Building for Better Decisions:
Multi-Scale Integration of Human Health
and Environmental Data

May 8–11, 2012
US EPA, Research Triangle Park, North Carolina

Meeting Materials

In an effort to be environmentally conscious, registrants are encouraged to use the online B4BD resources to view conference materials. Use these options to download materials to your computer, smartphone, or tablet.

Index

Abstracts Submissions	Organizing Committee
Accommodations/Travel Information	Invited Presenters
Poster Instructions	Registration Information
Program	Sponsors

Background

Protecting human health and the environment from chemicals or other environmental stressors involves analysis, translation, and integration of information from sources to transport, including characterization of exposure and effect pathways. With technological advances, the scientific community faces increased challenges to harness increasingly larger and more complex datasets in evaluating the potential for ecological impacts and to more accurately predict factors that contribute to illness or diagnose disease. To face theses challenges, scientists now need more than ever the ability to integrate data at different scales of impact, and for the output from computational tools in one discipline (e.g., exposure modeling) of the exposure-dose-response continuum to serve as input to modeling tools in another (e.g., dose-response analysis). The need for integrating and managing large amounts of data in a rigorous and transparent fashion is not unique to a particular discipline. There is a wealth of information to be gained from the interaction between involved scientific communities, including biomedical informatics, evidence-based medicine, regulatory science, and the Defense and Intelligence communities.

Objectives

This international conference will provide a unique opportunity to convene scientists from different sectors (government, industry, and academia), across the exposure-dose-response continuum for both ecological and health endpoints, and from other communities (e.g., clinical/biomedical informatics, defense, and intelligence) to discuss data interoperability, data integration, data management and model interface needs with software developers, software engineers, database architects and administrators, and data analysts.

Experts from these arenas will be brought together to discuss and explore the requirements for data accessibility, data storage, data management, data analysis, and data interoperability that are becoming increasingly critical for computational modeling, research, and regulatory decision making. Technology and design issues that transcend disciplines and that could exercise the science and organizational infrastructure required to ensure the success of these scientific endeavors and data integration will also be examined.

It is envisioned that the presentations of perspectives from these arenas will help to advance the application of data from emerging technologies in an integrated fashion to inform health and environmental-based decision making. Ultimately this exchange of information between scientists across multiple disciplines will inform how to advance applications of toxicological data in future risk assessment endeavors and ensure interoperability of approaches and data across the public and private sectors.

Specific issues to be discussed at the meeting include:

• Best practices for each major discipline
• Data access, integration, management and computational modeling needs to advance each discipline
• Ensuring transparency and data integrity
• Recommendations for data and model interoperability standards

Products

The benefits of this workshop will be universal to scientists involved in all aspects of the application of data for decision making that range from exposure to outcome, including expanded contact and possible development of collaborations among participants. The workshop will serve not only computational scientists that are focused on organizing and modeling data, but will also benefit scientists involved in understanding the relevance of data developed from new technologies and the application of them for decision making. The recommendations anticipated to result from this interdisciplinary dialogue will increase the transparency of data use and application across disciplines involved in safety/risk assessment.

Specific products will thus be to advance the understanding of the state-of-the-science for application and translation of clinical, toxicological, and environmental data in comprehensive risk characterizations. Proceedings of the meeting will be published as a set of disciplinary best practice perspectives and a summary of consensus positions on recommendations for standards on interoperability and computational systems to support data integration across the spectrum of exposure to impact.

Abstract and Poster Information

Abstract Submissions

Note: The abstract submission system deadline has passed. You may upload a poster for a previously submitted abstract here:

Upload Poster (Deadline May 8, 2012)

The Building for Better Decisions abstracts will be published on a secure website for the meeting attendees to access and to download. All accepted abstract presenters will be given the option to upload their Poster Presentations to the same site. Additionally, the abstracts will be available in booklet form.

Abstracts should describe the aims of the work, methods, and the key experimental findings in a clear and succinct manner. Brevity is important. All abstracts will be reviewed for scientific content and the Organizing Committee reserves the right to refuse abstracts that do not adhere to publication guidelines. It is hoped that abstracts and posters will be the first presentations of the study represented; however, abstracts previously presented at national/international meetings are welcomed.

All posters will be presented during a reception on the evening of Wednesday, May 9, 2012.

Please note that acceptance notifications will not be made until after all of the abstracts are reviewed. Notifications will be sent out by April 2, 2012.

Abstract Submission Deadline: Friday, March 23, 2012

Poster Information

Poster Instructions

Poster Presentation Date and Time: Wednesday, May 9, 2012, from 5:30 pm–7:30 pm

Poster Set-up and Tear-down Dates and Times: The posters will be displayed in a separate building immediately adjacent to the US EPA conference center where the reception will be held on Wednesday evening. Posters can put up anytime on Wednesday, May 9. 

For the B4BD meeting, SOT is asking poster presenters to provide SOT with an electronic version of their poster for posting in a secure, online gallery after the meeting that only meeting attendees will be able to access.

Prior to the meeting attendees will be able to download accepted abstracts and poster presentations submitted by presenters.

Program

Day 1: Tuesday, May 8, 2012

7:45 AM–8:30 AM	Registration
8:30 AM–9:15 AM	Welcome Remarks Peter Preuss, US EPA, ORD, Chief Innovation Officer Malcolm D. Jackson, US EPA OEI Assistant Administration and Chief Information Officer Glenn Paulson, US EPA Office of the Administrator, Science Advisor
9:15 AM–9:30 AM	Workshop Overview Annie M. Jarabek, SOT CCT Co-Chair, US EPA ORD National Center for Environmental Assessment
9:30 AM–10:15 AM	Plenary and Sector Perspectives: Federal Perspective David Lyons, US EPA, ORD, Office of Science Information Management Roger G. Perkins, US FDA NCTR Pierre D. Glynn, US Geological Survey
10:15 AM–10:30 AM	Break
10:30 AM–11:30 AM	Thomas Nicholson, Nuclear Regulatory Commission Edward J. Perkins, US DOD Army Corps of Engineers Linda S. Birnbaum, Director, National Institute for Environmental Health Science Olaf David, USDA
11:30 AM–12:45 PM	Lunch
12:45 PM–3:00 PM	Industry/Private Sector Perspective George P. Daston, Proctor & Gamble Co. Jinghai (Jim) Xu, Merck and Co. Inc Paul S. Price, Dow Chemical Steve Bartell, E2 Consulting Engineers Inc. Academic Perspective Elaine M. Faustman, University of Washington Daniel Ames, Idaho State University Anthony (Tony) I. Wasserman, Carnegie Mellon University—Silicon Valley Russell Thomas, The Hamner Institutes for Health Sciences, University of North Carolina at Chapel Hill
3:00 PM–3:15 PM	Break
3:15 PM–5:15 PM	NGO Perspective Topher Buck, GreenBlue Jennifer Sass, Natural Resources Defense Council Information Technology Perspective Roger V. Moore, OpenMI Luis Bermudez, Open GeoSpatial Consortium Bernadette Hyland, World Wide Web Consortium

Day 2: Wednesday, May 9, 2012

8:00 AM–8:20 AM	Disciplinary and Interdisciplinary Discussions Disciplinary Directions and Charge to Breakout Groups Robinan Gentry, SOT CCT Co-Chair, ENVIRON International Corporation
8:20 AM–11:50 AM	Discipline Discussions Theme A: Exposure, Transport and Transformation Theme B: Ecological Risk, Ecosystem Services and Climate Change Theme C: Dose Response, Tox21 and Risk Theme D: Life Cycle/Multi-criteria Assessment and Cost: Benefit Analysis Theme E: Information Technology Disciplinary and interdisciplinary breakout groups will be asked to address the following discussion questions during Days 2 and 3 of the workshop (link not yet available). The answers within a discipline will be used to develop a plenary report presented on Day 3 and the best practice perspective (manuscript) for each. Evaluation of the commonalities and differences across each discipline will serve to identify overarching issues and clarify recommendations regarding data integration and interoperability standards.
11:50 AM–1:00 PM	Lunch
1:00 PM–4:45 PM	Interdisciplinary Discussions Attendees may move from one discipline group to a second of their choosing to ensure the opportunity for diverse input to the theme discussions.
5:30 PM–7:30 PM	Poster Reception Posters illustrating best practice of data integration and analysis approaches submitted from attending participants for each theme will be available for review. Hors d’oevres and beverages will be served.

Day 3: Thursday, May 10, 2012

8:00 AM–10:00 AM	Discipline Discussions and Report Preparations
10:00 AM–10:30 AM	Break
10:30 AM–11:30 AM	Plenary Report and Discussion: Information Technology
11:30 AM–12:45 PM	Lunch
12:45 PM–1:45 PM	Plenary Report and Discussion: Theme A—Exposure, Transport, and Transportation
1:45 PM–2:45 PM	Plenary Report and Discussion: Theme B—Ecological Risk, Ecosystem Services, and Climate Change
2:45 PM–3:00 PM	Break
3:00 PM–4:00 PM	Plenary Report and Discussion: Theme C—Dose Response, Tox21, and Risk
4:00 PM–5:00 PM	Plenary Report and Discussion: Theme D—Life Cycle/Multi-criteria Assessment and Cost: Benefit Analysis
5:00 PM–5:30 PM	Recommendations Roundup Lyle D. Burgoon, SOT CCT Co-Chair, US EPA, ORD, National Center for Environmental Assessment
5:30 PM	Adjourn

Day 4: Friday, May 11, 2012

For Disciplinary Writing Team Only

	Breakfast
8:15 AM–8:45 AM	Recommendations Revisited
10:15 AM–10:45 AM	Break
10:45 AM–12:30 PM	Disciplinary Writing Team Meetings
12:30 PM	Adjourn

Breakout Groups

These theme groups will comprise the writing teams and be responsible for the “best practice/platform perspective” papers for that specific discipline area.

Note: The “Theme Ambassadors” will represent this theme when attending alternate theme meetings during the interdisciplinary breakout meeting time.

Theme A—Exposure, Transport, and Transformation

Theme A Lead:	Paul S. Price (Dow Chemical)
Ambassador to Theme B:	Olivier Jolliet (Univ Michigan)
Ambassador to Theme C:	Harvey Clewell (The Hamner Institutes for Health Sciences)
Ambassador to Theme D:	Sean Hays (Summit Toxicology)
IT Ambassador:	Bernadette Hyland (W3C)
Invited Perspective—Government:	Elaine Cohen Hubal (US EPA NCCT)
Invited Perspective—Industry:	Philip H. Howard (SRC, Inc.)
Invited Perspective—Academic:	H. Christopher Frey (NCSU)
NGO:	Topher Buck (GreenBlue)
Plenary Ambassador:	Olaf David (USDA)
*Rapporteur:	Brenda Barry (American Chemistry Council)

Interdisciplinary Discussion Members to Theme A:

Ambassador from Theme B:	Daniel Ames (Idaho State Univ.)
Ambassador from Theme C:	David M. Reif (US EPA NCCT)
Ambassador from Theme D:	Mitchell Small (Carnegie-Mellon University)

Theme B—Ecological Risk, Ecosystem Services, and Climate Change

Theme B Lead:	John Johnston (US EPA NERL)
Ambassador to Theme A:	Daniel Ames (Idaho State Univ.)
Ambassador to Theme C:	Pierre D. Glynn (USGS)
Ambassador to Theme D:	Bruce K. Hope (Oregon DEP)
IT Ambassador:	Scott Peckham (Univ. Colorado)
Invited Perspective—Government:	Edward J. Perkins (ACE)
Invited Perspective—Industry:	Katherine von Stackelberg (Harvard)
Invited Perspective—Academic:	Russell Thomas (Hamner Institutes/UNC Chapel Hill)
NGO:	Ed Zillioux (Environmental Bioindicators)
Plenary Ambassador:	Thomas Nicholson (NRC)
*Rapporteur:	Glenn W. Suter II (US EPA NCEA)

Interdisciplinary Discussion Members to Theme B:

Ambassador from Theme A:	Olivier Jolliet (Univ. Michigan)
Ambassador from Theme C:	Moiz Mumtaz (ATSDR)
Ambassador from Theme D:	Alexey Voinov (U. Twente; iEMSs)

Theme C—Dose Response, Tox21, and Risk

Theme C Lead:	Michael Waters (ILS Inc.)
Ambassador to Theme A:	David M. Reif (US EPA NCCT)
Ambassador to Theme B:	Moiz Mumtaz (ATSDR)
Ambassador to Theme D:	Michael Hucka (CalTech)
IT Ambassador:	Luis Bermudez (Open GeoSpatial Consortium)
Invited Perspective—Government:	George Thomas (DHHS)
Invited Perspective—Industry:	Jinghai (Jim) Xu (Merck and Co., Inc)
Invited Perspective—Academic:	Oliver Fiehn (UC Davis)
NGO:	Lynne Haber (TERA)
Plenary Ambassador:	Roger G. Perkins (US FDA NCTR)
IT Ambassador:	Clyde Ulmer (US FDA NCTR)
*Rapporteur:	Rory Conolly (US EPA NHEERL)

Interdisciplinary Discussion Members to Theme C:

Ambassador from Theme A:	Harvey Clewell (The Hamner Institutes for Health Sciences)
Ambassador from Theme B:	Pierre D. Glynn (USGS)
Ambassador from Theme D:	Thomas P. Seager (Univ. of Arizona)

Theme D—Life Cycle/Multi-Criteria Assessment and Cost: Benefit Analysis

Theme D Lead:	Bruce W. Vigon (SETAC)
Ambassador to Theme A:	Mitchell Small (Carnegie-Mellon University)
Ambassador to Theme B:	Alexey Voinov (U. Twente; iEMSs)
Ambassador to Theme C:	Thomas P. Seager (Univ. of Arizona)
IT Ambassador:	David Lyons (US EPA OSIM) Roger V. Moore (OpenMI)
Invited Perspective—Government:	Jane Bare (US EPA NRMRL)
Invited Perspective—Industry:	Steve Bartell (E2 Consulting)
Invited Perspective—Academic:	Scott M. Bartell (UC Irvine)
NGO:	Jennifer Sass (NRDC)
Plenary Ambassador:	Elaine M. Faustman (University of Washington)
IT Ambassador:	Clyde Ulmer (US FDA NCTR)
*Rapporteur:	Christina Powers (US EPA NCEA)

Interdisciplinary Discussion Members to Theme D:

Ambassador from Theme A:	Sean Hays (Summit Toxicology)
Ambassador from Theme B:	Bruce K. Hope (Oregon DEP)
Ambassador from Theme C:	Michael Hucka (CalTech)

Theme E—Information Technology

Theme E Lead:	David Lyons (US EPA OSIM)
IT Ambassador to Theme A:	Bernadette Hyland (W3C)
IT Ambassador to Theme B:	Scott Peckham (Univ. Colorado)
IT Ambassador to Theme C:	Luis Bermudez (Open GeoSpatial Consortium)
IT Ambassador to Theme D:	Roger V. Moore (OpenMI)
IT Plenary Ambassador:	Anthony (Tony) I. Wasserman, (Carnegie Mellon University—Silicon Valley)

Sponsors

The Society of Toxicology

Biological Modeling Specialty Section

Risk Assessment Specialty Section

American Chemistry Council

Environ Corporation

International Environmental Modelling & Software Society

ICF International

International Society of Exposure Sciences

Open Geospatial Consortium

OpenMI

Pacific Northwest National Laboratory

Society of Environmental Toxicology and Chemistry

Society for Risk Analysis

Dose Response Specialty Group of SRA

Toxicology Excellence for Risk Assessment

USACE/ERDC

US Department of Agriculture

US Environmental Protection Agency

US FDA NCTR

US Geological Survey

US Nuclear Regulatory Commission

Registration Information

Conference Fee is $200 US Dollars.

Fees include all general sessions, program materials, morning refreshments, breaks, and the poster reception.

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner’s Club, or American Express), or by a US Government Purchase Order (check must be drawn from the US Department of Treasury). Please use the registration form. All wire transfers should include an additional $40 processing fee.

Registration Form

To register, please send the registration form and payment or credit card information by one of the following methods:

1. Mail/USPS Express packages:
   B4BD CCT, Society of Toxicology
   1821 Michael Faraday Drive, Suite 300
   Reston, VA 20190
2. Fax: 703.438.3113
   

NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. SOT needs only one copy for processing.

Registration Deadline: After April 22, 2012, you must register on-site.

Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by May 1, 2012. These refunds will be processed, less a $30 fee, following the Meeting.

Organizing Committee

Co-Chairs

• Lyle D. Burgoon

Lyle D. Burgoon, PhD, is the Leader of the Systems Biology and Bioinformatics Team in the immediate office of the National Center for Environmental Assessment (NCEA) in the US EPA’s Office of Research and Development (ORD). Dr. Burgoon currently leads the implementation of NexGen at NCEA, working in collaboration with NCEA scientists to incorporate NexGen concepts into future NCEA risk assessments. He is also the NCEA matrix interface for the Chemical Safety for Sustainability (CSS) research action plan. As part of NexGen, he coordinates the translation of technology and data from ORD labs and centers into the next generation of risk assessments. Previously, he was at NHEERL, where he led the Biostatistics and Bioinformatics Research Core, developing novel computational methods for systems biology and knowledge management. Previous to that, he was faculty at Michigan State University, where his research program focused on high performance computing and network-based knowledge and inference, with special emphasis in systems biology and offensive cyberdefense research.

• Robinan Gentry

Robinan Gentry, PhD, DABT, a Principal Consultant with ENVIRON International Corporation, has over 20 years of experience in toxicological issues relevant in the determination of the potential safety or risk associated with exposure to chemicals in consumer products, pharmaceuticals or the environment. She has served an as officer in the Risk Assessment Specialty Section of the Society of Toxicology since 2009. Over her career, she has been a principal investigator or contributing author for numerous safety and risk assessments for both government and industry. The purpose for a number of these assessments has been to incorporate innovative quantitative approaches in the determination of acceptable levels of exposure of humans to chemicals in the environment, in pharmaceuticals, and in consumer products. She is a published author in the development of Physiologically Based Pharmacokinetic (PBPK) models, and their application into both the cancer and non-cancer risk assessment process. She has also been involved in projects using these types of models to investigate human variability by age and gender and the potential impact of this variation on risk assessment. Her recent work includes projects that are aimed at understanding the mode of action of adverse effects in animals and the implications to human health, as well as the development of innovative approaches that rely upon in vitro data and incorporation of these data into the risk assessment paradigm.

• Annie M. Jarabek

Annie M. Jarabek is a senior toxicologist in the immediate office of the National Center for Risk Assessment (NCEA) within the US EPA’s Office of Research and Development (ORD). Annie is the principal author of the US EPA’s Methods for Derivation of Inhalation Reference Concentrations (RfC) and Application of Inhalation Dosimetry, which introduced dosimetry and physiologically-based pharmacokinetic (PBPK) model structures and reduced forms into the RfC methods for interspecies adjustment. She has worked on several high-priority and interdisciplinary Agency assessments including the risk characterization of perchlorate ingestion and the inhalation of particulate matter (PM); and has served in an advisory capacity on other methods and assessments, including the guidance on body-weight scaling for harmonizing noncancer and cancer approaches for the interspecies adjustment of ingested chemicals. Her current research efforts focus on multi-scale modeling of dose-response and decision analysis. Annie has twice received awards for best manuscript in risk assessment application from the Risk Assessment Specialty Section (RASS) of the Society of Toxicology (SOT), along with several best abstract awards. She has also received the Lifetime Achievement Award from the University of Massachusetts, the Risk Practitioner of the Year award from the Society of Risk Analysis (SRA), the Superfund National Notable Achievement Award, and several award medals (1 gold, 1 silver and 5 bronze) and “S awards” for scientific leadership from the Agency for her various contributions. Annie has served as an elected Councilor to the Society for Risk Analysis and as the vice-president/president of the SOT RASS. Annie has also served the SOT on its awards, communications, nominations, and scientific program committees. She is currently on the editorial board of the international journal “Dose-Response.”

Members

• Richard A. Corley

Richard A. Corley, PhD, is a Laboratory Fellow in the Biological Sciences Division, Pacific Northwest National Laboratory (PNNL), Richland, WA. He received his PhD in Environmental Toxicology/Veterinary Biosciences from the University of Illinois in 1985 before joining The Dow Chemical Company’s Toxicology Research Laboratory; initially as a Postdoctoral Fellow in physiologically based pharmacokinetic (PBPK) modeling, and later as a scientist and group leader of the chronic toxicology and inhalation toxicology research groups. Since joining PNNL in 1996, Dr. Corley has worked to establish a multi-disciplinary research program in pharmacokinetic modeling and multi-scale computational toxicology. In that capacity, he continues to serve as a principle investigator or collaborator in government- and industry-sponsored studies to develop, validate, and apply biologically based computational models to reduce the uncertainties in target tissue dosimetry for human health risk assessments and improvements in therapeutic interventions. He currently directs a NIH/NHLBI-funded Bioengineering Research Partnership focused upon the development and validation of 3D, computational fluid dynamics models of the respiratory system to improve predictions of environment-disease interactions. He is also an Associate Director and Principle Investigator of a NIH/NIEHS U54 Center to develop new, modified protein biomarkers of inflammation and oxidative stress associated with the interactions between obesity and exposures to cigarette smoke under the NIH-wide Genes and Environment Initiative and is an Associate Director and Principle Investigator of a NIH/NIEHS Superfund Research Program to develop PBPK models for carcinogenic polycyclic aromatic hydrocarbons. He has served on several committees and advisory panels for the NAS, US EPA, ILSI, ATSDR, OTA, the former Chemical Industry Institute or Toxicology, as well as elected and appointed positions for the Society of Toxicology.

• George P. Daston

George P. Daston, PhD, is a Victor Mills Society Research Fellow at the Procter & Gamble Company. He has published over 100 articles and book chapters and edited five books in toxicology and risk assessment. His current research efforts are in the areas of toxicogenomics and mechanistic toxicology, particularly in addressing how findings in these fields can improve risk assessment for chemicals and the development of non-animal alternatives. Dr. Daston has served as President of the Teratology Society, Councilor of the Society of Toxicology, on the US EPA Board of Scientific Counselors, National Toxicology Program Board of Scientific Counselors, National Research Council’s Board of Environmental Studies and Toxicology, and National Children’s Study Advisory Committee. He is Editor-in-Chief of Birth Defects Research: Developmental and Reproductive Toxicology. Dr. Daston manages the AltTox website, which is devoted to the exchange of scientific information leading to the development of in vitro replacements for toxicity assessments. Dr. Daston has been awarded the Josef Warkany Lectureship by the Teratology Society, the George H. Scott Award by the Toxicology Forum, and was elected a Fellow of AAAS. Dr. Daston is an adjunct Professor of Pediatrics at University of Cincinnati.

• Edward J. Perkins

Edward J. Perkins, PhD, is a Senior Research Scientist (ST) in Environmental Networks and Genetic Toxicology in the US Army Corps of Engineers Engineer Research and Development Center (ERDC), Environmental Laboratory. Dr. Perkins received his PhD in Genetics and Cell Biology from Washington State University in 1987 studying the biodegradation of the herbicide 2, 4-D. Prior to joining ERDC, Dr. Perkins worked in development of transgenic plants for phytoremediation and molecular measures of soil quality. Dr. Perkins joined the ERDC Environmental Laboratory in 1996 where he established a genetics research lab. His research focuses on using biological networks and gene expression to understand how chemicals cause harmful effects in ecologically important organisms, use of genomics data in risk assessment, the use of environmental DNA to monitor invasive species, and using biology to develop novel materials.

• Paul S. Price

Paul S. Price is a Risk Assessment Leader in the Chronic Risk Assessment and Statistics group at The Dow Chemical Company. Current areas of research include mixtures risk assessment and simulation modeling of variation in dose and response in humans. Prior to joining Dow he worked at the US EPA,the American Petroleum Institute, and most recently, The LifeLine Group (where he developed software to perform aggregate and cumulative exposure assessments). He is a charter member of the Society for Risk Analysis and the International Society of Exposure Science and the author of more than 35 papers and book chapters in the fields of exposure and risk assessment.

• Glenn W. Suter II

Glenn W. Suter II, PhD, is the Science Advisor in the US EPA’s National Center for Environmental Assessment-Cincinnati and Chairman of the Risk Assessment Forum’s Ecological Oversight Committee. He has a PhD in Ecology from the University of California, Davis, and 35 years of professional experience. He is the principal author of three texts in the field of ecological risk assessment, editor of three other books and author of more than two hundred other publications. He is Associate Editor for Ecological Risk of Human and Ecological Risk Assessment, and Reviews Editor for Integrated Environmental Assessment and Management. He has served on the International Institute of Applied Systems Analysis Task Force on Risk and Policy Analysis, the Board of Directors of SETAC, an Expert Panel for the Council on Environmental Quality, the World Health Organization’s technical panel on Integrated Assessment, and the editorial boards of five journals. He is the recipient of numerous awards and honors; most notably, he is an Elected Fellow of the American Association for the Advancement of Science; and he received SETAC’s Global Founder’s Award, their award for career achievement, the Association of Environmental Health and Science’s Lifetime Achievement Award, and the US EPA’s Level 1 Scientific and Technical Achievement Award. His research experience includes development and application of methods for ecological risk assessment and ecological epidemiology, development of soil microcosm and fish toxicity tests, and environmental monitoring. His work is currently focused on the development of methods for determining the causes of biological impairments and developing environmental quality criteria from field data.

• Bruce W. Vigon

Bruce W. Vigon, Scientific Affairs Manager, Society of Environmental Toxicology and Chemistry (SETAC). Mr. Vigon has been involved in the development and practice of LCA for more than 20 years. He created and applied life-cycle based methods and tools for pollution prevention and product design decision support, leading many US EPA, Department of Defense, and industrial life cycle projects. His work includes extended LCA methods development and application for sustainable development analysis of organizations and product lines. He has published more than 25 peer reviewed articles, book chapters, and reports on LCA, including several of the seminal ones from the early 1990’s.

Since joining the SETAC staff in 2009, he has served as the technical focal point for the Society within the UNEP-SETAC joint venture Life Cycle Initiative. In this capacity he managed the Capability Maturing Modeling project and served as co-chair of the intensive workshop that produced the global guidance principles document for LCA databases. He also provides overall global science strategy and program development for SETAC, coordinating committees, advisory groups, and governance bodies toward achieving the Society’s goal of “…environmental quality through science.”

• Gene Whelan

Gene Whelan, PhD, is a Senior Multimedia Modeler in the Office of Research and Development at the US EPA in Athens, Georgia. Dr. Whelan holds a PhD in Civil and Environmental Engineering (Soil Chemistry minor) from Utah State University, an MS in Mechanics and Hydraulics, Iowa Institute of Hydraulic Research, at the University of Iowa and a BS in Civil Engineering from The Pennsylvania State University. Dr. Whelan conceives, develops, and applies physics-based, integrated, user-friendly computer-based multimedia contaminant transport and exposure/risk assessment methodologies, which simulate chemical, radionuclide, and microbial release, intermedia transport (through groundwater, surface water, overland, and air), exposure to human (by inhalation, ingestion, dermal contact, and external dose) and wildlife, and risk/hazard (to carcinogens and noncarcinogins). Prior to joining US EPA, he was a Chief Engineer at the Pacific Northwest National Laboratory and was involved in the development of 10 multimedia software systems and approaches (RAPS, MEPAS, FRAMES V1, 3MRA, FRAMES V2, ARAMS, RAAS, MRA, RRA, and CORE). With US EPA, he is focusing on integrated environmental modeling collaborations. One such collaboration is the development of Quantitative Microbial Risk Assessment frameworks to simulate the health impacts associated with the release, fate, and transport of pathogens and indicators from animal- and human-derived waste streams.

• Timothy Richard Zacharewski

Timothy Richard Zacharewski, PhD, is a Professor in the Department of Biochemistry & Molecular Biology and member of the Center for Integrative Toxicology at Michigan State University. He graduated with a PhD in Toxicology in 1990 from Texas A&M University under the mentorship of Dr. Stephen Safe. He received a Medical Research Council of Canada Post Doctoral Fellowship to study with Professor Pierre Chambon in Strasbourg, France from 1990–1992. In 1992, Dr. Zacharewski accepted an Assistant Professor position in the Department of Pharmacology & Toxicology at the University of Western Ontario. He relocated to the Department of Biochemistry & Molecular Biology at Michigan State University in 1997 where he has been pursuing research in the areas of biochemical and mechanistic toxicology. More specifically, his research interests include the elucidation of receptor-mediated mechanisms of toxicity using comparative omic and computational approaches that inform science-based quantitative risk assessment, identify biomarkers of toxicity, and develop high throughput assays to screen drugs and chemicals for toxicity. He has published more than 100 peer-reviewed research papers, presented at numerous national and international meetings, and participated in various workshops. He has also served as an independent consultant, external reviewer and scientific advisor for various national and international institutions, government agencies, private sector companies and advocacy groups. Dr. Zacharewski is currently serving a one year appointment within the National Center for Environmental Assessment as an Oak Ridge Institute for Science and Education (ORISE) Faculty Fellow at the United States Environmental Protection Agency in Research Triangle Park, North Carolina.

Invited Presenters

• Daniel Ames

Daniel Ames holds a PhD in Civil and Environmental Engineering from Utah State University, where his research emphasis was centered on hydrologic and water resources modeling using probabilistic Bayesian networks and GIS. Dr. Ames is the recipient of the 2010 Distinguished Researcher of the Year award at Idaho State University, where he leads the Geospatial Software Laboratory with a team of students and research associates, who develop open source geographic information systems and interfaces for hydrologic simulation models. His flagship project, MapWindow GIS, is the predominant open source GIS for the Windows platform with over 6000 downloads per month and developers and users from around the world.

• Jane Bare

Jane Bare is a chemical engineer with 26 years of experience in the US EPA’s Office of Research and Development. She was recently elected to the global Sustainability within Society of Environmental Toxicology and Chemistry (SETAC) (SwS) steering committee which is providing input to the Rio+ 20 process. She has served as the Chair of the Society of Environmental Toxicology and Chemistry (SETAC) Life Cycle Assessment (LCA) Steering Committee of the Advisory Group for North America since 2010. She is a founding international expert on the United Nations Environment Program (UNEP)/SETAC International Life Cycle Board which is the governing body of the UNEP/SETAC Life Cycle Initiative since 2001. She has organized and chaired three international special topic workshops on Life Cycle Impact Assessment and was involved in ISO 14040 series development. Jane developed the US EPA’s Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI) which is used for LCA and sustainability assessments. She has published over 40 peer reviewed publications and eight patents, and was recognized in 2006 with the US EPA’s individual Gold Medal for Exceptional Service.

• Brenda Barry

Dr. Brenda Barry is Senior Director for the Long-Range Research Initiative at the American Chemistry Council where her responsibilities include implementation and management of the LRI research program. One focus for these responsibilities is facilitating understanding of the role and activities of LRI within American Chemistry Council’s advocacy objectives through design and development of diverse communication materials for print and internet media. Dr. Barry’s background and areas of expertise include toxicology, health effects of indoor and outdoor environmental agents, nanotechnology, biosafety, and occupational health and safety. In previous positions in environmental consulting, Dr. Barry was senior project manager for investigations on indoor and outdoor environmental quality and the related exposure and health effect concerns and on environmental health and safety issues. Recent work focused on nanotechnology and the associated human health, environmental, and regulatory issues. She also served as the biosafety program manager for four Harvard University biomedical research institutions. As a staff scientist at the Health Effects Institute, she managed the review of studies concerning motor vehicle emissions and human health effects. Dr. Barry received her doctorate in pathology from Duke University and completed her postdoctoral studies at the Harvard School of Public Health. She received her BS in Zoology and MS in Biophysics from the University of Rhode Island. Dr. Barry is a member of the Society of Toxicology, the International Society of Exposure Science, and the Society for Risk Analysis.

• Scott M. Bartell

Scott M. Bartell, PhD, is an assistant professor in public health, statistics, and epidemiology at the University of California, Irvine. His research interest is in environmental health methodology, with applications in risk assessment, exposure science, and environmental epidemiology. Recent projects include linkage of fate and transport models and a pharmacokinetic model for perfluorooctanoic acid with data from the C8 Health Project, epidemiologic studies of exposure to polychlorinated biphenyls in Anniston, Alabama, and development of methods for epidemiologic analysis of publicly available aggregated data. He has served on a variety of scientific advisory committees for the National Research Council, the Environmental Protection Agency, the Centers for Disease Control and Prevention, the National Institute of Environmental Health Sciences, and the Department of Energy. Scott earned his PhD in epidemiology and MS in statistics from the University of California, Davis, and his MS in environmental health from the University of Washington.

• Steve Bartell

Formerly a research scientist in the Environmental Sciences Division at the Oak Ridge National Laboratory, Dr. Steven M. Bartell is currently a Principal Scientist with E2 Consulting Engineers, Inc. and manages the E2 office in Maryville, Tennessee. He is also an adjunct faculty member in the Department of Ecology and Evolutionary Biology at the University of Tennessee, Knoxville. Dr. Bartell’s areas of expertise include systems ecology, ecological modeling, ecological risk analysis, risk-based decision analysis, vulnerability analysis, numerical sensitivity and uncertainty analysis, environmental chemistry, and environmental toxicology. He works with public and private clients in ecological risk assessment, environmental analysis, ecological planning, and ecosystem restoration. Dr. Bartell has conducted ecological risk assessments for a diverse set of environmental stressors: ecological disturbances from commercial navigation on the Upper Mississippi and Illinois Rivers (USACOE); risk of invasive species establishment (USDA); habitat alteration and degradation (USDOE, USACOE); multiple chemical stressors in the Patuxent River and estuary (NOAA, USEPA); radionuclides and toxic metals (several Canadian mining companies); and herbicides and pesticides (Syngenta). Bartell is currently working on large-scale projects in adaptive management and restoration for the Florida Everglades, the Lower Columbia River, and the Upper Mississippi River.

• Luis Bermudez

Luis Bermudez, PhD, is the Director of Interoperability Certification for the Open Geospatial Consortium (OGC). In this position, Dr. Bermudez manages the certification program, leads plug fest activities, and supports interoperability initiatives. These initiatives include testbeds, pilots and interoperability experiments designed to develop, test and validate specifications for geospatial information. He has a PhD and MS in Hydroinformatics from Drexel University, and an MS in Industrial Engineering from the Andes University in Bogota, Colombia. He has 15 years of experience in software development, GIS, knowledge representation, semantic web, data integration and international project management. His pioneered work of ontology and geospatial metadata frameworks have advanced the cyberinfrastructure of environmental observatories in the United States and abroad. As the Coastal Research Technical Manager at the Southeastern University Research Association (SURA), he managed the technical implementation of the SURA Coastal Ocean Observing Prediction (SCOOP), advancing the technologies to support improvement of numerical coastal models in research communities and the integration of ocean-observing systems around the world. He also served as the technical lead of the Marine Metadata Interoperability Project, providing the guidance and resources for data management, while developing advanced metadata tools and services needed by the community. He has co-authored multiple publications in geospatial web services, integration of observing systems, semantic web and integration and workflow of numerical models. He is the lead of the open source software OOSTethys, was the chair of the OGC Ocean Science Interoperability Experiment, and co-led the access working group at Global Earth Observing Systems of System (GEOSS) Architecture Implementation Pilot Phase II. He was member of several OGC Standard working groups and invited expert at the W3C Semantic Sensor Network working group.

• Linda S. Birnbaum

Linda S. Birnbaum is Director of the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH), and National Toxicology Program Division. As NIEHS and NTP director, Dr. Birnbaum oversees a budget that funds multidisciplinary biomedical research programs, prevention, and intervention efforts that encompass training, education, technology transfer, and community outreach. The NIEHS supports more than 1,000 research grants.

Dr. Birnbaum has received numerous awards, including the Women in Toxicology Elsevier Mentoring Award, the Society of Toxicology Public Communications Award, US Environmental Protection Agency’s (US EPA) Health Science Achievement Award and Diversity Leadership Award, and 12 Science and Technology Achievement Awards. She is the author of several hundred peer-reviewed publications, book chapters, abstracts, and reports. Dr. Birnbaum received her MS and PhD in microbiology from the University of Illinois, Urbana. A board certified toxicologist, Dr. Birnbaum has served as a federal scientist for 30 years, 19 years with the US EPA Office of Research and Development, and the first ten years at NIEHS as a senior staff fellow at the National Toxicology Program, then as a principal investigator and research microbiologist, and finally as a group leader for the Institute’s Chemical Disposition Group.

• Topher Buck

Topher Buck is a Senior Fellow at GreenBlue. Topher joined GreenBlue in early 2006 as a Senior Project Manager to manage the GreenBlue chemicals program and development of the CleanGredients database. CleanGredients provides information on the environmental and human health attributes of chemicals to help support the formulation of safer and environmentally preferable products. Under Topher’s guidance, CleanGredients grew from a prototype to a widely recognized resource and model for disclosure of detailed information about chemicals. He has over 20 years of experience working with government agencies, private-sector firms, nonprofit organizations, and academic institutions on various environmental issues. He also has a diverse academic background that encompasses environmental chemistry, toxicology, ecology, energy systems, information design, and IT systems development. Topher holds a Master of Forest Science degree from Yale University’s School of Forestry and Environmental Studies, as well as a BS in Chemistry and Religious Studies from Wesleyan University. In addition, Topher spent five years in the PhD program at the Energy and Resources Group at the University of California, Berkeley.

• Harvey Clewell

Harvey Clewell is the Director of the Center for Human Health Assessment at the Hamner Institutes for Health Sciences. He has gained an international reputation for his research on the application of Physiologically Based Pharmacokinetic (PBPK) modeling to chemical risk assessment and pharmaceutical safety assessment, having played a major role in the first uses of PBPK modeling by US FDA, ATSDR, OSHA, and US EPA. He has a Masters in Chemistry from Washington University, St. Louis, and a PhD in Toxicology from the University of Utrecht. His current research interests include PBPK modeling of early life exposures, computer simulation of drug-induced liver injury, modeling of nanoparticle disposition and effects, and the use of in vitro data and biological modeling to perform in vitro to in vivo extrapolation in support of risk and safety assessments.

• Elaine Cohen Hubal

Elaine Cohen Hubal, PhD, is currently a senior scientist in the US EPA’s National Center for Computational Toxicology (NCCT). The NCCT has a mission to integrate modern computing and information technology with molecular biology to improve Agency prioritization of data requirements and risk assessment of chemicals. Dr. Cohn Hubal leads ExpoCast, the US EPA research program in exposure science to support chemical prioritization and toxicity testing. Her primary research interests are in characterizing human exposure and developing approaches for using human exposure metrics to inform health studies and public health policy. The current focus of her research is on applying a systems approach to characterize complex relationships between environmental factors and health outcomes with an emphasis on vulnerable populations. Previously, she was Acting Associate Director for Human Exposure Modeling in the Human Exposure and Atmospheric Sciences Division of the US EPA’s National Exposure Research Laboratory (NERL) where she worked to develop and direct NERL’s human exposure modeling research program. Dr. Cohen Hubal has published in the areas of children’s exposure and human health risk modeling. Dr. Cohen Hubal has served as an expert on a variety of scientific panels and committees including the Voluntary Children’s Chemical Evaluation Program (VCCEP) Peer Consultation Panel and the Study Design Working Group for the National Children’s Study. Currently, she serves as chair of the WHO IPCS working group on “Identifying Important Life Stages for Monitoring and Assessing Risks from Exposures to Environmental Contaminants.” Dr. Cohen Hubal also serves as an associate editor for reviews for the Journal of Exposure Science and Environmental Epidemiology. Dr. Cohen Hubal received her PhD and MS in Chemical Engineering from North Carolina State University and a SB in Chemical Engineering from Massachusetts Institute of Technology.

• Olaf David

Olaf David has a PhD in computer science and is a research scientist at Colorado State University, Department of Civil Engineering & Department of Computer Science/USDA Agricultural Research Service (ARS) and USDA Natural Resources Conservation Service (NRCS). He is currently a Working Group Co-chairman of the Interagency Steering Committee for Multimedia Environmental Modeling (ISCMEM). Dr. David is the lead developer of the Object Modeling System (OMS) at USDA, a framework for environmental model development, integration, and application and its implementation in current integrated modeling projects at ARS and NRCS. This integrated research and OMS application are focusing on (i) natural resource management and water supply forecasting for Ag-system production using component based modeling; (ii) deployment of integrated modeling technology using the OMS modeling framework via cloud-computing and service-oriented architectures, and (iii) framework integration of methods for calibration, optimization, sensitivity, and uncertainty analysis to support and enhance Ag-system modeling.

• Oliver Fiehn

Oliver Fiehn, PhD, has pioneered developments and applications in metabolomics since 1998 with over 100 publications to date. Dr. Fiehn is currently serving as Director of Metabolomics in the University of California Davis Genome Center, overseeing strategies in the research laboratory as well as the service core laboratory to provide the most extensive and most in-depth analysis of metabolites for animal and human biology using a range of validated protocols. I oversee developments to integrate new methods and metabolic targets in addition to a research program for finding novel disease markers using unbiased metabolomics analyses. He further performs pathway-based mapping of results and perform statistical and data processing tasks in order to better understand the mechanisms of the onset and development of diseases, specifically in obesity and diabetes. Dr. Fiehn is engaged in the daily project work by discussing study designs, overseeing the research developments and sample analyses. He also continues to chair or spearhead efforts in establishing metabolomic standards through databases, libraries and reporting recommendations, including for the Metabolomics Society. Dr. Fiehn is on the Board of Directors of the Metabolomics Society, and is on the editorial board of several journals including the Journal of Biological Chemistry, Metabolomics, and Plant Methods.

• Elaine M. Faustman

Elaine M. Faustman, PhD, is a professor of environmental and occupational health sciences at the University of Washington, School of Public Health and directs the Institute for Risk Analysis and Risk Communication. Her research interests include understanding molecular mechanisms of developmental and reproductive toxicants, characterizing in vitro techniques and developing biologically based dose-response models for noncancer risk assessment. Her research expertise includes the development of tools for incorporating new scientific findings into risk assessment decisions. Dr. Faustman is an elected fellow of the American Association for the Advancement of Science and the Society for Risk Analysis. She is the Secretary General for the International Union of Toxicology. She has served on numerous committees for NIEHS including the NTP Board of Scientific Counselors and for the World Health Organization (including Environmental Health Criteria Document Committees for modeling dose-response and children’s risk assessment). She has also been involved in National Research Council committees, including the Committee on Spacecraft Exposure Guidelines, Sub Committee for Zinc-Cadmium Sulfide and Upper Reference Levels of Nutrients for the Food and Nutrition Board (IOM) and the Committee on Toxicology. She chaired the NAS Committee on Developmental Toxicology. She currently serves on the US EPA Scientific Advisory Panel and on the Science Panel for the Department of Ecology for the State of Washington. Dr. Faustman is a PI of a US EPA/NIEHS funded Center for Child Environmental Health Risks Research and the PI of the Pacific Northwest Center for the National Children’s Study. She has been the director of the NIEHS and NSF funded Pacific Northwest Center for Human Health and Ocean Studies and in that role, she has had to confront the complexity and magnitude of multidiscplinary databases that need translation for decision making. Dr. Faustman received a PhD in toxicology from Michigan State University.

• H. Christopher Frey

H. Christopher Frey, PhD, is a professor of environmental engineering in the Department of Civil, Construction, and Environmental Engineering at North Carolina State. His research interests are measurement and modeling of real-world fuel use and emissions of onroad and nonroad vehicles; modeling and evaluation of advanced energy conversion (e.g., combustion, gasification) and environmental control systems; development and application of methods for quantification of variability and uncertainty and for sensitivity analysis in environmental systems models; and exposure and risk analysis. He has been the principal investigator or co-principal investigator for over 50 externally sponsored research projects, and has published 87 journal papers, 148 conference papers, 61 technical reports, 7 book chapters, and one book. He teaches courses in air pollution control, air quality, and environmental exposure and risk assessment. He currently serves on the US EPA’s Clean Air Scientific Advisory Committee (CASAC) and on the Board of Environmental Studies and Toxicology of the National Research Council. In recent years, he has served on an US EPA Science Advisory Board panel on expert elicitation, National Research Council committees on review of the toxicological assessment of tetrachloroethylene and of US EPA’s New Source Review program, a NARSTO assessment of multipollutant air quality management, and a World Health Organization working group on uncertainty in exposure assessment. He was a lead author for 2006 guidance by the Intergovernmental Panel on Climate Change (IPCC) regarding uncertainty in greenhouse gas emission inventories. He is a Fellow and Past President of the Society for Risk Analysis and a Fellow of the Air & Waste Management Association. He received the 2008 NCSU Alumni Association Outstanding Research Award and 1999 Chauncey Starr Award of the Society for Risk Analysis. He has a BS Mechanical Engineering from the University of Virginia, and from Carnegie Mellon University he has a Master of Engineering in Mechanical Engineering and PhD in Engineering and Public Policy.

• Pierre D. Glynn

Pierre D. Glynn, currently serves as Branch Chief for the Eastern Branch of the US Geological Survey (USGS) National Research Program in Reston, Virginia. The scientists in his Branch conduct research in many fields and on many issues. These include numerical modeling of water flow and solute transport, environmental isotope forensics and characterization, groundwater dating, water and sediment contamination problems, nutrient cycling, ecological habitats, geomorphic processes, and the application of molecular and other techniques to the study of microbial processes. Beyond Dr. Glynn’s Branch responsibilities, he has undertaken a wide diversity of assignments for the USGS. Recently, these have included the advancement of integrated environmental and ecological modeling across a range of organizations and disciplinary interests. His research efforts have focused on geochemical modeling and characterization of groundwater contamination, nuclear waste disposal, and groundwater dating studies. Earlier in his career, Dr. Glynn also developed a thermodynamic framework to explain and predict how substitutional impurities affect the solubility and aqueous interactions of mineral phases, and how impurities are released and taken up by minerals. Dr. Glynn’s academic background includes a BA (with a major in Geological Sciences) from Columbia College and Lamont Doherty Earth Observatory, an MSc from University of Québec in Montréal in isotopic environmental geochemistry and the cycling of atmospheric 14CO2, and a PhD from the University of Waterloo, where his studies focused on groundwater studies and the thermodynamics of water-rock interactions.

• Lynne Haber

Lynne Haber, PhD, is the Associate Director of Toxicology Excellence for Risk Assessment (TERA). Lynne has extensive experience in the development of assessment documents and in risk assessment methods development, including consideration of mechanism/mode of action. She has led the development of numerous assessment documents, has been a coauthor or reviewer of 100’s more. She has served as a panel chairperson or panel member for scientific peer reviews organized by TERA, US EPA, and other US and foreign government agencies, and has served on two panels for the NAS/NRC and on the Board of Scientific Counselors for US EPA and ATSDR. Dr. Haber is active in communicating her findings to the broader scientific community through participation in professional societies, routine publication of her work, authoring book chapters (including lead author of the chapter on noncancer risk assessment for Patty’s Toxicology—2001, 2011), service as an editorial reviewer for scientific journals, and through presentation of invited lectures. She has done research into issues such as methods for improving the scientific basis for uncertainty factors by addressing genetic polymorphisms and risk to children; consideration of mode of action in cancer risk assessment; and use of biomarker data in risk assessment. She has served as chair, chair-elect, vice president and councilor of the SRA Dose-Response specialty group and as an officer of the SOT Risk Assessment Specialty Section (RASS), and is a Diplomat of the American Board of Toxicology. She is one of the lead teachers for TERA’s Dose-Response Assessment Boot Camp, developed a course on issues related to children’s risk assessment, and presents specialized courses to diverse groups of risk assessors and at professional society meetings.

• Sean Hays

Sean Hays, PhD, is the President and founder of Summit Toxicology, a toxicology and risk assessment consulting firm headquartered in Colorado. Sean received a BS in biomedical engineering from Texas A&M University, an MS in Physiology from the University of Vermont, an MS in chemical engineering from Colorado State University, and a PhD in Toxicology from the University of Utrecht. Sean has been a consultant since 1995, where he specializes in conducting exposure assessments, deriving acceptable exposure limits (i.e., reference doses and reference concentrations, cancer slope factors, permissible exposure limits, and minimal risk levels), and developing pharmacokinetic (PK), physiologically based pharmacokinetic (PBPK), and pharmacodynamic (PD) models for drugs and chemicals. Dr. Hays is also regarded as a leader in the field of interpreting human biomonitoring data. Sean has served as President of the Biological Modeling Specialty Section of the Society of Toxicology and President of the Industry Advisory Board for the Colorado State University School of Biomedical Engineering. Dr. Hays holds an adjunct faculty appointment with the University of Colorado and Colorado School of Public Health.

• Bruce K. Hope

Bruce K. Hope, PhD, is a senior environmental toxicologist with the Oregon Department of Environmental Quality (DEQ). His most recent assignment was with the Water Quality Division where he worked on identifying persistent pollutants in Oregon’s waters. Bruce also continues to do air toxics work for the Air Quality Division and was project manager for completion of the Umatilla chemical weapons incinerator risk assessment for the Land Quality Division. Prior to joining DEQ in 1995, he was a consultant in the private sector managing human health and ecological risk assessment projects for commercial and government clients throughout the US and Pacific Rim. In 2000–2001, Dr. Hope was on leave from DEQ as a AAAS risk policy fellow in Washington DC, working on food safety, microbial risk assessment, and bioterrorism issues. He has served on the North American Board of Directors for SETAC, and is on the editorial boards of Human and Ecological Risk Assessment and Environmental Toxicology and Chemistry. He has also served on several US EPA national advisory and review panels addressing cumulative risk, wildlife, ecological and probabilistic risk assessment issues, and environmental modeling. Dr. Hope was a member of a National Research Council committee evaluating US EPA’s human health risk assessment practices and is currently on one considering ecological risk assessment under FIFRA. Bruce has been an adjunct faculty member at Oregon Health & Science University, Concordia University, Portland State University, and Oregon State University. He holds MS and PhD degrees in biology from the University of Southern California and a BA degree from the University of California (Santa Barbara).

• Philip H. Howard

Dr. Philip H. Howard is a Senior Research Fellow with SRC, Inc. (formerly Syracuse Research Corporation). He has managed over 100 contracts with government and industry during the last 41 years that gathered and evaluated chemical fate, environmental effects, and health effects information as well as developing quantitative structure activity relationships (QSARs). His extensive experience in the development and use of QSARs for use in predicting environmental fate behavior have included the estimation of biodegradation rates, the identification of persistent, bioaccumulative, and toxic chemicals (PBTs), the prediction of physical properties of chemicals, and the development of the EPI Suite™ software that is available for free from US EPA’s website. For the last 32 years, Dr. Howard has directed, with US EPA support, the development of the Environmental Fate Data Base (EFDB), which presently contains almost 25,000 chemicals and maintained the Environmental Fate/Exposure Sections of the Hazardous Substances Data Bank (HSDB) from the US National Library of Medicine. Dr. Howard is an environment chemistry editor for the SETAC journal, Environmental Toxicology and Chemistry, and has published over 70 journal articles on QSARs, environmental chemistry and biodegradation.

• Michael Hucka

Michael Hucka, PhD, is a staff scientist at the California Institute of Technology in Pasadena, California. Mike’s background is in computer science, cognitive science and computational neuroscience. He is currently the principal investigator and general coordinator of the worldwide Systems Biology Markup Language (SBML) effort. SBML is today’s most widely-used format for representing computational models in systems biology, with over 230 software systems worldwide having incorporated support for it over the past decade. Mike also co-founded BioModels.net, the Systems Biology Graphical Notation (SBGN), the Systems Biology Ontology (SBO), and was instrumental in the early development of BioModels Database. Further back in the past, he was one of the developers of the original NeuroML format for neuroscience. Most recently, he co-founded the Computational Modeling in Biology Network (COMBINE) and the Hackathon on Resources for Modeling in Biology (HARMONY), to help bring together and better coordinate multiple related standardization efforts in systems biology.

• Bernadette Hyland

Bernadette Hyland brings a strong background in commercial and federal government data management strategies, coupled with expertise in leading high-growth software organizations. She is committed to articulating the practical use of the Semantic Web to corporate and government decision makers. Bernadette is a chapter author in two peer reviewed books focused on real world deployments of Linked Data, Linking Enterprise Data (David Wood editor, Springer, 2010) and Linking Government Data (David Wood editor, Springer, 2011). Bernadette is co-chair of the W3C Government Linked Data Working Group. She is a member of the Semantic Web Coordination Group. Bernadette is co-founder of several profitable early stage Internet companies delivering enterprise products. Each of these companies pioneered the development of Free/Libre/Open Source Software (FLOSS) projects, including the Mulgara Semantic Store, Persistent URL (PURLs), Freemix and the Callimachus Project. Bernadette served as CEO of Zepheira, a services firm focused on the library and healthcare/life sciences communities. Bernadette was CEO and co-founder and of Tucana Technologies Inc., a leading provider of graph based database technology. She lead the company’s successful exit via acquisition to Northrop Grumman in 2005. Bernadette holds a BS Computer Science and Linguistics, University of California, Los Angeles.

• Malcolm D. Jackson

Malcolm D. Jackson is US EPA’s Assistant Administrator for the Office of Environmental Information and Chief Information Officer. In this dual role, Mr. Jackson is responsible for IT operations and security, information quality and collection, and access to environmental information including the Toxics Release Inventory. His leadership focus includes IT strategic planning and governance, IT investment management and government transparency.

Malcolm D. Jackson was appointed to serve this role by President Barack Obama. Prior to being confirmed by the Senate in June 2010, Mr. Jackson served as the Senior IT Business Unit Director of CIGNA Group Insurance. At CIGNA, he managed all IT aspects that supported short term disability, long term disability, life and accident insurance products and services. From 2006 to 2008, Mr. Jackson also served as the Senior IT Business Unit Director for CIGNA Insurance Corporate Business Functions. During this tenure, Mr. Jackson directed the development of IT applications for Human Resources, Finance, Legal and Public Affairs, and Investments. In addition, Mr. Jackson had IT oversight for Corporate-Owned Life Insurance, Reinsurance, and Settlement Annuities.

Prior to joining CIGNA Insurance, Mr. Jackson held various positions in the areas of IT, engineering, marketing and general business management at Monsanto, Quaker Oats, General Dynamics, and Shell Oil Company. He has a broad business background which included consumer packaged goods, defense contracting, agriculture, pharmaceuticals, and the oil and gas industries. Throughout his career, Mr. Jackson has developed expertise in IT strategy, large-scale enterprise resource planning, performance metrics development, and business process re-engineering.

Mr. Jackson was a Board member of the Children’s Literacy Initiative in Philadelphia and the Jackson State University National Alumni Association, where he chaired the membership committee. Mr. Jackson holds a BS from Jackson State University and an MBA from Northwestern University, J.L. Kellogg School of Management.

• David Lyons

David Lyons is the Scientific Data Manager in the Office of Science Information Management (OSIM) within the US EPA’s Office of Research and Development (ORD). With experience in enterprise project management, geospatial information systems, and database design and development, David brings many years of expertise in systems integration to the “B4BD” Team. David is currently involved in development of a strategic research planning system. He is also working on developing a data architecture that leverages a semantic technology foundation.

• Roger V. Moore

Roger V. Moore, PhD, obtained a Civil Engineering degree in 1969 and set out to build small dams in Africa. Through an administrative error, he actually ended up working with the USGS on hydrological field work. This led on to a period of modeling UK water resource systems, made possible by the computing advances in the 1960’s. The UK legislative demand for integrated water management in the 1970’s created a matching need for integrated data systems. Dr. Moore spent from 1974 onwards designing and researching integrated systems for storing environmental data that varied in time and space for commercial, operational, and research projects around the world. Drawing on this experience, the last ten years have been spent leading the development of the Open Modeling Interface (OpenMI), which allows the linking of models to each other, to databases, and to other modeling components. Development of interfaces is one of the keys to opening up the highly exciting possibilities offered by integrated modeling. Dr. Moore is currently Chairman of the OpenMI Association.

• Moiz Mumtaz

Moiz Mumtaz, MS, PhD, is the Science Advisor in the Computational Toxicology Laboratory in the Division of Toxicology and Environmental Medicine, at the Agency for Toxic Substances and Disease Registry (ATSDR), Centers for Disease Control and Prevention (CDC). He is an adjunct associate professor at the Department of Environmental and Occupational Health, School of Public Health, Emory University, Atlanta, Georgia. Prior to joining ATSDR Dr. Mumtaz worked at the Office of Research and Development (ORD) at the US EPA. He is a member of the Society of Toxicology (SOT), and the Past President of the SOT Mixtures Specialty Section. He has extensively published his research findings in peer-reviewed journals over the past three decades. In 2010, he edited a book entitled Principles and Practice of Mixtures Toxicology. His research has focused on methods development for the human health risk assessment of environmental chemicals mixtures and stressors. His involvement in several agency-wide activities at ATSDR has led to a) the establishment of a mixtures research program for determining significant human exposures to environmental chemicals, and b) the foundation of the Computational Toxicology Laboratory. He is the principal representative of ATSDR on the Department of Health and Human Services (DHHS) Interagency Coordinating committee on the validation of alternative methods (ICCVAM).

• Thomas Nicholson

Thomas Nicholson is a Senior Technical Advisor in the Division of Risk Analysis of the Office of Nuclear Regulatory Research (RES) within the US Nuclear Regulatory Commission (NRC) and has worked at the NRC for 33 years. His principal responsibility is to provide technical advice to NRC management and staff concerning radionuclide transport in the subsurface at NRC-licensed facilities. His work focuses on research in hydrogeologic conceptual model, parameter and scenario uncertainty; application of model abstraction techniques for transport in soils; and accidental radionuclide releases at nuclear power plant sites. He formulated and directed numerous research studies involving integrated groundwater modeling, and subsurface monitoring, modeling, and remediation. He serves as co-chair of the US Federal Work Group on Uncertainty and Parameter Estimation under the Interagency Steering Committee on Multimedia Environmental Modeling (ISCMEM) of which he was a founding member and charter co-author. He chairs two NRC Technical Advisory Groups involving Groundwater and Performance Monitoring, and Uncertainty Assessment of Environmental Modeling. He served on the 2006 NRC Lessons Learned Task Force on Liquid Radioactive Release, and the recent Groundwater Contamination Task Force. He is the NRC appointed member of ANS 2.17 writing committee on Evaluation of Radionuclide Transport in the Subsurface at Commercial Nuclear Power Plants. He worked with NRC Region I Inspectors on evaluation of the groundwater characterization and monitoring studies at the Indian Point Energy Center and Vermont Yankee sites, and with Region III Inspectors on the Braidwood and Dresden nuclear power plant sites. He holds a BS in geological sciences and an MS in geology. He is a registered geologist in the State of Indiana and a certified Professional Hydrogeologist with the American Institute of Hydrology. He is an active member of the American Geophysical Union, Geological Society of America, American Institute of Hydrology, International Association of Hydrological Sciences, National Ground-Water Association and the International Hydrogeologic Society.

• Glenn Paulson

While earning his doctorate in environmental sciences and ecology at The Rockefeller University, Dr. Paulson studied under René Dubos, a pillar of the scientific and environmental communities and the man who authored the idea, “Think globally, act locally.” After receiving his doctorate, Dr. Paulson’s esteemed academic career included time as a classroom instructor, a researcher and in administration. Most notably, he held posts as the director of the Center for Hazardous Waste Management at the Illinois Institute of Technology and served as both associate dean for research in the School of Public Health and director of the New Jersey Center for Public Health Preparedness at the University of Medicine and Dentistry of New Jersey.

Dr. Paulson has distinguished himself outside of academia as well. In addition to founding his own environmental and energy consulting firm and serving as assistant commissioner for science at the New Jersey Department of Environmental Protection, he has worked as director of the Scientific Support Program for the Natural Resources Defense Council and as senior vice president at the National Audubon Society, where he managed the 2.5 million-acre Audubon wildlife sanctuary system. Dr. Paulson has directly managed emergency response, site assessment and cleanup at more than 100 Superfund sites and RCRA facilities; reviewed cleanup plans for more than 5,000 Superfund, RCRA and brownfield sites and facilities in the US and Canada; and joined the New Jersey State Police Commander in leading the state’s response to the Three Mile Island accident.

• Scott Peckham

The Community Surface Dynamic Modeling System (CSDMS) Project is an NSF-funded, international effort to develop a suite of modular numerical models able to simulate the evolution of landscapes and sedimentary basins, on time scales ranging from individual events to many millions of years. The earth system surface dynamic models, like the established Community Climate System Model or the Regional Ocean Modeling System, are based on algorithms that mathematically describe the processes and conditions relevant to water, sediment and solute transport, and would incorporate all the important input and boundary conditions that define an environmental system. The CSDMS effort is coordinated and funded by government agencies and industry, to support the development of optimum algorithms, input parameters, feedback loops, and observations at the relevant scales necessary, to better provide an understanding of earth-surface systems. The CSDMS is being designed to address issues, for example, when the earth was abiotic, hotter or colder, when there was no flocculation, when the moon was closer, or the oceans were more saline. CSDMS provides modeling support to those working on modern environmental applications, future global warming scenarios, natural disaster mitigation efforts, natural hazard efforts, reservoir characterization, oil exploration, and national security. New satellite and geophysical databases will only realize their full potential in collaboration with efforts like the CSDMS.

• Roger G. Perkins

Roger G. Perkins is the Associate Director of the Center of Excellence for Bioinformatics at the US Food and Drug Administration’s (US FDA) National Center for Toxicological Research (NCTR). During his 18 years at NCTR he has co-authored some 80 manuscripts involving computational science and predictive modeling for toxicological endpoints and biomarker discovery. Past research areas include development of chemometric and QSAR predictive models for endpoints associated with endocrine activity, development of phenotype-anchored knowledge bases, development of integrative databases used for high throughput data interpretation, and determination of best practices for predictive model development from microarray and next generation sequencing data. He also serves on several US FDA governance boards and committees involving IT, scientific computing and high performance computing. Prior to joining US FDA, he was Director of the US Navy’s Advanced Scientific and Engineering Computational Center, and prior to that a program manager and nuclear codes specialist at the National Science Foundation’s San Diego Supercomputer Center. He was trained as a nuclear engineer at the University of Florida and spent more than a decade as a core physicist in fast breeder reactor and fusion reactor research and development.

• Christina Powers

Christina Powers, PhD, is a Postdoctorate Biologist in the National Center for Environmental Assessment (NCEA) at the US EPA in Research Triangle Park, North Carolina. Dr. Powers received her BA in Biopsychology from Agnes Scott College and her PhD in Pharmacology and Toxicology from Duke University. While at Duke she investigated the potential developmental neurotoxicity of silver and silver nanoparticles using in vitro and in vivo models. Since joining the US EPA she has focused on the development and implementation of the Comprehensive Environmental Assessment (CEA) approach for nanomaterials. Developed in NCEA, CEA is an approach for research planning and risk management of emerging materials, such as nanomaterials. Her recent work includes contributing to the latest CEA case study on Nanoscale Silver in Disinfectant Spray, initiating a new case study on multi-walled carbon nanotubes in flame retardant textiles, and working to develop communication materials detailing the application of CEA for nanomaterials or other emerging materials.

• Peter Preuss

Peter Preuss, PhD, is the Chief Innovation Officer in the Office of Research and Development (ORD), US EPA. Dr. Preuss leads an interdisciplinary team charged with building an innovation infrastructure for science that will move US EPA forward on the path to sustainability. In their first year, Dr. Preuss and his team have already introduced several innovative ideas and approaches to ORD, including the use of collaborative platforms for research planning and competitive internal awards to promote high-risk, high-reward research. The team has established a cross agency innovation workgroup to help US EPA make effective use of open innovation challenges, prizes and awards delegated under the America Competes Act. Additionally, the team has launched an environmental pavilion on InnoCentive.com; a company that specializes in open source innovation for scientific and technical challenges. Currently Dr. Preuss and team are working closely with ORD’s National Program Directors on high profile signature projects oriented around topics such as sustainable alternatives to toxic chemicals and net zero structures and communities. As his team endeavors to promote new air monitoring sensors and applications to enhance citizen science and citizen empowerment, Dr. Preuss continues to work to bring innovative science and technology research to the forefront of ORD’s activities.

• David M. Reif

David M. Reif earned his BS (Biology) from the College of William and Mary, where he was a Monroe Scholar. He earned both his MS (Statistics) and PhD (Human Genetics) from Vanderbilt University. His graduate work focused on novel statistical and bioinformatical approaches to integrate multiple data types for the analysis of complex human diseases. As a postdoc at the US Environmental Protection Agency, David worked with Elaine Cohen-Hubal (US EPA/NCCT) on developing visualization and analysis strategies for epidemiological exposure studies and the ToxCast program. Currently, he is a Statistician with the National Center for Computational Toxicology (NCCT), where he works on the statistical/bioinformatical aspects of NCCT research efforts and collaborates on a variety of projects across the Agency. David leads the development of the ToxCast analytical workflow/pipeline, the implementation of web interfaces (“Dashboards”) for translating high-dimensional data into decision-support tools for US EPA program offices, and the ToxPi project. He also holds an adjunct professorship at North Carolina State University, where he teaches courses on statistical programming and analytical graphics. He is a winner of the Presidential Early Career Award for Scientists and Engineers (PECASE).

• Jennifer Sass

Dr. Sass is a Senior Scientist in the Health and Environment program of the Natural Resources Defense Council (NRDC), and a Professorial Lecturer at George Washington University, Department of Environmental and Occupational Health. Dr. Sass has degrees in Anatomy and Cell Biology from the University of Saskatchewan, Canada, and Toxicology from the University of Maryland. In her work with NRDC she reviews the science underpinning the regulation of toxic chemicals, and advocates for health-protective regulations consistent with the environmental laws.

• Thomas P. Seager

Dr. Thomas P. Seager is an Associate Professor in the School of Sustainable Engineering & the Built Environment at Arizona State University, where he studies the life-cycle environmental impacts of alternative energy technologies. He has published several papers that describe novel multi-criteria decision analytic tools in the context of environmental decision-making under high uncertainty, such as applies in the context of emerging technologies and sustainability. Dr. Seager is also a Senior Scientist in the ASU School of Sustainability, a Lincoln Fellow for Ethics and Sustainability at the ASU Lincoln Center for Applied Ethics, and an expert in pedagogical strategies and curriculum for an integrative approach to sustainability science education. He chairs the Society for Environmental Toxicology and Chemistry (SETAC) Advisory Group on Sustainability, and is a member of the SETAC AG on Life-cycle Assessment (LCA). His most current published works are a critique of classic normalization methods in life-cycle impact assessment, a description of a new method called anticipatory LCA appropriate for understanding the potential environmental impacts of emerging nanomaterials at commercial scales, and a study of resilience in the context of catastrophe.

• Mitchell Small

Mitchell Small is the H. John Heinz III Professor of Environmental Engineering at Carnegie Mellon University (CMU). He joined the Departments of Civil & Environmental Engineering and Engineering & Public Policy (EPP) at CMU in 1982, following completion of his PhD in Environmental & Water Resources Engineering at the University of Michigan. He serves as the associate department head for graduate education in EPP.

Professor Small’s research involves mathematical modeling of environmental systems, risk assessment, statistical methods, and decision support. Current projects include the design and evaluation of monitoring networks for leak detection at geologic CO2 sequestration sites; risk assessment and trend evaluation for tropical cyclones; and the development of decision support tools for ecosystem management (current focus on coral reefs) for multiple stakeholders with conflicting beliefs and objectives.

Dr. Small has served as a member of the US EPA Science Advisory Board (SAB) and has been a member of a number of US National Research Council committees addressing issues of environmental risk assessment and management. He is a Fellow and former Secretary of the Society for Risk Analysis, and a featured columnist for the Journal of Industrial Ecology. He recently completed a 16-year appointment as an associate editor for the journal Environmental Science & Technology, with particular responsibility for the environmental modeling and policy analysis sections of the publication.

• Russell Thomas

Russell Thomas is a senior investigator and director of the Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences, with an adjunct assistant professorship in the Eschelman School of Pharmacy at the University of North Carolina at Chapel Hill. His laboratory has diverse interests that range from basic research in cancer biology to applied research in chemical risk assessment. Dr. Thomas completed his MS in radiation ecology and PhD in Toxicology at Colorado State University. Following his doctoral studies, Dr. Thomas performed postdoctoral research in molecular biology and genomics at the McArdle Cancer Research Laboratory at the University of Wisconsin. Prior to coming to The Hamner, Dr. Thomas worked in the biotech and biopharmaceutical industry.

• Clyde Ulmer

Clyde Ulmer is a Research and Regulatory Data Specialist in the Center of Excellence for Bioinformatics at the US FDA’s National Center for Toxicological Research (NCTR). Originally trained in Microbiology, he ran an infectious disease and immunology research lab for ten years. Then, the lure of computing compelled him to take a degree in Computer Science, after which he joined NCTR. During his 27 years there, he has worked as a systems administrator, database administrator, software developer, data modeler and database architect. He has worked closely with research toxicologists and utilized his background in biology to better understand the scientific requirements for scientific software developed at NCTR. In this process, he has absorbed a reasonable core of the the tenets of toxicology. Recently, he has been involved in enterprise projects for US FDA, including the US FDA’s Clinical Trials Repository. He also serves on several workgroups in both the Health Level 7 (HL7) and the Clinical Data Standards Interchange (CDISC) healthcare standards development organizations, working on data standards of interest to US FDA.

• Alexey Voinov

Alexey Voinov, PhD, has an MS is Applied Mathematics and a PhD in Biophysics, Ecosystem Modeling. He is currently the President of the International Environmental Modeling & Software Society (iEMSs) and is Editor of the Journal for Environmental Modeling & Software. Dr. Voinov currently teaches at the University of Twente, Netherlands. His area of expertise is in simulation modeling of ecosystems and sustainability science in application to decision support and policy making. In particular, the focus is on strategic environmental assessment, environmental impact assessment, spatial dynamic models, modeling of aquatic and watershed ecosystems, integrated assessment, systems analysis in ecology and economics, energy and natural resources, participatory modeling, sustainability and environmental policy, model integration, and interoperability.

• Katherine von Stackelberg

Katherine von Stackelberg, PhD, is a Principal at E Risk Sciences, LLP and holds a research affiliation at the Harvard Center for Risk Analysis (HCRA) where she co-directs the Superfund Research Program Research Translation Core. She specializes in developing risk-based tools and methods to support sustainable approaches to environmental decision-making. An emerging area of interest includes approaches and tools for quantifying changes in ecosystem services, and identifying relationships between ecosystem services and expected benefits with the goal of integrating economics and risk assessment to better quantify the benefits of proposed risk reductions as a result of management or regulatory actions for use in cost-benefit, cost-effectiveness, and value of information analyses. Much of her work has focused on incorporating quantitative uncertainty analysis (e.g., analytical, probabilistic, and fuzzy methods) into the environmental management process, and she stays at the forefront of the effort to explore methods for effectively communicating and interpreting scientific uncertainty to support environmental decision-making, particularly with respect to complex, integrated models and model development. At both E Risk and at HCRA, Dr. von Stackelberg is engaged in multidisciplinary projects requiring synthesis and integration across different kinds of datasets and models. Dr. von Stackelberg serves as peer reviewer for numerous journals, and is on the editorial board for Risk Analysis and Human and Ecological Risk Assessment. Dr. von Stackelberg serves on the US EPA Board of Scientific Counselors, and is a member of the Scientific Advisors on Risk Assessment for the European Commission in Brussels. She is a member of the Society for Risk Analysis, Society for Environmental Toxicology and Chemistry (Chair of the Technical Committee), Ecological Society of America, International Society for Ecological Economics, and the Association of Environmental and Resource Economists. Dr. von Stackelberg received an AB cum laude from Harvard College, and a ScM and ScD from the Harvard School of Public Health in Environmental Science and Risk Management.

• Anthony (Tony) I. Wasserman

Anthony I. (Tony) Wasserman is a Professor of Software Management Practice at Carnegie Mellon Silicon Valley, and the Executive Director of its Center for Open Source Investigation (COSI), focused on evaluation and adoption of open source software. In 1980, as a Professor at UC San Francisco, he released the software for his User Software Engineering research project under a BSD license. Subsequently, as CEO of Interactive Development Environments (IDE), he incorporated some of that software in IDE’s Software through Pictures multiuser modeling environment, released in 1984, making it among the very first commercial products to include open source software. After IDE, Tony was VP of Engineering for a dot-com, and later became VP of Bluestone Software, where Bluestone’s open source Total-e-Mobile toolkit allowed mobile devices to connect to JavaEE web applications. Tony is very active in the international open source research community, and served as General Chair of the 2009 Int’l. Conf. on Open Source Systems. He is on the Board of Directors of the Open Source Initiative (OSI), Board of Advisors of Open Source for America, and was co-founder of the Business Readiness Rating project. Tony is a Fellow of the ACM and a Life Fellow of the IEEE for his contributions to software engineering and software development environments. Tony has been to more than 55 countries, including some that no longer exist, and posts his photos on Flickr.

• Michael Waters

Dr. Michael Waters joined Integrated Laboratory Systems (ILS), Inc. in January 2007 as Chief Scientific Officer. He is a former government scientist with more than 35 years experience in research and research management positions at US EPA and NIEHS. His research interests have centered on the evaluation of chemically-induced mutations and altered molecular expression in the etiology of genetic disease. A widely-published scientist, Dr. Waters has edited Mutation Research-Reviews for more than 10 years and he has held adjunct professorships at both UNC and Duke University. He served as President of the Environmental Mutagen Society and the International Association of Environmental Mutagen Societies. His databases and several of his papers are recognized as important advances that have significantly impacted the fields of genetic toxicology, carcinogenesis, toxicogenomics, and risk assessment.

For 30 years, Dr. Waters directed research in cellular pathology, biochemistry, and genetic toxicology in various capacities at the US EPA in RTP, NC. He also served US EPA as an Assistant Laboratory Director with programmatic responsibility for international, waste, and multi-media research programs. At US EPA he conceived, designed, and helped to develop the US EPA Gene-Tox database, now hosted by the National Library of Medicine. He also developed the US EPA/International Agency for Research on Cancer (IARC) Genetic Activity Profile (GAP) Database which forms the basis for the use of short-term tests in the evaluation of presumptive human carcinogens by the IARC.

For six years prior to coming to ILS, Dr. Waters served as Assistant Director of the National Center for Toxicogenomics where he was responsible for a major initiative to develop the Chemical Effects in Biological Systems (CEBS) knowledge base. CEBS is being utilized by the NIH and other government agencies as well as the academic, industrial, and international regulatory scientific communities as a data repository and analytical toolset for the interpretation of toxicogenomics data. At NIEHS, Dr. Waters served on the NIH Bioinformatics and Computational Biology Roadmap Working Group, the US FDA Advisory Committee for Pharmaceutical Science, Pharmacology and Toxicology Subcommittee, the Toxicogenomics and Risk Assessment Committee of the International Programme on Chemical Safety (IPCS), the Advisory Board of the Microarray Gene Expression Data (MGED) Society, and the Scientific Advisory Board of the Rat Genome Database (RGD).

• Jinghai (Jim) Xu

Jinghai (Jim) Xu, PhD, is Senior Director and Head of Research Services, Knowledge Discovery and Knowledge Management (KDKM) at Merck Research Laboratories. His group is responsible for KDKM activities across drug research and development spectrum, from drug target evaluation to safety de-risking to clinical trial site identification. Before joining Merck, Jim has led research activities at Pfizer in predictive toxicology, ADME, in vitro in vivo correlations, high content screening, and systems biology. Jim received his PhD in Toxicology from the Massachusetts Institute of Technology (MIT). He has been honored with a number of awards including the Pfizer Central Research Achievement Award, Whitaker Health Sciences Fellowship, and Rhone-Poulenc Rorer Young Investigator Award. He is an author, editor, and reviewer for Cambridge University Press, Wiley & Sons, and Bentham Science.

• Ed Zillioux

Ed Zillioux, PhD, is currently the owner and president at Zillioux Environmental, LLC, a consultancy performing environmental toxicology and risk assessment studies, environmental impact statements, natural resource damage assessments and life cycle analysis. Concurrent with that position he founded the nonprofit International Society of Environmental Indicators, organized international conferences,and served as Editor-in-Chief of the Journal of Environmental Indicators for its first four years. He also serves as an Adjunct Professor at the University of Massachusetts, School of Public Health, Amherst. Prior to this Dr. Zillioux was an Environmental Toxicologist with Florida Power & Light Co ,on the Research Faculty of the Rosenstiel School of Marine and Atmospheric Science, University of Miami, and Senior Scientist for Ecological Effects at the US EPA, Office of Toxic Substances. In the latter capacity he managed an extramural program in areas of ecology, ecological toxicology and environmental effects, and coordinated projects with all relevant US EPA laboratories. He provided final review of branch products including bioassay protocol documents; served as representative to Science Review & Science Policy Boards and was an US EPA appointee to the Interagency Testing Committee.

Contact Information

SOT Headquarters
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
USA
Tel: 703.438.3115
Fax: 703.438.3113
Email: sothq@toxicology.org

Accommodations/Travel Information

The following hotels are located near the US EPA. For your convenience, information is provided from the hotel websites with links to their home pages. We have chosen those known to offer excellent service at reasonable rates, and which offer free shuttle service to and from the US EPA campus.

To make your hotel reservations, please select the hotel name provided for your choice.

• Comfort Suites—Raleigh Durham Airport—Rooms starting at $109 per night.

  • All rooms non smoking.
  • Free airport transportation
  • Free area transportation within a five-mile radius
  • Free wireless high-speed Internet access
  • Manager’s reception Monday–Wednesday 5:30 pm–7:00 pm, featuring hors d’oeuvres, wine, beer, and cold beverages.
    
    
• Hilton—Raleigh Durham Airport—Rooms starting at $169 per night.

  Adjacent to the Research Triangle Park area and 10–15 minutes from both Raleigh and Durham.

  Our well-appointed newly renovated guestrooms feature one king or two double beds, 2 telephones each with two lines, voicemail and dataports. Large work desk, high speed Internet access is available for a fee, coffee maker, hairdryer, iron/board, and luxurious bath amenities by Crabtree & Evelyn®. All guest rooms are non-smoking.

• Holiday Inn Express—Research Triangle Park—Rooms starting at $99 per night.

  Join us at this Holiday Inn Express® hotel in Durham every Tuesday and Wednesday from 5:30 pm to 7:00 pm for the complimentary Manager’s Reception. Drop by for two complimentary drinks (beer, wine, soda, and bottled water); light hors d’oeuvres are also served as a “thank you” for your friendly patronage.

• Homewood Suites by Hilton—Rooms starting at $159 per night.

  Our spacious studio, one- and/or two-bedroom suites feature separate living and sleeping areas. Each has a fully-equipped kitchen with full-size refrigerator, microwave, 2-burner stove and dishwasher. You’ll find enough space for work, study or entertaining—plus all the comforts of home including two remote control TVs, complimentary high speed internet access, and two phones with voice mail. Enjoy a complimentary Suite Start® hot breakfast seven days a week and a Welcome Home Reception® featuring a complimentary light meal and beverages Monday through Thursday evenings (local laws apply).

• Radisson Hotel—Rooms starting at $139 per night.

  We have been awarded a 3 key rating from the Green Key Eco-Rating Program—recognizing us as a hotel that has taken significant steps to protect the environment. Strong environmental programs, best management practices, training programs and engineering solutions have been implemented which have benefited the environment and the local community.

Security/Campus Access

All visitors must show a photo ID and keep their ID with them at all times. Visitors will be issued a visitor badge and will be required to wear their badge at all times.

US EPA Campus Brochure

Internet Access

The US EPA campus has public internet access available in the conference center. US EPA’s network is PC-based. Details on how to access the internet will be made available at the meeting.