Events

How Do We Make Cogent Causal Arguments with Adverse Outcome Pathways for Regulatory Risk Assessment?

Hosted by: The SOT Risk Assessment, Biological Modeling, and Ethical, Legal, Forensics, and Societal Issues Specialty Sections

Registration required for this free webinar.

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Speaker:
Lyle D. Burgoon, PhD, President and CEO, Raptor Pharm & Tox, Ltd.

What’s the objective of regulatory risk assessment? To me, it’s making a science-based argument that a chemical, a material, or a product is safe for use under specific conditions. Knowing that something causes a hazard isn’t enough. We need to really understand when something is safe for the intended use. In other words, we need to suss out under what conditions an exposure does not cause adverse effects (i.e., identifying conditions that cause an adverse effect should not be the goal—we are about safety). That cause-effect relationship, and the argument we use to articulate that relationship is critical because this is what the courts will use to determine whether or not liability exists, or whether or not a regulatory agency acted justly based on the science, rather than being arbitrary and capricious. There’s a lot of talk right now about using Adverse Outcome Pathways (AOPs) to either help formulate these causal arguments or to serve as a scaffolding for a causal weight of evidence determination. Although many do believe AOPs are always causal by their very nature, where they are a chain of key events, from some starting event (the molecular initiating event), that ultimately lead to an adverse outcome, the fact that an AOP is a chain of events does not make it inherently causal. Rather, there must be more to it than that. In this talk, we’ll explore how to make AOPs into causal chains. We won’t be relying upon Sir Austin Bradford Hill’s Conjecture; it is insufficient by his own admission. Rather, we will explore the same concepts for determining causality that are used in philosophy and in courts. By framing truly causal AOPs on causal philosophy, informed by reliable science, where we eschew pseudoscience, we will not only raise the quality bar for AOPs, but we will also begin to move regulatory toxicology and risk assessment arguments into something that will withstand muster in court. If we make weak arguments before the court, our arguments will suffer in court. After all, our goal should be to make cogent causal arguments with AOPs for regulatory safety and risk determinations.

Registration required for this free webinar.

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Integrating Machine Learning and Quantitative Structure Activity Relationships Modeling Approaches to Develop AI-assisted Interactive Physiologically Based Pharmacokinetic Modeling Web Dashboard

Hosted by: The SOT Risk Assessment and Biological Modeling Specialty Sections and the SOT American Association of Chinese in Toxicology Special Interest Group

Speaker:
Zhoumeng Lin, PhD, Associate Professor, Department of Environmental and Global Health, University of Florida
Wei-Chun Chou, PhD, Research Assistant Professor, Department of Environmental and Global Health, University of Florida

Materials:
Webinar Recording
Zhoumeng Lin Presentation
Wei-Chun Chou Presentation

A Machine Learning Model for PFAS Toxicokinetic Half-Lives: Enhancing Machine Learning with Biologically-Relevant Descriptors

Hosted by: The SOT Biological Modeling Specialty Section

Speaker:
John Wambaugh, PhD, Research Physical Scientist, US EPA

Materials:
Webinar Recording
Presentation

Generic Pharmacokinetic Models for Mother-to-Offspring Transfer of Chemicals

Hosted by: SOT Risk Assessment Specialty Section and Biological Modeling Specialty Section

Speaker:
Dustin F. Kapraun, PhD, US EPA

Materials:
Webinar Recording
Presentation

Improving Best Practices in Mathematical Modeling

Speaker:
Herbert Sauro, PhD
Professor and Director of Center of Reproducibility
University of Washington, Department of Bioengineering
Seattle, WA

Materials:
Webinar Recording
Presentation

Standardization of PBPK Modeling Practice

Speaker(s):
Cecilia Tan, PhD, US EPA
Paul Schlosser, PhD, US EPA

Materials:
Webinar Recording
Dr. Tan’s Presentation
Dr. Schlosser’s Presentation

Opportunities and Challenges Related to Saturation of Toxicokinetic (TK) Processes: Implications for Risk Assessment

Speaker(s):
Michelle Embry, PhD

Materials:
Webinar Recording
Presentation

Assessing the Impact of Multi-route Co-exposures on Human Variability in Toxicokinetics of Drinking Water Contaminants in Binary and Quaternary Mixtures

Speaker(s):
Mathieu Valcke, PhD
Sami Haddad, PhD

Materials:
Webinar Recording
Presentation

Mathematical models and COVID-19

Speaker(s):
Dr. Ben Lopman

Materials:
Webinar Recording
BMSS Business and Reception
COVID-19 transmission Abstract

Comparison of Various Approaches to AOP Quantification

Speaker(s):
F. Y. Bois
W. Gao
D. Reddyhoff

Materials:
Webinar Recording
Presentation

Migration of AcsIX Model Code to Magnolia

Speaker(s):
Conrad Housand

Materials:
Webinar Recording
Presentation

In Vitro to In Vivo Extrapolation (IVIVE) to Support New Approach Methodologies (NAMs)-based Safety Assessment: A Tiered Approach with a Focus on the Consideration of Kinetics and Metabolism

Speaker(s):
Miyoung Yoon

Materials:
Webinar Recording
Presentation

Quantitative Systems Toxicology as a Tool for Explaining and Predicting Drug-Related Organ Toxicity

Materials:
Webinar Recording (Unavailable)
Presentation

A Liver-centric Multiscale Modeling Framework for Xenobiotics

Speaker(s):
James P. Sluka
Xiao Fu
Maciek Swat
Julio M. Belmonte
Alin Cosmanescu
Sherry Clendenon
John F. Wambaugh
James A. Glazer

Materials:
Webinar Recording (Unavailable)
Presentation

An introduction to PK-Sim: the open source platform for PBPK

Speaker(s):
Andrea Edginton

Materials:
Presentation

There was no recording for this Webinar.

TRA Vitro—Vivo

Speaker(s):
Miyoung Yoon

Materials:
Webinar Recording (Unavailable)
Presentation

Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models from acslX to Berkeley Madonna, MATLAB, and R language.

Speaker(s):
Zhoumeng Lin

Materials:
Webinar Recording (Unavailable)
Presentation

Application of Physiologically-Based Pharmacokinetic Modeling to Explore the Role of Kidney 2 Transporters in Renal Reabsorption of Perfluorooctanoic Acid in the Rat

Materials:
No Recording Available.
No Slides Available.

PharmML-Exchange Format for Models Used in Quantitative System Pharmacology and Pharmacometrics

Speaker(s):
Maciej J. Swat

Materials:
Webinar Recording (Unavailable)
Presentation

Saying I do to the QSAR/PBPK marriage in GastroPlus to predict chemical exposure for safety evaluation

Speaker(s):
John DiBella, MS
Fagen Zhang and Leah Luna

Materials:
Webinar Recording (Unavailable)
Presentation DiBella
Presentation Fagen Zhang and Leah Luna

Biological Modeling Webinar Series: Developing PBPK Models in MATLAB and SimBiology

Materials:
Webinar presentations and recording have been removed at the presenter’s request.

Understanding Dermal Drug Disposition Using TC`AT—A Novel PBPK Model

Materials:
Webinar Recording (Unavailable)
Presentation

PBPK Modelling

Speaker(s):
George Loizou
Drs. Paul Hinderliter and Christopher Ruark
R. Woodrow Setzer

Materials:
Webinar Recording (Unavailable)
George Loizou Presentation
Drs. Paul Hinderliter and Christopher Ruark Presentation
R. Woodrow Setzer Presentation