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Considerations for the Determination of Adversity in Food Chemical Safety Evaluations—March 27, 2018

Chair: A. Wallace Hayes, University of South Florida College of Public Health, Tampa, FL, and Institute for Integrative Toxicology, Michigan State University, East Lansing, MI

Co-chair: Suzanne Compton Fitzpatrick, US FDA, College Park, MD

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Current risk assessments of chemicals in food do not generally consider exposure to multiple substances but rely instead on the assessment of individual substances in individual food commodities. Humans however are routinely exposed simultaneously to numerous chemicals in food. These mixtures can be variable and constantly changing and defining them presents a challenge. Models could be used independently and in an integrated manner to assess health impacts. This symposium will examine whether new testing approaches such as in vitro, in silico models, and non-mammalian in vivo models could be used to assess the potential health impacts of exposure to chemical mixtures in food.

8:00 AM–8:30 AM Badge Pick Up
8:30 AM–8:35 AM US FDA Welcome and Overview, Conrad J. Choiniere, Director, Office of Analytics and Outreach, CFSAN, US FDA, College Park, MD
8:35 AM–8:45 AM Welcome from SOT and Introductions, Suzanne Fitzpatrick, CFSAN, USFDA, College Park, MD

Speaker Introductions, A. Wallace Hayes, Colloquium Chair, University of South Florida College of Public Health, Tampa, FL, and Institute for Integrative Toxicology, Michigan State University, East Lansing, MI
8:45 AM–8:50 AM Why a New Approach is Needed, A. Wallace Hayes, University of South Florida College of Public Health, Tampa, FL, and Institute for Integrative Toxicology, Michigan State University, East Lansing, MI
8:50 AM–9:30 AM Can High Thru-put Assays/Tox 21 Inform Hazard Assessment?
Michael J. Devito, NTP, Research Triangle Park, NC
9:30 AM–10:10 AM Proposed In Silico Approach for Botanical Mixtures
Catherine Mahony, Procter & Gamble Technical Centres Ltd, Surrey, UK
10:10 AM–10:30 AM Break
10:30 AM–11:10 AM Non-Mammalian In Vivo Models: C. elegans as a Model System to Inform Hazard Identification
Piper Reid Hunt, US FDA, Laurel, MD
11:10 AM–11:50 AM Extrapolating New Approaches into a Tiered Approach to Mixtures Risk Assessment
Mike Dourson, Toxicology Excellence for Risk Assessment, Cincinnati, OH
11:50 AM–12:50 PM Roundtable Discussion
Moderator: A. Wallace Hayes
All speakers
On-site Participation

Advance registration to participate on-site is closed. US Federal employees may register on-site.

On-site seating has no cost. Preregistration is required for participants who are not US federal employees.

A cafeteria is available outside the security entrance to the facility.

Webcast Registration

Register for webcast.

Webcast participants can submit questions online during the event. These will be answered as time allows.

Questions about the SOT FDA Colloquia registration?
Contact Jim Dailey or 703.438.3115 Ext. 1428.

Location, Transportation, and Parking


Wiley Auditorium

Harvey W. Wiley Federal Building
US FDA, Center for Food Safety and Applied Nutrition
5001 Campus Dr., College Park, Maryland 20740


Metro Rail
We strongly encourage visitors to take the Metro via the Green Line to the College Park-University of Maryland station stop, which is across the street from the Wiley Building.

Directions from the Capital Beltway (I-495) to CFSAN

  • Take the Capital Beltway in Maryland and exit at Exit 23
  • Drive on MD-201 S/Hwy 201S/Kenilworth Ave in Greenbelt
  • Proceed to Campus Drive in College Park; turn left onto River Road
  • The CFSAN campus is on the left
  • CFSAN is across from the College Park/U of MD Metro Station


For those who must drive, there is limited public parking at CFSAN which must be reserved in advance by indicating the parking request on the registration form. Alternatively, paid parking is available at the College Park Metro Station across the street from the campus.


Wiley Auditorium is a secured space. All on-site participants will pass through security, which will require a photo ID for those who are not FDA employees. In addition, anyone who is not a US citizen or permanent resident will be required to complete a Foreign Visitor Form to submit to SOT by March 12, 2018.

Organizing Committee
  • Bryan Delaney, PhD, DABT, ATS, Colloquium Series Chair, DuPont Pioneer, Johnston, IA
  • Jason L. Aungst, PhD, US FDA, College Park, MD
  • Suzanne Compton Fitzpatrick, PhD, DABT, US FDA, College Park, MD
  • Norbert E. Kaminski, PhD, Michigan State University, East Lansing, MI
  • Jieun Lee, PhD, DABT, Kellogg, Battle Creek, MI
  • Stephen M. Roberts, PhD, University of Florida, Gainesville, FL
  • Allen Rudman, PhD, US FDA, College Park, MD
  • Jeffrey J. Yourick, PhD, DABT, ATS, US FDA, Laurel, MD
  • John B. Morris, SOT Council Contact, University of Connecticut, Storrs, CT
  • A. Wallace Hayes, PhD, Colloquium Chair, Harvard T.H. Chan School of Public Health, Temple Terrace, FL
  • Betty Eidemiller, SOT staff, SOT, Reston, VA