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Mechanisms-Sponsored Programming at SOT




The Role of Cellular Redox Balance in Toxicity


Alcohol Metabolism and Hepatotoxicity


Mechanisms of Species Differences in the Toxicity of Chemicals


Poster Discussion Sessions

  • Mechanisms of TCDD Toxicity
  • Oxygen Toxicity


Immunologic and Genetic Mechanisms in Carcinogenesis


Mechanisms of Lung Injury by Systemically Administered Chemicals


SelectiveIinhibitors of Cytochrome P-450


New Advances in Mechanisms of Lethal Cell Injury

The Biliary Tree: ATtarget for Chemically-Induced Injury and Proliferation


Is Carnitine a Key Toxicological Target?

Compartmentation of Glutathione: Implications for the Study of Toxicity and Disease

Selective Protein Covalent Binding and Target Organ Toxicity

Water Chlorination: Essential Process or Cancer Hazard?

Mechanisms of Inflammatory Liver Injury

Adhesion Molecules and Cytotoxicity of Neutrophils


Oxidative Stress and Glutathione Redox Status in Mechanisms of Developmental Embryotoxicity

Mitochondrial Mediated Cell Injury

Sphingolipids: The Enigmatic Lipid Class


Cell Signaling and Cell Injury

Neuroreceptor Subtypes Involved in Cognition

Toxicity of Non-Coplanar PCBs

Genetic Polymorphisms in Human Drug Metabolic Enzymes

Nephrotoxicity: Basic Mechanisms and Recent Advances

Techniques for Determining Genetic Polymorphisms


Role of Nitric Oxide in Chemical-Induced Toxicity

The Role of Glutathione in Neuroprotection and Neurotoxicity

Mitochondrial Membrane Permeability Changes in Necrotic and Apoptotic Cell Death

Cellular and Molecular Pathways in Apoptosis and Necrosis


The Role of Quinones in Toxicology

Molecular and Cellular Mechanisms of Antioxidant Action

The Role of DNA Repair in Maintenance of Genome Stability

Chemical Modifiers of Response to Food-Borne Microbial Pathogens

Exogenous Estrogens As Carcinogens: Metabolic Activation through Oxidative mechanisms

Xenobiotic Effects on Cell Adhesion Molecules and Extracellular Matrix Interactions


  • Carcinogenicity of Cigarette Smoke: Bridging the Gap between Complex Mixtures and Individual Components
  • Endocrine Disruption and Neurotoxicity: Why Toxicologists Should Be Concerned About the Actions of Estrogenic Chemicals in the CNS

Innovations in Toxicological Sciences

  • Regulation of Gene Expression via the Electrophile Response Element


Molecular Approaches to the Studies of Glutathione Metabolism and Function

Advances in the Use of Mechanism-Based Biomarkers in Risk Assessment


  • Fritz Haber and his impact on Toxicology

Inhalation, Occupational Health, Risk Assessment

Innovations in Toxicology Session

  • Role of Co-Repressors and Co-Activators in Regulation of Soluble Receptor Mediated Transcription

Continuing Education Courses

  • Molecular Approaches to a Comprehensive Understanding of Cardiotoxicity
  • Rodent Toxicity and Nongenotoxic Carcinogenesis: Knowledge-Based Human Risk Assessment from Molecular Mechanisms

Sunrise Sessions

  • Introduction to Proteomics
  • A New Approach to Drug Toxicity Screening Using NMR Spectroscopy. Pattern Recognition and Experts Systems


Continuing Education Course

  • Liver Toxicology


  • Proteomics and Functional Genomics in Toxicology
  • Genetic Polymorphisms in DNA Repair and Cancer Risk
  • Pharmacogenomics and Drug Metabolism
  • Mechanisms of Hepatotoxicity
  • Toxic, Catalytic, and Protective Mechanisms of Phenoxy Radical Intermediates
  • Methods for Indentifying Potential Breast Carcinogens
  • Molecular Mechanism of Xenobiotic-Induced Autoimmunity
  • Cellular and Molecular Mechanisms of Ocular Toxicity:  Oxidative Stress, Calcium Overload, and Lipid Derangements
  • Oxidant Stress Mechanisms in Pathological and Toxic Responses


Continuing Education Courses

  • Two-Stepping through Toxicogenomics. A Basic Primer
  • Alterations in Gene Expression As a Mechanism of Toxicant Action
  • Toxicity Profiling of Genes and Proteins by Toxicologists. Advanced Topics in Toxicogenomics

Innovations In Toxicological Sciences

  • Toxicological Application of Metabonomics Technology


  • Imaging the Mitochondrial Permeability Transition Pore in Toxic Injury
  • Regulation of the Ah Receptor Signal Transduction Pathway
  • Thioredoxins/Thioredoxin Reductases: Central Roles in Toxicity and Cancer
  • Molecular Models of Smoking-Induced Immune Suppression
  • Defining the Cellular and Molecular Mechanisms of Toxicant Action in the Testis
  • Molecular Mechanisms of Chemical Teratogenesis


  • Perfluorooctanesulfonate: Risk Characterization of a Persistent and Pervasive Fluorochemical
  • Examples of Rodent Nongenotoxic Mechanisms of Neoplasia
  • Application of Genomics for Mechanism-Based Risk Assessment


Continuing Education Course

  • Unfolding the Secrets in Culturing Brain Cells: Theory, Techniques, and Beyond
  • Genomic and Proteomic Array Formats on the Cutting-Edge


  • Dose-Dependent Transitions in Toxic Mechanisms
  • Vanilloid Receptors: Mediators of Respiratory Injury


  • Understanding Mechanisms of Toxicity of Immunosuppressive Drugs to Improve and Broaden the Scope of Their Use
  • Free Radicals in the Toxicity of Alcohols
  • Stress Activated Signal Transduction Pathways
  • Innovations in Toxicological Sciences: Beyond Genomics: Image Analysis and Computational Biology
  • Innovation in Applied Toxicology: Genomic and Proteomic Analysis of Surrogate Tissues for Assessing Toxic Exposures and Disease States


Continuing Education Course

  • Basic Neurotoxicology


  • Nutraceuticals As Double-Edged Swords: Weighing Benefits and Risks of Dietary Chemicals to Human Health


  • Steroid Inactivation: Alternative Mechanisms of Endocrine Toxicity
  • Gene Expression Influences on Metal Immunomodulation
  • Mechanisms of Cardiovascular Toxicity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Halogenated Aromatic Hydrocarbons
  • New Developments in Oxidative Phospholipid Signaling in Apoptosis and Phagocytic Regulation of Inflammatory Response
  • Arsenic Disruption of Cell Cycle: Mechanisms and Effects on Apoptosis, Differentiation, and Carcinogenesis
  • Use of Molecular Approaches to Examine Mechanisms of Neurotoxicity
  • Molecular Profiling and Computer Modeling in Early Detection and Treatment of Cancer


Continuing Education Course

  • Evaluation of Cardiac Drug Toxicity in Pharmaceutical Discovery and Development


  • Role of Nutrigenomics in Safety Assessment of Functional Foods


  • Nucleosytoplasmic Trafficking in Mechanisms of Toxicity
  • Proteomics and Antibody Microarrays: Applications in Toxicology
  • Molecular Pathways to Toxicant-Induced Osteoporosis
  • Biomarkers of Oxidative Stress: New Prospects and Approaches
  • Role of Cell-Cell and Cell-Matrix Interactions in Regulation of Toxicant-Mediated Cell Death
  • The Ubiquitin-Proteasome System As a Biological Target in Toxic Responses and Disease
  • Developmental Expression of Human Phase I and Phase II Toxicant Metabolizing Enzymes: Impact on Early Life State Susceptibility


Continuing Education Courses

  • Use of Genome Databases for Toxicology
  • Essentials of Metal Toxicology
  • Functional Analysis of Gene and Protein Expression: From Experimental Design to Data Analysis


  • Towards the Virtual Human: Adding More Physiological Detail to Biologically-Based Models
  • Comprehensive Responses of Lipids Classes to Toxicants and Involvement in Diseases


  • Advancing Toxicology by Improving Linkage of Traditional Toxicity and Pathology Endpoints with Toxicogenomics
  • Mode of Action Associated with Induction of Endothelial Cell Tumors—Hemangiosarcoma
  • New Insights into Mechanisms of Cell Death and Survival
  • Role of Mitochondria in Toxic Oxidative Stress
  • Gene-Nutrient-Envieoment-Interactions As Risk Factors for Birth Defects: Fumonisin, Folate, Genetic Variation and Neural Tube Defects
  • Obesity As a Modulator of Chemical Toxicity
  • The Role of MAP Kinases in Metal Toxicity
  • Determinants of Manganese Neurotoxicity: From Worms to Man
  • The Path for Assessing Human Relevance and Advancing New Safety Biomarkers for Drug Induced Vascular Injury
  • Role of Epigenetics in the Fetal Basis of Adult Disease



  • Application of Humanized Mouse Lines to Toxicological and Pharmacological Studies
  • Non-Classical Mechanisms of Receptor-Mediated Transcription
  • Mechanistic Biomarkers and Innovative Methodologies to Detect Acute Kidney Injury
  • Critical Roles of C-Activators and Co-Repressors during Transcriptional Activation by Xenobiotic Receptors
  • Emerging Technologies for Imaging for Toxicology
  • The Vascular System As a Target of Metal Toxicity
  • Biliary Hyperplasia and Cholestasis: Relevance to Human Risk Assessment
  • Epigenetic Regulation in Development, Reproduction and Disease: Implications for Toxicology
  • Cardiovascular Effects of Inhaled Ultra-Fine and Fine Particles in Human Volunteers
  • Aging As a Modulator of Chemical Toxicity
  • Impact on Drug Development and Regulatory Review of the Qualification of Novel Safety Biomarkers by the Predictive Safety Testing Consortium


  • Methods for Investigating Skin Irritation
  • Advances and Challenges in Incorporation of Mode of Action in Human Health Risk Assessment
  • Advances in Causation and Therapy of Parkinson and Parkinson-Like Movement Disorders: Views from Toxicologists and Clinicians
  • Can Species and Strain Differences in Dioxin Sensitivity Be Explained by Differences in the AH Receptor?
  • Target-Based Toxicity of Novel Pharmaceutical Targets



  • Molecular Basis of Susceptibility to Chemical Toxicity and Disease
  • New Developments in Liver Tumor Biology
  • Drug-Induced Mitochondrial Toxicity: Novel Insights-Novel Tools
  • Environmental Influence on Female Puberty and Breast Tumorigenesis
  • Stem Cells: New Tools for Neurotoxicologists
  • Molecular and Genomic Insights into the Nrf-2-Regulated Oxidative Stress Response: Impact on Carcinogenesis
  • New Concepts in the Etiology of Breast Cancer: From Genes to Environment and Back Again
  • Endothelial Dysfunction: More Than Just a ‘No NO’ Phenomenon
  • Neurotoxicant-Induced Alterations in Developmental and Adult Neurogenesis: Structure-Function Studies and Clinical Relevance
  • Arsenic and Cardiovascular Disease
  • Cellular Redox Status and Zinc Signaling


  • Current Perspectives on Ocular and Systemic Safety Risks of Therapeutics


  • The Future of Toxicology
  • Informational Session: Detection of Biological Free Radicals in Time and Space


Continuing Education Course

  • New Frontier in Metal Toxicology: Genetic Susceptibility, Early
    Diagnosis, and Related Biological Indices


  • Transcriptional Changes in Immunotoxicology: Transcription Factors, Signal Transduction, and Epigenetics
  • Incorporating ‘Omics in the Study of Reproduction and Development
  • MicroRNAs in Biology and Toxicology
  • Genomic, Non-Genomic and Epigenetic Mechanisms of Nuclear Hormone Receptor Action
  • Nitrative and Oxidative Stress in Toxicology and Disease
  • Novel Signaling Mechanisms That Regulate Dopaminergic Neuronal Survival or Death: Implications in Parkinson’s Disease
  • The Molecular Mechanism of Alpha, Beta: Unsaturated Carbonyl Toxicity—Getting in Touch with the Soft Side of Chemistry
  • Regulation of Drug Transporters in Different Disease States and Its Toxicological and Clinical Implications
  • Oxidative Stress As a Regulator of Normal Function and Mediator of Toxicant-Induced Damage with Impacts on Reproduction and Development
  • Eat Well, Breathe Well: Nutritional Determinants of Susceptibility to Airborne Pollutants
  • The Future of Environmental Health Science: Featuring NIEHS Funded Early Career Investigators


  • Is Modulation of the Immune System by Perfluoroalkyl Acids a Human Health Concern?
  • Mammalian Retrotranspositional Elements: Epigenetic Regulation, Species Differences, and Potential Roles as Mediators of Cellular Responses to Toxic Stress


  • What Is an Adverse Effect in the Age of Omics?

Historic Highlights

  • Dioxin, Forty Years of Science: Are We Any Closer to Assessing
    Potential Risk

Education-Career Development Sessions

  • The Future of Environmental Health Science: Featuring NIEHS-Funded
    Early Career Investigators


Continuing Education Course

  • Predictive Power of Novel Technologies (Cells to ‘Omics): Promises, Pitfalls, and Potential Applications


  • Mechanistic Role of Reactive Intermediate Protein Covalent Binding in Target Organ Toxicity: Past, Present, and Future
  • Silica and Asbestos Immunotoxicity: Mechanisms of Fibrosis, Autoimmunity, and Modified Tumor Resistance
  • Metabolic Syndrome and Increased Sensitivity to Drug-Induced Liver Injury (DILI): Nonclinical Models and Clinical Implications
  • Bile Salt Transport and Liver Injury
  • MAP Kinase Signaling: A Common Target Eliciting Unique Tissue Responses
  • Molecular Determinants of Mitochondrial Disease
  • It’s Not Your Father’s Aryl Hydrocarbon Receptor: New Biological Roles for a Misunderstood Receptor
  • Mechanism of Chemical-Induced Liver Cancer: Putting the Pieces Together
  • Recent Knowledge of Clinical Regulators of Lipid Homeostasis in Metabolic Disease
  • Zinc, Copper, and Their Metabolic Effect: Myths and Musts
  • Mitochondrial Toxicity in Disease and Death
  • The Fetal Basis of Adult Disease
  • Aging As a Determinant of Xenobiotic Toxicity
  • TRPing the Sensor: The Role of TRP Channel Signaling in Cardiopulmonary Toxicity


  • Toxicology in the 21st Century: Stem Cells in Drug Discovery and Development
  • Humanized Models in Toxicology and Their Application to Hazard Characterization and Risk Assessment


  • Weighing Complex Data in Risk Decisions: Concepts of Evidence-Based Toxicology Regional Interest Session
  • Signaling Mechanisms for Metabolic Dysfunction Following Low Level Arsenic Exposures: From Mouse to Man

Student and Postdoctoral Fellow Event

  • MAP Kinase Signaling: A Common Target Eliciting Unique Tissue Responses


Continuing Eduction Course

  • Epigenetics in Toxicology: Introduction, Mechanistic Understanding, and Applications in Safety Assessment


  • Environmental Oxidative Pollutant-Induced Pulmonary Toxicity
  • Ribotoxic Stress: Mechanisms and Models for Human Disease
  • Epigenetics, Metals, and Cancer
  • Vascular Developmental Toxicity: Identification, Prioritization, and Application
  • Metabolic Basis of Respiratory Tract Chemical Toxicity
  • Uncovering the Role of Non-Coding RNAs in Toxicology
  • Livers on a Plate: Next Generation Hepatocyte Models for High-Throughput Screening and Mode of Action Prediction
  • Macrophages: Regulators of Toxicity and Disease Pathogenesis
  • New Insights into the Nrf2-Keap1 Pathway and its Impact on Human Disease
  • Gene-Environment Disease Interactions in Fish Models of Human Disease
  • Autophagy in Toxicology: Essential Process, Adaptive Process, and Disease Process
  • Progress of the Tox21 Consortium in High-Throughput Bioactivity Profiling of Chemicals
  • Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases




  • Breast Cancer As a Multifactorial Disease: Interaction of Genetics, Life Stage, and the Environment
  • Cross-Species Analysis of Toxicogenomics Data: Approaches for Assessing Differences in Sensitivity and Conservation of Mode of Action
  • Emerging Evidence for Novel Noncholinergic Mechanisms of Organophosphate-Induced Neurotoxicity
  • Emerging Mechanistic Targets in Lung Injury Induced by Combustion-Generated Particles
  • Epigenetic and miRNA Regulations in Carcinogenesis: Toxicological Implications
  • Molecular Basis for Prevention of Cardiotoxicity
  • New Visions in Toxicology: Lysosomes—Roles in Disease, Toxicity, and Drug Development
  • Realizing the Vision of 21st Century Toxicity Testing: Genetic Approaches to Pathway Analysis
  • The Thick and Thin of Nuclear Receptors and Nrf2 in Diabetes and Obesity
  • Toxic Cell-Death: Signaling Pathways, Cross-Talk, and High-Throughput Analysis
  • Toxicological Considerations of Epigenetic Targets in Product Development
  • Trivalent Arsenic Metabolites and Arsenic Toxicity


  • Caught in the Act: Free Radical Detection and Implications in Pathways to Toxicity
  • How Useful Are Liver In Vitro Models for Toxicity and Mode-of-Action Prediction?
  • Novel Topics in Environmental Polycyclic Aromatic Hydrocarbon Metabolism Leading to Carcinogenesis



  • Mechanistic Role(s) of Cytochrome(s) P450 in Oxidative Stress and Inflammation: New Opportunities for Drug Discovery   
  • Bone As a Target Tissue for Environmental Toxicants
  • Modeling Human Genetic Variability and Susceptibility in the Laboratory
  • The Dynamics of Neuroinflammation and Inflammatory Cell Responses in Neurologic Disease
  • Toxicoepigenomics, Disease Susceptibility, and Implications for Risk Assessment
  • Understanding Toxicities of Abnormal Lipid Metabolism: Alcoholic, Nonalcoholic, and Toxicant-Induced Fatty Liver Disease


  • Are We Like Rodents, Rabbits, or Something Else? Mechanisms of Developmental and Reproductive Toxicity across Species



  • Adverse Outcome Pathways As an Integrative Framework for Predictive Toxicology: Combining Top-Down and Bottom-Up Thinking 
  • Does This Chemical Make My Liver Look Fat? (Environmental Exposures and Steatosis)
  • Exploring the Interface between Air Pollution and Metabolic Syndrome: The Bittersweet Dilemma
  • Mechanisms of Metal-Induced Disruption of DNA Repair
  • Methylmercury's Modes of Action: New Approches to Understanding an Old Problem
  • Molecular Mechanisms Involved in Neuro/Glial Toxicity: From Oxidative Stress to Redox Signal Transduction
  • The Emerging Role of Mitochondrial Turnover, Biogenesis, and Dynamics in Tissue Injury
  • Use of Stem Cells in Toxicity Testing—From Basic Research to Personalized Toxicology


  • Adverse Outcome Pathways: A Conceptual Framework for 21st Century Risk Assessment
  • Databases Facilitating Systems Biology Approaches to Toxicology
  • Developmental Programming of Hepatic Metabolism: Assessing the Impact of Perinatal Exposure to Xenobiotics
  • Is Manganese-Induced Parkinsonism Mediated via Dopamine Neuron Degeneration or Dysfunction?
  • New Concerns and New Science Addressing Environmental Asbestos Exposures
  • Understanding Weight of Evidence: Exploring Different Approaches to Integrating Evidence from Diverse Data Streams