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The Dose Response – The Cornerstone of Toxicology and Challenges for Risk Assessment National Capital Area Chapter - Society of Toxicology Spring Symposium Maryland STAMP Student Union University of Maryland College Park Campus May 16, 2002 NCAC-SOT Spring Symposium The goal of this symposium is to generate discussion about one of the central tenants in toxicology – the dose response relationship. As was stated so long ago by Paracelsus – it is the dose that makes the poison. Or is it? As our approaches to measuring various toxicological responses become more sensitive, questions can be raised as to whether a change from a control response is truly an adverse change. As our understanding progresses regarding the body’s physiological mechanisms for response to toxic insult, what appears to be a toxic effect may actually be a compensatory mechanism with no adverse outcome. In contrast to the traditional perspective of a linear dose-response relationship, evidence exists for varying responses at low versus high doses. All these complexities need to be considered and factored into interpretation of the data for risk assessment purposes. This series of presentations will take us from traditional study designs and treatment of data into the current world of mechanistic risk assessment where the lines become blurred between cancer and non-cancer assessments, quantitative vs qualitative approaches, threshold vs. nonthreshold events, including such phenomena as discontinuous dose response and U-shaped dose response curves. Featured at the end of this symposium will be a poster session and reception 7:45 AM Registration, Continental Breakfast, and Posters Set-Up 8:30 AM Welcome and Opening Comments Bernard A. Schwetz President, NCAC-SOT 8:45 AM The Central Role of Dose Response in a Risk Assessment Carole Kimmel, U.S. Environmental Protection Agency 9:25 AM Cancer vs Non-cancer Risk Assessment Bette Meek, Health Canada 10:05 AM U-shaped Dose Response Curves – What, Why and How? Edward Calabrese, University of Massachusetts 10:35–10:55 AM Discussion 10:55–11:20 AM Break 11:20 AM Discontinuous Dose Response Curves William Slikker, National Center for Toxicological Research 11:50 AM Future Approaches to Dose Response Assessment Jeanette Wiltse, U.S. Environmental Protection Agency (retired) 12:30–2:15 PM Lunch and Poster Session (posters manned from 1-2 PM) 2:15 PM Welcome and Remarks Marion Ehrich Vice President, SOT 2:30 PM Poster Awards 2:30–3:30 PM Poster Discussion (3-5 minutes on selected posters)
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