The
Dose Response –
The
Cornerstone of Toxicology and
Challenges
for Risk Assessment
National
Capital Area Chapter - Society of Toxicology
Spring
Symposium
May 16, 2002
NCAC-SOT
Spring Symposium
The goal of this symposium is
to generate discussion about one of the central tenants in toxicology – the
dose response relationship. As was
stated so long ago by Paracelsus – it is the dose that makes the poison. Or is it?
As our approaches to measuring various toxicological responses become
more sensitive, questions can be raised as to whether a change from a control
response is truly an adverse change. As
our understanding progresses regarding the body’s physiological mechanisms for
response to toxic insult, what appears to be a toxic effect may actually be a
compensatory mechanism with no adverse outcome. In contrast to the traditional perspective of
a linear dose-response relationship, evidence exists for varying responses at
low versus high doses. All these
complexities need to be considered and factored into interpretation of the data
for risk assessment purposes. This
series of presentations will take us from traditional study designs and
treatment of data into the current world of mechanistic risk assessment where
the lines become blurred between cancer and non-cancer assessments,
quantitative vs qualitative approaches, threshold vs. nonthreshold events,
including such phenomena as discontinuous dose response and U-shaped dose
response curves.
Featured
at the end of this symposium will be a poster session and reception
7:45 a.m. Registration,
Continental Breakfast, and Posters Set-Up
8:30 a.m. Welcome
and Opening Comments
Bernard A. Schwetz
President,
NCAC-SOT
8:45 a.m. The Central Role of Dose
Response in a Risk Assessment
Carole Kimmel, US
Environmental Protection Agency
9:25 a.m. Cancer vs Non-cancer Risk Assessment
Bette Meek,
Health
10:05 a.m. U-shaped
Dose Response Curves – What, Why and How?
Edward Calabrese,
10:35-10:55 a.m. Discussion
10:55-11:20 a.m. Break
11:20 a.m. Discontinuous
Dose Response Curves
William
Slikker,
11:50 a.m. Future
Approaches to Dose Response Assessment
Jeanette
Wiltse, US Environmental Protection Agency (retired)
12:30-2:15
p.m. Lunch
and Poster Session
(posters
manned from 1-2 p.m.)
2:15 p.m. Welcome
and Remarks
Marion Ehrich
Vice
President, SOT
2:30 p.m. Poster Awards
2:30-3:30 p.m. Poster Discussion
(3-5
minutes on selected posters)