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Translating Genomics and Proteomics for Toxicology and Risk Assessment

National Capital Area Chapter
Society of Toxicology

Spring Symposium
Tuesday, May 16, 2000

Tower Auditorium
Howard University Cancer Center
Howard University Hospital
Washington, DC

NCAC-SOT Spring 2000 Meeting

The National Capital Area Chapter (NCAC) of the SOT held another successful meeting on May 16, 2000, at the Tower Auditorium, Howard University Hospital Cancer Center, Washington, DC. The topic of this year's Spring Symposium was "Translating Genomics and Proteomics for Toxicology and Risk Assessment." Another record-breaking attendance for the NCAC-SOT was established with 150 persons registered, and 15 new members joined the chapter.

The all-day symposium focused on the quantum leap in interest in genomics and proteomics among toxicologists. The following speakers highlighted the basic technology of genomics and proteomics, shared current research data, and discussed opportunities for translating these technologies into preclinical and clinical development programs. David Brusick (Covance Laboratories, Inc., Vienna, VA) presented his views on the value of these technologies to pharmaceutical companies with "Toxicogenomics and Proteomics: A Revolution in the Practice of Toxicology." Hisham Hamadeh (NIEHS Microarray Center, NIEHS, Research Triangle Park, NC) presented an overview of genomics technology and how to exploit the technology for understanding low-dose exposure effects and mechanisms with "Microarray Technology in Molecular Toxicology." Thomas Dooley (IntegriDerm, Inc., Huntsville, AL) discussed the contribution of genomics for evaluating the safety of cosmetics and understanding skin-related conditions in "Gene Expression DNA Microarrays in Dermatologic Pharmacology and Toxicology." Daniel Casciano (NCTR, FDA, Jefferson, AR) presented "Species Comparisons Using Gene Expression Microarrays." Frank Sistare (CDER, FDA, Laurel, MD) spoke on "Applications of Genomics and Proteomics to the Development of Practical Biomarkers for Cardiovascular Toxicities." Joy Cavagnaro (Access BIO, Leesburg, VA) chaired a panel discussion on "Transitioning from Methodologies to Toxicology" that raised important concerns and limitations regarding the adaptation of these technologies for regulatory purposes. The symposium was organized and chaired by NCAC-SOT President Peter Goering (CDRH, FDA, Rockville, MD) and other chapter officers. A brief report on this meeting written by Sara Thurin Rollin, a journalist for the Bureau of National Affairs, Inc., appears in the May 22 issue of the Chemical Regulation Reporter, Vol. 24, no. 20, pp. 1042-1043.





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