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Contemporary Concepts In Toxicology

 

Perfluoroalkyl Acids and Related Chemistries:
Toxicokinetics and Mode-of-Action Workshop
Society of Toxicology – Current Concepts in Toxicology

February 14-16, 2007
Westin Arlington Gateway, Arlington, VA

Revised Agenda —Due to the inclement weather we've pushed the schedule back to begin at 3:00 PM February 14, which affects the rest of the schedule for Wednesday through Friday as well.

Registration Form

Abstracts/Poster Reception	Hotel Information
Speaker Profiles	Airline Information
Agenda with Presentations	Transportation
Sponsors	About Location
Organizing Committee	Touring Programs
Programming Committee	Previous SOT Mixtures Meetings
Registration Information

Purposes and objectives of the SOT-CCT Workshop

The perfluoroalkyl acids (PFAA) and their salts, such as perfluoroalkyl sulfonates and their derivatives, perfluoroalkyl carboxylates, and telomer alcohols and their derivatives are important chemicals that have wide consumer and industrial applications. However, recent discoveries of their global distribution, environmental persistence, presence in humans and wildlife, as well as adverse health effects detected in laboratory animal models have generated considerable scientific, regulatory, and public interest on an international scale. Several national and international regulatory bodies, including those from Canada, Germany, OECD, Sweden, the UK, and USA, are currently assessing the toxicological hazards and potential health risks of certain PFAA. As an example, the U.S. EPA has prepared a preliminary draft health risk assessment for perfluorooctanoate (PFOA), and OECD has prepared hazard assessments for PFOS and PFOA. In addition, numerous human and wildlife biomonitoring studies have been conducted or are planned. At present, the Centers for Disease Control and Prevention in the USA has included some of the PFAA in their National Health and Nutrition Examination Survey (NHANES) and population-based evaluation of these chemicals will be available in their 2007 report. Because of the emerging interests in this class of chemicals, several workshops have been held, including SOT (2002), SETAC (2003), U.S. EPA/3M (2004), FLUOROS (2005), and OECD (2006), to address trace analysis of PFAA in various media, their fate and transport, and their toxicity.

Although the presence of certain PFAA in wildlife species, the detection in human body compartments (liver, serum, cord blood, breast milk), as well as the toxicological profiles of these chemicals (mostly PFOS and PFOA) in laboratory animal models have been increasingly reported in the literature, two major informational gaps still exist that considerably hamper the risk assessment efforts by the regulatory agencies. First, although the variability of elimination rates between species and, in some cases, between sexes within species, is known, including significantly lower elimination rates of some PFAA that lead to long elimination half-lives in humans, the underlying mechanisms for these differences in retention in the body are not well understood. Secondly, while some of the PFAA are known to be agonists for the peroxisome proliferator-activated receptor signaling pathways, and some may alter mitochondrial function and intercellular communication, little else is known about their modes of action that can account for the observed toxicity outcomes. Because the PFAA family is composed of over twenty individual chemicals (known to exist in the environment) with different carbon-chain lengths and functional substitutes and derivatives, an understanding of their kinetic properties and potential common modes of action will facilitate modeling of these chemicals for cross species extrapolation, and ultimately provide a reliable basis for their risk assessment for human health.

The proposed SOT-CCT workshop will therefore focus on these two issues. The three-day workshop will: (1) provide an overview of PFAA toxicity and description of recent findings with the sulfonates, carboxylates and telomer alcohols; (2) address the toxicokinetic profiles of various PFAA among animal models and humans, and the biological processes that are responsible for these toxicokinetic observations; (3) examine the possible modes of action that determine the toxicities observed in animal models and their relevance to human health risks; and (4) identify the critical research needs and strategies to fill the existing informational gaps that hamper risk assessment of these chemicals. Each of these topics will be led by expert investigators in these areas, and discussions will be initiated by several invited speakers who will lend insights to these subject matters. A substantial portion of this meeting will be devoted to an open forum discussion among all participants, as well as individual interactions during the poster sessions. A report summarizing the discussions will be submitted for publication in a peer-reviewed journal (with Toxicological Sciences having the first right of refusal).

Goal:
Identify and prioritize future research directions.

Aims:

• Open discussion of research needs
• Expert guidance in determining research priorities
• Insight on human relevance of toxicological data

Product:
The Workshop and publication of Workshop report in Toxicological Sciences

Abstracts and Poster Presentations

Individuals conducting research on toxicology, pharmacokinetics, biomonitoring and health risk evaluation of perfluorinated organic chemicals are encouraged to submit abstracts for presentation during the February 14-16, 2007, Poster Session. All PFAD topics are welcomed. Abstract submission will close on January 8, 2007. Please submit according to the instructions below.

Abstract Instructions:

1. Each Abstract is limited to 400 words.
2. Complete abstracts using Times New Roman, 12 point text. Please format abstracts using Microsoft Word. All formatting should be single spaced. Title, authors, affiliations, and body of the abstract should be separated by a paragraph break. Titles should be formatted in bold caps, 12-point Arial. Authors, affiliations, and body of the abstract should be formatted in regular 12-point times new roman. For authors, provide first name, middle initial(s), and last name. For affiliations, provide institution, department, and city, state/province, and country. Use superscipt numbers to distinguish author affiliations. Separate three or more authors with a comma, and separate affiliations with semicolon(s). Do not include figures or tables. The following example can be used as a guide: Example Abstract (Microsoft Word format)
3. The title should be as brief as possible, but long enough to indicate clearly the nature of the study. Capitalize the first letter of each word. No full stop at the end.
4. Follow title with First Author: first initial, last name, affiliation; then second author, etc. same format.
5. Abstracts text should state briefly and clearly the purpose, methods, results and conclusions of the work.
   
   

   Introduction:	Clearly state the purpose of the abstract.
   Methods:	Describe your selection of observations or experimental subjects clearly.
   Results:	Present your results in a logical sequence in text, tables and illustrations.
   Discussion:	Emphasize new and important aspects of the study and conclusions that are drawn from them.

6. Papers may be submitted even if previously presented at a national/international meeting.
7. Completed abstracts should be e-mailed to clarissa@toxicology.org.
8. A confirmation of receipt will be sent to submitters within one week of submission. Following the organizing Committee review, a confirmation of acceptance will be sent.
9. Abstract submitter MUST register for the meeting using the regular registration process.
10. Questions should be e-mailed to clarissa@toxicology.org.

Abstracts reviewed for pertinence (expect ~ 50 for posters)
Speakers provide talk abstracts

 

Agenda and Presentations

Due to the inclement weather we've pushed the schedule back to begin at 3:00 PM February 14, which affects the rest of the agenda for Wednesday through Friday as well.

Time:	Topic:	Speaker:
10:00 AM– 5:30 PM	Registration Open
3:00 PM– 3:10 PM	Welcome and Opening Remarks by the President of SOT	James A. Popp, Stratoxon, LLC, Lancaster, PA
3:10 PM– 3:20 PM	Workshop Goals	Jennifer Seed, U.S. EPA, Washington, DC
3:20 PM– 4:00 PM	Comparative Toxicokinetics among PFAA and Related Chemistries (Chain Length, Telomers)	Naomi Kudo, Josai University, Sakado, Saikama, Japan
4:00 PM– 5:00 PM	Cross-Species Comparisons and Modeling of In Vivo Toxicokinetics of PFAA	Melvin E. Andersen, CIIT, Research Triangle Park, NC
5:00 PM– 5:30 PM	Break and Poster Viewing
5:30 PM– 6:10 PM	Overview of Transporters—What are They? Where are They? How Do They Function?	Bruno Hagenbuch, University of Kansas Medical Center, Kansas City, KS
6:15 PM– 7:15 PM	Reception

Day 2
Thursday, February 15, 2007

Session Three, 9:00 AM–11:00 AM: Pharmacokinetics II: What are the Research Directions and Priorities for PFAAs?
Session Co-Chairs: Melvin E. Andersen, CIIT, Research Triangle Park, NC and Hugh A. Barton, U.S. EPA, Research Triangle Park, NC

Time:	Topic:	Speaker:
9:00 AM– 9 :45 AM	Background on Perfluoroalkyl Sulfonates: Background on Perfluoroalkyl Carboxylates, and Background on Telomer Alcohols	John L. Butenhoff, 3M Company, St. Paul, MN, Gerald L.Kennedy, Jr., DuPont Haskell Laboratories, Newark, DE, Reinhard Jung, Clariant, Sulzbach am Taunus, Germany
9:45 AM– 10:05 AM	Serum Concentrations of Perfluorochemicals in the General U.S. Population: Data from the National Health and Nutrition Examination Survey 1999–2000	Antonia Calafat, National Center for Environmental Health Center for Disease Control and Prevention, Atlanta, GA
10:05 AM– 10:30 AM	Relating Concentrations with Effects In Vivo and In Vitro	John L. Butenhoff, 3M Company, St. Paul, MN
10:30 AM– 11:00 AM	Panel-Led Forum: Open Questions and Research Directions and Priorities	Moderator, Melvin E. Andersen, CIIT, Research Triangle Park, NC
11:00 AM– 11:15 AM	Break and Poster Viewing

Session Four, 11:15 AM–4:30 PM: Adult Effects—PPAR-Dependent and Independent Modes of Action
Session Chair: Kendall B. Wallace, University of Minnesota, Duluth, MN

Time:	Topic:	Speaker:
11:15 AM– 11:55 AM	Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action	Cliff Elcombe, CXR Biosciences, Dundee, UK
11:55 AM– 1:30 PM	Lunch Break
1:30 AM– 2:10 PM	Nuclear Receptor Activation—Metabolic and Carcinogenic Consequences	Jack Vanden Heuvel, Penn State University, University Park, PA
2:10 PM– 2:50 PM	Nuclear Receptor Activation—Risk Assessment and Regulatory Implications	Chris Corton, U.S. EPA, Research Triangle Park, NC
2:50 PM– 3:30 PM	Mechanism-Based Cancer Risk Assessment	Samuel Monroe Cohen, University of Nebraska, Omaha, NB
3:30 PM– 3:45 PM	Break and Poster Viewing
3:45 PM– 4:30 PM	Panel-Led Forum: Open Questions and Research Directions and Priorities	Moderator, Kendall B. Wallace, University of Minnesota, Duluth, MN

Session Five, 4:30 PM–5:30 PM: Poster Session
Session Co-Chairs: Sue Tanaka, 3M, St. Paul, MN and Sandi Murphy, Arkema, Inc., Philadelphia, PA

 

Day 3
Friday, February 16, 2007

Session Six, 8:30 AM–12:30 PM: Determinants of Perinatal and Developmental Toxicity
Session Chair: Christopher S. Lau, U.S. EPA, Research Triangle Park, NC

Time:	Topic:	Speaker:
8:30 AM– 9:10 AM	Overview of Perinatal and Developmental Effects in Animal Models	John M. Rogers, U.S. EPA, Research Triangle Park, NC
9:10 AM– 9:50 AM	Possible Etiologies of PFAA-Induced Developmental Effects: Reflections From a Pediatric Perspective	Lynn R. Goldman, Johns Hopkins University, Baltimore, MD
9:50 AM– 10:30 AM	PPAR Signaling Pathway Involvement in PFAA-Induced Developmental Toxicity	Barbara Abbott, U.S. EPA, Research Triangle Park, NC
10:30 AM– 11:00 AM	Break
11:15 AM– 12:00 PM	Panel-Led Forum: Open Questions and Research Directions and Priorities	Moderator, John M. Rogers, U.S. EPA, Research Triangle Park, NC

Session Seven, 12:00 PM–12:30 PM: Workshop Summation–Identification of Critical Research Needs and Strategies
Session Co-Chairs: Melvin E. Andersen, CIIT, Research Triangle Park, NC and
Kendall B. Wallace, University of Minnesota, Duluth, MN

 

 

Sponsors:

3M

DuPont

Plastics Europe

Society of Toxicology

U.S. Environmental Protection Agency

 

Organizing Committee:

John L. Butenhoff–3M
Janice E. Chambers–SOT
Gerald L. Kennedy–DuPont
Christopher S. Lau–U.S. EPA
Geary W. Olsen–3M
John M. Rogers–U.S. EPA
Jennifer Seed–U.S. EPA
Sue Tanaka–3M
Kendall B. Wallace–University of Minnesota
Clarissa R. Wilson–SOT

Programming Committee:

Melvin E. Anderson–CIIT
Hugh A. Barton–U.S. EPA
Kendall B. Wallace–University of Minnesota
Reinhard Jung–Clariant
Sandi Murphy–ARKEMA
David Farrar–IneosChlor
John L. Butenhoff–ad hoc
Christopher S. Lau–ad hoc
John M. Rogers–ad hoc
Jennifer Seed–ad hoc

 

Registration Information

Perfluorinalkyl Acids and Related Chemistries: Toxicokinetics and Mode-of-Action Workshop to be held at the Westin Arlington Hotel on February 14-16, 2007.

Please contact SOT Headquarters to register for this meeting.

Registration fees:

Registration Type	Early Bird	Advance	Extended Mail/Fax	On-site
	October 1– December 5, 2006	December 6, 2006– January 15, 2007	January 16– February 7, 2007	February 14, 2007
SOT Member	$275	$325	$375	$375
Non-Member	$375	$425	$475	$475
Student	$100	$125	$150	$150

Note: Limited financial assistance may be available upon written request. Please send any such request to clarissa@toxicology.org.

Make payment to:
PFAR, Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190

Fees include all general sessions, program materials; refreshments and the opportunity to participation in discussions of one breakout group (see registration form for details).

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner's Club, or American Express), or U.S. Government Purchase Orders (check must be drawn from the U.S. Department of Treasury). Please use the attached registration form.

No telephone registrations will be accepted.

To register, please send registration form and payment or credit card information by one of the following methods:

1–Mail/USPS Express packages:
Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190

2–Fax: (703) 438-3113

NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. SOT needs only one copy for processing.

DEADLINE: After February 7, 2007, you must register on-site.

CANCELLATION REFUND POLICY: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by January 15, 2007. These refunds will be processed, less a $30 fee, following the Workshop.

Hotel Information

The Westin Arlington Gateway Hotel for the Workshop and meeting functions. One of the newest hotels in the Washington D.C. area, The Westin Arlington Gateway enjoys prime access to its surrounding area. In the active Ballston area of Arlington, and just a short walk from the Ballston Metro Station, guests have the option of exploring Arlington, Virginia or venturing into the nation’s capital.
The Westin Arlington Gateway
801 North Glebe Road
Arlington, VA 22202
Phone: (703) 537-4248, (703) 717-6200, Fax: (703) 717-6204

The Society of Toxicology has reserved a block of rooms at a discounted rate at the Westin Arlington Gateway Hotel. The room rate is $189 Single / Double. There is an additional $25 for a third and fourth person. The room tax is 10.5%. Deadline: The Housing Deadline is January 26th. Please make your hotel reservation prior to January 26th in order to receive the SOT discounted rate.

Attire
The official attire for the PRA Meeting is business casual. No coats or ties are required! We encourage you to bring comfortable clothing and extra shoes.

Transportation

Airports
There are three airports in and around the metropolitan DC area: Reagan National Airport (DC), Dulles International Airport (VA) & Baltimore Washington International Airport (MD).

Airline Information
To book your flights, you may contact SOT's travel agents:
American Express Travel, 1 (800) 872-9954, direct (410) 772-8500, columbiamdctn@aexp.com or Carlson Wagonlit (formerly Navigant) 1 (800) 525-6061, direct (703) 276-2030, niki.markun@carlsonwagonlit.com.

Expedia: www.expedia.com
Priceline: www.priceline.com
Travelocity: www.travelocity.com
AirTran: www.airtran.com
American Airlines: www.aa.com
US Airways: www.usair.com
American West Airlines: www.americanwest.com
Continental Airlines: www.continental.com
United Airlines: www.ual.com
Delta: www.delta.com/home/index.jsp

Car
By car, the Northern Virginia / Capital Region is easily accessible from the I-95 corridor which dissects the area. I-95 becomes I-495 (The Capital Beltway) and encircles Washington, DC and the inner suburbs of Virginia and Maryland. From I-95 (Northbound) approaching from south of Washington, DC, I-395 runs from the Capital Beltway into downtown Washington, DC through the portions of Virginia. From the West, I-66 runs from the intersection of I-81 in the northwestern area of Virginia near Front Royal, through the Northern Virginia suburbs to across the Potomac River terminating near the Lincoln Memorial on Constitution Avenue in downtown Washington, DC. Access to the area is also provided by US Routes 50 and 29 from the East and West and US Route 1 form North to South. It is highly recommended that visitors avoid these roads during rush hours during the week.

Driving Directions from Airports

From East
Take State Route 50 to Interstate 495 (Outerloop/Exit 7B). Continue on I-495 to State Route 267 (Exit 45B) which joins with Interstate 66 East. Continue on I-66 to North Fairfax Drive (Exit 71). Proceed pass the light and turn right on Vermont Avenue.
From North
Take Interstate 95 or Interstate 270 to Interstate 495 (Outerloop). Follow I-495 to State Route 267 (Exit 45B).SR-267 joins with Interstate 66 East. Continue on I-66 East and exit onto North Fairfax Drive (Exit 71).Proceed pass the light and turn right on Vermont Avenue.
From West
Take Interstate 66 and exit onto North Fairfax Drive (Exit 71). Proceed pass the light and turn right on Vermont Avenue. The hotel is 1 block further on the left.
From South
Take Interstate 95 North to Interstate 395. Continue on I-395 to State Route 120 (Exit 7B/South Glebe Road). Continue on SR-120 North for 3.2 miles, the hotel is located on the right.

Train/Bus
Amtrak & Greyhound Bus run through DC's Union Station; from Union Station you can take the Metro to the Westin Gateway Hotel. Visit www.amtrak.com or call 1 (800) USA-RAIL for Amtrak reservations. Visit www.greyhound.com or call 1 (800) 231-2222 for Greyhound reservations.

Transportation around town
Public transportation is encouraged when exploring Northern VA and Washington, DC to avoid parking problems. Northern VA / Washington DC have an excellent subway train system called "Metro" or "MetroRail" & a bus "Metro Bus." Metrorail and Metrobus provide the safest, cleanest and most efficient way of getting around Northern VA and Washington, DC. Five rail lines and an extensive bus system connect DC with the Maryland and Virginia suburbs. Train lines are named for colors. Station entrances are marked by brown pylons, capped with the letter “M” and colored stripes indicate which lines are available. For more information on using Metro & a map of its destinations, visit www.wmata.com.

About the Area

About Arlington, VA
Arlington, VA lies across the Potomac River from Washington, DC and is part of the Metropolitan DC area. Rich in history, immersed in tradition, and painted with the colors, culture, and art of neighboring Washington, DC, Northern Virginia captures your heart and soul with its breathtaking countryside, heart-stopping monuments to courage, inspiring world of arts and antiquities, and tempting palette of regional cuisines. There are many attractions close at hand to Arlington, VA. One of the most well known attraction is the Arlington National Cemetery. America’s most hallowed site and resting place for thousands of heroes and casualties-of-war, from Civil War times until the present. The 612-acre site along the Potomac River includes such famed monuments as: the Tomb of the Unknowns, the Confederate Monument, and the Custis-Lee Mansion. Catch one of the public daily tours and see the Pentagon, headquarters of the United States Department of Defense and the nerve center for command and control, the Pentagon is a virtual city within itself. To learn more about Arlington, VA, please visit www.arlingtonvirginia.com.

About Washington, DC
Washington DC lies in the center of the Eastern Seaboard, about 90 miles from the coast and is nestled between Maryland and Virginia. Located midway along the eastern seaboard of the United States, south of Maryland, north of Virginia and 233 miles south of New York City, the Washington, DC metropolitan area refers to the District of Columbia, plus 7 Maryland counties, 5 Virginia counties, and 6 Virginia cities. The District of Columbia is 67 square miles and divided into 4 quadrants: Northwest, Southwest, Northeast and Southeast. The U.S. Capitol building marks the center where the quadrants meet. Numbered streets run north and south. Lettered streets run east and west (there are no J, X, Y or Z streets), becoming two-syllable names, and then three-syllable names as you travel farther out from the center. Avenues named for US states run diagonally, often meeting at traffic circles and squares.

Elevation
Highest is 420 feet; lowest is sea level.

Population
The population is approximately 202,000 in Arlington proper and 5.4 million for the entire metro area.

Time Zone
Arlington, VA is in the EST/EDT time’s zone

Area Code
The area codes for Arlington, VA are (703) and (571); Washington, DC is (202).

Climate
Northern VA and the Washington DC metropolitan area experience the beauty of all four seasons. Warm weather usually prevails from April until as late as October. Winters here are short, with more rain than snow. The high and low average temperature for the month of February is 43 C/29 F.

Sales Tax
Arlington, VA: Sales tax is 5%. Washington, DC: Sales tax is 5.75%. Total VA hotel tax including sales tax is 10.5%.

Disabled Travelers
Washington, DC is one of the most accessible cities in the world for physically-challenged visitors. Visit www.disabilityguide.org, the premier source of disability related information in the Washington, DC metro area. Please contact SOT Headquarters if you need special assistance for this meeting. SOT HQ phone number is (703) 438-3115.

International Travelers
Washington is more than just the Nation's Capital—it is also home to more than 150 embassies, chancelleries and diplomatic residences where colors, cultures and languages mix like nowhere else. The following sections contain some tips and information to make international visitors feel more at home.

Embassies
Many embassies offer guided tours with prior notification. Arrangements can also be made by some embassies to host meeting functions and private parties, offering an unmatched asset for any meeting planner. Embassy phone numbers are available by calling directory assistance at (202) 555-1212. A comprehensive listing of embassies is also available online at www.embassy.org.

Multilingual Services
Many of the attractions in Arlington, VA and in Washington, DC offer brochures in several languages. The Smithsonian Institution provides multilingual information at the visitor’s center in the Castle building. Meridian International Center offers multilingual services at its information desk at Washington Dulles International Airport, plus a telephone language bank. For details, call Meridian International Center at (202) 667-6800 or visit www.meridian.org. (See Interpreters & Translating Services section for more information.)

Electricity
The electricity used in Northern VA is standard electricity, which is 110 volts. European appliances will require a voltage transformer.

International Currency Exchange
You may want to visit a Customer Service Booth at the airport when you arrive into Northern VA, DC, or BWI. Either the customer service representative can exchange currency at the booth or direct you to a special ATM that can exchange your currency.

Touring Programs

Visit the Official Tourism Site of Washington, DC for information on touring The White House, The Capitol Building and museums and/or monuments.

For more information about Washington, DC please visit: www.washington.org. For more information about Arlington, VA, please visit www.arlingtonvirginia.com.

Previous SOT CCT Meetings