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Non-SOT Publications & Discounts

The SOT Publications of Interest is a comprehensive listing of all submitted scientific publications.

We invite you to submit a publication listing to the SOT website. Only publications related to the field of toxicology or pertinent to science are permissible. All submissions are reviewed and approved before they display in the Publications of Interest.

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A Story of Health

This eBook is available online and offers FREE continuing education for health professionals.  I have attached a promotional media release ready for inclusion on your website or newsletter (please let me know if you do share and/or publish the announcement).

We tell A Story of Health through the lives of fictional characters and their families - Brett, a young boy with asthma; Amelia, a teenager with developmental disabilities; and a toddler Stephen, recently diagnosed with leukemia. Each fictional case features the latest scientific research about disease origin and helpful facts about disease prevention.

Colorful illustrations, graphics, and videos enhance each page. Pop-ups with essential “key-concepts” link to a wide range of additional resources and hundreds of scientific papers to enhance each story with information you can use today to promote health and prevent disease. A Story of Health includes multiple levels of detail, which are useful to professionals from different health-related backgrounds (e.g., physicians, nursing professionals, health educators, etc.).

A Story of Health was developed by ATSDR, the Collaborative on Health and the Environment (CHE), the Office of Environmental Health Hazard Assessment, California EPA (OEHHA), the Science and Environmental Health Network (SEHN), and the University of California, San Francisco, Pediatric Environmental Health Specialty Unit (UCSF PEHSU).

4th Edition of the Handbook on the Toxicology of Metals

By Gunnar F. Nordberg, Bruce A. Fowler, and Monica Nordberg

Handbook on the Toxicology of Metals, 4th Edition bridges the established
knowledgebase and new advances in metal toxicology to provide one essential reference
for all those involved in the field. This book includes comprehensive coverage of basic
toxicological data and emphasizes the toxic effects in humans, but also discusses toxic
effects in animals and biological systems in vitro whenever relevant. The thoroughly
updated 4th edition has been divided into two volumes. Volume I covers “General
Considerations” and Volume II is devoted to “Specific Metals.” A peer-reviewed resource
with contributions from internationally-recognized experts, the 4th Edition of the
Handbook on the Toxicology of Metals is a prominent and indispensable reference for
toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity
of metals.

Encyclopedia of Toxicology, 3rd edition

A broad ranging and extensive 4 volume A-Z compendium covering all aspects of toxicology including key scientific concepts, selected chemicals, organizations, laws, and more.

Integrated Environmental Assessment and Management

By Richard J. Wenning, Editor-in-Chief

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels: Part B

By Committee on Acute Exposure Guideline Levels; Committee on Toxicology; Board on Environmental Studies and Toxicology; Division of Earth and Life Studies; National Research Council

In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001; it provided updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects.

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels: Part A

By Committee on Acute Exposure Guideline Levels; Committee on Toxicology; Board on Environmental Studies and Toxicology; Division of Earth and Life Studies; National Research Council

Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fire, or accidents involving railroad cars or trucks transporting EHSs, or they can be released intentionally through terrorist activities. These substances can also be released by improper storage or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental or intentional releases.

Research Universities and the Future of America: Ten Breakthrough Actions Vital to Our Nation's Prosperity and Security

By Committee on Research Universities; Board on Higher Education and Workforce; Policy and Global Affairs; National Research Council

Research Universities and the Future of America presents critically important strategies for ensuring that our nation's research universities contribute strongly to America's prosperity, security, and national goals. Widely considered the best in the world, our nation's research universities today confront significant financial pressures, important advances in technology, a changing demographic landscape, and increased international competition. This report provides a course of action for ensuring our universities continue to produce the knowledge, ideas, and talent the United States needs to be a global leader in the 21st century.

Role of Science and Judgment in Setting National Ambient Air Quality Standards: How Low is Low Enough?

By McClellan, R. O.

The Clean Air Act (CAA) requires listing as criteria air pollutants those pollutants that arise from multiple sources and are found across the United States. The original list included carbon monoxide, nitrogen oxides, sulfur oxides, particulate matter, photochemical oxidants (later regulated as ozone), and hydrocarbons. Later, the listing of hydrocarbons was revoked and lead was listed. The CAA requires the US EPA Administrator to set National Ambient Air Quality Standards (NAAQS) for these pollutants using the “latest scientific knowledge” at levels that, in the judgment of the Administrator, are “requisite to protect public health” while “allowing an adequate margin of safety” without considering the cost of implementing the NAAQS. The NAAQS are set using scientific knowledge to inform the Administrator’s policy judgments on each NAAQS. Recently, there has been increasing tension and debate over the role of scientific knowledge versus policy judgment in the setting of NAAQS. This paper reviews key elements of this debate drawing on the opinion of Supreme Court Justice Stephen Breyer, in Whitman v. American Trucking Associations, to resolve the conundrum posed by the CAA language. I conclude that scientists should carefully distinguish between their interpretations of scientific knowledge on specific pollutants and their personal preferences as to a given policy outcome (i.e., specific level and form of the NAAQS), recognizing that these are policy judgments as to acceptable levels of risk if the science does not identify a threshold level below which there are no identifiable health risks. These policy judgments are exclusively delegated by the CAA to the US EPA Administrator who needs to articulate the basis for their policy judgments on the level and form of the NAAQS and associated level of acceptable risk.

Product Stewardship and Science: Safe Manufacture and Use of Fiber Glass

By Hesterberg, T. W., R. Anderson, D. M. Bernstein, W. B. Bunn, G. A. Chase, G. M. Marsh, A.L. Jankousky, and R. O. McClellan

This paper describes a proactive product stewardship program for glass fibers. That effort included epidemiological studies of workers, establishment of stringent workplace exposure limits, liaison with customers on safe use of products and, most importantly, a research program to evaluate the safety of existing glass fiber products and guide development of new even safer products. Chronic inhalation exposure bioassays were conducted with rodents and hamsters. Amosite and crocidolite asbestos produced respiratory tract cancers as did exposure to “biopersistent” synthetic vitreous fibers. “less biopersistent” glass fibers did not cause respiratory tract cancers. Corollary studies demonstrated the role of slow fiber dissolution rates and biopersistence in cancer induction. These results guided development of safer glass fiber products and have been used in Europe to regulate fibers and by IARC and NTP in classifying fibers. IARC concluded special purpose fibers and refractory ceramic fibers are “possibly carcinogenic to humans” and insulation glass wool, continuous glass filament, rock wool and slag wool are “not classifiable as to their carcinogenicity to human.” The NTP’s 12th report on carcinogens lists “Certain Glass Wool Fibers (Inhalable)” as “reasonably anticipated to be a human carcinogen.” “Certain” in the descriptor refers to “biopersistent” glass fibers and excludes “less biopersistent” glass fibers.

Evaluation of Carcinogenic Hazard of Diesel Engine Exhaust Needs to Consider Revolutionary Changes in Diesel Technology

By McClellan, R.O., T.W. Hesterberg, and J.C. Wall

Diesel engines, a special type of internal combustion engine, use heat of compression, rather than electric spark, to ignite hydrocarbon fuels injected into the combustion chamber. Diesel engines have high thermal efficiency and thus, high fuel efficiency. They are widely used in commerce prompting continuous improvement in diesel engines and fuels. Concern for health effects from exposure to diesel exhaust arose in the mid-1900s and stimulated development of emissions regulations and research to improve the technology and characterize potential health hazards. This included epidemiological, controlled human exposure, laboratory animal and mechanistic studies to evaluate potential hazards of whole diesel exhaust. The International Agency for Research on Cancer (1989) classified whole diesel exhaust as–“probably carcinogenic to humans.” This classification stimulated even more stringent regulations for particulate matter that required further technological developments. These included improved engine control, improved fuel injection system, enhanced exhaust cooling, use of ultra low sulfur fuel, wall-flow high-efficiency exhaust particulate filters, exhaust catalysts, and crankcase ventilation filtration. The composition of New Technology Diesel Exhaust (NTDE) is qualitatively different and the concentrations of particulate constituents are more than 90% lower than for Traditional Diesel Exhaust (TDE). We recommend that future reviews of carcinogenic hazards of diesel exhaust evaluate NTDE separately from TDE.