Title

1982

The role of cellular redox balance in Toxicity

1983

Alcohol metabolism and hepatotoxicity

1984

Mechanisms of species differences in the toxicity of chemicals

1987

Poster discussion sessions:

Mechanisms of TCDD toxicity

Oxygen toxicity

1988

Immunologic and genetic mechanisms in carcinogenesis

1989

Mechanisms of lung injury by systemically administered chemicals

1993

Selective inhibitors of cytochrome P-450

1994

New advances in mechanisms of lethal cell injury

The biliary tree: A target for chemically-induced injury and proliferation

1995

Is carnitine a key toxicological target?

Compartmentation of glutathione:Implications for the study of toxicity and disease

Selective protein covalent binding and target organ toxicity.


Water chlorination: Essential process or cancer hazard?

Mechanisms of inflammatory liver injury.

Adhesion molecules and cytotoxicity of neutrophils

1996

Oxidative stress and glutathione redox status in mechanisms of developmental embryotoxicity

Mitochondrial mediated cell injury.

Sphingolipids: the enigmatic lipid class

1997

Cell signaling and cell injury

Neuroreceptor subtypes involved in cognition

Toxicity of non-coplanar PCBs

Genetic polymorphisms in human drug metabolic enzymes

Nephrotoxicity: Basic mechanisms and recent advances

Techniques for determining genetic polymorphisms

1998

Role of nitric oxide in chemical-induced toxicity

The role of glutathione in neuroprotection and neurotoxicity

Mitochondrial membrane permeability changes in necrotic and apoptotic cell death

Cellular and molecular pathways in apoptosis and necrosis

1999

The role of quinones in toxicology

Molecular and cellular mechanisms of antioxidant action

The role of DNA repair in maintenance of genome stability

Chemical Modifiers of response to food-borne microbial pathogens

Exogenous estrogens as carcinogens: metabolic activation through oxidative mechanisms

Xenobiotic effects on cell adhesion molecules and extracellular matrix interactions

Workshop: Carcinogenicity of cigarette smoke: bridging the gap between complex mixtures and individual components

Workshop: Endocrine disruption and neurotoxicity: why toxicologists should be concerned about the actions of estrogenic chemicals in the CNS

Innovations in Toxicological Sciences: Regulation of gene expression via the electrophile response element

2000

Molecular approaches to the studies of glutathione metabolism and function

Advances in the use of mechanism-based biomarkers in risk assessment

Workshop: Fritz Haber and his impact on Toxicology

Inhalation, Occupational Health, Risk Assessment

Innovations in Toxicology Session: Role of co-repressors and co-activators in regulation of soluble receptor mediated transcription

CE Course: Molecular approaches to a comprehensive understanding of cardiotoxicity

CE Course: Rodent toxicity and nongenotoxic carcinogenesis: Knowledge-based human risk assessment from molecular mechanisms

Sunrise Session: Introduction to proteomics

Sunrise Session: A new approach to drug toxicity screening using NMR spectroscopy. Pattern recognition and experts systems

2001

CE Course: Liver Toxicology

Symposium: Proteomics and Functional Genomics in Toxicology

Symposium: Genetic Polymorphisms in DNA Repair and Cancer Risk

Symposium: Pharmacogenomics and Drug Metabolism

Symposium: Mechanisms of Hepatotoxicity

Symposium: Toxic, Catalytic and Protective Mechanisms of Phenoxy Radical Intermediates

Symposium:  Methods for Indentifying Potential Breast Carcinogens

Symposium:  Molecular Mechanism of Xenobiotic-Induced Autoimmunity

Symposium:  Cellular and Molecular Mechanisms of Ocular Toxicity:  Oxidative Stress, Calcium Overload and Lipid Derangements

2002

CE Course: Two-stepping Through Toxicogenomics. A Basic Primer

CE Course: Alterations in Gene Expression as a Mechanism of Toxicant Action

CE Course: Toxicity Profiling of Genes and Proteins by Toxicologists. Advanced Topics in Toxicogenomics

Innovations In Toxicological Sciences: Toxicological Application of Metabonomics Technology

Symposium: Imaging the Mitochondrial Permeability Transition Pore in Toxic Injury

Symposium: Regulation of the Ah Receptor Signal Transduction Pathway

Symposium: Thioredoxins/Thioredoxin Reductases: Central Roles in Toxicity and Cancer

Symposium:: Molecular Models of Smoking-Induced Immune Suppression

Symposium: Defining the Cellular and Molecular Mechanisms of Toxicant Action in the Testis

Symposium: Molecular Mechanisms of Chemical Teratogenesis

Workshop: Perfluorooctanesulfonate: Risk Characterization of a Persistent and Pervasive Fluorochemical

Workshop: Examples of Rodent Nongenotoxic Mechanisms of Neoplasia

Workshop: Application of Genomics for Mechanism-Based Risk Assessment

2003

CE Course: Unfolding the Secrets in Culturing Brain Cells: Theory, Techniques, and Beyond

CE Course: Genomic and Proteomic Array Formats on the Cutting-Edge

Workshop: Dose-Dependent Transitions in Toxic Mechanisms

Workshop: Vanilloid Receptors: Mediators of Respiratory Injury

Symposium: Understanding Mechanisms of Toxicity of Immunosuppressive Drugs to Improve and Broaden the Scope of Their Use

Symposium: Free Radicals in the Toxicity of Alcohols

Symposium: Stress Activated Signal Transduction Pathways

Symposium: Innovations in Toxicological Sciences: Beyond Genomics: Image Analysis and Computational Biology

Symposium: Innovation in Applied Toxicology: Genomic and proteomic Analysis of Surrogate Tissues for Assessing Toxic Exposures and Disease States

2004

CE Course: Basic Neurotoxicology

Workshop: Nutraceuticals as Double-edged Swords: Weighing Benefits and Risks of Dietary Chemicals to Human Health

Symposium: Steroid Inactivation: Alternative Mechanisms of Endocrine Toxicity

Symposium: Gene Expression Influences on Metal Immunomodulation

Symposium: Mechanisms of Cardiovascular Toxicity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Halogenated Aromatic Hydrocarbons

Symposium: New Developments in Oxidative Phospholipid Signaling in Apoptosis and Phagocytic Regulation of Inflammatory Response

Symposium: Arsenic Disruption of Cell Cycle: Mechanisms and Effects on Apoptosis, Differentiation and Carcinogenesis

Symposium: Use of Molecular Approaches to Examine Mechanisms of Neurotoxicity

Symposium: Molecular Profiling and Computer Modeling in Early Detection and Treatment of Cancer

2005

CE Course: Evaluation of Cardiac Drug Toxicity in Pharmaceutical Discovery and Development

Workshop: Role of Nutrigenomics in Safety Assessment of Functional Foods

Symposium: Nucleosytoplasmic Trafficking in Mechanisms of Toxicity

Symposium: Proteomics and Antibody Microarrays: Applications in Toxicology

Symposium: Molecular Pathways to Toxicant-Induced Osteoporosis

Symposium: Biomarkers of Oxidative Stress: New Prospects and Approaches

Symposium: Role of Cell-Cell and Cell-Matrix Interactions in Regulation of Toxicant-Mediated Cell Death

Symposium: The Ubiquitin-Proteasome System as a Biological Target in Toxic Responses and Disease

Symposium: Developmental Expression of Human Phase I and Phase II Toxicant Metabolizing Enzymes: Impact on Early Life State Susceptibility

2006

CE Course: Use of Genome Databases for Toxicology

CE Course: Essentials of Metal Toxicology

CE Course: Functional Analysis of Gene and Protein Expression: From Experimental Design to Data Analysis

Workshop: Towards the Virtual Human: Adding more Physiological Detail to Biologically-Based Models

Workshop: Comprehensive Responses of Lipids Classes to Toxicants and involvement in Diseases

Symposium: Advancing Toxicology by Improving Linkage of Traditional Toxicity and Pathology Endpoints with Toxicogenomics

Symposium: Mode of Action Associated with Induction of Endothelial Cell Tumors – Hemangiosarcoma

Symposium: New Insights into Mechanisms of Cell Death and Survival

Symposium: Role of Mitochondria in Toxic Oxidative Stress

Symposium: Gene-Nutrient-Envieoment-Interactions as Risk Factors for Birth Defects: Fumonisin, Folate, Genetic Variation and Neural Tube Defects

Symposium: Obesity as a Modulator of Chemical Toxicity

Symposium: The Role of MAP Kinases in Metal Toxicity

Symposium: Determinants of Manganese Neurotoxicity: From Worms to Man

Symposium: The Path for Assessing Human Relevance and Advancing New Safety Biomarkers for Drug Induced Vascular Injury

Symposium: Role of Epigenetics in the Fetal Basis of Adult Disease

2007

Symposium: Application of Humanized Mouse Lines to Toxicological and Pharmacological Studies

Symposium: Non-Classical Mechanisms of Receptor-Mediated Transcription

Symposium: Mechanistic Biomarkers and Innovative Methodologies to Detect Acute Kidney Injury

Symposium: Critical Roles of C-Activators and Co-Repressors During Transcriptional Activation by Xenobiotic Receptors

Symposium: Emerging Technologies for Imaging for Toxicology

Symposium: The Vascular System as a Target of Metal Toxicity

Symposium: Biliary Hyperplasia and Cholestasis: Relevance to Human Risk Assessment

Symposium: Epigenetic Regulation in Development, Reproduction and Disease: Implications for Toxicology

Symposium: Cardiovascular Effects of Inhaled Ultra-fine and Fine Particles in Human Volunteers

Symposium: Aging as a Modulator of Chemical Toxicity

Symposium: Impact on Drug Development and Regulatory Review of the Qualification of Novel Safety Biomarkers by the Predictive Safety Testing Consortium

Workshop: Methods for Investigating Skin Irritation

Workshop: Advances and Challenges in Incorporation of Mode of Action in Human Health Risk Assessment

Workshop: Advances in Causation and therapy of Parkinson and Parkinson-Like Movement Disorders: Views from Toxicologists and Clinicians

Workshop: Can Species and Strain Differences in Dioxin Sensitivity be Explained by Differences in the AH Receptor?

Workshop: Target-Based Toxicity of Novel Pharmaceutical Targets

2008

Symposium: Molecular Basis of Susceptibility to Chemical Toxicity and Disease

Symposium: New Developments in Liver Tumor Biology

Symposium: Drug-Induced Mitochondrial Toxicity: Novel Insights-Novel Tools

Symposium: Environmental Influence on Female Puberty and Breast Tumorigenesis

Symposium: Stem Cells: New Tools for Neurotoxicologists

Symposium: Molecular and Genomic Insights into the Nrf-2-Regulated Oxidative Stress Response: Impact on Carcinogenesis

Symposium: New Concepts in the Etiology of Breast Cancer: From Genes to Environment and Back Again

Symposium: Endothelial Dysfunction: More Than Just a ‘No NO’ Phenomenon

Symposium: Neurotoxicant-Induced Alterations in Developmental and Adult Neurogenesis: Structure-Function Studies and Clinical Relevance

Symposium: Arsenic and Cardiovascular Disease

Symposium: Cellular Redox Status and Zinc Signaling

Workshop: Current Perspectives on Ocular and Systemic Safety Risks of Therapeutics

Roundtable: The Future of Toxicology

Informational Session: Detection of Biological Free Radicals in Time and Space