valdez-Flores C, Sielken RL Jr, Teta MJ. 2010. Quantitative cancer risk assessment based on NIOSH and UCC epidemiological data for workers exposed to ethylene oxide. Regulatory Toxicology and Pharmacology 56(3):312–20.

Yang JM, Salmon AG, Marty MA. 2010. Development of TEFs for PCB congeners by using an alternative biomarker—thyroid hormone levels. Regulatory Toxicology and Pharmacology 56(2):225–36.

Best Published Paper Advancing the Science of Risk Assessment

Louisse J, de Jong E, van de Sandt JJ, Blaauboer BJ, Woutersen RA, Piersma AH, Rietjens IM, Verwei M. 2010. The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man. Toxicological Sciences 118(2):470–84.

Top Ten Publications

Bercu JP, Jolly RA, Flagella KM, Baker TK, Romero P, Stevens JL. 2010. Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens. Regulatory Toxicology and Pharmacology 58(3):369–81.

Billington R, Lewis RW, Mehta JM, Dewhurst I. 2010. The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides. Critical Reviews in Toxicology 40(1):35–49.

Dellarco VL, Rowland J, May B. 2010. A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals. Critical Reviews in Toxicology 40(1):16–23.

Dorne JL. 2010. Metabolism, variability and risk assessment. Toxicology 268(3):156–64.

Ginsberg G, Foos B, Dzubow RB, Firestone M. 2010. Options for incorporating children’s inhaled dose into human health risk assessment. Inhalation Toxicology 22(8):627–47.

Hasegawa R, Hirata-Koizumi M, Dourson ML, Parker A, Sweeney LM, Nishikawa A, Yoshida M, Ono A, Hirose A. 2010. Proposal of new uncertainty factor application to derive tolerable daily intake. Regulatory Toxicology and Pharmacology 58(2):237–42.

Luke NS, Sams R 2nd, DeVito MJ, Conolly RB, El-Masri HA. 2010. Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. Toxicological Sciences 115(1):253–66.

Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. 2010. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological Sciences 117(2):348–58.

Teunis PF, Kasuga F, Fazil A, Ogden ID, Rotariu O, Strachan NJ. 2010. Dose-response modeling of Salmonella using outbreak data. International Journal of Food Microbiology 144(2):243–9.

Zhang Q, Bhattacharya S, Andersen ME, Conolly RB. 2010. Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. Journal of Toxicology and Environmental Health, Part B Critical Reviews 13(2–4):253–76.

View the Historical Listing of the RASS Award Winners

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