Award Recipients

Top 5 Abstracts

Listed alphabetically by author

Celeste Carberry, University of North Carolina at Chapel Hill
Title: Extracellular Vesicles Altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Concentration-Dependent Release, Chemical Content, and MicroRNA Signatures Involved in Liver Health

Catalina Cobos-Uribe, University of North Carolina at Chapel Hill
Title: The Upper Airway Exposomics Associated with E-cigarette Use

Jolyn Fernandez, University of Oklahoma Health Sciences Center
Title: Extracellular Vesicles Altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Concentration-Dependent Release, Chemical Content, and MicroRNA Signatures Involved in Liver Health

Cynthia Rider, NIEHS
Title: In Vivo Evaluation of Polycyclic Aromatic Compounds and Mixtures

Catherine Wise, Duke University
Title: Environmental Exposure Mixtures Associated with Bladder Cancer in Pet Dogs

Top 5 Abstracts

Listed alphabetically by author

Tyler Armstrong, University of North Texas
Title: Traffic-Generated Pollutant-Exposure Combined with High-Fat Diet Exacerbates the Expression of Factors Associated with Alzheimer’s Disease Pathophysiology in Aged C57BL/6 Wild-Type Mice

Lucie Ford, Texas A&M University
Title: A Population-Based Human In Vitro Approach to Characterize Inter-Individual Variability in Responses to Complex Mixtures

David Leuthold, Helmholtz Centre for Environmental Research
Title: Combined Effects of Chemical Mixtures Are Predictable for the Whole Transcriptome: A Proof-of-Concept Study with Zebrafish Embryos

Shayla Victoria, University of Mississippi
Title: Indoor Fuel Sources Influence PM2.5 Chemical Composition and Alter Zebrafish Behavior

Qiang Zhang, Emory University
Title: Flexible Physiologically Based Pharmacokinetic (PBPK) Model for Mixtures of Dioxin-Like Compounds

Best Mixtures Abstract

Brianna Rivera, Oregon State University
Title: A Novel Framework to Form Sufficiently Similar Mixtures from Environmental Exposure Data

Postdoctoral Award

Emily Green, US EPA
Title: Application of the Generalized Concentration Addition Model to Predict In Vitro Responses of Tertiary Mixtures of Glucocorticoid Ligands

Postdoctoral Award

Emily Brehm, University of Illinois at Urbana-Champaign
Title: Perinatal Exposure to an Environmentally Relevant Phthalate Mixture Accelerates Biomarkers of Reproductive Aging in a Multigenerational and Transgenerational Manner in Female Mice

Top 5 Abstracts

Listed alphabetically by author

Justin Conley, US EPA
Title: Dose Additive Developmental Toxicity of a Mixture of Three PFAS (HFPO-DA, NBP2, PFOS) in the Sprague-Dawley Rat

Justin Griffin, California State University, Long Beach
Title: Addressing the Activity of Binary and Complex Environmental Polychlorinated Biphenyl Mixtures toward the Dopamine Transporter

Jacklyn Kelty, Rutgers University
Title: Pulmonary Tissue Dysfunction and Cytotoxicity in Precision-Cut Lung Slices Exposed to E-cigarette Condensate

Brianna Rivera, Oregon State University
Title: A Novel Framework to Form Sufficiently Similar Mixtures from Environmental Exposure Data

Davide Sciuscio, PMI
Title: Flavor Ingredients in E-vapor Products: A Structure-Based Grouping Approach to Predict Their Biological Activity

Graduate Student Award

Alyssa K. Merrill, University of Rochester
Title: Endocrine Disrupting Chemical Exposure during Pregnancy and Metabolic Reprogramming

Postdoctoral Award

Genoa R. Warner, University of Illinois at Urbana-Champaign
Title: Phthalate and Phthalate Metabolite Mixtures Alter Gene Expression in Mouse Neonatal Ovaries

Top 5 Abstracts

Listed alphabetically by author

L. E. Grey, US EPA
Title: Development of an AOP Network for the Developmental Effects of Exposure to the PFAS

D. N. Williams, Oak Ridge Institute/US EPA
Title: Identification of Co-occurrence Patterns of Persistent Organic Pollutants with Data Mining Methods

J. Schlezinger, Boston University
Title: Modeling Induction of Proximal and Distal Endpoints Following PPARγ Activation by Ligand Mixtures

D. L. Cucchiara, University of Florida
Title: Using Gene Expression Analysis to Support Risk Assessment of Metal Mixtures in Freshwater Systems

Y. Chang, Oregon State University
Title: Linking Co-regulated Gene Modules with Polycyclic Aromatic Hydrocarbon-Related Cancer Risk (RPF) in the 3D Human Bronchial Epithelium

Best Mixtures Abstract

Jennifer Schlezinger, Boston University
Title: Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition

Graduate Student Award

Emily Brehm, University of Illinois-Champaign
Title: Prenatal Exposure to a Phthalate Mixture Alters Sex Steroid, Peptide, and Gonadotropin Hormones in the F1, F2, and F3 Generations of Female Mice

Postdoctoral Award

Courtney Roper, Oregon State University
Title: PM2.5 Characterization in Biomass and Non-biomass Burning Households

Top 5 Abstracts

Listed alphabetically by author

Zunwei Chen, Texas A&M University
Title: A Multi-Tissue Organotypic Human In Vitro Model for Rapid Hazard Identification of Environmental Chemicals and Mixtures

Yunjia Lai, University of North Carolina at Chapel Hill
Title: Amniotic Fluid Exposomics Identifies Novel Prenatal Exposures and Metabolic Signatures in Relation to Preterm Birth: A Prospective Case-Control Study

Jennifer Ong, University of New Mexico
Title: Cytokine Expression Profiles and Metals Exposure Cluster Analysis within a Population Study

Jennifer Schlezinger, Boston University
Title: Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition

Eva Tanner, Icahn School of Medicine at Mount Sinai
Title: A Novel Risk Assessment Model for Incorporating Co-Exposures Provides Preliminary Guideline Values for Unregulated Chemicals

Best Mixtures Abstract

Courtney Roper, Oregon State University
Title: Impacts of PM2.5 Filter Extraction Methods on Chemical and Toxicological Analyses

Graduate Student Award

J.T. Salley, University of Louisiana-Monroe
Title: Use of Chemometrics and Partial Least Squares Regression to Determine the Toxic Constituents within Various Crude Oils to Select Adverse Responses

Postdoctoral Award

Jeanette Reyes, US EPA
Title: Temporal Trends of Cumulative Risks to Phthalate Mixtures in the United States from 2005 to 2014

Top 10 Abstracts

Listed alphabetically by author

Monica Andreassen, Norwegian Institute of Public Health
Title: Real-Life Exposure to Mixtures of Chemicals in the Euromix Human Biomonitoring Study: Results from Repeated 24-Hour Diaries Reporting the Use of Personal Care Products

Yvonne Chang, Oregon State University
Title: Mechanistically Profiling PAH Biosignatures in 3D HBEC

Justin Conley, US EPA
Title: How Low Can You Go? Adverse Effects of a Mixture of 15 Pesticides and Phthalates on Reproductive Tract Development in the Male Rat

Tim Cristy, Battelle Memorial Institute
Title: The National Program Synthetic Turf/Recycled Tire Crumb Research: Characterization of a Crumb Rubber Lot for Use in In Vitro and In Vivo Studies

Nicola Evans, US EPA
Title: Cumulative Assessment of Steroid Hormone Receptor-Mediated Activity of Contaminants in Water Samples Using In Vitro Bioassays

William Gwinn, NIEHS
Title: The National Toxicology Program Research on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Leachability and Cytotoxicity of Crumb Rubber In Vitro

Elizabeth Medlock Kakaley, US EPA
Title: Validation of a Glucocorticoid Receptor Effects-Based Environmental Sample Screening Tool

Christopher Kassotis, Duke University
Title: Adipogenic Activity of House Dust Extracts

Courtney Roper, Oregon State University
Title: Impacts of PM2.5 Filter Extraction Methods on Chemical and Toxicological Analyses

Kristen Ryan, NIEHS
Title: An Approach to Evaluate Chemical-Induced Biological Response Similarities across Multiple Echinacea purpurea Extracts

Best Mixtures Abstract

Yvonne Chang, Oregon State University
Title: PAHs Differentially Regulate Transcription in Human 3D Bronchial Epithelium

Graduate Student Award

Changquing Zhou, University of Illinois
Title: Prenatal Phthalate Mixture Exposure Adversely Affects Female Reproduction in Mice

Postdoctoral Award

Justin M. Conley, US EPA
Title: A Mixture of 18 Anti-Androgens at Concentrations below Individual Chemical Effect Levels Produces Reproductive Tract Malformations in the Male Rat

Top 5 Abstracts

Listed alphabetically by author

Yvonne Chang
Title: PAHs Differentially Regulate Transcription in Human 3D Bronchial Epithelium

Justin Conley
Title: A Mixture of 18 Anti-Androgens at Concentrations below Individual Chemical Effect Levels Produces Reproductive Tract Malformations in the Male Rat

Kristian Dreij
Title: Development and Application of In Vitro-Based Mixture Potency Factors for Improving Health Risk Assessment of Airborne PAHs

Katherine Harvey
Title: Neurochemical and Behavioral Consequences of Developmental Exposure to Low Dose EDCs and Their Mixture

Jeanette Reyes
Title: An Analysis of Cumulative Risks Indicated by Biomonitoring Data of Six Phthalates Using the Maximum Cumulative Ratio

Best Mixtures Abstract

Cynthia Rider, NTP/NIEHS
Title: In Vitro Screening to In Vivo Testing of Polycyclic Aromatic Compounds at the National Toxicology Program

Graduate Student Award

Parker Duffney, University of Rochester Medical Center
Title: Cigarette Smoke Dampens Antiviral Response by Disrupting TLR3/IFN Axis in Lung Epithelial Cells

Postdoctoral Award

Justin Conley, US EPA
Title: In Vitro to In Vivo Extrapolation of Xenoestrogens Using an Estrogen Responsive In Vitro Transcriptional Activation Assay and the In Vivo Uterotrophic Assay

Top 6 Abstracts

Listed alphabetically by first author

David Mattie
Title: Health Hazard Assessment of Alcohol-To-Jet (ATJ) Synthetic Kerosene with Aromatics (SKA) Alternative Jet Fuel

Margaret Pratt
Title: Advancing the State-of-the-Science in Estimating Cancer Risk of Polycyclic Aromatic Hydrocarbon Mixtures

Cynthia Rider
Title: In Vitro Screening to In Vivo Testing of Polycyclic Aromatic Compounds at the National Toxicology Program

Joshua Salley
Title: Use of Partial Least Squares Regression to Identify GC/MS Spectral Peaks Correlated with Toxicity Outcomes in Rats of Crude Oil from Various Sources

Mathieu Valck
Title: Evaluation of the Magnitude of the Age-Dependent Adjustment Factor (ADAF): A Kinetics-Based Case Study with Trichloroethylene and Vinyl Chloride

Thomas Webster
Title: Mixtures of Full and Partial Agonists: Several Mechanisms of Receptor Activation Are Consistent with Generalized Concentration Addition

Best Mixtures Abstract

Krystin Carlson, University of Michigan
Title: Assessment of Ototoxicity Due to Chronic Lead and Cadmium Exposure with and without Noise Exposure in CBA/J Mice

Graduate Student Award

Axelle Marchand, Université de Montréal
Title: Evaluation and Modeling of the Impact of Co-exposures to VOC Mixtures on Urinary Biomarkers

Postdoctoral Award

Melissa Badding, NIOSH
Title: Pro-inflammatory Responses and Inflammasome Activation by Sintered Indium-Tin Oxide Particles

Top 5 Abstracts

Listed alphabetically by first author

Krystin Carlson
Title: Assessment of Ototoxicity Due to Chronic Lead and Cadmium Exposure with and without Noise Exposure in CBA/J Mice

Deborah Cory-Slechta
Title: Developmental Methylmercury Exposure Produces Behavioral Toxicity in Female Mice That Is Only Seen in Combination with Prenatal Stress in Male Mice

Susie Huang
Title: Quantitative Metabolomics Informs a Systems Biological Approach to Characterize Toxicity in Zebrafish Larvae

Axelle Marchand
Title: Evaluation and Modeling of the Impact of Co-exposures to VOC Mixtures on Urinary Biomarkers

David Mayfield
Title: Examination of Multiple Dose-Response Analysis Methods for Estimating Dermal Cancer Risks for PAH Mixtures

Best Mixtures Abstract

Kembra Howdeshell, NIEHS/NTP

Graduate Student Award

Axelle Marchand, Université de Montréal
Title: Studying the Impact of Volatile Organic Chemical Co-exposures on the Urinary Excretion of Their Metabolites in Human Volunteers

Postdoctoral Award

Laura Datko-Williams, ORISE
Title: Assessment of In Vivo Toxicological Interactions from Criteria Air Pollutant Mixtures

Top 5 Abstracts

Listed alphabetically by first author

N. Catlin, S. M. Huse, K. Boekelheide
Title: The Stage-Specific Apoptotic Response of the Rat Testis to Low-Dose 2,5-Hexanedione and X-Irradiation Co-exposure

K. L. Howdeshell, C. V. Rider, J. R. Furr, V. S. Wilson, L. E. Gray
Title: Dose Addition Predicts Effects of Phthalate Mixture on Male Reproductive Tract Development and Associated Fetal Testis Gene Expression in Rats

A. Leblanc, E. Blanc, A. Ambolet-Camoit, C. Benelli, S. Bortoli, R. Barouki, M. Aggerbeck
Title: Xenobiotic Mixtures Decrease Human Hepatic Gluconeogenesis and Glucose Oxidation

A. Marchand, R. Aranda-Rodriguez, A. Nong, S. Haddad
Title: Studying the Impact of Volatile Organic Chemical Co-exposures on the Urinary Excretion of Their Metabolites in Human Volunteers

A. M. Vinggaard, N. Hadrup, M. Pedersen, K. Skov, L. O. Bertelsen, H. Frandsen, K. G. Kongsbak, J. Boberg, U. Hass
Title: Mixture Effects at Human Relevant Exposure Levels?

Best Mixtures Abstract

Daniel Borg, Karolinska Institutet

Graduate Student Award

Dana Lauterstein, New York University
Title: Effects of a Smokeless Tobacco, Gutkha on Neurotransmitter Levels and Associated Parameters in the Mouse Brain

Postdoctoral Award

Rhiannon David, Imperial College London
Title: Mixtures of Benzo[a]pyrene with Direct or Indirect Acting Mutagens Have a Nonmonotonic Mutation Profile

Top 10 Abstracts

Listed alphabetically by first author

G. V. Alexeeff, J. Faust, L. August, R. Cendak, W. Wieland, T. Kadir, L. Cushing, K. Randles, C. Milanes, L. Zeise
Title: California Communities Environmental Health Screening Tool (CalEnviroScreen)

D. Borg, B. O. Lund, N. G. Lindquist, H. Håkansson
Title: Individual and Cumulative Health Risk Assessment of 17 PFASs in the Swedish Population

J. Gruber, R. D. Patel, J. E. Rager, A. P. Sanders, S. Edwards, J. E. Gallagher, R. C. Fry
Title: Exposure to Metals Mixtures: Genomic Alterations of Infectious Disease Response Pathways in Children Exposed to Environmental Metals

B. Hannas, J. R. Furr, L. E. Gray, V. S. Wilson
Title: Comparison of Estrogen Mixtures In Vitro vs In Vivo

W. Lichtensteiger, C. Bassetti-Gaille, O. Faass, J. Boberg, S. Christiansen, U. Hass, A. Kortenkamp, M. Schlumpf
Title: Effects of Different Endocrine Disruptor Mixtures on Gene Expression in Neonatal Rat Brain Regions: Focus on Developing Excitatory Synapses

A. K. Tiwary, R. I. Magaw, D. A. Zemo, K. T. O’Reilly, R. E. Mohler, K. A. Synoweic
Title: Reference Dose (RfD)-Based Chronic Human Health Hazard Ranking System for Complex Mixtures—Assessment of Polar Nonhydrocarbons in Groundwater at Biodegrading Petroleum Sites

V. S. Wilson, J. R. Furr, C. Lambright, B. Hannas, L. E. Gray
Title: Cumulative Effects of a 9 Phthalate Mixture on Charles River-Sprague-Dawley (CR-SD) Fetal Rat Testis Testosterone (T) Production and Gene Expression

C. J. Wolf, C. Rider, C. Lau, B. D. Abbott
Title: Evaluation of Additivity of Binary Mixtures of Perfluoroalkyl Acids (PFAAs) on Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) Activation In Vitro

K. Zaccaria, P. McClure
Title: Associations between Carcinogenic and Immune Suppression Activities of PaHs: Insights into Improving Cancer Risk Assessment for PAH Mixtures

J. Zavala, K. Lichtveld, S. Ebersviller, G. W. Walters, H. E. Jeffries, K. G. Sexton, W. Vizuete, I. Rusyn, I. Jaspers
Title: Development of a Portable In Vitro System for Lab and Field Aerosol Exposure Studies

Best Mixtures Abstract

Carl J. Johnston, University of Rochester

Graduate Student Award

Paul R. Eden, Mississippi State University

Postdoctoral Award

Michelle C. DeSimone, North Carolina State University

Top 10 Abstracts

Listed alphabetically by first author

S. Flor, G. Ludewig
Title: Evaluation of Steroidogenic Pathway Disruption and Adrenal Steroid Hormone Secretion in the Human Adrenocortical H295R Cells by Lower Chlorinated PCBs, Their Metabolites and Commercial Mixtures

C. Gennings, L. G. Stork
Title: Data-Derived Extrapolations, QSAR, In Silico Strategies, and Surrogates: Testing for Sufficient Similarity in Environmental Mixtures Using Exposure Data and Mixture Toxicology

F. Glahn, Q. D. Nguyen, J. Wiese, J. G. Hengstler, I. Grosse, H. W. Foth
Title: Toxicity of Mixtures: Are In Vitro Effects of Metal Mixtures Predictable from the Responses to the Single Components?

C. J. Johnston, R. Gelein, D. A. Cory-Slechta, J. N. Finkelstein, G. Oberdorster
Title: Early Life Inhalation of Ambient Particles and Ozone Mixtures Sensitizes the Lung to Later Life Challenges

A. J. Larkin, L. K. Siddens, S. K. Krueger, S. C. Tilton, K. M. Waters, W. M. Baird, D. E. Williams
Title: Signature Applications and Network Analyses: Developing a Fuzzy Neural Network Model for Predicting the Interactive Effects of Complex PAH Mixtures on the CYP1B1 Transcriptional Regulatory Network

M. Mumtaz, P. Bourdillon; P. Ruiz; D. Mellard
Title: Implementation of the Hazard Index Approach in Field Assessment of Chemical Mixtures

P. S. Price, X. Han
Title: Application of a Decision Tree Tool to the Evaluation of Cumulative Risks from Mixtures of Polar Compounds Measured in European Surface Waters

D. T. Szabo, R. R. Shah, L. S. Birnbaum
Title: A Transcriptomics Approach Using HBCB to Prioritize Chemicals and Mixtures for Developmental Neurotoxicity Risk Assessment

S. C. Tilton, L. K. Siddens, S. K. Krueger, A. Larkin, K. M. Waters, D. E. Williams, W. M. Baird
Title: Distinct Cytochrome P450 Regulation by PAH Mixtures in Mouse Skin: Insights on Carcinogenic Mechanisms from Transcriptional Profiling of Tumor Initiation

T. Webster
Title: Toxicity of Mixtures: Mixtures of Endocrine Disruptors: How Similar Must Mechanisms Be for Concentration Addition to Apply?

Best Student Abstract Award

Marc-André Verner, Université du Québec à Montréal
Title: Drug Interference with Biotransformation of Bisphenol A and Nonlyphenol in Rats

Sheppard Martin, University of Georgia
Title: Inhalation Kinetics of Jet Fuel Components in the Rat

Sookwang Lee, Pacific Northwest National Laboratory
Effect of Nicotine Exposure on In Vitro CYP450S-Mediated Metabolism of Chlorpyrifos (CPF) in Sprague-Dawley (S-D) Rats