The older adult population is growing faster than the total population in practically all regions of the world—and this difference in growth rates is accelerating. The proportion of older adults is projected to more than double worldwide over the next half century. At the global level, one in every 12 individuals was at least 60 years of age in 1950. By the year 2050, more than one in every five persons is projected to be aged 60 or over. Despite this increase, few issues in toxicological science associated with the aging process have been addressed. Older adults have uniquely increased susceptibilities to pharmaceuticals and environmental toxicants, but remain largely unrecognized as a sensitive or vulnerable population.
Although considerable effort has been spent addressing the biological aspects of aging, including genetics and pharmacology, toxicological effects specific to older populations have been understudied. The primary goal of this CCT meeting is to increase understanding of the changes associated with the aging process and discuss ways in which these changes may influence toxicity outcomes. The discussions will have potential impact on the development of toxicological assessments, the drug development process, and clinical practice.
This meeting will address the following:
Florence G. Burleson, PhD, Burleson Research Technologies Inc., Morrisville, NC
Rafael de Cabo, PhD, Experimental Gerontology Section and Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD
Co-Chairs:
Kenneth L. Hastings, MPH, DrPH, Hastings Toxicology Consulting LLC, Mount Airy, MD
Charles E. Wood, DVM, PhD, DACVP, US Environmental Protection Agency, Research Triangle Park, NC
9:45 AM–10:15 AM Diseases in Older Adults: Toxicological Consequences
George Taffet, MD, Baylor College of Medicine , Waco, TX
10:15 AM–10:45 AM The Aging Immune System Modulating Susceptibilities to Chemicals and Drugs
Rodney R. Dietert, PhD, Cornell University, Ithaca, NY
10:45 AM–11:00 AM Break
11:00 AM–11:30 AM Physiological Changes Associated with Aging: Impact on Xenobiotic Susceptibility
S.W. Johnny Lau, RPh, PhD, DABCP, US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD
11:30 AM–12:00 Noon Polypharmacy in the Older Patient
Catherine K. Yeung, PharmD, PhD, MPH, University of Washington, Seattle, WA
12:00 Noon–12:30 PM Aging and Increased Susceptibility to Environmental Toxicants
Wayne Cascio, MD, US Environmental Protection Agency, Research Triangle Park, NC
Co-Chairs:
Charles E. Wood, DVM, PhD, DACVP, US Environmental Protection Agency, Research Triangle Park, NC
John “Jack” R. Fowle III, PhD, DABT, Science To Inform LLC, Pittsboro, NC
Co-Chairs:
Donna L. Mendrick, PhD, US Food and Drug Administration, National Center for Toxicological Research, Silver Spring, MD
Rosalie Elespuru, PhD, US Food and Drug Administration, Silver Spring, MD
2:30 PM–3:00 PM Clinical Experience in the Aging Population
Dean L. Kellogg, Jr., MD, PhD, Departments of Medicine and Physiology, University of Texas Health Science Center and Geriatric Research, Education, and Clinical Center, Audie L. Murphy VA Hospital, San Antonio, TX
3:00 PM–3:30 PM Air Pollution Accelerates Aging Processes
Caleb E. Finch, PhD, School of Gerontology, University of Southern California, Los Angeles, CA
Co-Chairs:
S.W. Johnny Lau, RPh, PhD, DABCP, US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD
Sharmilee P. Sawant, PhD, DABT, Halyard Health, Alpharetta, GA
3:30 PM–4:00 PM Modulation of Human Aging and Pharmacologic Interventions
Warren Ladiges, DVM, MS, Department of Comparative Medicine, University of Washington, Seattle, WA
4:00 PM–4:15 PM Break
4:15 PM–4:45PM Mitochondrial Dysfunction and Aging: Challenges and Future Directions
Yvonne Will, PhD, Pfizer Inc., Drug Safety Research and Development, Groton, CT
Co-Chairs:
John DeSesso, PhD, ATS, Exponent Inc., Alexandria, VA
Mary Jeanne Kallman, PhD, DSP, Kallman Preclinical Consulting, Greenfield, IN
Proposed discussion topics:
Florence G. Burleson, PhD, Burleson Research Technologies Inc., Morrisville, NC
Abstracts should relate to the topics and themes for this CCT meeting, as conveyed in the Background section of this page. Accepted abstracts will be displayed for the duration of the CCT meeting with poster presentations occurring during the luncheon portion of the agenda.
Abstract submission is open to all attendees, and there is no fee associated with submission. The submission deadline is March 2, 2018.
Abstract acceptance notifications will occur in February 2018. If your abstract is accepted, please consult and follow the CCT meeting’s poster preparation and display instructions for preparing and displaying your poster.
San Antonio, Texas
more infoAttendees should make their hotel reservations for this event through the 2018 SOT Annual Meeting Housing System
Fees include all CCT meeting sessions, program materials, and refreshments throughout the course of the CCT meeting.
If you need special assistance for this meeting, please contact SOT Headquarters at 703.438.3115.
When using the mail-in registration form, payment must be submitted in one of the following ways:
Submit your completed registration via:
Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by February 10, 2018. These refunds will be processed, less a $30 fee, following the CCT meeting.
SOT reserves the right to review all registrations and to determine that individuals or organizations meet the Society’s criteria for participation.
For non-SOT members, participation in this CCT meeting is reserved for bona fide individuals who are engaged in or promote the field of toxicology or biotechnology research and support the growth and development of the toxicology field. In addition, participation in this CCT meeting is reserved for bona fide organizations with public policy positions and business practices that are generally consistent with SOT’s mission, goals, reputation, and its policies and principles as determined by the Society. SOT reserves the right to review registration applications for this CCT meeting to confirm that the applicant meets these criteria and may, at the Society’s sole discretion, reject a registration by an individual or business or withdraw registration privileges at any time if any individual or organization is found to be inconsistent with SOT’s principles and interests.
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