Français Translation

Environmental Stressors in the Developmental Origins of Disease:
Evidence and Mechanisms

(Prenatal Programming and Toxicity)

May 14–16, 2012
Paris, France

In an effort to be environmentally conscious, registrants are encouraged to use the online PPTOX III resources to view conference materials. Use these options to download materials to your computer, smartphone, or tablet.

Index

Abstracts Submissions	Organizing Committee
Accommodations	Registration Information
Poster Instructions	Sponsors
Program	Visa Information

 

Background

Fetal and early postnatal development constitutes the most vulnerable time period of human life, in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. This hypothesis, which states that environmental exposures lead to altered programming and thereby to increased susceptibility to disease/dysfunction later in life, has gathered much support from both experimental and epidemiological studies. Similar observations have been made on the long-term impact of nutritional unbalance during early development. Such effects during prenatal and early postnatal environment may be mediated through gene expression and epigenetic changes as important mechanisms for functional programming. Since epigenetic disruption is most likely to occur during specific times during development, the timing of environmental exposures is critical for their effects on disease etiology.

The first PPTOX conference took place in Torshavn, Faroe Islands in 2007.

The second PPTOX conference took place in Miami, Florida in 2009.

View a listing of the previous SOT CCT Meetings.

Objectives

This international conference will focus on the role of environmental exposures and nutrients during development on subsequent diseases/dysfunctions later in life. The goal of the conference is to examine the animal and human data supporting this hypothesis (developmental basis of disease) by disease, organ system, and mechanism in order to review the current state of the literature and to identify mechanisms for the effects as well as to identify research gaps and challenges and to integrate the basic and applied science.

The following items will be discussed during the meeting:

• New epidemiological and toxicological evidence for the contribution of developmental exposure to adult disease
• Predictive value of animal and alternative models
• The essential contribution of epigenetics to programming
• The effect of chemical or physicals insults as well as nutritional imbalance on stem cells
• The long path from discovery to regulation

Product

A “consensus paper” was drafted by the PPTOX III Organizing Committee regarding the current scientific insight in this field and the implications for future research and public health. Registered PPTOX III participants were encouraged to provide comments on the draft. The plan is to publish it with open access in Environmental Health (www.ehjournal.net) by mid-June. As the manuscript had already undergone peer review with conference participants, no further review has been required, which helps speeding up the publication process!

Following publication, we invite conference participants to co-sign the white paper by submitting their name, affiliation (for identification purposes only), and country to pptox3@gmail.com. The email account will send an automated confirmation that your message has been received. A list of co-signatories will be accessible as a Comment with the published article, and the Comment will be repeatedly updated as the number of co-signers increases (up to three months after publication). So please tell your colleagues about this option!

A separate conference report discussing novel findings in this field and future prospects will be prepared for Toxicological Sciences (pending acceptance).

Abstract and Poster Information

Abstract Submissions

Note: The abstract submission system deadline has passed. You may upload a poster for a previously submitted abstract here:

Upload Poster

The PPTOX III abstracts will be published on a secure website for the meeting attendees to access and to download. All accepted abstract presenters will be given the option to upload their Poster Presentations to the same site.

Abstracts should describe the aims of the work, methods, and the key experimental findings in a clear and succinct manner. Brevity is important. All abstracts will be reviewed for scientific content and the Scientific Review Committee reserves the right to refuse abstracts that do not adhere to publication guidelines. It is hoped that abstracts and posters will be the first presentations of the study represented; however, abstracts previously presented at national/international meetings are welcomed.

In order to accommodate Visa requests and oral presentation deadlines, PPTOX III has established two abstract submission deadlines for the meeting.

Standard Review Deadline: March 22, 2012

Poster Information

Poster Instructions

Poster Presentation Dates, Time, and Order

Accepted Poster Presentations

• Poster Number 1–44 presentation times are Monday, May 14, 2012, between 12:30 and 14:00
• Poster Numbers 45–90 presentation times are Tuesday, May 15, 2012, between 13:00 and 14:30
• Poster Number 91–130 presentation times are Wednesday, May 16, 2012, between 13:00 and 14:30

Poster Set-up and Tear-down Dates and Times: On the day of the poster presentation, presenters should set up their poster between 08:00–09:00. On the same day, please remove the poster after 16:30.

For the PPTOX III meeting, SOT is asking poster presenters to provide SOT with an electronic version of their poster for posting in a secure, online gallery after the meeting that only meeting attendees will be able to access.

Prior to the meeting attendees will be able to download accepted abstracts and poster presentations submitted by presenters.

Student Travel Award Winner: Please join the Society of Toxicology in congratulating the student travel award winners. The PPTOX III sponsors helped to provide travel funding for the winners.

Student Travel Award Winner List

Program

Sunday, May 13, 2012

Université Paris-Descartes, 12 rue de l’Ecole de Médecine, 75006 Paris

16:30–18:00	Registration for preregistered attendants (Badges will be available at this time.)
17:00–18:00	Pre-event: Science and the Precautionary Principle (European Environment Agency) Presentation of Late Lessons From Early Warnings: Science, Precaution, Innovation (An EEA monograph just completed. It is possible for all PPTOX III participants to order a free copy.)
18:00–19:30	Conference Reception and Welcome Guided tours of Musée d’Histoire de la Médecine, where precious medical instruments among the oldest in Europe are exhibited along with surgery and physiology tools up to the end of the 19th century. (Tours start at 18:00 and every 30 minutes thereafter until 19:30, to registration for the reception and to reserve a slot for a tour, please RSVP for the Musée d’Histoire de la Médecine. When you click on the RSVP, please select your registration type and the reception and tour are inclusive of the meeting registration fee.)

Monday, May 14, 2012

Espace Saint Martin, 199bis, rue Saint Martin, 75003 Paris

08:00–09:30	Registration, Coffee Service
09:30–11:00	Session I: Opening and State-of-the-Art Chairs: Robert Barouki (France), and Philippe Grandjean (Denmark) Opening and Welcome by the Chairs and Mark Hanson, DOHaD, UK Global Perspective on Children’s Environmental Health—Maria Neira, PhD, World Health Organization, Switzerland Developmental Programming As an Environmental Health Challenge—Jacqueline McGlade, PhD, European Environment Agency, Denmark Developmental Programming by Nutrition or Environmental Chemical Exposures: Two Sides of the Same Coin—Jerry J. Heindel, PhD, National Institute of Environmental Health, United States
11:00–11:30	Refreshment Break
11:30–12:30	Session I: Opening and State-of-the-Art (cont’d) Evidence for Decision-Making—When Enough Is Enough—David Gee, European Environmental Agency, Denmark DOHAD: Political and Policy Implications for Disease Prevention—Sir Peter Gluckman, MD, University of Auckland, New Zealand
12:30–14:00	Lunch and Posters
14:00–15:45	Session II: Programming and Epigenetics Chairs: Shuk-mei Ho (USA), and Claudine Junien (France) The Human Placenta: Prediction of Future Health—Danièle Evain-Brion, MD, University of Paris, France Nutritional Programming in Health and Disease—Karen A. Lillycrop, PhD, University of Southampton, United Kingdom Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms—Moshe Szyf, PhD, McGill University, Canada
15:45–16:15	Refreshment Break and Posters
16:15–18:00	Session III: Immune System Programming Chairs: Anders Glynn (Sweden), and Cheryl Lyn Walker (USA) In Utero Exposure and Immunological Programming—John W. Hollingsworth, MD, Duke University Medical Center, United States Early Life Exposures, Lung Development, and the Impact on Immunity—B. Paige Lawrence, PhD, University of Rochester, United States Immunotoxicant Effects on Children’s Response to Vaccinations—Carsten Heilmann, MD, National University Hospital, Denmark

Tuesday, May 15, 2012

08:30–10:45	Session IV: Developmental Basis of Obesity/Metabolic Syndrome Chairs: Linda S. Birnbaum (USA), and Juliette Legler (Netherlands) Mechanisms Underlying the Developmental Origins of Obesity and the Metabolic Syndrome—Sue Ozanne, PhD, University of Cambridge, United Kingdom Stem Cell Programming in Obesity—Bruce Blumberg, PhD, University of California Irvine, United States Consequences of Protein Malnutrition during Prenatal and Early Postnatal Stages—Pierre Fafournoux, PhD, INRA-CRS, France Timing of Developmental BPA Exposure As Predictor of Diabetes Development—Angel Nadal, PhD, Universidad Miguel Hernandez de Elche, Spain
10:45–11:15	Refreshment Break and Posters
11:15–13:00	Session V: Developmental Origins of Neurobehavioral Deficits and Disease Chairs: Brenda Eskenazi (USA), and Anna Price (Italy) In Vitro Assessment of Developmental Neurotoxicity: Species Can Make a Difference—Ellen Fritsche, MD, Leibniz Research Institute for Environmental Medicine, Germany Brain Anomalies in Children Exposed Prenatally to a Common Organophosphate Pesticide—Virginia A. Rauh, PhD, Columbia University, United States Developmental Effects of Perinatal Usage of Anaesthetics—Merle G. Paule, PhD, National Center for Toxicological Research, United States
13:00–14:30	Lunch and Posters
14:30–16:00	Session VI: Gene Expression, Metabolomics, and Cancer Chairs: Gail Prins (USA), and Yorghos Remvikos (France) Gene Expression Analysis and Pathway Mapping in BPA Toxicity—Toshi Shioda, MD, Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, United States Metabolomic Biomarkers in Programming—Daniel Zalko, PhD, National Institute for Agricultural Research, France The Endocrine Disruptor Bisphenol A Programs for Mammary Cancer Development—Coral Lamartiniere, PhD, University of Alabama at Birmingham, United States
16:00–16:30	Refreshment Break and Posters
16:30–18:00	Session VII: National and Synthetic Birth Cohorts Chairs: Ludwine Casteleyn (Belgium), and Eun-hee Ha (Korea) Developmental Origins of Obesity in the Spanish INMA Birth Cohorts—A Tale of Different Exposures—Martine Vrijheid, PhD, Center for Research in Environmental Epidemiology, Spain Gut Microbiota and Environmental Toxicants: Infants under Double Attack—Merete Eggesbo, MD, Norwegian Institute of Public Health, Norway Japan Environment and Children’s Study in the Wake of the Great East Japan Earthquake and Accompanying Disasters—Hiroshi Satoh, PhD, National Center for the Japan Environment and Children’s Study, Japan

Wednesday, May 16, 2012

08:30–10:45	Session VIII: Developmental Origins of Reproductive Diseases/Dysfunctions Chairs: Sylvaine Cordier (France), and Tina Kold Jensen (Denmark) Multiorgan Effects of Endocrine Disruption—Heather B. Patisaul, PhD, North Carolina State University, United States Impact of Environmental Chemicals on Early Human Development—Russ Hauser, MD, Harvard School of Public Health, United States Secular Trends in Timing of Puberty and Role for Environmental Exposure—Anders Juul, MD, Rigshospitalet Hospital, University of Copenhagen, Denmark Hormonal and Semen Abnormalities in Adults—Whose Mothers Were Exposed to Dioxin in Seveso—Paolo Mocarelli, MD, University of Milano—Biccocca, Italy
10:45–11:15	Refreshment Break and Posters
11:15–13:00	Session IX: Developmental Basis of Cardiovascular Disease Chairs: Pal Weihe (Faroe Islands), and Denis Zmirou (France) Molecular Basis for Toxicant-Induced Cardiovascular Disease—Alvaro Puga, PhD, University of Cincinnati, United States The Impact and Mechanisms of Bisphenol A in the Heart—Scott M. Belcher, PhD, University of Cincinnati, United States Long-Term Cardiovascular Effects of Fetal Smoke Exposure—Vincent W.V. Jaddoe, MD, Erasmus Medical Center, Netherlands
13:00–14:30	Lunch and Posters
14:30–16:15	Session X: Environment-Nutrition Interactions and Disease Prevention Chairs: Gérard Lasfargues (France), and John Balbus (USA) Impact of Early Nutrition on Long-Term Health—Veit Grote, MD, University of Munich Medical Centre, Germany Early Life Exposures to Flame Retardants and Developmental Consequences—Heather M. Stapleton, PhD, Duke University, United States The Early Life Exposome and Future Disease Risk—Martyn T. Smith, PhD, University of California Berkeley, United States
16:15–17:30	Session XI: Future Agenda and Conference Conclusions Chairs: Jerry Heindel (USA), and Toshihiro Kawamoto (Japan) Taking Action on Developmental Programming to Protect Future Generations—Kristin Shrader-Frechette, PhD, University of Notre Dame, United States Environmental Stressors in the Development of Disease: Where Do We Go from Here?—Linda S. Birnbaum, PhD, National Institute of Environmental Health, United States Conference Conclusions—Robert Barouki, MD, University of Paris Descartes, France and Philippe Grandjean, MD, University of Southern Denmark, Denmark

 

Organizing Committee

• Robert Barouki (France) (Co-Chair)
• Peter Gluckman (New Zealand)
• Philippe Grandjean (Denmark) (Co-Chair)
• Mark Hanson (United Kingdom)
• Jerrold Heindel (United States)
• Gérard Lasfargue (France)

Scientific Committee

• Bruce Blumberg (United States)
• Ludwine Casteleyn (Belgium)
• Sylvaine Cordier (France)
• Danièle Evain-Brion (France)
• Ruth Etzel (WHO)
• Shuk-mei Ho (United States)
• Claudine Junien (France)
• Toshihiro Kawamoto (Japan)
• Berthold Koletzko (Germany)
• Paige Lawrence (United States)
• Anna Price (Italy)
• John Rogers (United States)
• William Slikker Jr. (United States)
• William Suk (United States)
• Jordi Sunyer (Spain)
• Jorma Toppari (Finland)
• Cheryl Lyn Walker (United States)

Contact Information

SOT Headquarters
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
USA
Tel: 703.438.3115
Fax: 703.438.3113
Email: sothq@toxicology.org

Sponsors

The Society of Toxicology

ANSES

Aviesan

Endowment Fund, SOT

Eunice Kennedy Shriver National Institute of Child Health and Human Development
Grant No. R13HD072606

European Environment Agency

Forsythia Foundation

International Society for Developmental Origins of Health and Disease (DOHaD)

National Center For Toxicological Research

National Institute of Environmental Health Sciences

National Institute for Environmental Studies

Santé Environnement Toxicologie Ile-de-France

Superfund Research Program

Université Paris Descartes

World Health Organization

Invitation to PPTOX III Meeting

The PPTOX III Meeting welcomes all participants interested in the evolving area of science. The meeting is open to all paid attendees. If for Visa purposes, you need a formal Letter of Invitation to the meeting, please contact SOT Headquarters.

Registration Information

Conference Fees

Registration Type	Early Bird	Advanced	On-Site
	January 12, 2012	January 13, 2012– April 20, 2012	After April 20, 2012
SOT Member	$625	$675	$725
Non-Member	$675	$725	$775
Student/Postdoc Member	$200	$250	$300
Student/Postdoc Non-Member	$250	$300	$350

Fees include all general sessions, program materials, morning refreshments, breaks, and the opening reception. Attendees will be provided access to a secure website to access all the meeting materials.

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner’s Club, or American Express), or by a US Government Purchase Order (check must be drawn from the US Department of Treasury). Please use the registration form. All wire transfers should include an additional $40 processing fee.

No telephone registrations will be accepted.

Registration Form

To register, please send the registration form and payment or credit card information by one of the following methods:

1. Mail/USPS Express packages:
   CCT-PPTOX III, Society of Toxicology
   1821 Michael Faraday Drive, Suite 300
   Reston, VA 20190
2. Fax: 703.438.3113
   

NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. SOT needs only one copy for processing.

Registration Deadline:  After April 20, 2012, you must register on-site.

Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by May 1, 2012. These refunds will be processed, less a $30 fee, following the Meeting.

Congress Fees

Paid registrants will have the right to participate in all the scientific programs held over May 14–16, 2012. Registrants will have access to a secure website with real-time meeting content that includes the scientific program, abstracts, poster presentations, and attendee list. In an effort to be environmentally conscious, registrants are encouraged to use the online PPTOX III recourses to view conference materials.

All registrants are welcome to partake in the morning coffee served prior to the start of the meeting and during the morning break times. A light fork buffet lunch will be served during the mid-day poster sessions. On Monday, May 14, 2012, there will an afternoon poster presentation with light refreshments.

Registrants will receive an attendee badge upon arrival at the meeting (see Program for registration hours).

Visa Information

All foreign nationals entering and staying on French territory must be in possession of a valid passport/entry and stay Visa, unless you are exempt from this requirement. To learn more about obtaining a French Visa visit the France Diplomatie website.

Accommodations

Paris offers a full range of hotels, in all categories.

Special congress rates have been negotiated especially in hotels located within walking distance from the congress center, or easily accessible with transport system. For more information and rates visit the PPTOX III 2012 website.

WIP, official housing agency part of Colloquium Group, is at your disposal for all your hotel reservations:

View the hotels specially selected for your event.

Make your reservations online for individual bookings (up to 4 rooms).

For group bookings (min. 5 rooms), please contact:

Sales Department: +33 (0)1 70 36 04 30
Fax: +33 (0)1 70 36 04 21
Email: info@wipresa.com

Attire

The official attire for the meeting is business casual. No coats or ties are required! We encourage you to bring comfortable clothing.

Green Meeting

The Espace Saint Martin is locate within walking distance of four metro stops, view the Area Map of the Espace Saint Martin.

The facility has many earth-friendly features like low emission glass that controls heat gain and loss, and maximizes natural lighting.

The Society of Toxicology and the contributing sponsors of the PPTOX III meeting are committed to be environmental conscious. QR (Quick Response) codes will provide easy access to the online meetings materials so attendees can view the latest meeting content via their personal computers, PDA, etc.

Facilities Information

All scientific presentations and poster presentations will be held at the Espace Saint Martin located at:

199bis, rue Saint Martin
75003 PARIS
Tel: 01 44 54 38 54
Fax: 01 44 54 38 53

PPTOX III Location Map

There are four metro stations located within walking distance of the facility. View the Area Map of the Espace Saint Martin.

Internet Access

The Escape Saint Martin has internet access throughout the building. Details on how to access the internet will be made available at the meeting.

Family Care Services Information

Child Care Options

Créches de France is a nationwide childcare provider with several day care facilities in Paris. Parents seeking childcare facilities during the PPTOX III meeting are encouraged to contact them.

Pending approval of formal application, the hourly rate ranges between 3–6 euros per hour per child depending on age.

For more information, please contact:

Créches de France
31, boulevard de la Tour Maubourg
75007 Paris
Tél: 01 44 11 74 78
Fax: 01 44 09 90 23

Adult Care Option

For attendees needing assistance with adolescents and adult care, non-medical facilities are available at the Espace St. Martin. Rates are dependent on level of assistance required.

For more information, please contact:

Clarissa Russell Wilson
Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
Tel: 703.438.3115
Fax: 703.438.3113

Lydie Rosario
INSERM UMR-S 747
“Toxicologie, Pharmacologie et Signalisation Cellulaire”
Université Paris Descartes
Centre Universitaire des Saints-Pères
45 Rue des Saints-Pères—75270 PARIS Cédex 06
Tel: (33)(0)1 42 86 38 66
Fax: (33)(0)1 42 86 38 68

Important Dates

Accommodation Deadline	May 1, 2012
Abstract Early Deadline	December 15, 2011
Abstract Standard Deadline	March 22, 2012
Cancellation Deadline	May 1, 2012
Early Registration Cut-off	January 12, 2012
Standard Registration Cut-off	April 20, 2012
On-site Registration Begins	April 21, 2012

Language

All conference materials and scientific presentations will be conducted in English.

Press Release

Scientists Explore Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms—Experts from around the world are gathering in Paris to examine the animal and human data supporting a hypothesis that subtle effects during fetal and postnatal development can lead to functional deficits and increased disease later in life.

Read more information about the third International Conference on Fetal Programming and Developmental Toxicity (PPTOX III).

Paris, France

View the 2010–2011 Paris for You guidebook and explore the many aspects of Paris, multifaceted and festive city. Brochure courtesy of the Paris Convention and Visitors Bureau.

Paris, the “City of Light” is a million different things to a million different people. Over 19 percent of the French populations live in Paris. Paris has all but exhausted the superlatives that can reasonably be applied to any city. Notre Dame and the Eiffel Tower—at sunrise, at sunset, at night—have been described countless times, as have the Seine and the subtle (and not-so-subtle) differences between the Left and Right Banks. But what writers have been unable to capture is the grandness and even the magic.

Paris probably has more familiar landmarks than any other city in the world. As a result, first-time visitors often arrive in the French capital with all sorts of expectations: of grand vistas, of intellectuals discussing weighty matters in cafés, and of romance along the Seine. View the Lonely Plant Photo Gallery.

Weather

May is a lovely time to be in Paris. The region has some of the lowest precipitation on the country, but rainfall is perfect in May.

You can find out the weather forecast in French for the Paris area by calling 0 892 680 275. The national forecast can be heard on 0 899 701 234 in French or 0 899 701 111 in one of 11 different languages. The summary can also be read for free on the Météo France website (in French).

In case of inclement weather, coat racks will be provided at the Espace St. Martin, but the cloak room will be unattended.