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From: Dalton, Tim (daltontp)
Sent: Tuesday, September 13, 2005, 8:04 AM
Subject: OVSOT Seminar Announcement

TELESEMINAR ANNOUNCEMENT

Monday, September 26, 2005, 12:00 NOON

The Ohio Valley Society of Toxicology is pleased to announce the upcoming seminar entitled,

Effects of Low-Level Exposure to Arsenic on Human Bladder Cells by

Jay Gandolfi, Ph.D.
Acting Department Head, Pharmacology & Toxicology
Assistant Dean, Pharmacy Research & Graduate Affairs
Professor, Anesthesiology
Professor, Bio5 Institute
Professor, Pharmacology
Professor, Pharmacology & Toxicology
College of Pharmacy
Pharmacology and Toxicology

Dr. Gandolfi’s research interests broadly focus on the molecular and cellular mechanisms of toxicity. Current studies concentrate on the use of in vitro systems to evaluate cell-specific injury. Specific studies examine the effects of low level metal exposure on cell signaling and gene expression and the development of in vitro models to reflect in vivo toxicity. Tissues of interest are the liver, kidney, bladder, and prostate.

Recent topical publications by Dr. Gandolfi’s research group include:

Bredfeldt, T.G., Kopplin, M.J., Gandolfi, A.J.

Related Articles, Links

Abstract

Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels.
Toxicol Appl Pharmacol. 2004 Aug 1;198(3):412-8.
PMID: 15276421 [PubMed - indexed for MEDLINE]

Zheng XH, Watts GS, Vaught S, Gandolfi AJ.

Related Articles, Links

Abstract

Low-level arsenite induced gene expression in HEK293 cells.
Toxicology. 2003 May 1;187(1):39-48.
PMID: 12679051 [PubMed - indexed for MEDLINE]

Kirkpatrick DS, Dale KV, Catania JM, Gandolfi AJ.

Related Articles, Links

Abstract

Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells.
Toxicol Appl Pharmacol. 2003 Jan 15;186(2):101-9. Erratum in: Toxicol Appl Pharmacol. 2003 Dec 15;193(3):393.
PMID: 12639501 [PubMed - indexed for MEDLINE]

Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Henderson CJ, Wolf CR, Clark AJ, Brendel K, Fisher RL, Gandolfi AJ.

Related Articles, Links

Abstract

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.
Toxicol In Vitro. 2003 Apr;17(2):201-5.
PMID: 12650674 [PubMed - indexed for MEDLINE]

Kirkpatrick DS, Dale KV, Catania JM, Gandolfi AJ.

Related Articles, Links

Abstract

Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells.
Toxicol Appl Pharmacol. 2003 Jan 15;186(2):101-9. Erratum in: Toxicol Appl Pharmacol. 2003 Dec 15;193(3):393.
PMID: 12639501 [PubMed - indexed for MEDLINE]

Carter DE, Aposhian HV, Gandolfi AJ.

Related Articles, Links

Abstract

The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review.
Toxicol Appl Pharmacol. 2003 Dec 15;193(3):309-34. Review.
PMID: 14678742 [PubMed - indexed for MEDLINE]

Dr Gandolfi will present the seminar via telephone conference bridge.

The slide file may be downloaded from the following website. CAUTION! When you click to open this presentation you will be asked if you want to open the presentation or save the presentation. Your computer will perform much better if you save the presentation to your computer and then open it.

To download the presentation go to:

1. http://superfund.pharmacy.arizona.edu/cpg/

2. click on "Public Files"

3. click on File icon

4. click on File icon (Gandolfi OVSOT Presentation)

5. click on File icon again

6. click save (not open) in the “file download” dialog box

If you have any difficulties, please email me and let me know. I can send the file by email but because of its large size many email accounts will not accept it.

The call-in number is (513) 569-7897, the access code is 2772#

If you have difficulties, please telephone the help desk at (513) 569-7754. The conference bridge will open at 11:30 AM and remain open for two hours.

Slides will be best viewed from a computer monitor or from a projection system.