Contemporary Concepts In Toxicology
Perfluoroalkyl Acids and Related Chemistries:
Toxicokinetics and Mode-of-Action Workshop
Society of Toxicology – Current Concepts in Toxicology
February 14-16, 2007
Westin Arlington Gateway, Arlington, VA
Revised Agenda —Due to the inclement weather we've pushed the schedule back to begin at 3:00 PM February 14, which affects the rest of the schedule for Wednesday through Friday as well.
Registration
Form
Purposes and objectives of the SOT-CCT Workshop
The perfluoroalkyl acids (PFAA) and their salts, such as perfluoroalkyl
sulfonates and their derivatives, perfluoroalkyl carboxylates, and
telomer alcohols and their derivatives are important chemicals that
have wide consumer and industrial applications. However, recent discoveries
of their global distribution, environmental persistence, presence in
humans and wildlife, as well as adverse health effects detected in
laboratory animal models have generated considerable scientific, regulatory,
and public interest on an international scale. Several national and international
regulatory bodies, including those from Canada, Germany, OECD, Sweden,
the UK, and USA, are currently assessing the toxicological hazards
and potential health risks of certain PFAA. As an example, the U.S. EPA
has prepared a preliminary draft health risk assessment for perfluorooctanoate
(PFOA), and OECD has prepared hazard assessments for PFOS and PFOA.
In addition, numerous human and wildlife biomonitoring studies have
been conducted or are planned. At present, the Centers
for Disease Control and Prevention in the USA has included some of the PFAA in their National
Health and Nutrition Examination Survey (NHANES) and population-based
evaluation of these chemicals will be available in their 2007 report.
Because of the emerging interests in this class of chemicals, several
workshops have been held, including SOT (2002), SETAC (2003), U.S.
EPA/3M (2004), FLUOROS (2005), and OECD (2006), to address trace analysis
of PFAA in various media, their fate and transport, and their toxicity.
Although the presence of certain PFAA in wildlife species, the detection
in human body compartments (liver, serum, cord blood, breast milk), as
well as the toxicological profiles of these chemicals (mostly PFOS and
PFOA) in laboratory animal models have been increasingly reported in
the literature, two major informational gaps still exist that considerably
hamper the risk assessment efforts by the regulatory agencies. First,
although the variability of elimination rates between species and, in
some cases, between sexes within species, is known, including significantly
lower elimination rates of some PFAA that lead to long elimination half-lives
in humans, the underlying mechanisms for these differences in retention
in the body are not well understood. Secondly, while some of the PFAA
are known to be agonists for the peroxisome proliferator-activated receptor
signaling pathways, and some may alter mitochondrial function and intercellular
communication, little else is known about their modes of action that
can account for the observed toxicity outcomes. Because the PFAA family
is composed of over twenty individual chemicals (known to exist in the
environment) with different carbon-chain lengths and functional substitutes
and derivatives, an understanding of their kinetic properties and potential
common modes of action will facilitate modeling of these chemicals for
cross species extrapolation, and ultimately provide a reliable basis
for their risk assessment for human health.
The proposed SOT-CCT workshop will therefore focus on these two issues.
The three-day workshop will: (1) provide an overview of PFAA toxicity
and description of recent findings with the sulfonates, carboxylates
and telomer alcohols; (2) address the toxicokinetic profiles of various
PFAA among animal models and humans, and the biological processes that
are responsible for these toxicokinetic observations; (3) examine the
possible modes of action that determine the toxicities observed in
animal models and their relevance to human health risks; and (4)
identify the
critical research needs and strategies to fill the existing informational
gaps that hamper risk assessment of these chemicals. Each of these
topics will be led by expert investigators in these areas, and discussions
will
be initiated by several invited speakers who will lend insights to
these subject matters. A substantial portion of this meeting will
be devoted
to an open forum discussion among all participants, as well as individual
interactions during the poster sessions. A report summarizing the discussions
will be submitted for publication in a peer-reviewed journal (with Toxicological
Sciences having the first right of refusal).
Goal:
Identify and prioritize future research directions.
Aims:
- Open discussion of research needs
- Expert guidance in determining research
priorities
- Insight on human relevance of toxicological data
Product:
The Workshop and publication of Workshop report in Toxicological Sciences
Abstracts and Poster Presentations
Individuals conducting research on toxicology, pharmacokinetics, biomonitoring
and health risk evaluation of perfluorinated organic chemicals are encouraged
to submit abstracts for presentation during the February 14-16, 2007,
Poster Session. All PFAD topics are welcomed. Abstract submission will
close on January 8, 2007. Please submit according to the instructions
below.
Abstract Instructions:
- Each Abstract is limited to 400 words.
- Complete abstracts using Times
New Roman, 12 point text. Please format abstracts using Microsoft Word.
All formatting should be single spaced. Title, authors, affiliations,
and body of the abstract should be separated by a paragraph break.
Titles should be formatted in bold caps, 12-point Arial. Authors, affiliations,
and body of the abstract should be formatted in regular 12-point times
new roman. For authors, provide first name, middle initial(s), and last name. For affiliations, provide institution, department, and city, state/province, and country.
Use superscipt numbers to distinguish author affiliations. Separate
three or more authors with a comma, and separate affiliations with
semicolon(s). Do not include figures or tables. The following example
can be used as a guide: Example
Abstract (Microsoft Word format)
- The title should be as brief as
possible, but long enough to indicate clearly the nature of the study.
Capitalize the first letter
of each word. No full stop at the end.
- Follow title with First
Author: first initial, last name, affiliation; then second author,
etc. same format.
- Abstracts text should state briefly and clearly
the purpose, methods, results and conclusions of the work.
Introduction: |
Clearly state the purpose of the abstract. |
Methods: |
Describe your selection of observations or experimental subjects
clearly. |
Results: |
Present your results in a logical sequence in text, tables
and illustrations. |
Discussion: |
Emphasize new and important aspects of the study and conclusions
that are drawn from them. |
- Papers may
be submitted even if previously presented at a national/international
meeting.
- Completed abstracts should be e-mailed to clarissa@toxicology.org.
- A confirmation of receipt will be sent to submitters within one
week of submission. Following the organizing
Committee
review, a confirmation
of acceptance will be sent.
- Abstract submitter MUST
register for the meeting using the regular registration process.
- Questions
should be e-mailed to clarissa@toxicology.org.
Abstracts reviewed for pertinence (expect ~ 50 for posters)
Speakers provide talk abstracts
Agenda and Presentations
Due to the inclement weather we've pushed the schedule back to begin at 3:00 PM February 14, which affects the rest of the agenda for Wednesday through Friday as well.
Day 1
Wednesday, February 14, 2007
Session One: Introduction
and Overview
Session Co-Chairs: John L. Butenhoff, 3M Company, St. Paul, MN and Christopher S. Lau, U.S. EPA, Research Triangle Park, NC
Session Two: Pharmacokinetics I: What Processes Are Responsible for Toxicokinetic Oobservations in Animals and Humans?
Session Co-Chairs: Melvin E. Andersen, CIIT, Research Triangle Park, NC and Hugh A. Barton, U.S. EPA, Research Triangle Park, NC
| Time: |
Topic: |
Speaker: |
10:00 AM–
5:30 PM |
Registration Open |
3:00 PM–
3:10 PM |
Welcome and Opening Remarks by the President of SOT |
James A. Popp, Stratoxon, LLC, Lancaster, PA |
3:10 PM–
3:20 PM |
Workshop Goals |
Jennifer Seed, U.S. EPA, Washington, DC |
3:20 PM–
4:00 PM |
Comparative Toxicokinetics among PFAA and Related Chemistries (Chain Length, Telomers) |
Naomi Kudo, Josai University, Sakado, Saikama, Japan |
4:00 PM–
5:00 PM |
Cross-Species Comparisons and Modeling of In Vivo Toxicokinetics of PFAA |
Melvin E. Andersen, CIIT, Research Triangle Park, NC |
5:00 PM–
5:30 PM |
Break and Poster Viewing |
|
5:30 PM–
6:10 PM |
Overview of Transporters—What are They? Where are They? How Do They Function? |
Bruno Hagenbuch, University of Kansas Medical Center, Kansas City, KS |
6:15 PM–
7:15 PM |
Reception |
Day 2
Thursday, February 15, 2007
Session Three, 9:00 AM–11:00 AM: Pharmacokinetics II: What are the Research Directions and Priorities for PFAAs?
Session Co-Chairs: Melvin E. Andersen, CIIT, Research Triangle Park, NC and Hugh A. Barton, U.S. EPA, Research Triangle Park, NC
| Time: |
Topic: |
Speaker: |
9:00 AM–
9 :45 AM |
Background on Perfluoroalkyl Sulfonates: Background on Perfluoroalkyl Carboxylates, and Background on Telomer Alcohols |
John L. Butenhoff, 3M Company, St. Paul, MN, Gerald L.Kennedy, Jr., DuPont Haskell Laboratories, Newark, DE, Reinhard Jung, Clariant, Sulzbach am Taunus, Germany |
9:45 AM–
10:05 AM |
Serum Concentrations of Perfluorochemicals in the General U.S. Population: Data from the National Health and Nutrition Examination Survey 1999–2000 |
Antonia Calafat, National Center for Environmental Health Center for Disease Control and Prevention, Atlanta, GA |
10:05 AM–
10:30 AM |
Relating Concentrations with Effects In Vivo and In Vitro |
John L. Butenhoff, 3M Company, St. Paul, MN |
10:30 AM–
11:00 AM |
Panel-Led Forum: Open Questions and Research Directions and Priorities |
Moderator, Melvin E. Andersen, CIIT, Research Triangle Park, NC |
11:00 AM–
11:15 AM |
Break and Poster Viewing |
|
Session Four, 11:15 AM–4:30 PM: Adult Effects—PPAR-Dependent and Independent Modes of Action
Session Chair: Kendall B. Wallace, University of Minnesota, Duluth, MN
| Time: |
Topic: |
Speaker: |
11:15 AM–
11:55 AM |
Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action |
Cliff Elcombe, CXR Biosciences, Dundee, UK |
11:55 AM–
1:30 PM |
Lunch Break |
|
1:30 AM–
2:10 PM |
Nuclear Receptor Activation—Metabolic and Carcinogenic
Consequences |
Jack Vanden Heuvel, Penn State University, University Park, PA |
2:10 PM–
2:50 PM |
Nuclear Receptor Activation—Risk Assessment and Regulatory
Implications |
Chris Corton, U.S. EPA, Research Triangle Park, NC |
2:50 PM–
3:30 PM |
Mechanism-Based Cancer Risk Assessment |
Samuel Monroe Cohen, University of Nebraska, Omaha, NB |
3:30 PM–
3:45 PM |
Break and Poster Viewing |
3:45 PM–
4:30 PM |
Panel-Led Forum: Open Questions and Research Directions and Priorities |
Moderator, Kendall B. Wallace, University of Minnesota, Duluth,
MN |
Session Five, 4:30 PM–5:30 PM: Poster Session
Session Co-Chairs: Sue Tanaka, 3M, St. Paul, MN and Sandi Murphy, Arkema,
Inc., Philadelphia, PA
Day 3
Friday, February 16, 2007
Session Six, 8:30 AM–12:30 PM: Determinants of Perinatal and Developmental
Toxicity
Session Chair: Christopher S. Lau, U.S. EPA, Research Triangle Park, NC
| Time: |
Topic: |
Speaker: |
8:30 AM–
9:10 AM |
Overview of Perinatal and Developmental Effects in Animal Models |
John M. Rogers, U.S. EPA, Research Triangle Park, NC |
9:10 AM–
9:50 AM |
Possible Etiologies of PFAA-Induced Developmental Effects: Reflections
From a Pediatric Perspective |
Lynn R. Goldman, Johns Hopkins University, Baltimore, MD |
9:50 AM–
10:30 AM |
PPAR Signaling Pathway Involvement in PFAA-Induced Developmental
Toxicity |
Barbara Abbott, U.S. EPA, Research Triangle Park, NC |
10:30 AM–
11:00 AM |
Break |
11:15 AM–
12:00 PM |
Panel-Led Forum: Open Questions and Research Directions and Priorities |
Moderator, John M. Rogers, U.S. EPA, Research Triangle Park, NC |
Session Seven, 12:00 PM–12:30 PM: Workshop
Summation–Identification
of Critical Research Needs and Strategies
Session Co-Chairs: Melvin E. Andersen, CIIT, Research Triangle Park,
NC and
Kendall B. Wallace, University of Minnesota, Duluth, MN
Sponsors:
Organizing Committee:
John L. Butenhoff–3M
Janice E. Chambers–SOT
Gerald L. Kennedy–DuPont
Christopher S. Lau–U.S. EPA
Geary W. Olsen–3M
John M. Rogers–U.S. EPA
Jennifer Seed–U.S. EPA
Sue Tanaka–3M
Kendall B. Wallace–University of Minnesota
Clarissa R. Wilson–SOT
Programming Committee:
Melvin E. Anderson–CIIT
Hugh A. Barton–U.S. EPA
Kendall B. Wallace–University of Minnesota
Reinhard Jung–Clariant
Sandi Murphy–ARKEMA
David Farrar–IneosChlor
John L. Butenhoff–
ad hoc
Christopher S. Lau–
ad hoc
John M. Rogers–
ad hoc
Jennifer Seed–
ad hoc
Registration Information
Perfluorinalkyl Acids and Related Chemistries: Toxicokinetics and Mode-of-Action
Workshop to be held at the Westin Arlington Hotel on February 14-16,
2007.
Please contact SOT Headquarters to
register for this meeting.
Registration fees:
| Registration Type |
Early Bird |
Advance |
Extended Mail/Fax |
On-site |
October 1–
December 5, 2006 |
December 6, 2006–
January 15, 2007 |
January 16–
February 7, 2007 |
February 14, 2007 |
| SOT Member |
$275 |
$325 |
$375 |
$375 |
| Non-Member |
$375 |
$425 |
$475 |
$475 |
| Student |
$100 |
$125 |
$150 |
$150 |
Note: Limited financial assistance may be available upon written request.
Please send any such request to clarissa@toxicology.org.
Make payment to:
PFAR, Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
Fees include all general sessions, program materials; refreshments and
the opportunity to participation in discussions of one breakout group
(see registration
form for details).
Registration fees may be paid by check (please list all registrants on the
check stub), money order, credit card (Visa, MasterCard, Diner's Club, or American
Express), or U.S. Government Purchase Orders (check must be drawn from the
U.S. Department of Treasury). Please use the attached registration form.
No telephone registrations will be accepted.
To register, please send registration form and payment or credit
card information by one of the following methods:
1–Mail/USPS Express packages:
Society of Toxicology
1821 Michael Faraday Drive, Suite 300
Reston, VA 20190
2–Fax: (703) 438-3113
NOTE: To prevent double-billing, if you are registering
by fax, DO NOT mail your original registration form. SOT needs only one
copy for processing.
DEADLINE: After February 7, 2007, you must register
on-site.
CANCELLATION REFUND POLICY: All requests for cancellations
and/or refunds must be received in writing to SOT Headquarters by January
15, 2007. These refunds will be processed, less a $30 fee, following
the Workshop.
Hotel Information
The Westin Arlington Gateway Hotel for the Workshop and meeting functions.
One of the newest hotels in the Washington D.C. area, The Westin Arlington
Gateway enjoys prime access to its surrounding area. In the active
Ballston area of Arlington, and just a short walk from the Ballston
Metro Station, guests have the option of exploring Arlington, Virginia
or venturing into the nation’s capital.
The Westin Arlington Gateway
801 North Glebe Road
Arlington, VA 22202
Phone: (703) 537-4248, (703) 717-6200, Fax: (703) 717-6204
The Society of Toxicology has reserved a block of rooms at a discounted
rate at the Westin Arlington Gateway Hotel. The room rate is $189 Single
/ Double. There is an additional $25 for a third and fourth person. The
room tax is 10.5%.
Deadline: The Housing Deadline is
January 26th. Please make your hotel reservation prior to January 26th
in order to receive the SOT discounted rate.
Attire
The official attire for the PRA Meeting is business casual. No coats
or ties are required! We encourage you to bring comfortable clothing
and extra shoes.
Transportation
Airports
There are three airports in and around the metropolitan DC area: Reagan National
Airport (DC), Dulles International Airport (VA) & Baltimore Washington
International Airport (MD).
Airline Information
To book your flights, you may contact SOT's travel agents:
American Express Travel, 1 (800) 872-9954, direct (410) 772-8500, columbiamdctn@aexp.com or
Carlson Wagonlit (formerly Navigant) 1 (800) 525-6061, direct (703) 276-2030, niki.markun@carlsonwagonlit.com.
Expedia: www.expedia.com
Priceline: www.priceline.com
Travelocity: www.travelocity.com
AirTran: www.airtran.com
American Airlines: www.aa.com
US Airways: www.usair.com
American West Airlines: www.americanwest.com
Continental Airlines: www.continental.com
United Airlines: www.ual.com
Delta: www.delta.com/home/index.jsp
Car
By car, the Northern Virginia / Capital Region is easily accessible from
the I-95 corridor which dissects the area. I-95 becomes I-495 (The Capital
Beltway) and encircles Washington, DC and the inner suburbs of Virginia
and Maryland. From I-95 (Northbound) approaching from south of Washington,
DC, I-395 runs from the Capital Beltway into downtown Washington, DC
through the portions of Virginia. From the West, I-66 runs from the intersection
of I-81 in the northwestern area of Virginia near Front Royal, through
the Northern Virginia suburbs to across the Potomac River terminating
near the Lincoln Memorial on Constitution Avenue in downtown Washington,
DC. Access to the area is also provided by US Routes 50 and 29 from the
East and West and US Route 1 form North to South. It is highly recommended
that visitors avoid these roads during rush hours during the week.
Driving Directions from Airports
From East
Take State Route 50 to Interstate 495 (Outerloop/Exit 7B). Continue on
I-495 to State Route 267 (Exit 45B) which joins with Interstate 66 East.
Continue on I-66 to North Fairfax Drive (Exit 71). Proceed pass the light
and turn right on Vermont Avenue.
From North
Take Interstate 95 or Interstate 270 to Interstate 495 (Outerloop). Follow
I-495 to State Route 267 (Exit 45B).SR-267 joins with Interstate 66 East.
Continue on I-66 East and exit onto North Fairfax Drive (Exit 71).Proceed
pass the light and turn right on Vermont Avenue.
From West
Take Interstate 66 and exit onto North Fairfax Drive (Exit 71). Proceed
pass the light and turn right on Vermont Avenue. The hotel is 1 block
further on the left.
From South
Take Interstate 95 North to Interstate 395. Continue on I-395 to State
Route 120 (Exit 7B/South Glebe Road). Continue on SR-120 North for 3.2
miles, the hotel is located on the right.
Train/Bus
Amtrak & Greyhound Bus run through DC's Union Station; from Union
Station you can take the Metro to the Westin Gateway Hotel. Visit www.amtrak.com or
call 1 (800) USA-RAIL for Amtrak reservations. Visit www.greyhound.com or
call 1 (800) 231-2222 for Greyhound reservations.
Transportation around town
Public transportation is encouraged when exploring Northern VA and Washington,
DC to avoid parking problems. Northern VA / Washington DC have an excellent
subway train system called "Metro" or "MetroRail" & a
bus "Metro Bus." Metrorail and Metrobus provide the safest,
cleanest and most efficient way of getting around Northern VA and Washington,
DC. Five rail lines
and an extensive bus system connect DC with the Maryland and Virginia
suburbs. Train lines are named for colors. Station entrances are marked
by brown pylons, capped with the letter “M” and colored stripes
indicate which lines are available. For more information on using Metro & a
map of its destinations, visit www.wmata.com.
About the Area
About Arlington, VA
Arlington, VA lies across the Potomac River from Washington, DC and is
part of the Metropolitan DC area. Rich in history, immersed in tradition,
and painted with the colors, culture, and art of neighboring Washington,
DC, Northern Virginia captures
your heart and soul with its breathtaking countryside, heart-stopping
monuments to courage, inspiring world of arts and antiquities, and tempting
palette of regional cuisines. There are many attractions close at hand
to Arlington, VA. One of the most well known attraction is the Arlington
National Cemetery. America’s most hallowed site and resting place
for thousands of heroes and casualties-of-war, from Civil War times until
the present. The 612-acre site along the Potomac River includes such
famed monuments as: the Tomb of the Unknowns, the Confederate Monument,
and the Custis-Lee Mansion. Catch one of the public daily tours and see
the Pentagon, headquarters of the United States Department of Defense
and the nerve center for command and control, the Pentagon is a virtual
city within itself. To learn more about Arlington, VA, please visit
www.arlingtonvirginia.com.
About Washington, DC
Washington DC lies in the center of the Eastern Seaboard, about 90 miles
from the coast and is nestled between Maryland and Virginia. Located
midway along the eastern seaboard of the United States, south of Maryland,
north of Virginia and 233 miles south of New York City,
the Washington, DC metropolitan area refers to the District of Columbia,
plus 7 Maryland counties, 5 Virginia counties, and 6 Virginia cities.
The District of Columbia is 67 square miles and divided into 4 quadrants:
Northwest, Southwest, Northeast and Southeast. The U.S. Capitol building
marks the center where the quadrants meet. Numbered streets run north
and south. Lettered streets run east and west (there are no J, X, Y or
Z streets), becoming two-syllable names, and then three-syllable names
as you travel farther out from the center. Avenues named for US states
run diagonally, often meeting at traffic circles and squares.
Elevation
Highest is 420 feet; lowest is sea level.
Population
The population is approximately 202,000 in Arlington proper and 5.4 million
for the entire metro area.
Time Zone
Arlington, VA is in the EST/EDT time’s zone
Area Code
The area codes for Arlington, VA are (703) and (571); Washington,
DC is (202).
Climate
Northern VA and the Washington DC metropolitan area experience the beauty
of all four seasons. Warm weather usually prevails from April until as
late as October. Winters here are short, with more rain than snow. The
high and low average temperature for the month of February is 43 C/29 F.
Sales Tax
Arlington, VA: Sales tax is 5%. Washington, DC: Sales tax is 5.75%. Total
VA hotel tax including sales tax is 10.5%.
Disabled Travelers
Washington, DC is one of the most accessible cities in the world for
physically-challenged visitors. Visit
www.disabilityguide.org, the
premier source of disability related information in the Washington, DC
metro
area. Please contact SOT Headquarters if you need special assistance
for this meeting. SOT HQ phone number is (703) 438-3115.
International Travelers
Washington is more than just the Nation's Capital—it is also home to
more than 150 embassies, chancelleries and diplomatic residences where
colors, cultures and languages mix like nowhere else. The following sections
contain some tips and information to make international visitors feel
more at home.
Embassies
Many embassies offer guided tours with prior notification. Arrangements
can also be made by some embassies to host meeting functions and private
parties, offering an unmatched asset for any meeting planner. Embassy
phone numbers are available by calling directory assistance at (202)
555-1212. A comprehensive listing of embassies is also available online
at
www.embassy.org.
Multilingual Services
Many of the attractions in Arlington, VA and in Washington, DC offer
brochures in several languages. The Smithsonian Institution provides
multilingual information at the visitor’s center in the Castle
building. Meridian International Center offers multilingual services
at its information desk at Washington Dulles International Airport, plus
a telephone language bank. For details, call Meridian International Center
at (202) 667-6800 or visit
www.meridian.org.
(See Interpreters & Translating
Services section for more information.)
Electricity
The electricity used in Northern VA is standard electricity, which is
110 volts. European appliances will require a voltage transformer.
International Currency Exchange
You may want to visit a Customer Service Booth at the airport when you
arrive into Northern VA, DC, or BWI. Either the customer service representative
can exchange currency at the booth or direct you to a special ATM that
can exchange your currency.
Touring Programs
Visit the
Official
Tourism Site of Washington, DC for information on
touring The White House, The Capitol Building and museums and/or monuments.
For more information about Washington, DC please visit:
www.washington.org.
For more information about Arlington, VA, please visit
www.arlingtonvirginia.com.
Previous SOT CCT Meetings
