Carcinogenesis Specialty Section (CSS) and Computational Toxicology Specialty Section (CTSS) Joint Webinar
Integrating Computational Tools into Carcinogenicity Assessments
Tuesday, December 14, 2021 at 10:00 AM ET
Duration: 1 Hour
The webinar will explore computational tools and predictive models for assessing carcinogenicity as well as address opportunities to improve on current methods and increase their implementation in safety evaluations for drugs and potentially hazardous chemicals.
This session will introduce foundational aspects of computational toxicology and detail how computational methods can be used to improve cancer safety assessments. The primary concepts covered in this webinar will include 1) an overview of in silico methods, including artificial intelligence and machine learning, and 2) potential application of in silico methods in regulatory science. The webinar will be of broad interest to SOT members, especially graduate students, and postdoctoral fellows who may not directly work in the field of carcinogenesis or computational toxicology but wish to expand their knowledgebase.
The webinar will consist of two 20-minute presentations followed by a 20-minute moderated question/answer session with the speakers.
Title: In Silico Methods for the Prediction of Carcinogenicity
Speaker: Dr. Mark Cronin, PhD
Affiliation: School of Pharmacy and Biomolecular Science, Liverpool John Moores University, Liverpool, UK
Abstract: An overview of in silico methods to predict carcinogenicity will be provided. The complexity of this endpoint means it is one of the most challenging adverse outcomes to predict, although much progress has been made, especially for DNA reactive carcinogens. The methods currently available and routinely used include read-across, structural alerts and quantitative structure-activity relationships (QSARs). Potential future applications of machine learning and artificial intelligence will be considered.
Title: The EURL ECVAM Curated Database of Genotoxicity & Carcinogenicity Results: Opportunities for Application in Regulatory Science
Speaker: Dr. Federica Madia, PhD
Affiliation: European Commission, Joint Research Centre (JRC) Ispra, Italy
Abstract: Collection of data, consolidation of databases, criteria for the selection and expert review of data results are all prerequisites for the design and development of new testing tools. The EURL ECVAM Consolidated Genotoxicity and Carcinogenicity Database as a reference for a number of scientific endeavors in the area of genotoxicity and carcinogenicity testing across different product-type sectors is presented as well the potential application within regulatory science.
CSS Webinar Series—Fundamentals and Frontiers in Carcinogenesis—4 parts
CSS Webinar: Part 2—Modernization of Cancer Risk Assessment—February 2020
Webinar Recording | Dr. Casey Presentation | Dr. Papineni Presentation