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Update on MSS Happenings from Our Current President, Jane Ellen Simmons
Greetings from your Current-and-Soon-to-be-Past President. Having just returned from this year’s meeting in Salt Lake City, I am sure that you came back as excited and eager as I am to jump into another exciting mixtures venture. The first day was ‘All About Mixtures’! The morning started off in grand style with an excellent mixtures posters session where many groups presented their latest mixtures findings to an overflow crowd. While many posters (including multiple MSS Top Ten Abstract Award winners) were presented in other sessions, having one poster session devoted to the topic of chemical mixtures provides a focal point for members to gather and share their views and thoughts. This meeting also saw very well received programs sponsored and/or endorsed by the Mixtures Specialty Section (MSS). Monday afternoon highlights were a Workshop ‘Determination of the Contribution of Individual Stressors in Cumulative Risk Assessments’ sponsored by MSS and a Symposium ‘Phthalate Reproductive and Developmental Toxicity: Implications for Cumulative Risk Assessment’ which sent most of us running back and forth between these two important sessions. Both of these sessions were very well attended and the presenters were a nice mixture of MSS members and nonmembers. Of course, a major focal point is our annual MSS reception, held on Tuesday night, which was very well attended this year; the meeting was designed to provide a low-key opportunity for net-working and I’ve heard from members that they enjoyed this format.
The MSS is of interest to those members of the Society of Toxicology for whom research on chemical mixtures is either the primary focus of their job responsibilities or for whom understanding interactions and mixtures is one aspect of their research program or job responsibility. The MSS provides a forum for those interested in the theory, experimental assessment and risk assessment of mixtures and interactions. This goes from exposure assessment to design, conduct and interpretation of experiments to risk assessment and risk management. A growing area in which MSS will be playing a role is that of cumulative risk, where cumulative refers to consideration of more than chemical stressors, to include other factors and stressors that affect that particular community or population including life style factors and non-chemical stressors.
The past year has seen significant growth in our membership and an emphasis on membership recruitment will be a focus during the coming year. The MSS is blessed to have active members which resulted in a very strong slate of candidates for this year’s election. This is an indication of the strength of the MSS, which while among the smaller is definitely among the more active. This year, we are planning to have more teleconferences/webinars over the course of the year and sponsor state-of-the-art workshops, symposia and continuing education courses for the upcoming SOT 50th Anniversary (in Washington, D.C., March 6–10, 2011). With regard to submission of proposals for symposia, workshops and continuing education courses at next year’s meeting, please refer to link for that information in this edition of the newsletter.
Do You Have SOT 2011 Proposal Submission Ideas for Sessions that Involve Mixtures?
The deadline for program proposal submissions for SOT 2011 Annual Meeting is fast approaching (April 30)! At the SOT 2010 Annual Meeting, MSS officers identified some ideas for mixtures-related programs slated for submission to the SOT 2011 Annual Meeting. If you would like to be involved or contribute suggestions to these programs, please contact the associated officers (see officer contact list):
Workshop Session Proposal: Approaches for Incorporating Non-chemical Stressors into Cumulative Risk Assessments (Chair—Cynthia Rider; Co-Chair being sought). Brief description—Development of a systematic approach for assessing the joint action of chemical and non-chemical stressors is needed in order to prioritize non-chemical stressors for inclusion in cumulative risk assessments, determine the type of data needed to incorporate non-chemical stressors, and develop methods for assessing their contribution to overall risk. The overarching goal of this workshop is to provide a rational starting place for moving forward. The panel of experts will put the issue in context, describe data needs, and propose methods for incorporating nonchemical stressors into cumulative risk assessments. Participants represent perspectives from the U.S. EPA (the primary regulatory agency concerned with cumulative risk assessments), industry, non-profit and academia.
Symposium Session Proposal: Mixtures and Nanomaterials (co-sponsored by the Nanotoxicology Specialty Section; Chair—Bruce Fowler). This session would consider nanomaterials that are binary compounds (e.g. CdSe or CdTe) and mixtures of nanomaterials with other compounds.
Symposium Session Proposal: Cumulative Risk and Pesticides (Chair—Jan Chambers)—In development.
Roundtable Session Proposal: Regulation of Mixtures Past and Future (Chair—Paul Price, Co-Chair being sought). Mixtures/cumulative exposures are a significant concern in the evaluation of public health. Programs have been addressing this issue for more than 20 years (Superfund) and 15 years (Pesticides). Questions for the first two speakers (representatives from a U.S. Regulatory Agency and Industry): What are the lessons learned? How was the regulation enforced? How important were the findings of cumulative risk? New programs are being considered. Mixtures is a key issue for TSCA. New initiatives for EU on mixtures. Questions for the second two speakers (representatives from EU mixtures program and U.S. Government): What are the drivers for the new regulations? How will this be implemented? What are the scientific issues that need to be addressed in order to regulate cumulative exposures and mixtures?
We would love to hear your ideas on what kind of mixtures-related programs you would like to see at the SOT 2011 Annual Meeting. If you have a mixtures-related proposal idea for a continuing education course, workshop, platform or symposium session and would like MSS to sponsor it, please send your proposal to (Jane Ellen Simmons) no later than April, 26, 2010. We look forward to hearing from you!
Congratulations to Our MSS Award Recipients from the Annual Meeting of SOT at Salt Lake City, Utah
Dr. Jane Ellen Simmons1, Ms. Linda K. Teuschler1, Dr. Glenn E. Rice1, Dr. Cheryl Dingus2, Dr. Elizabeth D. Wagner3, and Dr. Michael Plewa3 received the Best Presentation in Mixtures for their work entitled “Nine and Ten Chemical Haloacetic Acid Mixtures Exhibit Concentration-Dependent Departure from Dose Additivity.” 1U.S. Environmental Protection Agency; 2Batelle; 3University of Illinois.
Dr. Sarah Campion of Brown University received the MSS Award for Best Presentation in Mixtures by a Postdoctoral Scientist for her work on “Gene Alterations Underlying 2,5-Hexanedione-Mediated Suppression of Radiation-Induced Germ Cell Apoptosis.”
Mr. David T. Sabo of University of North Carolina, Chapel Hill received the MSS Award for Best Presentation in Mixtures by a Graduate Student for his work on “Toxicokinetic Differences between two HBCD Stereoisomers: Effect of Dose, Time, Repeated Exposure and Route.”
The Top 10 Mixtures Abstracts were:
Modeling the Interaction of Binary and Ternary Mixtures of Estradiol and Bisphenol A or its Analogues in an in vitro Estrogen Mediated Transcriptional Activation Assay (T47D-KBluc)—D.S. Bermudez1, L.E. Gray1, and V.S. Wilson1. 1U.S. Environmental Protection Agency.
Genotoxicity of Organic Extracts from the Air Particles Measured in an Acellular System with a native DNA—J. Topinka1,2, J. Hovarka2, A. Milcova1, J. Schmuczerova1, J. Krouzek2, R.J. Sram1. 1Genetic Ecotoxicology, Institute of Experimental Medicine ASCR, v.v.i., Prague, Czech Republic; 2Institute of Environmental Studies, Prague, Czech Republic.
Unveiling Associations between Lactational Exposure to Polychlorinated Biphenyls (PCBs) and Infant Neurodevelopment: Use of PBPK Modeling vs Traditional Exposure Metrics—M. Verner1, P. Plusquellec2, G. Muckle2, P. Ayotte2, E. Dewailly2, S.W. Jacobson3, J.L. Jacobson3, M. Charbonneau4, S. Haddad1. 1Université du Québec á Montréal, QC, Canada; 2Université Laval, Québec, QC, Canada; 3Wayne State University School of Medicine, Detroit, MI, U.S.; 4INRS-Institut Armand-Frappier, Laval, QC, Canada.
Development and Demonstration of a Computational Framework for Forward and Reverse Dosimetry of Organophosphorous Insecticide Mixtures—J.H. Ivy1,2, J.M. Wright1, A.N. Mayeno1,3, M.A. Lyons1,2, B. Reisfeld1,2,3. 1Quantitative & Computational Toxicology Research Group, Colorado State University; 2Department of Chemical and Biological Engineering, Colorado State University; 3Department of Environmental and Radiological Health Sciences, Colorado State University.
The Impact of Repeated Nicotine and Alcohol Co-Exposure on the in vivo Chlorpyrifos Pharmacokinetics and Pharmacodynamics—S. Lee, T.S. Poet, J.N. Smith, A.L. Busby-Hjerpe, C. Timchalk
Effects of Haloacetic Acid Mixtures in a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay—H. Nichols1, S. Jeffay1, M. Barrier1, M.G. Narotsky1, J.E. Simmons1, S. Hunter1. 1U.S. Environmental Protection Agency.
Effects of Styrene Co-Exposure on Formation of 1,3-butadiene Derived N7-Guanine Adducts—M.T. Thompson1, S. Goel1, L.M. Hallberg2, J.B. Ward2, J.A. Swenberg3, G. Boysen1. 1Envioronmental and Occupational Health, University of Arkansas; 2Preventive Medicine and Community Health, University of Texas Medical Branch; 3Environmental Sciences & Engineering, University of North Carolina, Chapel Hill.
Comparative Pharmacokinetics of Chlorpyrifos versus its Major Metabolite Following Oral Administration in the Rat—C. Timchalk1, J.A. Campbell1, A.L. Busby1, J.N. Smith1, S. Lee1, T.S. Poet1, D.B. Barr2. 1Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA; 2Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA.
Mixture Effects of Three Flavonoid Phytochemicals on Adrenal and Sex Hormone Secretion in the Human Adrenocortical Cell Line H295R—A. Okarsson1, Å. Ohlsson1, N. Cedergreen2, E. Ullerås1. 1Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences; 2Agricultural Sciences, University of Copenhagen, Copenhagen, Denmark.
Increasing the Mixtures Researcher Network to Promote Communication and Advance the Science
The SOT Mixtures Specialty Section came into being in 2006. Since that time, we have been very active: sponsoring meeting programs, conducting continuing education courses, providing awards for mixtures-related research, and arranging webinars on mixtures research. We could be even more effective with greater membership! We are asking that our members reach out to other scientists that are conducting mixtures research or cumulative risk assessments and ask them to join. We currently have approximately 70 members. Help us reach the 100 member mark by the 2011 SOT 50th Anniversary Annual Meeting. Membership is only $15 and provides many benefits.
Benefits to membership:
- Find out the latest on mixtures-related SOT events, MSS-sponsored webinars, and more through our MSS e-mails!
- Network with other mixtures researchers
- Help determine the future direction of mixtures programs at SOT
- Vote on MSS officers
- Run for MSS office
Upcoming Mixtures-Related Events
Meeting with Mixture Presentation and Workshops:
2010 Toxicology and Risk Assessment Conference—Computational Toxicology: Applications to Risk Assessment, April 26–29, Cincinnati, OH
Register or view the full agenda at: http://www.team-psa.com/trac2010/home.asp
Mixture events include a talk by past MSS president Moiz Mumtaz Ph.D., ATSDR on Chemical Mixtures (Wednesday, April 28, 1:00 PM) and two workshops that feature mixtures topics: W-2. Workshop: New Developments in Occupational Risk Assessment (Thursday, April 29, 8:00 AM–12:00 PM) and W-3. Workshop: Cumulative Risk Assessment: Concepts, Methods and Resources (Thursday, April 29, 8:00 AM–12:00 PM)
Hot Off the Press—New Mixtures Book by MSS Past President, Moiz Mumtaz Out Now!
Principles and Practice of Mixtures Toxicology
Moiz Mumtaz (Editor)
ISBN: 978-3-527-31992-3
Hardcover
520 pages
August 2010
Summary from Bigger Books.com: The laboratory study of toxic substances usually involves one substance at a time. In the real world, however, organisms are often exposed to a complex mixture of toxins from air, water, food or medications. Assessing the toxic effects of these mixtures requires special know-how and techniques that can account for interactions between toxins in the human body, or in a natural ecosystem.
This is the first comprehensive treatment of the subject for more than a decade, and includes such recent findings as research on nanoparticle toxicology. Divided into two distinct parts, this practical handbook begins by introducing the basic concepts involved, before moving on to address all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. Since no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for those working in industry or healthcare institutions with little time for academic study.
Endorsed by the Society of Toxicology and the U.S. Agency for Toxic Substances.
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