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Recipients

Congratulations:

 

2016 President Award for Research Competition (PARC)

First Place:

Dr. Justin Conley
US Environmental Protection Agency

Oral Exposure to a Broad Mixture of Anti-Androgens with Varying Mechanisms of Action at Concentrations below Individual Chemical Effect Levels Produces Reproductive Tract Malformations in the Male Rat

Second Place:

Dr. Jennifer Israel
University of North Carolina at Chapel Hill

Mouse Strain-Specific Chromatin and Transcriptional States Modulate the DNA-Damage Response to the Inhalational Carcinogen 1,3-Butadiene

Third Place:

Dr. Samira Brooks
University of North Carolina at Chapel Hill

miRNAs as Common Regulators of the Transforming Growth Factor (TGF)-β Pathway in the Preeclamptic Placenta and Cadmium-treated Trophoblasts: Links between the Environment, the Epigenome and Preeclampsia

2016 Annual Meeting Poster Competition

First Place:

Emma Bowers
University of North Carolina at Chapel Hill

Ozone Exposure Modeled across Primary Cell Donors Reveals the Role of Mapk Signaling in Governing Response Heterogeneity and Inflammatory Adaptation

Second Place:

Mimi Huang
University of North Carolina at Chapel Hill

Inorganic Arsenic and Its Methylated Metabolites Inhibit Calcium Influx during Glucose-Stimulated Insulin Secretion in Pancreatic Islets

Third Place:

Nicole Dover
University of North Carolina at Chapel Hill

Arsenite and Methylarsonite Inhibit Glucose Stimulated Insulin Secretion through an Impairment of Mitochondrial Function

2016 Annual Meeting Student Platform Competition

First Place:

Blake Rushing
East Carolina University

Aflatoxin B1 Reacts with Dietary Components to Form a Novel Pyrrole Adduct with Reduced Genotoxicity

Three Runners Up:

Andres Henriquez
University of North Carolina at Chapel Hill

Stressed Lungs: Unveiling the Role of Circulating Stress Hormones in Ozone-Induced Lung Injury and Inflammation

Myles Hodge
East Carolina University

Scavenger Receptor B-1 Mitigates Ozone-Induced Pulmonary and Vascular Inflammation

Mark Ihrie
North Carolina State University

Adjuvant Effects of Multi-Walled Carbon Nanotube Sensitization with House Dust Mite Allergen Lead to an Exaggerated Asthmatic Phenotype in Mice

2016 Spring Meeting Poster Competition

First Place:

Alisa Suen
National Institute of Environmental Health Sciences, University of North Carolina at Chapel Hill

Aberrant Expression of SIX 1 in a Developmental Mouse Model of Hormonal Carcinogenesis and in Human Endometrial Cancer

Second Place:

Gina Hilton
North Carolina State University

Identification of Biomarkers for Nano-Safety Assessment through Proteomic Analysis of Multi-Walled Carbon Nano Tubes Functionalized by Atomic Layer Deposition Coating

Samira Brooks
University of North Carolina at Chapel Hill

Cadmium Exposure Influences Angiogenic Pathways in the Preeclamptic Placenta via Epigenetic Mechanisms

2016 Spring Meeting Student Platform Competition

First Place:

Phillip Clapp
University of North Carolina at Chapel Hill

Flavored Electronic Cigarette Liquids Impair Respiratory Innate Immune Cell Function

Second Place:

Katelyn Lavrich
University of North Carolina at Chapel Hill

Monitoring Bioenergetic Effects of Environmental Quinones in Human Airway Epithelial Cells Using Extracellular Flux Technology

Third Place:

AtLee Watson
North Carolina State University

TCDD Dysregulates Osteoblast Differentiation in Human Bone-Derived Mesenchymal Cells, and in Japanese Medaka In Vivo


Past Recipients

2015 President Award for Research Competition (PARC)

First Place:

Dr. Ntube O. Ngalame
National Toxicology Program, National Institute of Environmental Health Sciences
Molecular characterization of exosomes released by arsenic-malignantly transformed prostate epithelial cells and their potential role in the recruitment of nearby, but noncontiguous normal stem cells into an oncogenic phenotype

Second Place:

Dr. James Sollom
University of North Carolina at Chapel Hill
Environmental Contaminants and microRNA Regulation: Transcription Factors as Master Regulators of Toxicant-Altered microRNA Expression

Third Place:

Dr. Natasha Catlin
National Toxicology Program, National Institute of Environmental Health Sciences

In utero exposure to the dietary supplement vinpocetine is associated with rat and rabbit embryo-fetal toxicity

Dr. Satya Achanta
Duke University
TRPV4 inhibitor improves pulmonary function and oxygen saturation in a pig translational model of chemically induced acute lung injury

Dr. Ngome Makia
National Toxicology Program, National Institute of Environmental Health Sciences

Cadmium and arsenic transformed human peripheral lung cells expressing CD34 display stem cell-like and malignant properties

2015 Student Poster Awardees

First Place:

Samira Brooks
Regulation of Gene Expression Profiles in Clear Cell Renal Cell Carcinoma by Cadmium Exposure

Second Place:

Natalie Holman
In Vitro Assessment of Primary Hepatocyte-Derived Extracellular Vesicles and Their Role in Drug-Induced Liver Injury

Third Place:

Deirdre Tucker
Perinatal Exposures to Bisphenol (BP) Analogs and Their Effects in Early and Pubertal Development in CD-1 Mice

2015 Student Platform Competition

First Place:

Place Bevin Blake,
East Carolina University

Elevated Prenatal Hormones Program Autism-Like Behavior in the Rat

Three Runners Up:

Dana Walsh
University of North Carolina
Detection of Airway Microbiota by Next Generation Sequencing Following Burn and Inhalation Injury

Phillip Wages
University of North Carolina at Chapel Hill

Exposure to 1,2-Naphthoquinone Induces Protein Sulfenylation in Human Bronchial Epithelial Cells

AN vonderEmbse
East Carolina University

Neurotoxicological Disruption of Microglial Development and Early Vulnerabilities For Alzheimer’s Disease

2015 Postdoctoral Travel Award

Dr. Justin Conley
Environmental Protection Agency

In Vitro-to-In Vivo Extrapolation of Xenoestrogens Using an Estrogen Responsive In Vitro Transcriptional Assay and the In Vivo Uterotrophic Assay


2014 President Award for Research Competition (PARC)

First Place:

Dr. Samantha J. Snow
ORISE, Environmental Protection Agency
Acute Ozone Exposure Accelerates Diet-Induced Metabolic Alterations in a Rat Model of Type II Diabetes Mellitus

Second Place:

Dr. Yongquan Lai
University of North Carolina at Chapel Hill

Third Place:

Dr. Yong Ho Kim
University of North Carolina at Chapel Hill, Environmental Protection Agency

2014 Spring Meeting Poster Competition

First Place:

Grace Chappell
University of North Carolina at Chapel Hill
Genotoxic and Epigenotoxic Effects of 1,3-Butadiene: Putative Mechanisms of Tissue Specificity in Adverse Health Outcomes

Second Place:

Jenna Strickland
North Carolina State University
Silver Nanoparticles and Ionic Silver Have Opposite Effects on Spontaneous Activity and Pharmacological Responses in Neuronal Networks In Vitro

Third Place:

Grace Silva
University of North Carolina at Chapel Hill
Assessment of DNA Copy Number Alterations in Fibrosis-Associated Mouse Liver Tumors

Hann Tam
North Carolina State University
Ablation of the bZIP Transcription Factor, CCAAT Enhancer Binding Protein-(C/EBP), in Skin Protects Mice Skin Cancer Induced by Ultraviolet B Radiation


2013 President Award for Research Competition (PARC)

First Place:

Dr. Yuanyuan Xu
National Toxicology Program, National Institute of Environmental Health Sciences
Arsenic Induces an Oncogenic Phenotype In Human Breast Epithelia through an Estrogen Receptor-Independent Pathway by Aromatase Activation

Second Place:

Dr. Yong Ho Kim
University of North Carolina at Chapel Hill
Pulmonary Inflammatory Responses to Wildfire Particulate Matter: Concordant Toxicity Patterns Between In Vivo and Ex Vivo Screening Tests

Dr. Samantha J. Snow
University of North Carolina at Chapel Hill
Health Effects Associated with Inhalation Exposure to Diesel Emission Generated with and without CeO2 Nano Fuel Additive

2013 Student Poster Awardees

First Place:

Nour Abdo
University of North Carolina at Chapel Hill
“The 1000 Genomes Toxicity Screening Project: Utilizing the Power of Human Genome Variation for Population-Scale in Vitro Testing

Second Place:

Julia Rager
University of North Carolina at Chapel Hill
Formaldehyde-Induced Changes in microRNA Signaling

Third Place (Tie):

Samira Brooks
University of North Carolina at Chapel Hill
Prognostic Biomarker Discovery for a Distinct Gene Signature in Clear Cell Renal Cell Carcinoma

Jessica Wignall
University of North Carolina at Chapel Hill
Conditional Toxicity Value (CTV) Predictor for Generating Toxicity Values for Data Sparse Chemicals

2013 New Student Platform Competition

First Place:

Rebecca Bauer
University of North Carolina at Chapel Hill
The Interaction between Human Bronchial Epithelial Cells and Alveolar Macrophages Modifies the Innate Immune Response to Ozone

Runners Up:

Suvarthi Das
University of South Carolina
Free Radical Metabolism Promotes Autophagy in Environment-Associated Steatohepatitic Lesions

Jessica Sorrentino
University of North Carolina at Chapel Hill
In Vivo Expression of p16^INK4a in Response to Toxicological Exposures

Phillip Wages,
University of North Carolina at Chapel Hill
Linking Early Oxidative Events to Adaptive Gene Expression Induced by Zinc


2012 Student Poster Awardees

First Place (Tie):

Jessica Sorrentino, UNC-Chapel Hill
Investigating the Mechanisms of P16 Expression In Vivo in Response to Toxicological Exposures
Advisor: Dr. Norman Sharpless )

Xinyu Yang, Duke
Silver Nanoparticle Toxicity Is Associated with Oxidative Dissolution and Strongly Mitigated by Natural Organic Matter
Advisor: Dr. Joel Meyer

Second Place (Tie)

Sandra Losa-Ward, NCSU
Advancement of Vaginal Opening in the Female Rat Following Neonatal BPA Exposure Is Associated with Disruption of Hypothalamic RFRP3 Signaling Pathways
Advisor: Dr. Heather Patisaul

Jessica Wignall, UNC-Chapel Hill
Modeling Toxicity Values Using Chemical Structure, In Vitro Screening, and In Vivo Toxicity Data
Advisor: Dr. Ivan Rusyn

2012 New Student Platform Competition

First Place:

Maxwell Leung, Duke University
Later-Life Effects of Mitochondrial DNA Damage during Development in the Whole Organism Model Ceanorhabditis Elegans
Advisor Dr. Joel Meyer

Runners Up:

Samantha Snow, UNC-Chapel Hill
Soluble Components of Ultrafine Particulate Matter Induce Pro-coagulant Responses in Endothelial Cells
Advisor: Dr. David Diaz-Sanchez

Raju Prasad, UNC-Chapel Hill
Effect of Treatment Media on Size and Cellular Uptake of TiO2 Nanoparticles: Impact on Genotoxicity
Research Advisor: Dr. David Demarini

Leslie Thompson, ECU
Pulmonary Exposure to Multiwalled Carbon Nanotubes and C60 Fullerenes Activate Indomethacin Sensitive Coronary Responses to ET-1
Advisor: Dr. Christopher Wingard


2011 PARC Recipient

Catherine Kurtz, The Hamner
“Population Based Toxicity Assessment Implicates Mitochondrial Dysfunction As an Early Event in Isoniazid-Induced Liver Injury.” (mentor: Dr. Alison Harrill).

2011 PARC Runners Up

Second Place: Nicole Kleinstreuer, US EPA
“In Silico Testing of Chemical Impact on Embryonic Vascular Development.” (mentor: Dr. Tom Knudsen)

Third Place: Yang Sun, NIEHS
“Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic.” (mentor: Dr. Mike Waalkes)

2011 Student Poster Awardees

The North Carolina Regional Chapter of the SOT sponsors Student Poster Awards for undergraduate or graduate students enrolled in training programs in the area served by the NC Regional Chapter. These awards are based on judging of the student’s poster at the Annual Spring Meeting by the NC regional chapter past presidents. Winners of the award receive a monetary prize and their award-winning posters display a ribbon at the spring NCSOT meeting.

First Place: Katie Paul, University of North Carolina-Chapel Hill (UNC-CH)
Triclosan Decreases Rat Thyroxine: Mode-of-Action, Developmental Susceptibility and Human Relevance
Authors: K.B. Paul, J.M. Hedge, S.O. Simmons, M.J. DeVito, and K.M. Crofton

Second Place (Tie): Jonathan Shanahan, UNC-CH
Libby Amphibole-Induced Inflammation Is Modulated by Iron In Vitro and In Vivo
Authors: J.H. Shannahan, M.C.J. Schladweiler, J.K. McGee, J.H. Richards, S.H. Gavett, A.H. Ghio, and U.P. Kodavanti

Second Place (Tie): Chris Grigsby, Duke University
Reduced Toxicity of Nanocomplexes Synthesized with Microfluidics-Assisted Confinement
Authors: C.L. Grigsby, Y-P. Ho, and K.W. Leong

Second Place (Tie): Nour Abdo, UNC-CH
Population-Based Quantitative High-Throughput Screening (QHTS) for Chemical Toxicity
Authors: N. Abdo, S. O’Shea, O. Kosyk, E. Lock, F. Wright, R. Huang, M. Xia, C. Austin, R. Rice, and I. Rusyn


2010 PARC Recipient

Yuanyuan Xu, NIEHS: “Epithelia Malignantly Transformed by Arsenic or Cadmium Drives Nearby Normal Stem Cells towards a Malignant Phenotype.” (mentor: Dr. Mike Waalkes)

2010 PARC Runners Up

Yang Sun, NIEHS: “Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic.” (mentor: Dr. Mike Waalkes)

Zhengyu Yin, NIEHS: “RAP80 Plays a Critical Role in Maintaining Genomic Stability.” (mentor: Dr. Anton Jetten)

2010 Student Poster Awardees

First Place: Miyuki Breen

Adaptive responses to prochloraz exposure in the hypothalamic-pituitary-gonadal axis of fathead minnows
North Carolina State University (mentors: Drs. Alun Lloyd and Rory Conolly)

Second Place: Samantha Snow

Soluble components of ultrafine particulate matter stimulate endothelial H2O2 production
University of North Carolina-Chapel Hill (mentor: Dr. Ivan Rusyn)

Third Place: Shannon O’Shea

In Vitro Screening for Population Variability in Chemical Toxicity
University of North Carolina-Chapel Hill (mentor: Dr. Marsha Sue Carraway)


2009 PARC Recipient

Erik J. Tokar, NIEHS: “Evidence for dysregulation of self-renewal genes and loss of imprinting during arsenic-induced formation of human cancer stem cells.”

2009 PARC Runners Up

Josh Harrill, US EPA: “Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived neurons using automated high-content image analysis.”

Melissa Barhoover, The Hamner Institutes: “The AHR regulates cell cycle progression in human breast cancer cells via a functional interaction with CDK4.”

2009 Student Poster Awardees

The North Carolina Regional Chapter of the SOT sponsors Student Poster Awards for undergraduate or graduate students enrolled in training programs in the area served by the NC Regional Chapter. These awards are based on judging of the student’s poster at the Annual Spring Meeting by the NC regional chapter past presidents. Winners of the award receive a monetary prize and their award-winning posters display a ribbon at the spring NCSOT meeting.

First Place: Katie Paul

Triclosan disrupts thyroxine: Mechanisms and life-stage susceptibility
K.B. Paul1, J.M. Hedge2, M.J. DeVito2, K.M. Crofton2

  1. Curriculum in Toxicology, UNC, Chapel Hill, NC
  2. NHEERL, US EPA, RTP, NC

First Place: Miyuki Breen

The role of cholesterol utilization in a computational adrenal steroidogenesis model to improve predictability of biochemical response to endocrine active chemicals
M. Breen1,2, M.S. Breen3, N. Terasaki4, M. Yamazaki4, A.L. Lloyd2, R.B. Conolly1

  1. NCCT, US EPA, RTP, NC
  2. Department of Statistics, NCSU, Raleigh, NC
  3. NERL, US EPA, RTP, NC
  4. Mitsubishi Tanable Pharma Corporation, Kisarazu, Chiba, Japan

Second Place: David Szabo

Toxicokinetics of the stereoisomer specific flame retardant hexabromocylododecane (HBCD) gamma: Effects of dose, time, and repeated exposure
D.T. Szabo1, J.J. Dilliberto2, J. Huwe3,L.S. Birnbaum4

  1. Curriculum in Toxicology, UNC, Chapel Hill, NC
  2. NHEERL, US EPA, RTP, NC
  3. ARS/USDA, Fargo, NC
  4. NCEA, US EPA, RTP, NC

Second Place: Nick Manzo

Differential oxidative properties of diesel exhaust particles
M. Manzo 1, J. Richards2, R. Slade2, L. Martin1, J. Dye2

  1. Molecular Biomedical Sciences, NCSU, Raleigh, NC
  2. NHEERL, US EPA, RTP, NC

2008

Student Poster Awardees

First Place: Alison Hege from the University of North Carolina; second Place: Miyuki Breen from the US EPA; and third Place: Pamela Ross from the University of North Carolina. Poster abstracts are presented in the August 2008 newsletter:

Phenotypic anchoring of gene expression data from acetaminophen hepatotoxicity studies in the mouse model of the human population reveals biomarkers of response.
A. Hege1, P. Ross2, D. Threadgill1,3, I. Rusyn1,2

  1. Curriculum in Toxicology
  2. Department of Environmental Sciences and Engineering
  3. Department of Genetics, UNC, Chapel Hill, NC
In silico steroidogenesis model: predicting dynamic biochemical response to endocrine active chemicals in H295R cells
M. Breen1,2, M.S. Breen3, N. Terasaki4, M. Yamazaki4, R.B. Conolly1
  1. NCCT, US EPA, RTP, NC
  2. Biomathematics Program, Department of Statistics, NCSU, Raleigh, NC
  3. NERL, US EPA, RTP, NC
  4. Molecular Toxicology Group, Safety Research Laboratory, Mitsubishi Tanable Pharma Corporation, Kisarazu, Chiba, Japan
Time-course comparison of gene expression signatures of xenobiotic activators of CAR and PPARalpha in mouse liver.
P.K. Ross1, C.G. Woods2,3, B.U. Bradford1, O. Kosyk1, I. Rusyn1
  1. UNC, Chapel Hill, NC
  2. Hamner Institutes for Health Sciences, RTP, NC
  3. ExxonMobil Biomedical Sciences, Annandale, NJ

2008 PARC Recipients

Erik J. Tokar, NIEHS: “CStem cell selection facilitates arsenic-induced malignant transformation via innate resistance, hyper-adaptability and over-production.”

2008 PARC Recipients

Scott S. Auerbach, NIEHS: “Prediction of hepatocarcinogenic potential in male rats using machine learning methods informed by genome-wide expression analysis.”

Brante P. Sampey, UNC: “Genistein elicits concentration dependent effects in estrogen-stimulated endometrial models: The involvement of the IGF-signaling axis.”


2007

Student Poster Awardees

First Place was won by Kari Loomis from NC State University; second Place went to Alison Hege from the University of North Carolina; and third Place to Kymberly Gowdy, also from NC State University. Poster abstracts are presented in the August 2007 newsletter:

Genetic Ablation of C/EBP in Epidermis Reveals its Role in Suppression of Epithelial Tumorigenesis.
Loomis, Kari D.1,2, Zhu, S.1, Yoon, K.1, Johnson, P.F.3, and Smart, R.C.1

  1. Cell Signaling and Cancer Group, Department of Environmental & Molecular Toxicology
  2. Functional Genomics Program, North Carolina State University, Raleigh, NC
  3. Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD

Cross-Species Association Mapping Identifies Genetic Risk Factors for Liver Toxicity
Hege, Alison I.1,2, Russo, M.W.3, Su, S.4, Ross, P.K.2, Stylianou, I.M.5, Boorman, G.A.6, Tennant, R.6, Bogue, M.A.5, Paigen, K.5, Wiltshire. T.4, Watkins, P.B.3, Rusyn, I.1,2, and Threadgill, D.W.1,7

  1. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC
  2. Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC
  3. Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC
  4. Department of Mouse Genetics, Genomics Institute of the Novartis Research Foundation, San Diego, CA
  5. The Jackson Laboratory, Bar Harbor, ME
  6. National Institute of Environmental Health Sciences, Research Triangle Park, NC
  7. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC

Comparison of On and Off Road Diesel Exhaust Sources on Susceptibility to Influenza Infection in Mice.
Gowdy, Kymberly1, Ciencewicki, J.2, Jaspers, I.2, Krantz, Q.T.3, Boykin, E.3, Linak, W.P.4, Gilmour, M.I.3

  1. NCSU, Raleigh, NC
  2. UNC, Chapel Hill
  3. ETD, NHEERL
  4. NRMRL, RTP, NC


2007 PARC Recipient

Adam Kuhl, The Hamner Institute: “C/ebp B, but not SF-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis”

2007 PARC Runners Up

Jean-Francois Coppin, NIEHS: “Interplay between cellular methyl metabolism and adaptive efflux during chronic arsenic exposure in human cells”

Eric Tien, NIEHS: “Protein kinase C up-regulates hepatic drug metabolism through stabilization of the pregnane-X-receptor”

Erik Tokar, NIEHS: “Potential generation of cancer stem cells during arsenic-induced malignant transformation of human urogenital progenitor cells”

2007 PARC Honorable Mentions

Pei-Jen Chen, US EPA: “Alterations in All trans- retinoic acid metabolism in liver microsomes from mice treated with hepatotumorigenic and non-hepatotumorigenic conazoles”

Chikara Kojima, NIEHS: “Oxidative DNA damage induced by inorganic arsenite depends on cellular ability to methylate arsenic”

Chester Rodriguez, US EPA: “Predicting age-dependent pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically-based pharmacokinetic modeling”


2006

Dr. Michelle Block, National Institute of Environmental Health Sciences (NIEHS), recipient of the 2006 North Carolina SOT Presidents Award for Research Competition (PARC) based on her work titled “Extracellular µ Calpain Mediates Microglial Activation and Progressive Dopaminergic Neurotoxicity in Response to Neuronal Injury: Mechanism of Reactive Microgliosis.” This is Dr. Block's second PARC award in as many years.

PARC Award Honorable Mention recipients Dr. Anika M. Hartz, NIEHS (Diesel Exhaust Particles Alter Blood-Brain Barrier Properties) and Dr. Erik Tokar, NCI at NIEHS (Arsenic-induced Carcinogenic Transformation of Human Urogenital Progenitor Cells).

 

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