FutureTox IV

Predictive Toxicology for Healthy Children

The Westin Crystal City | Arlington, VA

about FutureTox IV

 

FutureTox IV Progress to Maturity: Predictive Developmental and Reproductive Toxicology for Healthy Children is focused on bringing together basic, clinical, and regulatory scientists to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making for matters pertaining to developmental health, lifestage progression, and the human reproductive cycle. The meeting also will look at implementing the 21st-century vision and regulatory considerations relevant to commercial chemicals in the environment and medical products for guidance based on new results.

The FutureTox series focuses on building the road for 21st-century toxicology and risk assessment practices, utilizing in vitro data and in silico models for predictive toxicology, and taking the high-throughput risk assessment paradigm forward to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making.


Background and Vision for the Conference


  Why Children’s Health?

The prevalence of adverse children’s health outcomes in the US demonstrates a growing need for research to understand the impact of environmental factors on human development and for actionable solutions to ensure well-being across lifestages and to recognize that adverse consequences may not manifest until later in life or in subsequent generations.

Adverse developmental outcomes such as preterm labor, low birth weight, birth defects, childhood asthma, neurodevelopmental impairment, pubertal timing, cardiovascular disease, metabolic syndrome, subfertility, and pediatric cancers are some examples of important considerations for healthy children.

  What FutureTox IV Will Address

Current translational opportunities and challenges for in vitro data and in silico models in developmental effects assessment, such as:

  • Integration of high-throughput data from biomolecular screening efforts with current and emerging biological understanding;
  • Engineering human cell-based organotypic culture models that effectively recapitulate key events in developmental-reproductive processes;
  • Constructing adverse outcome pathways (AOPs) relevant to regulatory decision-making on potential developmental hazards; and
  • Exposure-based metrics to address risk assessment for children’s health and well-being.

  Regulatory Implications

With the 2016 Frank R. Lautenberg Chemical Safety for the 21st Century Act highlighting children and pregnant women as susceptible lifestages/populations, there is renewed impetus for implementing new assays and technologies to address the safety, including for susceptible populations, of the >80,000 compounds in commerce. This requires confidence in the high-throughput testing paradigm, as well as effective communication of the emerging science and technology to stakeholders.

Recently, the Defense Advanced Research Projects Agency (DARPA), US Food and Drug Administration (US FDA), National Institutes of Health (NIH), US Environmental Protection Agency (US EPA), and other federal agencies in the US and Europe are investing in the development and implementation of alternative testing strategies such as human organ-on-chip and microphysiological system constructs to support human disease models; however, these platforms could be translated in support of regulatory decision-making for toxicity testing.

Agenda

ABSTRACTS

Abstracts submissions for FutureTox IV should relate to the development, utilization, or translation of 21st-century methodologies and data (e.g., in vitro screening assays, in silico predictive models, and other novel technologies) focused on developmental and reproductive health outcomes to support regulatory decision-making. For additional details on topics and themes for this Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) meeting, visit the Background section of this website. Abstracts should relate to the topics and themes for this CCT meeting, as conveyed in the Background section of this website. Accepted abstracts will be displayed for the duration of the CCT meeting with poster presentations occurring in the late afternoon of November 14 and November 15.

Abstract submission is open to all attendees, and there is no fee associated with submission. The submission deadline is Wednesday, September 26, 2018. Graduate students and postdoctoral scholars are encouraged to submit abstracts. Based on availability of funding, travel support will be provided to graduate students and postdoctoral scholars based on the merit of their submitted abstract and confirmation of their poster presentation at FutureTox IV. The travel support awards will be announced at the meeting. Recipients must be onsite to receive their award. Abstract acceptance notifications will occur by Wednesday, October 10, 2018. If your abstract is accepted, please consult and follow the SOT CCT meeting’s poster preparation and display instructions for preparing and displaying your poster.


SUBMIT AN ABSTRACT


Hotel Information

The Westin
Crystal City

Arlington, Virginia

Housing is now open for the SOT FutureTox IV meeting. SOT has reserved a limited block of discounted rooms at the Westin Crystal City.

Rate: single/double $179 (plus state & local taxes)

Room Rate includes complimentary internet in guest rooms and complimentary gym access for all overnight guests.

Reserve a Room

Conveniently located in the heart of Arlington’s Crystal City, The Westin is just steps away from great local dining, shopping, and the Metro, placing you a short ride away from Washington, DC


  Westin Crystal City
 
  1800 Jefferson Davis Highway
 
  Arlington, Virginia, 22202
  703.486.1111


If you have room reservation changes, cancellations, or other questions, please contact the Westin directly, using the contact information provided above.

register

Early-Bird
Before October 31, 2018
SOT Member
$375
SLC Member
$375
Federal Scientist
$375
Nonmember
$475
SOT Student/Postdoc Member
$200
Student/Postdoc Nonmember
$250

Final
After October 31, 2018
SOT Member
$425
SLC Member
$425
Federal Scientist
$425
Nonmember
$525
SOT Student/Postdoc Member
$250
Student/Postdoc Nonmember
$300

Organizing Committee

Chair:
Thomas B. Knudsen, PhD

US Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC

Co-Chair:
Suzanne Fitzpatrick, PhD

US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD

K. Nadira De Abrew, PhD

Procter & Gamble Company, Cincinnati, OH

Anne Chappelle, PhD

SOT Council Contact
International Isocyanate Institute, Chadds Ford, PA

Alison Elder, PhD

Contemporary Concepts in Toxicology (CCT) Conferences Committee Liaison
University of Rochester, Rochester, NY

Sue Euling, PhD

US Environmental Protection Agency, Office of Children’s Health Protection, Washington, DC

Elaine Faustman, PhD

University of Washington, Seattle, WA

Jill Franzosa

US Environmental Protection Agency, Office of Research and Development, Chemical Safety for Sustainability, Research Triangle Park, NC

Laurie Haws, PhD

ToxStrategies, Inc., Austin, TX

Nicole Kleinstreuer, PhD

National Toxicology Program, Durham, NC

Germaine Buck Louis, PhD

College of Health and Human Services, George Mason University, Fairfax, VA

Donna L. Mendrick, PhD

US Food and Drug Administration, National Center for Toxicological Research, Silver Spring, MD

Ruthann Rudel, MS

Silent Spring Institute, Newton, MS

Thad Schug, PhD

National Institute of Environmental Health Sciences, Research Triangle Park, NC

Robert Tanguay, PhD

Oregon State University, Corvallis, OR

Barbara Wetmore, PhD

US Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, NC

Kimberly White, PhD

American Chemistry Council, Washington, DC

Executive Committee


Linda S. Birnbaum, PhD

National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, NC

George P. Daston, PhD

Procter & Gamble Company, Cincinnati, OH

Dana C. Dolinoy, PhD,

NSF International Chair of Environmental Health Sciences, Professor of Environmental Health Sciences & Nutritional Sciences, University of Michigan, School of Public Health, Faculty Director, Epigenomics Core, Michigan Medicine, Ann Arbor, MI

Kristi Pullen Fedinick, PhD,

Natural Resources Defense Council, Washington, DC

Sponsors

Diamond Level


Society of Toxicology (SOT) Logo


Scientific Liasion Coalition (SLC) Logo


Gold Level


Contributor Level


Teratology Society Logo



AACT





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contact

 11190 Sunrise Valley Drive, Suite 300, Reston, VA 20191-4375

703.438.3115

sothq@toxicology.org