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Risk Assessment Specialty Section

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RASS Award Winners

2010 Award Winners

2010 RASS Perry J. Gehring Best Student Abstract Award

ID 143 Poster Board—225. Distribution and Molecular Dose of Inhalation-derived and Endogenous Formaldehyde DNA Adducts Support Causation of Nasal Carcinoma, but not Leukemia
K. Lu 1; L. B. Collins1; H. Ru2; E. Bermudez3; J. A. Swenberg1

  1. Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, United States.
  2. Department of Statistics and Operation Research, University of North Carolina, Chapel Hill, NC, United States.
  3. The Hamner Institutes for Health Sciences, Research Triangle Park, NC, United States.

2010 Perry J. Gehring Best Postdoctoral Fellow Abstract Award

ID 1384 Development of a Rat Gestation PBPK Model for PFOA/PFOS.
A. E. Loccisano1; Y. Tan2; M. E. Andersen1; H. J. Clewell1

  1. The Hamner Institutes, RTP, NC, United States.
  2. USEPA, RTP, NC, United States.

2010 RASS Best Overall Abstract Award

ID 2205 Nuclear Receptor (CAR/PXR) Humanized Mouse Models to Investigate Nongenotoxic Hepatocarcinogenesis
C. R. Elcombe1

CXR Biosciences Ltd, Dundee, United Kingdom. 

Additional RASS Top 10 Best Abstracts

ID 247 Poster Board—548.  Nine and Ten Chemical Haloacetic Acid Mixtures Exhibit Concentration-Dependent Departure from Dose Additivity   
J. Simmons1; C. Dingus2; E. D. Wagner3; L. K. Teuschler4; G. E. Rice4; M. J. Plewa3

  1. ORD/NHEERL, U.S. EPA, Research Triangle Park, NC, United States.
  2. Batelle, Columbus, OH, United States.
  3. Univ. of Illinois, Urbana, IL, United States.
  4. ORD/NCEA, U.S. EPA, Cincinnati, OH, United States.

ID 250 Poster Board – 603.  In vitro-in vivo extrapolation of the human dose-response relationship for cellular perturbations by a binary mixture of toluene (TOL) and n-hexane (HEX)
K. Krishnan1; T. Peyret1

  1. DSEST, Université de Montréal, Montréal, QC, Canada.

ID 37  The additivity to background argument for low-dose linearity—Is it viable?
K. S. Crump1

  1. Mathematics and Statistics, Louisiana Tech University, Ruston, LA, United States.

ID 40  Noncancer Toxicity Potential at Low Doses: Background Processes Considered Statistically and Biologically
L. R. Rhomberg1

  1. Gradient, Cambridge, MA, United States.

ID 542  High-Throughput Screening for Hazard and Risk of Environmental Contaminants
D. J. Dix1

  1. U.S. EPA, Research Triangle Park, NC, United States.

ID 857 Poster Board— 505.  Feasibility of the F1-extended-one generation reproduction toxicity study
L. Sheets1; I. Fegert2; S. Schneider2; B. van Ravenzwaay2; B. Stahl3; R. Lewis4; P. Botham4; T. Hanley5; R. Billington6; E. Carney7

  1. Toxicology, Bayer CropScience, RTP, NC, United States.
  2. Toxicology, BASF, Ludwigshafen, Germany.
  3. Toxicology, Bayer CropScience, Sophia-Antipolis, France.
  4. Toxicology, Syngenta, Raleigh, NC, United States.
  5. Toxicology, Syngenta, Greensboro, NC, United States.
  6. Toxicology, Dow AgroSciences, Abingdon, United Kingdom.
  7. Toxicology, Dow Chemical, Midland, MI, United States.

ID 1351 Need for a New Approach to Genetic Toxicity Assessment: Lessons Learned and New Opportunities
J. T. MacGregor1

  1. Toxicology Consulting Services, Arnold, MD, United States.

ID 1354 Beyond Positive or Negative: A Quantitative Approach for Interpreting Genotoxicity Data
B. Gollapudi1

  1. Dow Chemical Company, Midland, MI, United States.

ID 1914 Poster Board—524.  Evaluation of the magnitude of toxicokinetic inter-individual variability factor (IVF-TK): impact of subpopulations and chemical characteristics
M. Valcke1; K. Krishnan1

  1. Sante environnementale et sante au travail, Universite de Montreal, Montreal, QC, Canada
    Presented : Wednesday, March 10,  1:00-4:30, Exhibit Hall

ID 1939 Poster Board—601.  Mode of Action For the Cancer Risk Assessment of Ingested Hexavalent Chromium: Identifying and Resolving Data Gaps
C. Thompson1; D. Proctor2; L. Haws2; M. A. Harris1

  1. ToxStrategies, Inc., Katy, TX, United States.
  2. ToxStrategies, Austin, TX, United States.

Outstanding Published Paper in 2009 for Advancing the Science of Risk Assessment

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW.

Mouse Population-Guided Resequencing Reveals that Variants in CD44 contribute to
Acetaminophen-Induced Liver Injury in Humans.

Genome Research. 2009 Sep;19(9):1507-15.

Past Award winners for 2005–2008 are provided below.

2009 Award Winners

Outstanding Published Paper in 2009 Demonstrating an Application of Risk Assessment

DeSesso JM, Watson RE, Keen CL, Hazelden KP, Haws LC, Li AA.

Analysis and Integration of Developmental Neurotoxicity and Ancillary Data into Risk Assessment:
A Case Study of Dimethoate.

Journal of Toxicology and Environmental Health. 2009;72(2):94–109

Honorable Mention—Published Paper for Advancing the Science of Risk Assessment

Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals. Thomas RS, Bao W, Chu TM, Bessarabova M, Nikolskaya T, Nikolsky Y, Andersen ME, Wolfinger RD. Toxicol Sci. 2009 Dec;112(2):311–21.

Nonlinear cancer response at ultralow dose: A 40800-animal ED(001) tumor and biomarker study.
Bailey GS, Reddy AP, Pereira CB, Harttig U, Baird W, Spitsbergen JM, Hendricks JD, Orner GA, Williams DE, Swenberg JA. Chem Res Toxicol. 2009 Jul; 22(7):1264–76.

Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity. Taxvig C, Elleby A, Sonne-Hansen K, Bonefeld-Jørgensen EC, Vinggaard AM, Lykkesfeldt AE, Nellemann C Nutr Cancer. 2010;62(1):122–31.

Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamide.
Zeiger E, Recio L, Fennell TR, Haseman JK, Snyder RW, Friedman M. Toxicol Sci. 2009 Jan;107(1):247–57.

Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone.
Mörk AK, Jonsson F, Johanson G. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):423–32.

Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics.            Simon T, Aylward LL, Kirman CR, Rowlands JC, Budinsky RA. Toxicol Sci. 2009 Dec;112(2):490–506.

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management.
Warheit DB, Reed KL, Sayes CM. Inhal Toxicol. 2009 Jul;21 Suppl 1:61–7.

Dose-response modeling of high-throughput screening data.
Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. J Biomol Screen. 2009 Dec;14(10):1216–27.

CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW. Toxicol Appl Pharmacol. 2009 May 15;237(1):119–26.

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.
Goetz AK, Dix DJ. Toxicol Appl Pharmacol. 2009 Jul 1;238(1):80–9.

Honorable Mention—Published Papers Demonstrating an Application of Risk Assessment

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans. Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Toxicol Sci. 2009 Feb;107(2):544-52.

Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice.
Sweeney LM, Kirman CR, Gargas ML, Dugard PH. Toxicology. 2009 Jun 16;260(1-3):77-83.

Development of a unit risk factor for 1,3-butadiene based on an updated carcinogenic toxicity assessment.
Grant RL, Haney J, Curry AL, Honeycutt M. Risk Anal. 2009 Dec;29(12):1726-42.

Using biomonitoring equivalents to interpret human biomonitoring data in a public health risk context.
Hays SM, Aylward LL. J Appl Toxicol. 2009 May;29(4):275-88.

Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?
Valberg PA, Bruch J, McCunney RJ. Regul Toxicol Pharmacol. 2009 Jun;54(1):72-83.

Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7).
Aylward LL, Hays SM, Gagné M, Krishnan K. Regul Toxicol Pharmacol. 2009 Dec;55(3):249-58.

Development of a quantitative microbial risk assessment for human salmonellosis through household consumption of fresh minced pork meat in Belgium. Bollaerts KE, Messens W, Delhalle L, Aerts M, Van der Stede Y, Dewulf J, Quoilin S, Maes D, Mintiens K, Grijspeerdt K. Risk Anal.
2009 Jun;29(6):820-40.

Establishing a point of departure for risk assessment using acute inhalation toxicology data.
Rusch GM, Bast CB, Cavender FL. Regul Toxicol Pharmacol. 2009 Aug;54(3):247-55.

Derivation of biomonitoring equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). Aylward LL, Hays SM, Gagné M, Krishnan K.
Regul Toxicol Pharmacol. 2009 Dec;55(3):259-67.

Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Cunningham VL, Binks SP, Olson MJ. Regul Toxicol Pharmacol. 2009 Feb;53(1):39-45.

 

2009 RASS Perry J. Gehring Best Student Abstract Award

#1472 An assessment of the impact of exposure route on the interindividual variability factor (IVF) for drinking water contaminants (DWCs)
M. Valcke1, 2; K. Krishnan1

  1. Santé environnementale et santé au travail, Université de Montréal, Montréal, QC, Canada.
  2. Institut national de santé publique du Québec, Montréal, QC, Canada.

2009 RASS Perry J. Gehring Best Postdoc Abstract Award

# 1097 Independent validation of gene expression-based hepatocarcinogenicity prediction models
S. Auerbach1; D. Mav2; R. Shah2; M. K. Vallant1; N. J. Walker1; G. A. Boorman1; R. D. Irwin1

  1. NTP, NIEHS, Research Triangle Park, NC, USA.
  2. SRA International. Inc., Research Triangle Park, NC, USA.

2009 Best Risk Assessment Abstract

# 440 Translating in vitro estrogenic assay results to ecological risk assessment
C. Mori1; S. Thakali1; A. Tarrant2; M. Sharma1; H. Yekel3; T. Verslycke1

  1. Gradient Corporation, Cambridge, MA, USA.
  2. Woods Hole Oceanographic Institution, Woods Hole, MA, USA.
  3. Wyeth Pharmaceuticals, Malvern, PA, USA.

Poster Board 308
Location: Exhibit Hall
Time of Presentation: Mar 16 1:00 PM–1:00 PM
Category: Ecotoxicology, (Risk Assessment), (Safety Assessment: Pharmaceutical)

2009 Top 10 Risk Assessment Abstracts (Ordered by presentation date)

# 55 Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice
L. D. Burgoon1, 2, 5; Q. Ding1, 2, 3; A. N'jai1, 2, 3; E. Dere1, 2, 3; J. Rowlands4; R. A. Budinsky4; K. E. Stebbins4; T. R. Zacharewski1, 2, 3

  1. Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, USA.
  2. National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, USA.
  3. Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
  4. The Dow Chemical Company, Midland, MI, USA.
  5. Toxicogenomic Informatics and Solutions, LLC, Lansing, MI, USA.

# 467 Assessing the Influence of Dietary Manganese Variability and Inhaled Exposure by Pharmacokinetic Modeling
A. Nong1; M. D. Taylor2; D. C. Dorman1, 3; M. E. Andersen1; H. J. Clewell1

  1. The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA.
  2. Afton Chemical Corporation, Richmond, VA, USA.
  3. College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

# 477 Use of a physiologically based pharmacokinetic (PBPK) model to predict tissue disposition in pigs fed melamine.
J. L. Buur1; R. E. Baynes2; J. E. Riviere1

  1. College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA.
  2. Center for Chemical Toxicology and Pharmacokinetics, NCSU, Raleigh, NC, USA.

# 479 Age- and gender-structured distributions for physiological parameters: assessment of human variability in the exposure-internal-dose relationship for dichloromethane (DCM)
P. M. Schlosser1; A. Bale2; G. S. Cooper2

  1. NCEA, U.S. EPA, RTP, NC, USA.
  2. NCEA, U.S. EPA, Washington, DC, USA.

# 564 Evaluating Neurotoxicity of a Mixture of Five OP Pesticides Using a Composite Score
E. Nyirabahizi1; C. Gennings1; V. C. Moser2

  1. Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.
  2. Neurotoxicology Division, U.S. EPA-NHEERL, Research Triangle Park, NC, USA

# 719 Comparison of quantum dot biodistribution with blood flow-limited physiologically based pharmacokinetic model
H. A. Lee1; T. L. Leavens1; S. E. Mason1; N. A. Monteiro-Riviere1; J. E. Riviere1

  1. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC,

# 1201 Cryptosporidium exposure and recreational water contact in persons with HIV/AIDS in Baltimore, Maryland
C. C. McOliver1; E. K. Silbergeld1; T. K. Graczyk1

  1. Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

# 1275 The relationship between the IC50, toxic threshold, and the magnitude of stimulatory response in biphasic (hormetic) dose-responses
M. A. Nascarella1, 2; E. J. Calabrese2

  1. Gradient Corporation, Cambridge, MA, USA
  2. Environmental Health Sceinces, University of Massachusetts Amherst, Amherst, MA, USA.

# 1473 Your results may vary: exploring the sensitivity of titanium dioxide risk estimates to different modeling assumptions
D. A. Dankovic1; E. D. Kuempel1; M. W. Wheeler1

  1. Risk Evaluation Branch, CDC/NIOSH, Cincinnati, OH, USA.

2008 Award Winners

2008 Best Publication Advancing the Science of Risk Assessment:

Andersen ME, Clewell HJ 3rd, Bermudez E, Willson GA, Thomas RS., 2008. Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. Toxicol Sci. 105(2):368-83.

Rest of Top 10 Publications in 2008 Advancing the Science of Risk Assessment:

Clewell HJ, Tan YM, Campbell JL, Andersen ME., 2008. Quantitative interpretation of human biomonitoring data. Toxicol Appl Pharmacol. 231(1):122-33.

Hays SM, Aylward LL, LaKind JS, Bartels MJ, Barton HA, Boogaard PJ, Brunk C, DiZio S, Dourson M, Goldstein DA, Lipscomb J, Kilpatrick ME, Krewski D, Krishnan K, Nordberg M, Okino M, Tan YM, Viau C, Yager JW., 2008. Guidelines for the derivation of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop. Regul Toxicol Pharmacol. 51(3 Suppl):S4-15.

Kostich MS, Lazorchak JM., 2008. Risks to aquatic organisms posed by human pharmaceutical use. Sci Total Environ. 389(2-3):329-39.

Leslie M. Shama and Robert K. D. Peterson., 2008. Assessing Risks of Plant-based Pharmaceuticals: I. Human Dietary Exposure. Hum Ecol Risk Assess. 14(1):179-193.

Moore MM, Heflich RH, Haber LT, Allen BC, Shipp AM, Kodell RL., 2008. Analysis of in vivo mutation data can inform cancer risk assessment. Regul Toxicol Pharmacol. 51(2):151-61.

Rice G, MacDonell M, Hertzberg RC, Teuschler L, Picel K, Butler J, Chang YS, Hartmann H., 2008. An approach for assessing human exposures to chemical mixtures in the environment. Toxicol Appl Pharmacol. 233(1):126-36.

Swenberg JA, Fryar-Tita E, Jeong YC, Boysen G, Starr T, Walker VE, Albertini RJ., 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol. 21(1):253-65.

Willhite CC, Ball GL, McLellan CJ., 2008. Derivation of a bisphenol A oral reference dose (RfD) and drinking-water equivalent concentration. J Toxicol Environ Health B Crit Rev. 11(2):69-146.

Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller M, Miller GG, Schwartz JM, Alexeeff G, Anderson H, Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, Foster PM, Germolec DR, Gray E, Hattis DB, Kyle AD, Luebke RW, Luster MI, Portier C, Rice DC, Solomon G, Vandenberg J, Zoeller RT., 2008. Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ Health Perspect. 116(11):1568-75.

Yoon M, Barton HA., 2008. Predicting maternal rat and pup exposures: how different are they? Toxicol Sci. 102(1):15-32.

2008 Best Publication Demonstrating an Application of Risk Assessment:

Ginsberg GL, Asgharian B, Kimbell JS, Ultman JS, Jarabek AM., 2008. Modeling approaches for estimating the dosimetry of inhaled toxicants in children. J Toxicol Environ Health 71(3):166-95.

Rest of Top 10 Publications in 2008 Demonstrating an Application of Risk Assessment:

Aylward LL, Lakind JS, Hays SM., 2008. Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context. J Toxicol Environ Health 71(22):1499-508.

Berman DW, Crump KS., 2008. A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type. Crit Rev Toxicol. 38 Suppl 1:49-73.

Bogen KT., 2008. An adjustment factor for mode-of-action uncertainty with dual-mode carcinogens: the case of naphthalene-induced nasal tumors in rats. Risk Anal. 28(4):1033-51.

Burgoon LD, Zacharewski TR., 2008. Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets. Toxicol Sci.104(2):412-8.

Burns FJ, Rossman T, Vega K, Uddin A, Vogt S, Lai B, Reeder RJ., 2008. Mechanism of selenium-induced inhibition of arsenic-enhanced UVR carcinogenesis in mice. Environ Health Perspect. 116(6):703-8.

Cullen AC, Corrales MA, Kramer CB, Faustman EM., 2008. The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach. Risk Anal. 28(4):877-90.

Lu Y, Rieth S, Lohitnavy M, Dennison J, El-Masri H, Barton HA, Bruckner J, Yang RS., 2008. Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane. Regul Toxicol Pharmacol. 50(2):249-60.

Schroeter JD, Kimbell JS, Gross EA, Willson GA, Dorman DC, Tan YM, Clewell HJ 3rd., 2008. Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal Toxicol. 20(3):227-43.

Zhang Q, Pi J, Woods CG, Jarabek AM, Clewell HJ, Andersen ME., 2009. Hormesis and adaptive cellular control systems. Dose Response 6(2):196-208.

2007 Award Winners

2007 Overall Best Risk Assessment Abstract and Top Eleven

Best Risk Assessment Abstract:
#1482 “Visual Function Changes after Subchronic Toluene Inhalation in Long-Evans Rats” William Boyes, Laura Degn, Mark Bercegeay, Jean-Claude Mwanza, Charles Pinckney, Tracey Samsam, Andrew Geller, Philip Bushnell, USEPA

Best Graduate Student Abstract:
#623 “Cross-Species Association Mapping Identifies Genetic Risk Factors for Liver Toxicity” Alison I. Hege, University of North Carolina
Advisor: Ivan Rusyn

Best Postdoctoral Abstract:
#1606 “Characterization of Sensitivity of Risk Estimates to Uncertainties Associated with Biologically Based Modeling of Formaldehyde Carcinogenicity.”Yu-Ching Yang, CIIT Centers for Health Research
Advisor: Harvey Clewell

“Top Ten” Risk Assessment Abstracts:

#386 "Physiologically-motivated pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys and rats“, Cecilia Tan, CIIT Centers for Health Research

#399 "Improved physiological realism in PBPK modeling for variability analysis: A case study with ethanol“, Jeffry Schroeter, CIIT Centers for Health Research

#401 "Experimental and computational approaches to evaluate respiratory tract uptake and dosimetry of hexamethylene diisocyanate in rats“, Bahman Asgharian, CIIT Centers for Health Research

#781 “Interpretation of biomonitoring data for toluene: Use of PBPK modeling”, Lesa Aylward, Summit Toxicology

#1074 "Prediction of airflow and particle deposition in the human lung“, Kambiz Nazirdoust, CIIT Centers for Health Research

#1606 "Characterization of sensitivity of risk estimates to uncertainties associated with biologically based modeling of formaldehyde carcinogenicity“, Yu-Ching Yang, CIIT Centers for Health Research

#1684 "Physiologically-based pharmacokinetic (PBPK) modeling of inhaled manganese in rats“, Andy Nong, CIIT Centers for Health Research

#1690 "Bayesian physiologically based pharmacokinetic / pharmacodynamic (PBPK/PD) modeling of mixed route exposure of carbaryl." Harvey Clewell, CIIT Centers for Health Research

#1693 “Modeling the toxicokinetics of inhaled toluene in rats: The impact of feeding status, physical activity and strain." Elaina Kenyon, USEPA/NHEERL

#2002 "Non-linear exposure-response relationships between ambient PM10 and daily mortality. " Teresa Bowers, Gradient Corp.

#2042 “Old principles in a new field: particokinetics affects size- and time-dependent toxicity of nano-silica in macrophages“, Justin Teeguarden PNL

2006 Award Winners

2006 Best Published Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Yu, Xiaozhong; Griffith William C; Hanspers Kristina; Dillman James F; Ong Hansel; Vredevoogd Melinda A; Faustman Elaine M. 2006. A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences; Aug. 92 (2) p560–77.

  • Brandon, Esther F A; Oomen, Agnes G;Rompelberg, Cathy J M; Versantvoort, Carolien H M; van Engelen, Jacqueline G M; Sips, Adrienne J A M. 2006. Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment. Regulatory toxicology and pharmacology; Mar; 44 (2) p161–71.
  • Chiu, Weihsueh A; White, Paul. 2006. Steady-state solutions to PBPK models and their applications to risk assessment I: Route-to-route extrapolation of volatile chemicals. Risk analysis;Jun;26 (3) p769–80.
  • Goldbohm, R. Alexandra, Tielemans, Erik L.J.P., Heederik, Dick, Rubingh, Carina M., Dekkers, Susan, Willems, Marianne I. and Kroese, E. Dinant. 2006. Risk estimation for carcinogens based on epidemiological data: A structured approach, illustrated by an example on chromium. Regulatory Toxicology and Pharmacology. 44(3): 294–310.
  • Nong, A. McGarver, DG, Hines, RN., Krishnan, K. 2006. Modeling interchild differences in pharmacokinetics on the basis of subject specific data on physiology and hepatic CYP2E1 levels: A case study with toluene. Toxicology and Applied Pharmacology. 214:78–87.
  • Pery, Alexandre R R; Geffard Alain; Garric Jeanne. 2006. Mechanistic models to perform population risk assessment with the midge Chironomus riparius: application to heavy metals. Environmental science & technology; Oct 1;40 (19) p6026–31.
  • Rhomberg, L.R. And T.A. Lewandowski. 2006. Methods for identifying a default cross–species scaling factor. Human and Ecological Risk Assessment: 12: 1094–1127.
  • Sander P; Bergback B; Oberg T. 2006. Uncertain numbers and uncertainty in the selection of input distributions— Consequences for a probabilistic risk assessment of contaminated land. Risk Analysis. 26:(5):1363–1375.
  • Wu YP; Piegorsch WW (REPRINT); West RW; Tang DF; Petkewich MO; Pan W;2006. Multiplicity–adjusted inferences in risk assessment: Benchmark analysis with continuous response data. Environmental and Ecological Statistics;13:125 –141.

2006 Best Published Paper Demonstrating Application of Risk Assessment and Top Ten

Winner: Cox, Louis Anthony Tony;Sanders, Edward. 2006. Estimating preventable fractions of disease caused by a specified biological mechanism: PAHs in smoking lung cancers as an example. Risk Analysis. 26 (4) p881–92.

  • David, Raymond M;Clewell, Harvey J;Gentry, P Robinan;Covington, Tammie R;Morgott, David A;Marino, Dale J. 2006. Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations. Regulatory toxicology and pharmacology.45 (1) p55–65.
  • Dorman, David C;Struve, Melanie F;Clewell, Harvey J; Andersen, Melvin E.2006. Application of pharmacokinetic data to the risk assessment of inhaled manganese. Neurotoxicology;27 (5) p752–64.
  • Hack C Eric;Chiu Weihsueh A;Jay Zhao Q;Clewell Harvey J. 2006. Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. Regulatory toxicology and pharmacology. 46 (1) p63–83.
  • Hall, Jane R;Ashmore, Mike;Fawehinmi, Joseph;Jordan, Crawford;Lofts, Stephen;Shotbolt, Laura;Spurgeon, David J; Svendsen, Claus; Tipping, Edward. 2006. Developing a critical load approach for national risk assessments of atmospheric metal deposition. Environmental toxicology and chemistry.25 (3) p883–90.
  • Shao, Andrew and Hathcock, John N. 2006. Risk assessment for creatine monohydrate. Regulatory toxicology and pharmacology 45(3):242–251.
  • Sutter, Carrie Hayes, Rahman, Mostafizur and Sutter, Thomas R. 2006. Uncertainties related to the assignment of a toxic equivalency factor for 1,2,3,4,6,7,8,9–octachlorodibenzo–p–dioxin. Regulatory toxicology and pharmacology 44(3): 219–225.
  • Zartarian, VG; Xue, JP; Ozkaynak, H; Dang, W; Glen, G; Smith, L; Stallings, C. 2006. A probabilistic arsenic exposure assessment for children who contact CCA–treated playsets and decks, part I: Model methodology, variability results, and model evaluation. Risk Analysis. 26(2): 515–531.

2006 Overall Best Risk Assessment Abstract and Top Eleven

Winner: #901. Benchmark Dose Evaluation for Human Irritation. G.V. Alexeeff, K.K. Deng, R. Broadwin and A.G. Salmon. OEHHA, Cal/EPA.

#934. Assessment of Prenatal Development in PBDE Exposed Rats Sufficient or Marginal in Vitamin A. R. Ellis-Hutchings, G. Cherr and C. Keen. University of California Davis.

#882. Evaluation of the RD50 for determining acceptable levels of exposure to airborne sensory irritants. Y. Kuwabara, G.V. Alexeeff, R.L. Broadwin, and A.G. Salmon. OEHHA.

#792. Genetic Polymorphisms of Human N-acetyltransferase 2 Influence the Bioactivation of Aromatic and Heterocyclic Amines. Y. Zang, M.A. Doll, J. States and D.W. Hein. Pharmacology and Toxicology and Brown Cancer Center, University Louisville.

#51. Neighborhood environmental stress modifies the effect of lead on cognition: The Baltimore Memory Study. T. A. Glass, K. Bandeen-Roche, M. McAtee, and B.S. Schwatrz. Epidemiology, Johns Hopkins Bloomberg Scholl of Public Health.

#2382. Bayesian analysis of the inhalation pharmacokinetics of methyl tert-butyl ether (MTBE) and its metabolite tert-butanol in humans.A. Nong, L. Ernstgard, K. Krishnan and G. Johanson. Occupational and Environmental Health University de Montreal.

#2378. Improved Physiological Realism in PBPK Modeling for Variability Analysis: A Case Study with Ethanol. S. M. Hays and R.S. DeWoskin. Summit Toxicology.

#2339. Acute Hemodynamic and Hemolytic Effects of Intravenously Administered Ethylene Glycol in the Pig. R. Brown, D. Way-Cahen, A. Lucas, A. Steen, H. Baskar, J. Dux, and M. Stratmeyer. FDA/CDRH

#1641. Systems Biology Models For Integration Of Diverse Studies Of The Developing Neocortex After Exposure To Low Dose Radiation From External And Internal Sources. W. C. Griffith, N.M. DeFrank, J.M. Gohlke, E.J. Gribble, and E.M. Faustman. Environmental and Occupational Health Sciences, University of Washington.

#1633. The absorption and metabolism of inhaled benzo(a)pyrene in the isolated and perfused rat lung does not increase linearly with increasing exposures . P. Ewing, A. Ryrfeldt and P. Gerde. Environmental medicine. Karolinska Institute.

#1270. Using a PBPK Model to Explore Mechanisms of Observed Pharmocokinetic Differences of Phthalates across Life-Stages in Rats. R.A. Clewell, J. Kremer, M. Anderson and S. Borghoff. Environmental Sciences and Engineering. University of North Carolina at Chapel Hill.

#1256. Relation Of Urinary Metabolites Of Inorganic Arsenic With Transforming Growth Factor Alpha Concentration In Bladder Urothelial Cells From A Population Environmentally Exposed To Inorganic Arsenic. O.L. Valenzuela, D.R. Germolec, E.A. Garcia-Montalvo, L.C. Sanchez-Pena, A. Hernandez-Zavala, and L.M. Del Razo. Toxicology, Cinvstav, Mexico.

2006 Winner Best Graduate Student Abstract Award

#1207. Utilizing Human Cytochrome P450 Specific Content and Activity to Better Model Parathion and Chlorpyrifos Metabolism In Infants, Children, and Adults. R.J. Foxenberg, J.B. Knaak, B.P. McGarrigle, P.J., Kostyniak and J.R. Olson. Pharmacology and Toxicology, SUNY at Buffalo.

2006 Winner Best Postdoc Student Abstract Award

#646. Normal Gene Expression In Male And Female Sprague Dawley Rat Nasal Respiratory And Olfactory Epithelia. E. S. Roberts, N.V. Soucy, A.M. Bonner and D.C. Dorman. CIIT.

2005 Award Winners

2005 Winner Best Risk Assessment Abstracts and Top Ten

Winner:# 2110. Improved Dosimetric Adjustment Factors for Interspecies Extrapolation of Inhaled, Poorly Soluble Particles. B. Asgharian; O. Price; A. Jarabek; F. Miller

#377. A Framework/Approach for Incorporating PBPK Modeling into Cumulative Risk Assessment of Chemical Mixtures. R. Yang; J. Dennison; J. Lipscomb

#381. Risk Assessment in Nephrotoxicology Sensitivity of Renal Tests. P. Potnis; A. Maier; T. Guidotti

#402. Incorporation of Trichloroacetic Acid Plasma Binding in Human and Mouse in Trichloroethylene Risk Assessment. D. Keys; M. Lumpkin; J. Bruckner; J. Fisher

#404. Monte Carlo Analysis of Sources of Variability in Chloroform-induced Hepatic Cytolethality and Regenerative Proliferation in B6c3f1 Mice. Y. Tan; R. Conolly

#349. An integrated QSAR-PBPK model for simulating pharmacokinetics of chemicals in mixtures. K. Price; K. Krishnan

#847. A Harmonized PBPK Model for Trichloroethylene Risk Assessment . T. Covington; H. Clewell; J. Fisher; D. Keys; C. Hack; J. Zhao

#866. Validation of a Human Physiologically-Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data. P. Hinderliter; K. Thrall; R. Corley; L. Bloemen; B. Matthew

#1096. Assessment of neurotoxicity using zebrafish as a model organism. N. Roy; C. Ton; Y. Lin; C. Parng

#1304. A Mechanistic Model of Lifetime Cancer Risk for Inhalation Exposures to Reactive Gases. J. Kimbell; D. Kalisak; R. Conolly; F. Miller; A. Jarabek

#1934. Evaluation of Systemic Toxicity in Mixtures of Trichloroethylene (TCE), Heptachlor (HEPT), and Di(2-ethylhexyl)phthalate (DEHP) Assessed in a 5x5x5 Design. J. Simmons; S. Yeatts; J. Zhao; C. Gennings; A. McDonald; R. MacPhail

2005 Winner Best Student Risk Assessment Abstract

Rat Kidney injury molecule-1 (rKim–1) ELISA: A sensitive assay for early detection of kidney tubular injury in preclinical toxicity studies. V. Vaidya; T. Ichimura; J. Bonventre, Harvard Medical School, Brigham and Women’s Hospital. (Abstract 197)

Awards for Best Published Papers in Risk Assessment

2005 Best Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Simmons, J. E., Evans,M. V., and Boyes, W. K. (2005). Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. J Toxicol. Environ. Health A 68(11–12), 927–950.

  • Allen, B., Zeiger, E., Lawrence, G., Friedman, M., and Shipp, A. (2005). Dose-response modeling of in vivo genotoxicity data for use in risk assessment: some approaches illustrated by an analysis of acrylamide. Regul. Toxicol. Pharmacol 41(1), 6–27.
  • Beliveau, M., Lipscomb, J., Tardif, R., and Krishnan, K. (2005). Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals. Chem. Res. Toxicol. 18(3), 475–485.
  • Bosgra, S., Bos, P. M., Vermeire, T. G., Luit, R. J., and Slob, W. (2005). Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate. Regul. Toxicol. Pharmacol 43(1), 104–113.
  • Clewell, H. J., Gentry, P. R., Kester, J. E., and Andersen, M. E. (2005). Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene. Crit Rev. Toxicol. 35(5), 413–433.
  • Clewell, H. J., and Crump, K. S. (2005). Quantitative estimates of risk for noncancer endpoints. Risk Anal. 25(2), 285–289.
  • Corley, R. A., Grant, D. M., Farris, E., Weitz, K. K., Soelberg, J. J., Thrall, K. D., and Poet, T. S. (2005). Determination of age and gender differences in biochemical processes affecting the disposition of 2-butoxyethanol and its metabolites in mice and rats to improve PBPK modeling. Toxicol. Lett. 156(1), 127–161.
  • Jarabek, A. M., Asgharian, B., and Miller, F. J. (2005). Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP). Inhal. Toxicol. 17(7–8), 317–334.
  • Preston, R. J. (2005). Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints. Environ. Mol. Mutagen. 45(2–3), 214–221.
  • Simmons, J. E., Evans, M. V., and Boyes, W. K. (2005). Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. J Toxicol. Environ. Health A 68(11–12), 927–950.
  • Slob, W., Moerbeek, M., Rauniomaa, E., and Piersma, A. H. (2005). A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints. Toxicol. Sci 84(1), 167–185.

2005 Best Paper Demonstrating the Application of Risk Assessment and Top Ten:

Winner: Walker, N. J., Crockett, P. W., Nyska, A., Brix, A. E., Jokinen, M. P., Sells, D. M., Hailey, J. R., Easterling, M., Haseman, J. K., Yin, M., Wyde, M. E., Bucher, J. R., and Portier, C. J. (2005). Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113(1), 43–48.

  • Axelrad DA et al. (2005). Risk assessment for benefits analysis: framework for analysis of a thyroid-disrupting chemical. J Toxicol Environ Health 68(11–12), 837–855.
  • Collins, J. F., Salmon, A. G., Brown, J. P., Marty, M. A., and Alexeeff, G. V. (2005). Development of a chronic inhalation reference level for respirable crystalline silica. Regul. Toxicol. Pharmacol 43(3), 292–300.
  • Dennison, J. E., Bigelow, P. L., Mumtaz, M. M., Andersen, M. E., Dobrev, I. D., and Yang, R. S. (2005). Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling. J Occup. Environ. Hyg. 2(3), 127–135.
  • Fukushima, S., Kinoshita, A., Puatanachokchai, R., Kushida, M., Wanibuchi, H., and Morimura, K. (2005). Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 26(11), 1835–1845.
  • Jeffrey, A. M., and Williams, G. M. (2005). Risk assessment of DNA-reactive carcinogens in food. Toxicol. Appl. Pharmacol 207(2 Suppl), 628–635.
  • Kirman, C. R., Sweeney, L. M., Corley, R., and Gargas, M. L. (2005). Using physiologically-based pharmacokinetic modeling to address nonlinear kinetics and changes in rodent physiology and metabolism due to aging and adaptation in deriving reference values for propylene glycol methyl ether and propylene glycol methyl ether acetate. Risk Anal.
  • Kirman, C. R., Gargas, M. L., Marsh, G. M., Strother, D. E., Klaunig, J. E., Collins, J. J., and Deskin, R. (2005). Cancer dose-response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity. Regul. Toxicol. Pharmacol 43(1), 85–103.
  • Mielke, H., Gundert, A., Abraham, K., and Gundert-Remy, U. (2005). Acute inhalative exposure assessment: derivation of guideline levels with special regard to sensitive subpopulations and time scaling. Toxicology 214(3), 256–267.
  • Schwarz, M., and Appel, K. E. (2005). Carcinogenic risks of dioxin: mechanistic considerations. Regul. Toxicol. Pharmacol 43(1), 19–34.
  • Teeguarden, J. G., Deisinger, P. J., Poet, T. S., English, J. C., Faber, W. D., Barton, H. A., Corley, R. A., and Clewell, H. J., III (2005). Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid. Toxicol. Sci 85(1), 429–446.
  • Walker, N. J., Crockett, P. W., Nyska, A., Brix, A. E., Jokinen, M. P., Sells, D. M., Hailey, J. R., Easterling, M., Haseman, J. K., Yin, M., Wyde, M. E., Bucher, J. R., and Portier, C. J. (2005). Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113(1), 43–48.

2004 Award Winners

2004 Winner Best Risk Assessment Abstract

Winner: Approaches for Converting Adult Dose to Children of Various Age Groups: Relevance for the Risk Assessment of Environmental Chemicals by B. Gohore and K. Krishnan (Abstract 1770)

2004 Winner Best Student Abstract Award

Impaired Signal Trafficking Failed On-Demand Liver Tissue Repair Upon Hepatotoxic Challenge in Type 2 Diabetes by A.V. Sawant, J.R. Latendresse, and H.M. Mehendale. (Abstract 512)

2004 Best Published Paper Demonstrating Application of Risk Assessment and Top Ten

Winner: Kirman CR, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini RJ and Gargas ML (2004) Addressing non-linearity in the exposure-response relationships for a genotoxic carcinogen: cancer potency estimates for ethylene oxide. Risk Analysis 24: 1165–1183.

  • Babich MA, Chen SB, Greene MA, Kiss CT, Porter WK, Smith TP, Wind ML, Zamula WW. (2004). Risk assessment of oral exposure to diisononyl phthalate from children’s products. Regul. Toxicol. Pharmacol. 40(2): 151–67.
  • Booze TF, Reinhardt TE, Quiring SJ and Ottmar RD. (2004). A screening level assessment of the health risks of chronic smoke exposure for wildland firefighters. Journal of Occupational and Environmental Hygiene 1: 296–305.
  • Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J and Miller FJ. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: dose response predictions from biologically-motivated computational modeling of as combined rodent and human dataset. Toxicological Sciences 82: 279–296.
  • Farrrow S. (2004). Using risk assessment, benefit-cost analysis, and real options to implement a precautionary principle. Risk Anal. 24(3): 727–35.
  • Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM. (2004). Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. Toxicol. Sci. 79(1): 28–37.
  • Renwick AG. (2004). Establishing the upper end of the range of adequate and safe intakes for amino acids: a toxicologist’s viewpoint. J. Nutr. 134(6 Suppl): 1617S–1624S.
  • Schoen A, Beck B, Sharma R and Dubé E. (2004) Arsenic toxicity at low doses: epidemiological and model of action considerations. Toxicology and Applied Pharmacology 198: 253–267.
  • Sweeney LM, Andersen ME and Gargas ML. (2004). Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically-based nasal dosimetry model. Toxicological Sciences 79: 394–403.
  • Tsuji JS, Benson Rj, Schoof RA, Hook GC. (2004). Health effect levels for risk assessment of childhood exposure to arsenic. Regul. Toxicol. Pharmacol. 39(2): 99–110.

2004 Best Published Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker NJ, Martinez J, Portier CJ.(2004). Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta. Environ. Health Perspect. 112(12): 1217–

  • Ashani Y and Pistinner S. (2004). Estimation of the upper limit of human butrylchloinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model. Toxicological Sciences 77: 358–367.
  • Clark LH, Setzer RW and Barton HA. (2004) Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Analysis 24: 1697.
  • Calabrese EJ (2004). Hormesis: from marginalization to mainstream: a case for hormesis as the defaul dose-response model in risk assessment. Toxicol. Appl. Pharmacol. 197: 125–136.
  • Conolly RB and Lutz WK. (2004). Nonmonotonic dose response relationships: mechanics basis, kinetic modeling and implications for risk assessment. Toxicological Sciences 77: 153–157.
  • Dorne JL, Walton K, Renwick AG. (2004). Human variability in the renal elimination of foreign compounds and renal excretion–related uncertainty factors for risk assessment. Food Chem. Toxicol. 42(23): 275–98.
  • Englehardt JD (2004) Predictive Bayesian dose–response assessment for appraising absolute health risk from available information. Human and Ecological Risk Assessment 10: 69–78.
  • Gaylor DW and Aylward LL. (2004). An evaluation of benchmark dose methodology for noncancer continuous data health effects in animals due to exposed to dioxin. Regulatory Toxicology and Pharmacology 40: 9–17.
  • Gaylor DW, Lutz WK and Conolly RB. (2004). Statistical analysis of nonmonotonic dose-response relationships: research design and analysis of nasal cell proliferation in rats exposed to formaldehyde. Toxicological Sciences 77: 158–164.
  • Razzaghi M and Kodell R. (2004) Quantitative risk assessment for developmental neurotoxic effects. Risk Analysis 24: 1673.

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