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March 12, 2016
New Orleans, Louisiana

Register Online Now

MicroRNAs (miRNAs) are small, regulatory RNAs that control gene expression posttranscriptionally, thus acting as epigenetic regulators within cells. Recent data demonstrates that some miRNAs are specific to or enriched in certain cell types and/or organs and that they are released upon cellular damage, supporting their potential as non-invasive biomarkers of injury. Ease of detection and high stability at room temperature in biofluids contribute to enthusiasm of miRNAs as non-invasive biomarkers. MiRNA detection is relatively straightforward with low inputs of material by quantitative real-time-PCR, microarray, or next-generation sequencing.

Several consortia efforts have been established to discover and validate miRNA biomarkers that:

  1. Provide insight into injury mode of action.
  2. Distinguish the specific injury location and affected cell type.
  3. Are more sensitive for detection than “gold standard” protein biomarkers.

Critically, several of these biomarkers, particularly for liver injury, have progressed to clinical validation. Communication of recent discovery efforts and discussion of miRNA biomarker research efforts between consortia partners and independent researchers is a critical step toward the streamlined utilization of promising biomarkers for nonclinical and clinical safety assessment.

In an effort to be environmentally conscious, registrants are encouraged to use the online miRNA resources to view conference materials. Use these options to download materials to your computer, smartphone, or tablet.

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Conference Location

The CCT: MiRNA Biomarkers for Toxicology Meeting will be held in the Ernest N. Morial Convention Center on Saturday, March 12, 2016. CCT registrants are encouraged to participate in the 55th Annual Meeting that will be held March 13–17. Separate registration is required. Visit the Annual Meeting website for more information.

Room 207—New Orleans Convention Center
New Orleans, Louisiana
March 12, 2016

Meeting attendees may book their housing reservations through the SOT Annual Meeting housing reservation system. You may contact Connections Housing directly at 800.262.9974 or 404.842.0000, 9:00 am–7:00 pm EST Monday through Friday. You benefit when you book your hotel room within the room block by receiving significantly reduced hotel rates and superior reservation services.

Deadline: February 12, 2016

Organizing Committee
  • Alison Harrill, Chair, University of Arkansas for Medical Sciences, Little Rock, AR
  • Warren Glaab, Co-Chair, Merck Research Laboratories, West Point, PA
  • Brian Chorley, US EPA, Research Triangle Park, NC
  • Heidrun Ellinger-Ziegelbauer, Bayer Pharma AG, Wuppertal, NW, Germany
  • Jean-Charles Gautier, Sanofi, Vitry-sur-Seine, France
  • Michael Lawton, Pfizer, Groton, CT
  • Eric McDuffie, Janssen, San Diego, CA
  • Rounak Nassirpour, Pfizer, Cambridge, MA
  • Igor Pogribny, US FDA-NCTR, Jefferson, AR
  • Karol Thompson, US FDA, Silver Spring, MD
Registration Information
Registrant Type Pre-Registration Standard Registration Final Registration
Received by Jan 15

Jan 16–Feb 12

After Feb 12

SOT Member $220 $250 $280
Nonmember $370 $400 $430
Student/Postdoc
Member
$50 $75 $100
Student/Postdoc
Nonmember
$75 $100 $125

Registrants for this meeting are encouraged to also attend the AM05: Discovery and Validation of miRNA Biomarkers Bridging Preclinical and Clinical Toxicity: Lessons Learned from Hepatotoxicity CE Course. There is an additional fee to participate in the course. You may register for the course at the time of your CCT registration. This CE Course will be held on Sunday, March 13 as part of the SOT Annual Meeting.

SOT Members and Nonmembers alike are encouraged to use SOT’s online registration system. Please select the appropriate registration option below to get started.

*Please note that attendees not attending the SOT Annual Meeting may register for the AM05: Discovery and Validation of miRNA Biomarkers Bridging Preclinical and Clinical Toxicity: Lessons Learned from Hepatotoxicity CE Course using the CCT Meeting registration system. If you are attending the SOT Annual Meeting, you are encouraged to make your CE Course registrations with your SOT Annual Meeting registration.

You are encouraged to contact SOT Headquarters via email or via telephone 703.438.3115, with any questions about the registration process.

Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by February 12, 2016. These refunds will be processed, less a $30 fee, following the meeting.

Disabled Attendees: If you need special assistance for this meeting please contact SOT Headquarters at 703.438.3115.

Note: For individuals who are not members of SOT, participation in SOT’s miRNA Biomarkers of Toxicology meeting is available only to bona fide individuals who are engaged in or promote the field of toxicology or biotechnology research and support the growth and development of the toxicology field. For organizations, participation in the SOT’s miRNA Biomarkers of Toxicology meeting is available only to bona fide organizations with public policy positions and business practices that are generally consistent with SOT’s mission, goals, reputation, and its policies and principles as determined by SOT. SOT reserves the right to review applications for participation at SOT’s miRNA Biomarkers of Toxicology meeting to confirm that the applicant meets these criteria and may, at the SOT’s sole discretion, reject a registration by an individual or business or withdraw registration privileges at any time if any individual or organization is found to be inconsistent with SOT’s principles and interests.

Abstract/Poster Information

There will be a 90 minute poster session as part of the lunch break during the meeting. The poster session will be held in Convention Center Room 217.

 


Poster Instructions

Prior to the meeting attendees will be able to download accepted abstracts and poster presentations submitted by presenters.

Program: Saturday, March 12, 2016

The Scientific Sessions will be held in Room 207 of the New Orleans Convention Center

KEYNOTE LECTURE—9:00 AM–10:00 AM
About Chomsky, DNA Patterns, non-Coding RNAs and Cancer Patients

George Calin, MD Anderson Cancer Center, Houston, TX

PLENARY SESSION I: MiRNAs as Biomarkers of Tissue Injury or Disease across Organ
Systems
10:00 AM–1:00 PM
Chairs:
Heidrun Ellinger-Ziegelbauer, Bayer Pharma AG, Wuppertal, Germany
Igor Pogribny, US FDA-NCTR, Jefferson, AR

  • The ILSI/HESI miRNA Rat Atlas Project to Identify Tissue-Specific miRNA Expression
    Aaron Smith, Lilly Research Laboratories, Indianapolis, IN
  • Discovery of Glomerular Versus Tubular Injury Specific Urinary miRNA Biomarkers in Rodents
    Rounak Nassirpour, Pfizer, Andover, MA
  • MiRNA-206 As a Useful Biomarker of Skeletal Muscle Injury
    Masayuki Kanki, Astellas, Osaka, Japan
  • Plasma miRNAs as Potential Early Biomarkers for Acute Cardiac Injury
    Andre da Costa, UCB BioPharma, Brussels, Belgium
  • MiRNAs Signatures of Prostate Cancer in Urinary Exosomes
    Peter Mouritzen, Exiqon, Denmark

LUNCH AND POSTER SESSION—1:00 PM–2:30 PM
90 minute poster session and lunch.
Convention Center Room 217

PLENARY SESSION II: Technical Considerations for Measurement and Analysis of Small Non-Coding RNA in Biofluids—2:30 PM–5:30 PM
Chairs:
Karol Thompson, US FDA, Silver Spring, MD
Michael Lawton, Pfizer, Groton, CT

  • Measurement Methodology and Experimental Considerations for miRNA Quantification
    Jami Elliott, Quantigen Genomics, Indianapolis, Indiana
  • Extracellular Vesicle Enrichment of miRNA in Biofluids
    Kenneth Witwer, Johns Hopkins University, Baltimore, MD
  • Classes of Small Non-Coding RNA in Biofluids
    Kendall Van Keuren-Jensen, TGen, Phoenix, Arizona
  • Reference Samples for miRNA Measurements
    Scott Pine, National Institute of Standards and Technology, Gaithersburg, MD
  • Bioinformatics Challenges for Next Generation Sequencing Analysis of microRNA Expression
    Weida Tong, US FDA-NCTR, Jefferson, AR

CLOSING REMARKS
Alison Harrill, University of Arkansas for Medical Sciences, Little Rock, AR
Warren Glaab, Merck, West Point, PA

Continuing Education: Sunday, March 13, 2016

Meeting attendees also will have the opportunity to attend the AM05: Discovery and Validation of miRNA Biomarkers Bridging Preclinical and Clinical Toxicity: Lessons Learned from Hepatotoxicity CE Course on Sunday morning.

If you plan to attend the SOT Annual Meeting please register for the CE Course as part of your SOT Annual Meeting registration.

If you will only be attending the miRNA Biomarkers for Toxicology Meeting you may register for the CE Course as part of your CCT Meeting registration.

Supporters
Directions/Transportation/General Information

Please visit the SOT Annual Meeting website for complete information on New Orleans.