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Mark your calendar SOT Annual Meeting March 11–15, 2012.

Français Translation

Environmental Stressors in the Developmental Origins of Disease:
Evidence and Mechanisms

(Prenatal Programming and Toxicity)

May 14–16, 2012
Paris, France

Index

Abstracts Submissions	Organizing Committee
Accommodations	Registration Information
Poster Instructions	Sponsors
Program	Visa Information

Background

Fetal and early postnatal development constitutes the most vulnerable time period of human life, in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. This hypothesis, which states that environmental exposures lead to altered programming and thereby to increased susceptibility to disease/dysfunction later in life, has gathered much support from both experimental and epidemiological studies. Similar observations have been made on the long-term impact of nutritional unbalance during early development. Such effects during prenatal and early postnatal environment may be mediated through gene expression and epigenetic changes as important mechanisms for functional programming. Since epigenetic disruption is most likely to occur during specific times during development, the timing of environmental exposures is critical for their effects on disease etiology.

The first PPTOX conference took place in Torshavn, Faroe Islands in 2007.

The second PPTOX conference took place in Miami, Florida in 2009.

View a listing of the previous SOT CCT Meetings.

Objectives

This international conference will focus on the role of environmental exposures and nutrients during development on subsequent diseases/dysfunctions later in life. The goal of the conference is to examine the animal and human data supporting this hypothesis (developmental basis of disease) by disease, organ system, and mechanism in order to review the current state of the literature and to identify mechanisms for the effects as well as to identify research gaps and challenges and to integrate the basic and applied science.

The following items will be discussed during the meeting:

New epidemiological and toxicological evidence for the contribution of developmental exposure to adult disease
Predictive value of animal and alternative models
The essential contribution of epigenetics to programming
The effect of chemical or physicals insults as well as nutritional imbalance on stem cells
The long path from discovery to regulation

Product

The outcomes of this meeting will include updated information on the state of the front-line science in this field, expanded contact and possible development of collaborations among participants. In preparation for the conference, the organizing committee plans to collate a position paper (‘white paper’) on the pptox issues and the questions and opportunities they raise in regard to research and interventions. This document will be circulated before the meeting and will be used as background for discussions. A conference report discussing novel findings in this field and future prospects will be prepared for Toxicological Sciences (pending acceptance).

Abstract and Poster Information

Abstract Submissions

Submit an Abstract

The PPTOX III abstracts will be published on a secure Web site for the meeting attendees to access and to download. All accepted abstract presenters will be given the option to upload their Poster Presentations to the same site.

Abstracts should describe the aims of the work, methods, and the key experimental findings in a clear and succinct manner. Brevity is important. All abstracts will be reviewed for scientific content and the Scientific Review Committee reserves the right to refuse abstracts that do not adhere to publication guidelines. It is hoped that abstracts and posters will be the first presentations of the study represented; however, abstracts previously presented at national/international meetings are welcomed.

In order to accommodate Visa requests and oral presentation deadlines, PPTOX III has established two abstract submission deadlines for the meeting.

Standard Review Deadline: March 22, 2012

Poster Information

Poster Instructions

Poster Presentation Dates, Time, and Order

Monday, May 14, 2012, from 18:00–19:30 (posters on display, but not attended).
Tuesday, May 15, 2012, from 12:00–13:30; the odd number posters will present.
Wednesday, May 16, 2012, from 12:00–13:30; the even number posters will present.

For the PPTOX III meeting, SOT is asking poster presenters to provide SOT with an electronic version of their poster for posting in a secure, on-line gallery after the meeting that only meeting attendees will be able to access.

Program

Day 1: Monday, May 14, 2012

08:00–09:30	Registration, Coffee Service
09:30–12:30	Session I: Opening and State-of-the-Art Global Perspective on Children’s Environmental Health—Maria Neira, PhD, World Health Organization, Switzerland Programming Effects of Environmental Exposures and Human Disease—Jerry Heindel, PhD, National Institute of Environmental Health, United States Evidence for Decision-Making—When Enough is Enough—David Gee, European Environmental Agency, Denmark Political and Policy Implications for Disease Prevention—Peter Gluckman, MD, University of Auckland, New Zealand
12:30–14:00	Lunch and Posters
14:00–16:20	Session II: Programming and Epigenetics The Human Placenta: Prediction of Future Health—Danièle Evain Brion, MD, University of Paris, France Nutritional Programming in Health and Disease—Karen Lillycrop, PhD, University of Southampton, United Kingdom Epigenetic Effects of Developmental Stress—Moshe Szyf, PhD, McGill University, Canada
16:20–16:50	Refreshment Break and Posters
16:50–18:30	Session III: Immune System Programming In utero Exposure and Immunological Programming—John Hollingsworth, PhD, Duke University Medical Center, United States Early Life Exposures, Lung Development, and the Impact on Immunity—Paige Lawrence, PhD, University of Rochester, United States Immunotoxicant Effects on Children’s Response to Vaccinations—Carsten Heilmann, MD, National University Hospital, Denmark
18:30	Welcome Reception (Light refreshments served.)

Day 2: Tuesday, May 15, 2012

08:30–11:10	Session IV: Developmental Basis of Obesity/Metabolic Syndrome Experimental Models of the Developmental Origin of Obesity—Sue Ozanne, PhD, Cambridge University, United Kingdom Stem Cell Programming in Obesity—Bruce Blumberg, PhD, University of Southern California, United States Programming Effects of Perinatal Undernutrition—Pierre Fafournoux, PhD, National Institute for Agricultural Research, France Timing of Developmental BPA Exposure as Predictor of Diabetes Development—Angel Nadal, PhD, Miguel Hernández University of Elche, Spain
11:10–11:40	Refreshment Break and Posters
11:40–13:00	Session V: Developmental Origins of Neurobehavioral Deficits and Disease In Vitro Assessment of Developmental Neurotoxicity—Ellen Fritsche, MD, Leibniz Research Institute for Environmental Medicine, Germany Prospective Evidence of Developmental Pesticide Neurotoxicity—Virginia Rauh, PhD, Columbia Center for Children’s Environmental Health, United States Developmental Effects of Perinatal Usage of Anaesthetics—Merle Paule, PhD, National Center for Toxicological Research, United States
13:00–14:30	Lunch and Posters
14:30–15:45	Session VI: Gene Expression, Metabolomics, and Cancer Gene Expression Analysis and Pathway Mapping in BPA Toxicity—Toshi Shioda, MD, Massachusetts General Hospital, United States Prospects of Metabolomic Biomarkers of Endocrine Disruption—Daniel Zalko, PhD, National Institute for Agricultural Research, France Developmental Programming of Breast Cancer—Coral Lamartiniere, PhD, University of Alabama at Birmingham, United States
15:45–16:15	Refreshment Break and Posters
16:15–17:30	Session VII: National and Synthetic Birth Cohorts Developmental Origin of Obesity in European Birth Cohorts—Martine Vrijheid, PhD, Center for Research in Environmental Epidemiology, Spain Gut Microbiota and Environmental Toxicants: Infants under Double Attack—Merete Eggesbo, MD, Norwegian Institute of Public Health, Norway Japan Environment and Children’s Study after the Earthquake—Hiroshi Satoh, PhD, National Institute for Environmental Study, Japan

Day 3: Wednesday, May 16, 2012

08:30–10:30	Session VIII: Developmental Origins of Reproductive Diseases/Dysfunctions Multiorgan Effects of Endocrine Disruption—Heather Patisaul, PhD, North Carolina State University, United States In Vitro Fertilization and Disease Outcomes—Russ Hauser, MD, Harvard University, United States Secular Trends in Timing of Puberty and Role for Environmental Exposure—Anders Juul, MD, National University Hospital, Denmark Hormonal and Semen Abnormalities in Adults Whose Mothers Were Exposed to Dioxin in Seveso—Paolo Mocarelli, MD, University of Milano, Italy
10:30–11:00	Refreshment Break and Posters
11:00–13:00	Session IX: Developmental Basis of Cardiovascular Disease Molecular Basis for Toxicant-Induced Cardiovascular Disease—Alvaro Puga, PhD, University of Cincinnati, United States Cardiovascular Effects of Developmental Exposure to Environmental Chemicals—Scott Belcher, PhD, University of Cincinnati, United States Long-Term Cardiovascular Effects of Fetal Smoke Exposure—Vincent Jaddoe, MD, Erasmus Medical Center, The Netherlands
13:00–14:30	Lunch and Posters
14:30–16:30	Session X: Environment-Nutrition Interactions and Disease Prevention Effects of Nutrients on Development and Health Outcomes—Berthold Koletzko, MD, University of Munich, Germany Early Life Exposures to Flame Retardants and Developmental Consequences—Heather Stapleton, PhD, Duke University, USA The Early Life Exposome and Future Disease Risk—Martyn Smith, PhD, UC Berkeley, USA
16:30–17:30	Session XI: Future Agenda and Conference Conclusions Taking Action on Developmental Programming to Protect Future Generations—Kristin Shrader-Frechette, PhD, University of Notre Dame, United States Developmental Time Windows of Vulnerability as a Focus for Disease Prevention—Linda S. Birnbaum, PhD, National Institute of Environmental Health, United States Conference Conclusions—Robert Barouki, MD, University of Paris Descartes, France and Philippe Grandjean, MD, University of Southern Denmark, Denmark

Organizing Committee

Scientific Committee

Bruce Blumberg (United States)
Ludwine Casteleyn (Belgium)
Sylvaine Cordier (France)
Danièle Evain-Brion (France)
Ruth Etzel (WHO)
Shuk-mei Ho (United States)
Claudine Junien (France)
Toshihiro Kawamoto (Japan)
Berthold Koletzko (Germany)
Paige Lawrence (United States)
Anna Price (Italy)
John Rogers (United States)
William Slikker, Jr. (United States)
William Suk (United States)
Jordi Sunyer (Spain)
Jorma Toppari (Finland)
Cheryl Lyn Walker (United States)

Contact Information

SOT Headquarters
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
USA
Phone: 703.438.3115
Fax: 703.438.3113
E-mail: sothq@toxicology.org

Invitation to PPTOX III Meeting

The PPTOX III Meeting welcomes all participants interested in the evolving area of science. The meeting is open to all paid attendees. If for Visa purposes, you need a formal Letter of Invitation to the meeting, please contact SOT Headquarters.

Registration Information

Conference Fees

Registration Type	Early Bird	Advanced	On-Site
Registration Type	January 12, 2012	January 13, 2012– April 14, 2012	After April 14, 2012
SOT Member	$625	$675	$725
Non-Member	$675	$725	$775
Student/Postdoc Member	$200	$250	$300
Student/Postdoc Non-Member	$250	$300	$350

Fees include all general sessions, program materials, morning refreshments, breaks, and the opening reception. Attendees will be provided access to a secure Web site to access all the meeting materials.

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner’s Club, or American Express), or by a US Government Purchase Order (check must be drawn from the US Department of Treasury). Please use the registration form. All wire transfers should include an additional $40 processing fee.

No telephone registrations will be accepted.

On-Line Registration

Registration Form

To register, please send the registration form and payment or credit card information by one of the following methods:

Mail/USPS Express packages:
PPTOX III CCT, Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
Fax: 703.438.3113

NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. SOT needs only one copy for processing.

Registration Deadline: After April 14, 2012, you must register on-site.

Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by May 1, 2012. These refunds will be processed, less a $30 fee, following the Meeting.

Congress Fees

Paid registrants will have the right to participate in all the scientific programs held over May 14–16, 2012. Registrants will have access to a secure Web site with real-time meeting content that includes the scientific program, abstracts, poster presentations, and attendee list. In an effort to be environmentally conscious, registrants are encouraged to use the on-line PPTOX III recourses to view conference materials.

All registrants are welcome to partake in the morning coffee served prior to the start of the meeting and during the morning break times. A light fork buffet lunch will be served during the mid-day poster sessions. On Monday, May 14, 2012, there will an afternoon poster presentation with light refreshments.

Registrants will receive an attendee badge upon arrival at the meeting (see Program for registration hours).

Visa Information

All foreign nationals entering and staying on French territory must be in possession of a valid passport/entry and stay Visa, unless you are exempt from this requirement. To learn more about obtaining a French Visa visit the France Diplomatie Web site.

Accommodations

Paris offers a full range of hotels, in all categories.

Special congress rates have been negotiated especially in hotels located within walking distance from the congress center, or easily accessible with transport system. For more information and rates visit the PPTOX III 2012 Web site.

WIP, official housing agency part of Colloquium Group, is at your disposal for all your hotel reservations:

View the hotels specially selected for your event.

Make your reservations on-line for individual bookings (up to 4 rooms).

For group bookings (min. 5 rooms), please contact:

Sales Department: +33 (0)1 70 36 04 30
Fax: +33 (0)1 70 36 04 21
E-mail: info@wipresa.com

Attire

The official attire for the meeting is business casual. No coats or ties are required! We encourage you to bring comfortable clothing.

Green Meeting

The Espace Saint Martin is locate within walking distance of four metro stops, view the Area Map of the Espace Saint Martin.

The facility has many earth-friendly features like low emission glass that controls heat gain and loss, and maximizes natural lighting.

The Society of Toxicology and the contributing sponsors of the PPTOX III meeting are committed to be environmental conscious. QR (Quick Response) codes will provide easy access to the on-line meetings materials so attendees can view the latest meeting content via their personal computers, PDA, etc.

Facilities Information

All scientific presentations and poster presentations will be held at the Espace Saint Martin located at:

199bis, rue Saint Martin
75003 PARIS
Tel: 01 44 54 38 54
Fax: 01 44 54 38 53

There are four metro stations located within walking distance of the facility. View the Area Map of the Espace Saint Martin.

Internet Access

The Escape Saint Martin has internet access throughout the building. Details on how to access the internet will be made available at the meeting.

Important Dates

Accommodation Deadline	May 1, 2012
Abstract Early Deadline	December 15, 2011
Abstract Standard Deadline	March 22, 2012
Cancellation Deadline	May 1, 2012
Early Registration Cut-off	January 12, 2012
Standard Registration Cut-off	April 14, 2012
On-site Registration Begins	April 15, 2012

Language

All conference materials and scientific presentations will be conducted in English.

Press Release

Scientists Explore Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms—Experts from around the world are gathering in Paris to examine the animal and human data supporting a hypothesis that subtle effects during fetal and postnatal development can lead to functional deficits and increased disease later in life.

Paris, France

View the 2010–2011 Paris for You guidebook and explore the many aspects of Paris, multifaceted and festive city. Brochure courtesy of the Paris Convention and Visitors Bureau.

Paris, the “City of Light” is a million different things to a million different people. Over 19 percent of the French populations live in Paris. Paris has all but exhausted the superlatives that can reasonably be applied to any city. Notre Dame and the Eiffel Tower—at sunrise, at sunset, at night—have been described countless times, as have the Seine and the subtle (and not-so-subtle) differences between the Left and Right Banks. But what writers have been unable to capture is the grandness and even the magic.

Paris probably has more familiar landmarks than any other city in the world. As a result, first-time visitors often arrive in the French capital with all sorts of expectations: of grand vistas, of intellectuals discussing weighty matters in cafés, and of romance along the Seine. View the Lonely Plant Photo Gallery.

Weather

May is a lovely time to be in Paris. The region has some of the lowest precipitation on the country, but rainfall is perfect in May.

You can find out the weather forecast in French for the Paris area by calling 0 892 680 275. The national forecast can be heard on 0 899 701 234 in French or 0 899 701 111 in one of 11 different languages. The summary can also be read for free on the Météo France Web site (in French).

Previous and Upcoming CCT Meetings

SOT —Dedicated to Creating a Safer and Healthier World Through the Advancement of Science.

Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms