Recipients

Congratulations:

2009 PARC Recipient

Erik J. Tokar, NIEHS: "Evidence for dysregulation of self-renewal genes and loss of imprinting during arsenic-induced formation of human cancer stem cells."

2009 PARC Runners Up

Josh Harrill, U.S. EPA: "Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived neurons using automated high-content image analysis."

Melissa Barhoover, The Hamner Institutes: "The AHR regulates cell cycle progression in human breast cancer cells via a functional interaction with CDK4."

2009 Student Poster Awardees

The North Carolina Regional Chapter of the SOT sponsors Student Poster Awards for undergraduate or graduate students enrolled in training programs in the area served by the NC Regional Chapter. These awards are based on judging of the student’s poster at the Annual Spring Meeting by the NC regional chapter past presidents. Winners of the award receive a monetary prize and their award-winning posters display a ribbon at the spring NCSOT meeting.

First place: Katie Paul

Triclosan disrupts thyroxine: Mechanisms and life-stage susceptibility
K.B. Paul¹, J.M. Hedge², M.J. DeVito², K.M. Crofton²

1. Curriculum in Toxicology, UNC, Chapel Hill, NC
2. NHEERL, U.S. EPA, RTP, NC
   

First place: Miyuki Breen

The role of cholesterol utilization in a computational adrenal steroidogenesis model to improve predictability of biochemical response to endocrine active chemicals
M. Breen^1,2, M.S. Breen³, N. Terasaki⁴, M. Yamazaki⁴, A.L. Lloyd², R.B. Conolly¹

1. NCCT, U.S. EPA, RTP, NC
2. Department of Statistics, NCSU, Raleigh, NC
3. NERL, U.S. EPA, RTP, NC
4. Mitsubishi Tanable Pharma Corporation, Kisarazu, Chiba, Japan

Second place: David Szabo

Toxicokinetics of the stereoisomer specific flame retardant hexabromocylododecane (HBCD) gamma: Effects of dose, time, and repeated exposure
D.T. Szabo¹, J.J. Dilliberto², J. Huwe³,L.S. Birnbaum⁴

1. Curriculum in Toxicology, UNC, Chapel Hill, NC
2. NHEERL, U.S. EPA, RTP, NC
3. ARS/USDA, Fargo, NC
4. NCEA, U.S. EPA, RTP, NC

Second place: Nick Manzo

Differential oxidative properties of diesel exhaust particles
M. Manzo ¹, J. Richards², R. Slade², L. Martin¹, J. Dye²

1. Molecular Biomedical Sciences, NCSU, Raleigh, NC
2. NHEERL, U.S. EPA, RTP, NC

Congratulations to all!

Past Recipients

2008

Student Poster Awardees

First place: Alison Hege from the University of North Carolina; second place: Miyuki Breen from the U.S. EPA; and third place: Pamela Ross from the University of North Carolina. Poster abstracts are presented in the August 2008 newsletter:

Phenotypic anchoring of gene expression data from acetaminophen hepatotoxicity studies in the mouse model of the human population reveals biomarkers of response.
A. Hege¹, P. Ross², D. Threadgill^1,3, I. Rusyn^1,2

1. Curriculum in Toxicology
2. Department of Environmental Sciences and Engineering
3. Department of Genetics, UNC, Chapel Hill, NC

1. NCCT, US EPA, RTP, NC
2. Biomathematics Program, Department of Statistics, NCSU, Raleigh, NC
3. NERL, US EPA, RTP, NC
4. Molecular Toxicology Group, Safety Research Laboratory, Mitsubishi Tanable Pharma Corporation, Kisarazu, Chiba, Japan

1. UNC, Chapel Hill, NC
2. Hamner Institutes for Health Sciences, RTP, NC
3. ExxonMobil Biomedical Sciences, Annandale, NJ
   

2008 PARC Recipients

Erik J. Tokar, NIEHS: "CStem cell selection facilitates arsenic-induced malignant transformation via innate resistance, hyper-adaptability and over-production."

2008 PARC Recipients

Scott S. Auerbach, NIEHS: "Prediction of hepatocarcinogenic potential in male rats using machine learning methods informed by genome-wide expression analysis."

Brante P. Sampey, UNC: "Genistein elicits concentration dependent effects in estrogen-stimulated endometrial models: The involvement of the IGF-signaling axis."

2007

Student Poster Awardees

First place was won by Kari Loomis from NC State University; second place went to Alison Hege from the University of North Carolina; and third place to Kymberly Gowdy, also from NC State University. Poster abstracts are presented in the August 2007 newsletter:

Genetic Ablation of C/EBP in Epidermis Reveals its Role in Suppression of Epithelial Tumorigenesis.
Loomis, Kari D.^1,2, Zhu, S.¹, Yoon, K.¹, Johnson, P.F.³, and Smart, R.C.¹

1. Cell Signaling and Cancer Group, Department of Environmental & Molecular Toxicology
2. Functional Genomics Program, North Carolina State University, Raleigh, NC
3. Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD

Cross-Species Association Mapping Identifies Genetic Risk Factors for Liver Toxicity
Hege, Alison I.^1,2, Russo, M.W.³, Su, S.⁴, Ross, P.K.², Stylianou, I.M.⁵, Boorman, G.A.⁶, Tennant, R.⁶, Bogue, M.A.⁵, Paigen, K.⁵, Wiltshire. T.⁴, Watkins, P.B.³, Rusyn, I.^1,2, and Threadgill, D.W.^1,7

1. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC
2. Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC
3. Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC
4. Department of Mouse Genetics, Genomics Institute of the Novartis Research Foundation, San Diego, CA
5. The Jackson Laboratory, Bar Harbor, ME
6. National Institute of Environmental Health Sciences, Research Triangle Park, NC
7. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC

Comparison of On and Off Road Diesel Exhaust Sources on Susceptibility to Influenza Infection in Mice.
Gowdy, Kymberly¹, Ciencewicki, J.², Jaspers, I.², Krantz, Q.T.³, Boykin, E.³, Linak, W.P.⁴, Gilmour, M.I.³

1. NCSU, Raleigh, NC
2. UNC, Chapel Hill
3. ETD, NHEERL
4. NRMRL, RTP, NC

2007 PARC Recipient

Adam Kuhl, The Hamner Institute: "C/ebp B, but not SF-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis"

2007 PARC Runners Up

Jean-Francois Coppin, NIEHS: "Interplay between cellular methyl metabolism and adaptive efflux during chronic arsenic exposure in human cells"

Eric Tien, NIEHS: "Protein kinase C up-regulates hepatic drug metabolism through stabilization of the pregnane-X-receptor"

Erik Tokar, NIEHS: "Potential generation of cancer stem cells during arsenic-induced malignant transformation of human urogenital progenitor cells"

2007 PARC Honorable Mentions

Pei-Jen Chen, US EPA: "Alterations in All trans- retinoic acid metabolism in liver microsomes from mice treated with hepatotumorigenic and non-hepatotumorigenic conazoles"

Chikara Kojima, NIEHS: "Oxidative DNA damage induced by inorganic arsenite depends on cellular ability to methylate arsenic"

Chester Rodriguez, US EPA: "Predicting age-dependent pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically-based pharmacokinetic modeling"

2006

Dr. Michelle Block, National Institute of Environmental Health Sciences (NIEHS), recipient of the 2006 North Carolina SOT Presidents Award for Research Competition (PARC) based on her work titled "Extracellular µ Calpain Mediates Microglial Activation and Progressive Dopaminergic Neurotoxicity in Response to Neuronal Injury: Mechanism of Reactive Microgliosis". This is Dr. Block's second PARC award in as many years.

PARC Award Honorable Mention recipients Dr. Anika M. Hartz, NIEHS (Diesel Exhaust Particles Alter Blood-Brain Barrier Properties) and Dr. Erik Tokar, NCI at NIEHS (Arsenic-induced Carcinogenic Transformation of Human Urogenital Progenitor Cells).

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