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Contemporary Concepts in Toxicology (CCT) Meetings

Contemporary Concepts in Toxicology (CCT) meetings are one- to two-day focused, open registration, scientific meetings in contemporary and rapidly progressing areas of toxicological sciences. CCT meetings may be held as satellites to the SOT Annual Meeting, specialty or regional meetings, or may be held independently. Meetings may also be held virtually. The intent of the CCT meetings is to provide a forum for dissemination and discussion of those developments that are likely to have the greatest importance for advancing the science of toxicology. In order to maintain the quality standards of the Society, only meetings in which SOT maintains scientific and administrative control will be considered as CCT meetings.

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Upcoming CCT Meetings and Webinars

Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic

March 11, 2017
Baltimore, Maryland

Metabolic syndrome is defined by a combination of risk factors that can lead to greater potential of type 2 diabetes, obesity, lipid disorders, cardiovascular disease, and other circulatory disorders. There is currently a significant research focus to understand the key pathways that control metabolism, as these pathways would be likely targets of risk factors (e.g., exposure to xenobiotics, genetics) and lifestyle factors (e.g., microbiome, nutrition, and exercise). Understanding these pathways also can lead to the development of pharmaceutical interventions. Individuals with metabolic syndrome have signs similar to that of toxic responses (e.g., oxidative stress and inflammation) and organ dysfunction. Given the rapidly growing incidence of this syndrome, it is critical to understand these widespread abnormalities as it changes our definition of “normal.” While the causes for escalation in the individual risk factors are multiple and complex, there is no clear recognition of the bridges that unite these risk factors to yield increased disease. Indeed, it is likely that there are pathways that are of importance to controlling metabolism that would be targets of both environmental chemicals and pharmaceutical interventions. A multidisciplinary approach to understand the underlying biological mechanisms and translate that knowledge into prevention and treatment is required.

This conference will examine current knowledge on metabolic diseases including developmental aspects and challenges in therapeutic strategies for associated diseases.  Mechanisms (microbiome, inflammation, mitochondrial dysfunction) that underlie these pathologies will be discussed as will the effects of drugs and environmental agents. A lunchtime poster session will be a forum for data and hypothesis exchange. Our focus on understanding the pathways and risk factors leading to disease and how these pathways can be perturbed to develop drugs for disease interventions creates a unique combination that is likely to lead to new thought processes and scientific collaborations in addition to defining knowledge gaps, identifying research needs, protecting public health, and empowering product development.

Go to: Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic

Past CCT Meetings and Webinars
  • Toxicoepigenetics: The Interface of Epigenetics and Risk Assessment—November 2–4, 2016, Tysons, Virginia
  • The Use of Cardiomyocytes for the Assessment of Proarrhythmic Risk—October 25–26, 2016, Arlington, Virginia
  • Ocular Toxicology, Pharmacology and Drug Delivery: An Eye on the Future—June 27 & 28, 2016, South San Francisco, California
  • MiRNA Biomarkers for Toxicology—March 12, 2016, New Orleans, Louisiana
  • FutureTox III: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making—November 19–20, 2015, Arlington, Virginia
  • Risk Assessment of Humanized Monoclonal Antibodies and Antibody—Drug Conjugates; and Risk Assessment of Oligonucleotide Constructs—April 16, 2015, Webinar
  • Regulatory Toxicology Testing for Small Molecules: Strategies and Outcome Analysis; and Risk Assessment of “Traditional” Biologics—February 25, 2015, Webinar
  • FutureTox II: In Vitro Data and In Silico Models for Predictive Toxicology—January 16–17, 2014, Chapel Hill, North Carolina
  • FutureTox: Building the Road for 21st Century Toxicology and Risk Assessment Practices—October 18–19, 2012, Arlington, Virginia
  • PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms—May 14–16, 2012, Paris, France
  • Building for Better Decisions: Multi-Scale Integration of Human Health and Environmental Data—May 8–11, 2012, US EPA, Research Triangle Park, North Carolina
  • PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease—December 7–10, 2009, Arlington, Virginia
  • Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance Workshop—December 4–5, 2008, Arlington, Virginia
  • Perfluorinalkyl Acids and Related Chemistries: Toxicokinetics and Mode-of-Action Workshop—February 14–16, 2007, Arlington, Virginia
  • Probabilistic Risk Assessment (PRA): Bridging Components Along the Exposure-Dose-Response Continuum—July 25–27, 2005, Washington D.C.
  • Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment—February 16–17, 2005, Atlanta, Georgia
  • Joint Specialty Symposium on Renal Toxicology and Toxicology Pathology: An Integration of Mechanistic Investigation and Morphological Evaluation—September 27–October 1, 2004, Lindau / Bodensee, Germany
  • Vaccines: Non-Clinical Safety Evaluation of Preventive Vaccines: Recent Advances and Regulatory Considerations 2002—December 2–4, 2002, Arlington, Virginia
  • Use of Genomic Data in Risk Assessment: State-of-the-Art 2001—November 7–8, 2001, Washington D.C.
  • In Vitro Human Tissue Models in Risk Assessment—September 20–22, 2001
  • Mechanisms of Nephrotoxicity and Nephrocarcinogenicity—April 15–18, 2000, Martha's Vineyard, Maine
  • Harmonization of Cancer and Non-Cancer Risk Assessment—November 1–3, 1999, Arlington, Virginia

Recordings of select past CCT Webinars are available on the SOT Webinars page.

Proposing and Planning a CCT Meeting

Who Can Submit CCT Meeting Proposals?

Proposals may be submitted to the Society of Toxicology by Specialty Sections, Regional Chapters, individual members, or other not-for-profit organizations.

Resources and SOT Commitments

In order to facilitate organization of a successful CCT, the SOT assumes all administrative responsibilities with meeting logistics for approved CCT conferences, as well as potential liability for supplementing conference budgets failing to meet an expected objective of break-even financing. SOT will provide the conference organizers with $25,000 in seed money to facilitate securing resources necessary for a successful conference (e.g., conference facility deposits, food/beverage deposits, conference material costs, etc.). It is anticipated that this money serves solely as seed money and, as such, will be repaid to the Society following the completion of the CCT meeting. This allows the Society to continue providing this resource to future CCT meeting organizers and is essential for the success and continuation of this program. In planning the CCT meeting, the goal should be to develop a financially break-even budget based on registration fees and/or additional funding from external sources. Any funds in excess of breakeven are to be co-shared 50/50 with SOT and any endorsing Component Groups (Specialty Section, Regional Chapters, and Special Interest Groups and thus a successfully budgeted CCT can contribute to advancing the activities SOT Component Groups (Specialty Section, Regional Chapters, and Special Interest Groups).

Proposal Development and Submission Process

The CCT Committee recognizes that organizing a conference can be a daunting task and does not want this concern to prevent individuals from submitting their ideas for unique and important CCT meeting topics. Therefore, the CCT Committee has developed a 2-step process.

Step 1: Submission of the CCT Preproposal

To make it easier for interested parties to develop CCT conference proposals, the CCT Committee has designed a preproposal application. The preproposal application can be completed within a few hours and is intended to provide potential conference organizers a streamlined means of having their ideas reviewed by the CCT Committee at an early stage, before formal budget commitments or other specific details are required. Completed preproposal applications can be submitted to the CCT Committee at any time during the year for review and feedback.

The CCT will review prepoposal applications within 30 days of submission and provide feedback on whether the idea should move to the full proposal stage. The criteria for evaluation can be found here.

Step 2: Development and Submission of a Full CCT Proposal

Organizers who have submitted a successful preproposal and received review comments from the CCT Committee can submit a full CCT proposal by the stated deadlines. Full CCT proposals can be produced directly from the preproposal and with detailed information on the following items:

  1. Proposed title and focus of the meeting, as well as a brief description of the objectives.
  2. Statement of need for a CCT in particular field, justification of the importance to SOT members, evaluation of the timeliness of the topic, and whether a similar course has recently been held (and attendance).
  3. Composition of Organizing Committee (The chair and the co-chair of the Organizing Committee must be full members of the Society and must actively participate in the scientific development of the program). The chair of the Organizing Committee will be responsible for implementation of the scientific program. SOT Council will appoint a liaison from the Council and SOT Headquarters to the Organizing Committee for the purpose of reporting and coordinating program status, fiduciary arrangements, and physical operations.
  4. List of suggested topics and speakers with affiliations. It is important that the representation of all aspects of the topic be well represented. The balancing of the program content should include a diversity of speakers that’s reflective of the diversity of the Society.
  5. Proposed date and projected length of the meeting.
  6. Projected attendance and marketing (note: it is expected the CCT meeting will attract at least 100 participants).
  7. Proposed venue or will the meeting be held virtually. (The Organizing Committee may suggest a site or sites for the proposed meeting. Selection of the site, however, will be managed by SOT Headquarters and will depend on several parameters such as availability, accessibility, and costs.)
  8. Proposed meeting sponsors, both corporate and related societies.

The CCT Committee will work actively with the organizers to ensure that the prospective CCT meeting is as successful as possible for SOT members. In addition, SOT Headquarters will work with the organizer to prepare a budget and establish meeting pricing. (CCT meetings are expected to be revenue neutral or generate a profit for the Society.)

Review Process:

Applications for CCT meetings should be sent to Clarissa Russell. The CCT Conferences Committee strives to provide feedback on endorsement within two months from the date of submission. The CCT Conferences Committee uses this form as part of the review process.

Submitters of approved applications should allow 12 to 18 months for evaluation, organization, and promotion of the meeting.

Profit Sharing Policy:

CCT meeting proposals developed and submitted by SOT Regional Chapters/SOT Special Interest Groups/Specialty Sections (Component Groups) and approved by the CCT Committee will share 50/50 the profits generated from the CCT meeting. The profit sharing will occur after the initial seed funds provided by the Society are repaid ($25,000). The profits will be shared with the understanding that the funds will go to the respective Component Group and will flow into their general operating funds. If multiple RCs/SIGs/SSs are involved in the meeting coordination, then they will divide the available funds evenly among the Groups. Any CCTs proposed by organizations not affiliated with an SOT RC/SIG/SS would not have the option in sharing in the profits. The Society will continue to underwrite all the liabilities of the CCT meeting with the expectation that the meeting at least breakeven financially. The goal of providing $25,000 seed funds and the profit sharing component is to stimulate the creation of CCT meeting proposals.

Meeting Publications:

Toxicological Sciences retains the first right of publication for all publication materials produced from a CCT meeting. The CCT Organizing Chair should contact the Toxicological Science Editor to discuss publication requirements.