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CTTSS Message to Members: 2021 Session Proposal Deadline Alert

Greetings!

As we all adapt to our new normal with social distancing, it is important to remember that this will eventually end and we should plan for future days. While the 2020 SOT meeting was cancelled due to the pandemic, we can look forward to SOT in 2021 in Orlando, Florida.

CTTSS encourages you to submit a session proposal. SOT has communicated to the specialty sections that all of the sessions that were approved for SOT 2020 will be considered for the 2021 SOT meeting ONLY if they are updated in some manner, with the intention of keeping the presentations timely. Deadlines for submission have been slightly extended, but it is a short period of time regardless.

CTTSS is committed to continuing to evaluate and recommend high quality submissions for the annual meeting. Therefore, we invite you to send Emma Bowers (ebowers@tamu.edu) session summaries for endorsement. Three important points:

  1. SOT requires that the session be submitted for endorsement REGARDLESS of whether the session was endorsed last year or is a new session. Therefore, if you have a session you would like to present at SOT 2021, please submit it for endorsement to the specialty section(s). If you submitted a session last year, please be sure it is updated… a new title, more focused abstracts, and even new speakers are encouraged.
  2. The new deadline for submitting sessions is JUNE 12th. In order to make sure you have sufficient time to respond to comments and/or to meet the submission deadline for SOT, CTTSS respectfully requests that all sessions requesting endorsements be submitted to Emma Bowers (ebowers@tamu.edu) by COB May 29th. This will allow us to notify you of our endorsement by June 5th, allowing time for final submission. Useful information on how to prepare and submit a proposal can be found on the SOT’s web site (https://www.toxicology.org/events/am/AM2021/submitting-proposals.asp). Once a proposal has been reviewed by CTTSS, it will be the responsibility of the individual(s) preparing the proposal to submit. If you have difficulties with your proposal submission, you should contact the SOT liaisons David Rossé for Scientific Sessions and Kevin Merritt for Continuing Education courses.
  3. While preparing proposals, we wanted to make you aware that the Education and Career Development Committee (ECDC) is urging you to consider generating session proposals that focus on or integrate educational, mentoring, and/or career development components. The ECDC would gladly to provide timely feedback on session proposals received at least one week prior to the submission deadline and is available as an endorsing entity for qualifying session proposals. If you have such proposals please contact Pam Lein (pjlein@ucdavis.edu) and/or Darryl Hood (hood.188@osu.edu).

We look forward to reviewing your proposals and enjoying the 2021 SOT meeting in Florida. Stay safe and well.

The CTTSS Leadership

Previous Webinars

CTTSS Webinar: Acetaminophen Induced Liver Toxicity: Mechanisms, Diagnosis, and Treatment

Tuesday, October 30, 2018 1:00 pm Eastern Daylight Time (New York, GMT-04:00)
Duration: 1 hour 12 minutes

Acetaminophen (APAP) induced liver toxicity and liver failure remains a serious issue. APAP overdose, both intentional and unintentional, accounts for more than 50% of the overdose related acute liver failure cases in the United States annually. While the pathway for biological activation of APAP is well understood, the mechanisms, diagnosis, clinical presentations, and treatments are less well understood and more variable. A discussion of the basic mechanisms of cell death in mice and the translational application to human hepatocytes and humans in APAP toxicity will set the stage for the webinar. An understanding of these mechanisms may lead to potential new therapeutic targets. Next, liquid biopsies and their use in identifying mechanisms of APAP toxicity in humans, and the use of these various biomarkers for early diagnosis and predicting the potential outcome of APAP toxicity and acute liver failure, will be presented. Finally, a description of the clinical diagnosis of APAP overdose using protein adduct detection methods and applications as well as clinical treatment of liver toxicity will provide a translation of the mechanism to the bedside for patient care and impact. The webinar will end with a panel discussion to further integrate the information presented and encourage interactive learning.

Webinar Recording

Dr. Jaeschke Slides PDF icon

Dr. Aubrecht Slides PDF icon

Dr. James Slides PDF icon

Research Beyond Basic Science: Pursuing Topics in Clinical and Translational Toxicology

2:30PM EST, Wednesday, February 14th
Panelists: Sarah Campion, Jaime Mirowsky, Nisha Sipes

This webinar will explore the transition of both trainee scientists and established investigators from basic science-centered projects to those driven by clinical and translational toxicology. Three speakers from various employment sectors with experience transitioning to translational research will provide advice on how to navigate challenges with these projects. The importance of clinical and translational toxicology will be discussed as it relates to various employment fields as well as practical advice for trainee scientists interested in these fields.

Webinar Recording

Presentation Slides PDF icon

News & Events

Dear Members,

I hope you had a relaxing summer. Our membership has grown from approximately 100 when this Specialty Section was established to 241 and we hope to continue to attract new members. Translational research is multidisciplinary and our recent member survey showed a good mix of members from academia, government and consulting groups holding PhDs and/or MDs. It also provided us with information as to what the members see as a positive in this Specialty Section, possible webinar topics, etc. The anonymized survey will be distributed to the membership.

It would be wonderful if we could identify a topic for a Contemporary Concepts in Toxicology meeting. Putting together such a meeting takes a lot of effort but if you believe that a topic needs to be highlighted and it is not elsewhere, it is worth the effort. SOT will provide some money and, if the meeting proceeds exceed that amount, CTTSS can get some of the bounty! Feel free to contact any of the officers with ideas for CCT meetings and/or webinars.

This is an exciting time to be in science. A few highlights:

  1. The area of targeted oncology treatments has demonstrated some impressive results. It was hoped that they would have few side effects but, unfortunately, they do not. Side effects include hepatotoxicity, blood clotting disorders, etc.
  2. Regenerative medicine is on the forefront. Stem cell therapy has been used for many years in horses and dogs and is making its way into clinical practice. More research is needed to identify adverse effects in animals and humans, a perfect translational project!
  3. Another translational issue is Cushing’s disease. It is relatively common in dogs (one of my dogs had it) and clinicians can learn about the treatments and side effects from veterinarians.
  4. The microphysiological system (aka human on a chip) approach is demonstrating interesting results, for example, in mechanistic analysis. One question is if scientists will be satisfied if one relates the findings of human cells in vitro to clinical results (which is limited) of if a rodent version compared to in vivo rodent results (where we have a large dataset) will be required for acceptance.
  5. 3-D printing (aka additive manufacturing) is becoming more amenable to create implantable devices, scaffolds for organs, etc.
  6. DARPA announced a new initiative to develop an implantable neural interface to restore sensory restoration.

These and other new areas of science will present some challenges to translational and clinical science.

Officers

2017-2018

President:

Donna L. Mendrick

Vice President:

John-Michael Sauer

Vice President-Elect:

Jennifer L. Burkey

Secretary/Treasurer:

Haiyan Tong

Past President

Jiri Aubrecht

Councilors:

John G Benitez

Hartmut Jaeschke

Postdoctoral Representative:

Phillip A. Wages

Graduate Student Representative:

Courtney Nicole Jamison

Please consider applying to be an Officer in the CTTSS. Openings for 2018–2019 are: Vice-President Elect, Secretary/Treasurer, and Councilor

Already time to be thinking of the SOT 2018 meeting. The CTTSS was requested to endorse 17 Symposia, Workshops, Informational Sessions and Region Interest Sessions. The SOT is trying a new program whereby selected specialty sections may identify a symposium that must be included in the program. Some of the leadership of this Specialty Section put together such a symposium titled: “Clinical and Translational Toxicology: From Theory to Therapy.” We hope many of you graduate and postdoctoral fellows will be submitting abstracts for travel award consideration. Winners will be announced at our Specialty Section reception during the SOT 2018 meeting. Please consider nominating yourself or a colleague to be an officer for 2018. Information on officer nominations will be sent before the 2018 SOT meeting.

If you have ideas on how to improve the Clinical and Translational Specialty Section, please contact one of your officers.

CTTSS Membership Survey

A survey of our membership in 2017 was conducted to gather information on who we are and what we want as a group out of our specialty section. Approximately 30 scientists responded, with some interesting trends. As for who we are, mostly PhD’s, and mostly in academia and government. As a group, there is fairly consistent attendance at the annual meeting, although maybe not every year, which may suggests regional travel. Years in the specialty section is fairly consistent. As a group we add a steady number of members each year, but this appears to be almost entirely through the grapevine and not formal marketing means. If people are joining for networking, we as a section are meeting that need, but for the large number that are joining for collaboration, that looks like an unmet need.

In addition, we requested suggestions for topics of interest to the section for potential SOT webinars and other educational opportunities, and these are captured on the survey.

Survey Results