Scientific Sessions

Scientific Program Overview (dates and times)

To view Scientific Sessions as they are aligned to the 2016 Themes, click here.

Thematic Icon Key:

♜	Advances in Neurotoxicology
♞	Developmental Toxicity: Mechanisms and Evaluation
♥	Heath and Environmental Impacts of Man-Made and Naturally Released Toxicants
♦	Molecular Toxicology: Mechanistic Insights and Hazard Assessment
♠	Recent Advances in Safety Assessment
♣	Toxicity of Metals

Monday, March 14

8:00 AM–9:20 AM

Daily Plenary Session—Regenerative Medicine and Tissue Engineering

• Building a Heart: From Cells to Tissues to Organs
  Lecturer: Doris Taylor, Texas Heart Institute, Houston, TX.
• From 3D Microchip to Human Organ Culture Models: Trachea, Bronchi/Bronchiole and Lung Biomimetic Models for Disease Modeling, Drug Discovery and Toxicology Evaluation
  Lecturer: Joan Nichols, Galveston National Laboratory, Galveston, TX.

9:30 AM–12:15 PM

Symposium Session

• Opening the Black Box: Understanding the Molecular Mechanisms of Developmental Toxicity ♞ ♦

Workshop Sessions

• Dietary Exposures to Heterocyclic Amines As a Potential Risk Factor for Neurological Disease ♜
• Mitochondria As the Central Target of Environmental Contaminants, Pharmaceutical Agents, and Toxicants: Mechanisms of Toxicity and Disease
• Nanotoxicology and Ocular Drug Delivery: One Size Does Not Fit All
• Scientific Reproducibility: Does This Pose a Problem for 21st Century Toxicology? ♦ ♠
• The Cancer Risk Assessment for Ingested Hexavalent Chromium: Challenges and Controversies ♣
• Transient Receptor Potential A1 (TRPA1) Cation Channels: Fluttering Hearts, Headaches and Hot Flashes—Can One “Environmental Sensor” Be the Cause of All the Pain? ♜

Regional Interest Session

• The Toxicological Implications of the Gulf Oil Spill: Research Accomplishments and Research Needs ♥

Platform Sessions

• Investigating Mode of Action in Chemical Carcinogenesis
• Ozone Research ♥

9:30 AM–12:45 PM

Poster Sessions

• Arsenic Toxicity ♣
• Bioinformatics and Toxicology ♠
• Biomonitoring
• Cell Death and Apoptosis
• Immunotoxicology
• Neurotoxicology of Therapeutic Agents and Abused Substances ♜
• Neurotoxicology—Developmental Neurotoxicity ♜
• Neurotoxicology—Emerging Technologies for Neurotoxicity Screening ♜
• Neurotoxicology—General ♜
• Neurotoxicology—Halogenated Hydrocarbons ♜
• Respiratory Toxicology
• Systems Biology and Toxicology ♠
• Toxicity of Metal Mixtures ♣

12:30 PM–1:20 PM

Merit Award Lecture

• Forty-Five Years Modeling Dose-Response Relationships: An Unanticipated Career!
  Lecturer: Melvin Andersen, ScitoVation LLC, Research Triangle Park, NC.

12:30 PM–1:50 PM

Roundtable Sessions

• Is a “Thresholdable” Carcinogen Still a Delaney Carcinogen? ♠
• Trichloroethylene Exposure and Development of Fetal Cardiac Malformations: What Do the Data Tell Us About Inhalation Exposures Resulting from Vapor Intrusion and Potential Health Risks to Pregnant Women? ♞

1:15 PM–4:30 PM

Poster Sessions

• Exposure Assessment
• Genetic Toxicology I
• Genetic Toxicology II
• Mercury Toxicity ♣
• Metal Toxicity ♣
• Mixtures ♥
• Nanotoxicology: General
• Natural Products ♥
• Neurotoxicology—Mercury Neurotoxicity ♜ ♣
• Neurotoxicology—Metals: Lead, Cadmium, and Others ♜ ♣
• Ocular Toxicology
• Safety Assessment: Drug Development ♠
• Safety Assessment: Drug Discovery ♠
• Toxicology Education

1:30 PM–2:30 PM

Meet the Directors

• A Conversation with Linda Birnbaum and Pamela McInnes
  Lecturers: Linda Birnbaum, NIEHS, Research Triangle Park, NC; and Pamela McInnes, NCATS, Bethesda, MD.

2:00 PM–4:45 PM

Symposium Sessions

• Health and Environmental Hazard Assessments of Nanomaterials Along Their Lifecycle ♥
• The Promise and Reality of Alternative Methods in Inhalation Toxicology and the Development of Inhaled Therapeutics

Workshop Sessions

• Moving Beyond Prioritization towards True In Vitro-Based Safety Assessment ♠
• Quantitative Cumulative Risk Assessment: Is It Feasible Today? ♠
• The Role of the Epigenome in Exposure Effects, Susceptibility, and Public Health ♦
• Using 21st Century Approaches to Evaluate Endocrine-Active Compounds ♠

Historical Highlights Session

• Toxicologic Legacies of Major 21st Century Man-Made/Natural Disasters ♥

Platform Sessions

• AhR and Disease Processes ♥
• Pluripotent Stem Cells in Cardiovascular Research

4:45 PM–6:00 PM

SOT/EUROTOX Debate

• Preclinical (Safety) Toxicology Testing Predicts the Clinical Outcome
  SOT Debater: Thomas M. Monticello, Amgen, Inc., Thousand Oaks, CA.
  EUROTOX Debater: Ruth Roberts, ApconiX Ltd, United Kingdom.

Tuesday, March 15

8:00 AM–9:20 AM

Daily Plenary Session—Inflammation and Neurodegenerative Disease

• Mast Cells and Glia: Two Tracks on the Road to Neuroinflammation
  Lecturer: Stephen Skaper, University of Padua, Padua, Italy.

• Inflammation and Neurodegeneration in CNS Injury: Evolving Concepts and New Therapeutic Targets
  Lecturer: Alan I. Faden, University of Maryland School of Medicine, Baltimore, MD.

9:30 AM–12:15 PM

Symposium Sessions

• Drug-Induced Taste Change in Clinical Practice and Preclinical Safety Evaluation
• Genotypic and Intrinsic Risk Factors That Increase Susceptibility to Inhaled Pollutants
• Systems Understanding of the Impact of the Nrf2 Pathway on Chemical Toxicity and Cell Fate ♦
• Unknown, Unknowns: Exploring the Unidentified Fraction of Complex Mixtures

Workshop Sessions

• Bioactivity-Based Margin of Exposure Safety Assessment: The Next Stop along the Road to 21st Century Safety Assessments ♠
• Maternal Exposure to Nanoparticles—How Does It Affect the Fetus? Status, Mechanisms, and Future Directions ♞
• Multi-Omics in Predictive Toxicology: Development and Application in Environmental Monitoring Programs ♦
• Scientific and Regulatory Advances in Safety Evaluation of Heavy Metals in Food ♠ ♣

Platform Sessions

• Zebrafish Models: Advances and Applications in DART

9:30 AM–12:45 PM

Poster Sessions

• Alternative Models: Fish, Worms, and More ♦ ♠
• Carcinogenesis I
• Carcinogenesis II
• Chemical and Biological Weapons ♥
• Developmental Basis of Adult Disease ♞
• Endocrine Toxiciology
• Inflammation in Disease
• Inflammation: Methods and Mechanisms
• Liver—Mechanisms ♦
• Liver—Models
• Risk Assessment 1
• Stem Cell Biology and Toxicology
• Toxic Inhalants Research

12:30 PM–1:20 PM

Leading Edge in Basic Science Award Lecture

• New Frontiers at the Nexus of Epigenomics and Toxicology
  Lecturer: Cheryl Lyn Walker, Texas A&M Institute of Biosciences and Technology, Houston, TX.

1:15 PM–4:30 PM

Poster Sessions

• 3D Cell and Organ-on-a-Chip Models ♦ ♠
• Alternative Models for Ocular and Skin Toxicity
• Biological Modeling
• Clinical and Translational Toxicology
• Food Safety/Nutrition 1 ♥
• Gene Regulation and Signal Transduction ♦
• Medical Devices
• Neurotoxicology—Dopaminergic Systems and Toxicants ♜
• Neurotoxicology—Manganese Neurotoxicity ♜ ♣
• Neurotoxicology—Neurodegenerative Diseases ♜
• Neurotoxicology—Pesticide Neurotoxicity ♜
• Non-Pharmaceutical Safety Assessment ♠
• Oxidative Injury and Redox Biology ♦
• Particulate Matter Toxicology
• Receptors

2:00 PM–4:45 PM

Symposium Sessions

• New Mechanistic Insights into How the Immune System Drives Hepatic Adverse Drug Reactions
• Reciprocal Synergism: New Insights into Thyroid Hormone Action in Brain Development and Neurodevelopmental Toxicity ♜ ♞
• The Role of Gene SLC30A10 on Manganese Homeostasis and Functional Outcomes: Implications for Homeostasis and Neurotoxic ♜ ♣
• Using Multi- and Transgenerational Effects of Environmental Exposures in Diverse Animal Models for Assessment of Human Health Risks ♞

Workshop Sessions

• Cannabis in the Courtroom ♜
• Read-Across: Building Scientific Confidence in the Development and Evaluation of Read-Across for Regulatory Purposes Using Tox21 Approaches ♦ ♠
• Safety Assessment of Topically Exposed Cosmetic Ingredients: Lessons Learned ♠

Platform Sessions

• Nanotoxicology: In Vivo
• Qualification of “New” DART Tools for Hazard Identification ♞

Wednesday, March 16

8:00 AM–9:20 AM

Daily Plenary Session—Keynote Medical Research Council (MRC) Lecture

• Regenerating CNS Myelin—From Mechanisms to Medicines
  Lecturer: Robin J.M. Franklin, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

9:30 AM–12:15 PM

Symposium Sessions

• Patient-Specific Stem Cells As Models for Gene, Drug, and Environment Interactions in Disease
• Sulfur Mustard Poisoning: Mechanisms of Dermal and Pulmonary Toxicity and New Treatment Approaches ♥

Workshop Sessions

• An Update on Juvenile Animal Testing ♞
• Moving Beyond Cancer: Current State of the Science of Noncancer Health Effects of Arsenic ♣
• Paradigm Change in Toxicology: What Will It Take to Bring Advances in the Science of Toxicology into Regulatory Use? ♦ ♠
• Screening Chemicals for Neurotoxicity Outcomes—Using Large Datasets and Multiple Endpoints to Develop “Toxicity Profiles” ♜ ♦

Informational Session

• Tox21 Challenge To Build Predictive Models of Nuclear Receptor and Stress Response Pathways As Mediated by Exposure to Environmental Toxicants and Drugs ♦

Platform Sessions

• Effects of Food-Associated Agents on Inflammation, Metabolic Disease, and Cancer ♥
• Nrf2 in Redox Biology

9:30 AM–12:45 PM

Poster Sessions

• Autoimmunity/Hypersensitivity
• Biomarkers
• Cardiovascular Toxicology
• Computational and Systems Toxicology I ♠
• Computational and Systems Toxicology II ♠
• Ecotoxicology
• Nanotoxicology: In Vitro
• Nanotoxicology: In Vivo
• Pesticides
• Pharmacogenetics/Genetic Polymorphisms ♦
• Risk Assessment 2
• Risk Assessment 3

12:30 PM–1:20 PM

Distinguished Toxicology Scholar Award Lecture

• Bioactivation: An Initiating Event in Chemical-Induced Tissue Injury
  Lecturer: I. Glenn Sipes, University of Arizona, Tucson, AZ.

12:30 PM–1:50 PM

Roundtable Session

• Combination Toxicology: Are We Testing the Right Things?

Informational Sessions

• Updating FDA’s Redbook: The Importance of Stakeholder Involvement ♠
• Why Did the Scientific Program Committee Reject My Proposal? Developing a Good Idea Into an Accepted SOT Session

Education-Career Development Session

• The Evolution of the Postdoc: Transitioning from Trainee to Professional in the Modern Era

1:15 PM–4:30 PM

Poster Sessions

• Alternative In Vitro Toxicity Models ♠
• Animal Models of Disease
• Animal Models: Methods and Measurements
• Cytochrome P450
• Developmental and Juvenile Toxicology ♞
• Developmental Toxicology (Non-Rodent) ♞
• Epidemiology and Public Health
• Epigenetics ♦
• Food Safety/Nutrition 2
• Kidney—Models to Mechanisms and Molecular Biomarkers
• Liver—Translational
• Regulation and Policy
• Reproductive Toxicology ♞
• Tobacco Products

2:00 PM–4:45 PM

Symposium Sessions

• High-Content Imaging for Predictive Toxicology: Discriminating between Adverse and Adaptive Outcomes ♦
• Novel Roles of Reactive Oxygen Species (ROS) in Human Diseases: Why ROS Never Gets Stale
• Use of the Adverse Outcome Pathway (AOP) Concept to Link Epidemiological to Mechanistic Data on the Correlation of Pesticide Exposures and Parkinson’s Disease ♜ ♦

Workshop Sessions

• Advanced Techniques in PBPK Modeling to Improve Quantitative Risk Assessment for Infants and Children ♞ ♠
• “Breaking Bad”: Cardiovascular Autophagy Gone Rogue: A Putative Mechanism of Toxicity and a Drug Target in Disease
• In Vitro Dosimetry of Engineered Nanomaterials: Too Complicated to Consider, Too Important to Ignore
• Medical Device Biomaterials: Challenges in Assessing the Toxicity and Biocompatibility of Nanomaterials, Bioabsorbables, and Tissue Scaffolds

Platform Sessions

• Heavy Metals: Mechanisms and Disease Pathogenesis ♣
• Innovations in Toxicology Education

5:00 PM–6:20 PM

Education-Career Development Session

• “Talksicology”: Effective Oral Presentation Techniques

5:00 PM–5:50 PM

Translational Impact Award Lecture

• Translational Non-Invasive Biomarkers of Acetaminophen-Induced Liver Injury
  Lecturer: Richard Beger, US FDA-NCTR, Jefferson, AR.

5:00 PM–6:20 PM

Society of Toxicology–Japanese Society of Toxicology Mini-Symposium

• Advances in Metal Toxicity
  Lecturer: Michael Aschner, Albert Einstein College of Medicine, Bronx NY; and Yoshito Kumagai, University of Tsukuba, Tsukuba, Japan.

Thursday, March 17

9:30 AM–12:15 PM

Symposium Session

• Mitochondrial Dysfunction as a Pathogenic Mechanism and Therapeutic Target for Neurodegenerative Diseases ♜ ♣

Workshop Sessions

• Beyond Benchmark Dose: Advancing Probabilistic and Bayesian Approaches in Hazard Characterization ♠
• Bringing More Science into the Process of Risk Assessment for Endogenous Chemicals with Exogenous Exposures ♠
• Developmental Immunotoxicology—Are We Adequately Evaluating Safety? ♞
• Potential Health and Environmental Effects of Unconventional Hydraulic Fracturing ♥
• Which Human Cell Lines Should I Use? Choosing the Appropriate Biological Systems for High-Throughput Toxicity Testing ♠

Platform Sessions

• Advances in Mammary Gland Biology and Toxicology
• Electronic Cigarette Research
• Flame Retardants

9:30 AM–12:45 PM

Poster Sessions

• Biotransformation
• Disposition and Pharmacokinetics
• Emerging Technologies
• MicroRNA Biomarkers ♦
• Nanotoxicology—Carbon Based
• Persistent Organic Pollutants ♥
• Skin Responses and Toxicology

Late-Breaking Poster Session

• Late-Breaking Poster Session abstract supplement now available