ASIO Past Events
Association of Scientists of Indian Origin (ASIO) SOT Proudly Hosts the Webinar
Regulatory Network Models of Chemical-Induced Gene Perturbation
Date: December 15, 2017
Time: 12 PM EDT
Tissue-specific network models of chemical-induced gene perturbation can improve our mechanistic understanding of the intracellular events leading to adverse health effects resulting from chemical exposure. The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor (TF) that activates a battery of genes and produces a variety of species-specific adverse effects in response to the potent and persistent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Here we assemble a global map of the AHR gene regulatory network in the mouse liver from a combination of previously published gene expression and genome-wide TF binding data sets. Using various computational methods, we show that genes co-regulated by common upstream TFs in the AHR network show a pattern of co-expression. Specifically, directly-bound, indirectly-bound and non-genomic AHR target genes exhibit distinct patterns of gene expression, with the directly bound targets generally associated with highest median expression. Further, among the directly bound AHR target genes, the expression level tends to increase with the number of AHR binding sites in the proximal promoter regions. Finally, we show that co-regulated genes in the AHR network activate distinct groups of downstream biological processes, with the AHR-bound target genes enriched for metabolic processes and the AHR-unbound target genes primarily activating immune responses in the mouse liver. In summary, this work presents one approach to the reconstruction and analysis of the transcriptional regulatory cascades underlying adverse cellular response using bioinformatic and statistical tools.
Assistant Professor, Biomedical Engineering,
Pharmacology and Toxicology
Michigan State University
“Interactive Meet for Insights in Toxicology” a ToxGurukul Initiative on 25th and 26th November, 2017 at Bengaluru, India.
IMIT Registration Form
ASIO Annual Reception
Monday, March 13th, 7:00 to 9:30 pm at the Hilton Baltimore, Peale Room
Career talk with Toxperts
Monday, March 13th 2017, 4:45 to 5:45 pm
This year ASIO is re-organizing “Lunch & Learn” as “Career talk with Toxperts” to provide a more relaxed evening hour to chat with experts in toxicology. This features a panel discussion with professionals from government, academic, and industry. Panelists will discuss their jobs, their path in gaining their position, answering questions and concerns about careers in toxicology.
Throughout the duration of the SOT Annual Meeting
This is a platform for networking with experts in their fields by meeting over coffee. Students can have one to one interaction with mentors to glean from their knowledge and insight on theory, research, and how to make oneself marketable for a future job. Mentors and mentees will be matched according to similarities in research interests and career aspirations.
Coffee Hour Mentee Sign up
ASIO is proud to announce Tox-Webinar on the latest developments of Immunology. The speaker is Dr. Prakash Nagarkatti, Distinguished Professor and Vice President for Research at University of South Carolina, Columbia. Dr. Nagarkatti is an expert immunologist and his recent research focus on cannabinoids and other AhR ligands as potential anti-inflammatory agents.
Topic: Inflammation—Can we silence the secret killer?
Dr. Prakash Nagarkatti, PhD
Carolina Distinguished Professor,
Department of Pathology, Microbiology & Immunology
University of South Carolina, Colombia, South Carolina
Date: Friday, Oct 21, 2016
Time: 12:00 Noon–1:00 PM Eastern Daylight Time, USA (EDT)
This webinar will introduce the basic mechanisms of inflammation triggered by innate and adaptive immune system. The key role of AhR ligands in suppressing inflammation and dietary compounds that act as AhR ligands will be highlighted in light to the recent developments in immunological research.
Sponsored by Society of Toxicology
Topic: ASIO—Inflammation: Can we silence the secret killer?
Recording date: Friday, October 21, 2016 12:00 PM EDT
Description: The SOT-SIG Association of Scientists of Indian Origin (ASIO) proud to announce webinar on the new developments in immunotoxicology. The webinar will highlight the role of Aryl hydrocarbon Receptor (AhR) in the inflammatory pathway, and will provide insights on the use of dietary supplements that act via AhR and contribute towards suppressing inflammation.
The speaker is Dr. Prakash Nagarkatti serve as Vice president for Research at University of North Carolina. Dr. Nagarkatti has an extensive experience on inflammation mechanisms and his recent research focus on cannabinoids and AhR ligands as potential anti-inflammatory agents.
Inflammation is a double-edged sword. On one hand, it is critical for protecting the host from infections, and plays a key role in wound healing, while on the other hand, chronic inflammation can trigger a variety of clinical disorders including allergies, autoimmune diseases, cancer, cardiovascular and neurodegenerative diseases, and obesity. There are over 80 autoimmune diseases that result from the immune attack against specific organs and tissues. Because of such wide implications of the involvement of inflammation in disease, it is not only critical to uncover as-yet-unknown immune mechanisms and mediators of inflammation but also find novel treatment modalities. Currently, there is no effective treatment against chronic inflammation. The inflammation is also impacted by exposure to environmental chemicals, toxins, nutrition, and stress. Such factors may influence inflammation through alterations in the microbiome or causing epigenetic changes. In the webinar, basic mechanisms of inflammation triggered by innate and adaptive immune system will be introduced. While aryl hydrocarbon receptor (AhR) was identified for its role in the regulation of the biochemical and toxic effects of environmental chemicals, recent studies demonstrated that AhR ligands can also play a key role in suppressing inflammation. In the webinar dietary compounds that can act as AhR ligands and suppress inflammation will be discussed.
Speaker Presentation Slides
ASIO initiated Tox-Webinar series last year with the goal to educate students and fellow scientists on the latest developments of toxicological sciences. Based on the valuable inputs from the members of Society of Toxicology, ASIO is planning to host a topic on chemical carcinogenesis. The speaker is Dr. Udayan Apte from University of Kansas Medical Center, who is an expert in hepatotoxicology and has extensive experience working on mechanisms of liver regeneration, hepatic stem cells and mechanisms of chemical carcinogenesis.
Webinar Topic: New Frontiers in Chemical Carcinogenesis
Date: Friday, Sep 26, 2014
Dr. Udayan Apte, PhD
Department of Pharmacology, Toxicology and Therapeutics,
University of Kansas Medical Center Kansas City, Kansas
This webinar will introduce the basic mechanisms of chemical carcinogenesis and will highlight recent new developments in carcinogenesis field. Apart from discussing the current trends, it will also provide perspectives how the new information can be applied to ongoing research efforts.
“Omics” Applications in Drug Discovery and Development
Dr. Shashi K Ramaiah, DVM, PhD, DACVP, DABT
Translational Biomarker Head, Drug Safety Research and Development,
Pfizer-Biotherapeutics, Cambridge, MA
Date: Friday, Dec 13
Time: 12:00 noon–1:00 pm Eastern Standard Time, USA (EST)
[International attendees please convert your local time accordingly]
The webinar will address the application of “omics” approaches as biomarker tools in drug discovery and development. Understanding transcription (mRNA, miRNA), translation (and its modifications) and the metabolites are fundamental to interrogate the mechanistic toxicity of complex human disease. The insights lend itself to develop biomarker signature for understanding mechanism of action of drug and its efficacy, patient enrichment and stratification in clinical trials. Thereupon, the biomarker platforms and technologies have evolved to provide practical applications as well as less resource-intensive approaches. The presentation will provide broad perspectives and examples on the “omics” approaches and their utilization in drug discovery and development as biomarkers.
Dr. Shashi Ramaiah is pioneer in the field of biomarker “Omics” technology and currently serving as the head of Translational Biomarkers at Pfizer Biotherapeutics in Cambridge, MA. He received his doctoral degree in veterinary medicine in 1992 from University of Agricultural sciences, Bangalore, India and received PhD in Toxicology from University of Lousiana at Monroe in 1999. He completed his clinical pathology residency at University of Florida, Gainesville in 2002 and became faculty of Texas and A & M College of Veterinary Medicine. He obtained an independent NIH funded research program on alcoholic liver disease and trained several graduate students, residents and post-doctoral fellows. He is board certified in clinical Pathologist (DACVP) and toxicologist (DABT). He has published more than 50 peer-reviewed journal articles, manuscripts and book chapters. Dr. Ramaiah transitioned from academia to Pfizer.Inc in 2008 as Translational biomarker head and is currently responsible for scientific leadership, supervision of laboratory operations and development of translational pharmacology and safety biomarker strategies to support projects across different therapeutic areas and modalities in Pfizer-Biotherapeutics portfolio.
Preclinical GLP Study Director Workshop
October 8–10, 2012
Veterinary College, Hebbal, Bangalore
ASIO Annual Reception
Monday, March 12
7:00 pm–9:00 pm
55 Fourth Street
San Francisco, California 94103
Room: Salon C3
ASIO Student/Post-Doc Mentoring Program
Tuesday, March 13
12:00 pm–1:30 pm
55 Fourth Street
San Francisco, California 94103
Room: Foothills G
2011 Annual Meeting—Washington, DC
2010 Annual Meeting
Current Indo-US S&T Cooperation
Dr. Debapriya Dutta, S&T Counselor Embassy of India, Washington DC
Speaker Presentation Slides
Meet the ASIO-SOT 2010 Travel Awardees