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Exhibitor-Hosted Session

Monday | Tuesday | Wednesday


In Silico Strategies to Assess Potentially Mutagenic Impurities under ICH M7

Room 338

Monday, March 13, 10:30 AM to 11:30 AM

Presented by: Lhasa Limited

Lhasa Limited, the world leader for knowledge and data sharing in chemistry and the life sciences will present on the different strategies that can be used to assess the risk of impurities under ICH M7, including the generation of purge based arguments and mutagenicity prediction methodologies.

From Cells to Society and Beyond: Diversity and Scope of Neurotoxicology Testing at Battelle

Room 339

Monday, March 13, 10:30 AM to 11:30 AM

Presented by: Battelle

Explore the diverse applicability of neuroscience-based endpoints in toxicology studies. Highlights include neurobehavioral testing for pharmaceutical and chemical safety, novel applications like simultaneous cardiovascular measurements during real time performance in behavioral tests, in vitro and in vivo chemical weapon and nerve agent countermeasures, and pre-clinical support for clinical applications.

Optimized Testing of Nanomaterials: A Case Report

Room 337

Monday, March 13, 1:30 PM to 2:30 PM

Presented by: Fraunhofer ITEM

As an example of sophisticated nanomaterial testing, this session will present a tiered approach for different multi-walled carbon nanotubes. Information will include the generation of specific test atmospheres, results from different types of in vivo studies and innovative in vitro studies for elucidation of biological effects and their underlying mechanisms.


Integrated Approaches for Inhalation Toxicity Assessment

Room 337

Tuesday, March 14, 9:00 AM to 10:00 AM

Presented by: Fraunhofer ITEM

This session will focus on integrated approaches to testing and assessment (IATA) in inhalation toxicology combining the data from different alternative approaches such as human airway epithelial cells and fresh human lung material. A case study using these methods for a stepwise approach in risk assessment will be critically discussed.

Hepatocyte Spheroids for Toxicity Evaluation

Room 338

Tuesday, March 14, 10:30 AM to 11:30 AM

Presented by: In Vitro ADMET Laboratories Inc.

Hepatocyte spheroids maintain in vivo-like cell-cell contact with long-term maintenance of liver functions, including drug metabolic enzyme activities.  Properties of spheroids cultured from human and animal hepatocytes as hepatocyte monocultures and as hepatocyte/Kupffer cell co-cultures, and their application in the evaluation of drug metabolism and hepatotoxicity will be reviewed.

Detect Apoptosis in Real Time with a Plate Reader Using a Novel Homogeneous Luminescent Assay

Room 339

Tuesday, March 14, 10:30 AM to 11:30 AM

Presented by: Promega Corporation

We will describe novel homogeneous, multimode plate reader assays to detect apoptosis and necrosis in real time. Addition of annexin v–luciferase fragment fusion proteins generate light only when bound to apoptotic cells. Multiplexing with a DNA dye enables detection of necrotic cells from the same wells over multiple days.

A New Pathway and Related Assay Systems and Biomarkers for the Study and Prediction of Cholestasis Side Effects of Xenobiotics

Room 338

Tuesday, March 14, 12:00 PM to 1:00 PM

Presented by: Biopredic International

Our lecture will rely on two papers published that year and that explain that the bile canaliculi contraction and the RhoK and the MLCk enzymes regulating the level of phosphorylated light chain myosin are the targets of cholestatic compounds. 

Evaluating the Developmental Toxicity Potential of the ToxCast Chemical Library with devTOX quickPredict

Room 338

Tuesday, March 14, 3:00 PM to 4:00 PM

Presented by: Stemina Biomarker Discovery

devTOX quickPredict is a reliable, in vitro, human pluripotent stem cell-based assay used to assess chemicals for potential developmental toxicity affecting differing developmental lineages. We will discuss how the assay performs with the ToxCast chemical library and how the US EPA is using the data in support of Tox21.