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Artificial Intelligence Applications in Food and Cosmetic Safety—April 29, 2020

Chair: Jim E. Riviere, 1DATA Consortium, Institute of Computational Comparative Medicine

Co-chair: Ernest K. Kwegyir-Afful, US FDA CFSAN

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Overview

Artificial Intelligence (AI) is defined as the science and engineering of making intelligent machines. Machine learning is a subset of Artificial Intelligence in which analytical model building is automated and not explicitly programmed. It is based on the idea that systems can learn from data, identify patterns, and make decisions with minimal human intervention. As more data are generated in various scientific disciplines, AI promises to provide an analytical tool with more precision than existing standard methods. Advances in computational toxicology have benefited public health by reducing reliance on animal studies and reducing the cost of performing such experiments. Machine learning methods can extend the capacity of computational toxicology methods such as read across, QSAR, and kinetic models. In fact, natural language processing and deep learning methods are being used to develop predictive toxicology models to outperform the traditional QSAR and read across models.

These developments in science and technology show great potential in further advancing the safety of our food and cosmetic production.  In the broader food production and food safety space, AI technologies are being developed to enhance the growth of foods by monitoring and modifying growth parameters, managing supply chains, cleaning processing equipment, identifying plant diseases, developing new products, and enforcing employee personal hygiene procedures during food processing. In the cosmetic space, AI technologies are being used to augment data from in vitro studies and predict dermal absorption and toxicity in the absence of animal tests. As these technologies mature, we must start thinking about how to standardize procedures for safety assessments derived from AI generated data and how to best leverage these technologies to advance food and cosmetic safety.  

Schedule (All times are Eastern US, UTC-4)
10:00 AM–10:10 AM

Welcome
Amy P. Abernethy, US FDA, College Park, MD

Overview and Speaker Introductions
Ernest K. Kwegyir-Afful, US FDA CFSAN, College Park, MD

10:10 AM–10:45 AM

Artificial Intelligence: Introduction, Applications, and an Overview of the Colloquium
Jim Riviere, 1DATA Consortium, Institute of Computational Comparative Medicine, Raleigh, NC

10:45 AM–11:20 AM

General Introduction to AI and Some Common Applications
Steve Bennett, SAS Institute, Cary, NC

11:20 AM–11:55 AM

AI Technologies for Future Factory Cleaning
Nicholas Watson, University of Nottingham, Nottingham, UK

11:55 AM–12:30 PM

Using AI to Extend QSAR Models
Chaoyang (Joe) Zhang, University of Southern Mississippi, Hattiesburg, MS

12:30 PM–1:05 PM

Using Machine Learning for Cosmetics and Cosmetic Ingredients
Tim Allen, University of Cambridge, Cambridge, UK

1:05 PM–2 PM Roundtable Discussion
Moderator: Jim Riviere, 1DATA Consortium
All Speakers
Additional Panelist: Ernest K. Kwegyir-Afful, US FDA CFSAN, College Park, MD
Speaker Biographies

James Riviere, DVM, PhD; Chair

Jim Riviere is a Distinguished Professor Emeritus from both North Carolina State University (NCSU) and Kansas State University (KSU). He is an elected member of the National Academy of Medicine and an active Fellow of the Academy of Toxicological Sciences. At KSU, he held the McDonald Chair of Veterinary Medicine, was a University Distinguished Professor, a Kansas Bioscience Authority Eminent Scholar and Director of the Institute of Computational Comparative Medicine, a Certara Center of Excellence in Pharmacometrics where he co-founded the 1DATA consortium. Prior to joining the KSU faculty, Dr. Riviere was a faculty member at NCSU for 31 years, retiring both as an Alumni and Burroughs Wellcome Fund Distinguished Professor. At NCSU, he was the founding director of the Center for Chemical Toxicology Research and Pharmacokinetics and a past Director of NCSU’s Graduate Program in Biomathematics. His research focusses on developing computational models for predicting biological interactions of nanomaterials, the risk assessment of complex chemical mixtures, absorption of drugs and chemicals across skin, and the food safety and pharmacokinetics of tissue residues in food producing animals. The common theme is to define quantitative approaches including artificial intelligence (AI) and machine learning approaches to link model systems of different scales, that is from in silico to in vitro to in vivo to population endpoints in one species, and then to extrapolate across species. He was the co-founder of the Food Animal Residue Avoidance and Depletion (FARAD) program supported by USDA from 1981 to the present. Riviere holds six patents, has authored/edited 22 books and over 600 scholarly publications in pharmacokinetics, toxicology and food safety; and received over $21 million as principal investigator on extramural research grants. Among his honors are the 1991 Ebert Prize from the American Pharmaceutical Association, the Harvey W. Wiley Medal and FDA Commissioner's Special Citation, the University of North Carolina system’s O. Max Gardner Award, John Doull Award, Lloyd E. Davis Award, Lifetime Achievement Awards from both the American and European Associations of Veterinary Pharmacology, as well as being selected as the first honorary fellow in the American College of Veterinary Clinical Pharmacology.

Dr. Riviere earned his bachelor's degree in biology summa cum laude and a master's degree in endocrinology with distinction from Boston College. He earned a DVM and a PhD in pharmacology from Purdue University and was awarded an honorary DSc from Purdue in 2007. Currently Dr. Riviere lives in Raleigh with his wife and fellow toxicologist Dr. Nancy Ann Monteiro-Riviere. He serves as Science Advisor to FARAD and the 1DATA programs, is an active consultant with the FDA and continues collaborations with colleagues in pharmacokinetic and AI research topics.

Ernest Kwegyir-Afful, PhD, RAC; Co-chair

Ernest K. Kwegyir-Afful is Data Scientist in the Office of Food Additive Safety (OFAS) at the Center for Food Safety and Applied Nutrition, FDA. He is the current Acting Lead for the Informatics and Information Systems Team in OFAS. He is also an Executive Committee member of FDA’s Artificial Intelligence and Machine Learning Strategy group, and the Lead for the Center’s AI interest group. Dr. Kwegyir-Afful has previously led the Center’s efforts in designing an AI engine, “Emerging Chemical Hazard Intelligence Platform,” to assist the pilot Chemical Signals Program in detecting and predicting the emergence of potential chemical hazards of concern in the food supply. This work was publicized by a KM World publication and the Harvard Business Review. Dr. Kwegyir-Afful has advised various government organizations on the use of effective and appropriate tools to successfully implement AI powered applications that address specific challenges. He is currently leading an effort to build an intelligent analytic and knowledge discovery engine that will help streamline some of the Office’s horizon scanning activities related to premarket submissions and post market surveillance.

Dr. Kwegyir-Afful received his PhD in Neuroscience from the University of Maryland, Baltimore, and a Certificate in Data Science from Georgetown University. His graduate work and subsequent postdoctoral work at the University of Pittsburgh School of Medicine focused on signal transformation in neuronal networks involved in somatosensory perception and memory consolidation. In 2010, he joined the US Food and Drug Administration as Commissioner’s Fellow where he served as the technical lead on quantitative risk assessment projects.

Speakers

Tim Allen, PhD

Tim Allen is a Research Associate at the MRC Toxicology Unit, University of Cambridge. He completed his PhD in 2016 on Molecular Initiating Events (MIEs) and how computational methods can be used to predict them in the group of Professor Jonathan Goodman at the Department of Chemistry in Cambridge. Since then he has undertaken postdoctoral work in the Department of Chemistry in Cambridge and at the US EPA in North Carolina. This has included work using quantum chemistry density functional theory calculations to predict the mutagenicity of alpha-beta unsaturated carbonyls and understand their reactions with DNA, using 3D Quantitative Structure Activity Relationships to quantitatively predict MIEs and explore the chemical-biological interactions in several cases, and developing in-house computational tools for use by his industrial partners at Unilever’s Safety and Environmental Assurance Centre for use in safety decision making. Dr. Allen has also served as a member of ILSI Europe’s expert group on the application of Adverse Outcome Pathways (AOPs) in food ingredient risk assessment and has presented his research at over 20 national and international conferences. In 2019 Dr. Allen moved to the MRC Toxicology Unit to continue his work in predictive toxicology, including new investigations into how we can use and understand state-of-the-art machine learning approaches such as deep learning neural networks.

Steve Bennett, PhD

Nicholas Watson, MEng, PhD

Nicholas Watson has a MEng in Mechanical Engineering (University of Hull, 2005) and a PhD in Chemical Engineering (University of Leeds, 2010). From 2010 to 2014 he was a Postdoctoral Research Assistant in the School of Food Science and Nutrition at the University of Leeds. In 2013 Dr. Watson became a chartered engineer and he is a member of the Institute of Mechanical Engineers and an Associated Member of the Institute of Chemical Engineers. In 2014 he was appointed as an Assistant Professor of Chemical Engineering at the University of Nottingham. In 2015 he became a fellow of the Higher Education Academy. In addition, he is a member of the Engineering and Physical Sciences Research Council (EPSRC) Early Career Forum in Manufacturing the Future and on the Food Standards Agency Register of Experts.

Dr. Watson’s research is focused on developing industrial digital technologies, such as in process sensors and data analytical methods, for the food and drink manufacturing sector. He has led numerous research projects funded via the EPSRC and Innovate UK, tackling challenges such as optimizing industrial cleaning processes, detecting allergens within production environments, and real time monitoring of food product quality attributes. He collaborates extensively with industrial partners ranging from subject matter experts to multinationals.

Chaoyang (Joe) Zhang, PhD

Chaoyang Zhang is a Professor in the School of Computing Sciences and Computer Engineering at the University of Southern Mississippi (USM). He served as the Director of School of Computing from 2008 to 2014 at USM. His research focuses on data mining, machine learning, big data analytics and their applications in bioinformatics, and medical informatics and toxicology. His research has been supported by NSF, NIH, DOD and NAS. His studies resulted in more than one hundred peer-reviewed publications. Dr. Zhang was the co-founder and Program Committee Chair of the International Joint Conferences on Bioinformatics, Systems Biology, and Intelligent Computing (IJCBS’09), 2009. He also served as the Steering Committee Co-Chair of the 2010 ACM Bioinformatics and Computational Biology International Conference (ACM-BCB). Dr. Zhang was elected as President of the US Midsouth Computational Biology and Bioinformatics Society (MCBIOS) in 2014-2015. He received his PhD in Computational Modeling and Analysis from Louisiana Tech University.

Webcast Registration
Webcast Registration

Webcast participants can submit questions online during the event. These will be answered as time allows.

Questions about the SOT FDA Colloquia registration?
Contact Jim Dailey or 703.438.3115 Ext. 1428.

Organizing Committee
  • Allen Rudman, PhD, Colloquium Series Chair, College Park, MD
  • Jia-Sheng Wang, MD, PhD, Colloquium Series Co-Chair, University of Georgia, Athens, GA
  • Jason L. Aungst, PhD, FDA Liaison, US FDA, College Park, MD
  • Suzanne Compton Fitzpatrick, PhD, DABT, US FDA, College Park, MD
  • Wallace Hayes, PhD, DABT, ERT, ATS, FRSB, FACFE, University of South Florida and Michigan State University, Temple Terrace, FL
  • Jieun Lee, PhD, DABT, CJ Foods, Inc., La Palma, CA
  • Stephen M. Roberts, PhD, University of Florida, Gainesville, FL
  • Jeffrey J. Yourick, PhD, DABT, ATS, US FDA, Laurel, MD
  • Jim Riviere, DVM, PhD, DSc, ATS, 1DATA Consortium, Institute of Computational Comparative Medicine, Raleigh, NC
  • Ernest K. Kwegyir-Afful, PhD, Colloquium Co-chair, US FDA CFSAN, College Park, MD
  • Anne Chappelle, PhD, DABT, Council Contact, Chadd’s Ford, PA
  • Betty Eidemiller, PhD, SOT Staff, Reston, VA