PL01: Alternatives to Animal Testing
California Cruelty-Free Cosmetics Act Establishes First Law in North America That Bans the Sale of Animal-Tested Cosmetics and Ingredients. Elizabeth Baker, Kristie Sullivan. Physicians Committee for Responsible Medicine, Washington, DC, The United States of America.
Practical Implementation of New Approach Methodologies (NAMs): A Corporate Perspective for Diverse Toxicology Applications. Lawrence Milchak, David Brandwein, Colin Owens. 3M, St. Paul, MN, The United States of America.
Hepatocyte-Like Cells Derived from Human Induced Pluripotent Cells Using Small Molecules: Implications of a Transcriptomic Study. Xiugong Gao, Jeffrey Yourick, Robert Sprando. US FDA/CFSAN, Laurel, MD, The United States of America.
High-Throughput Transcriptomics Using Hepatocyte Spheroids to Identify Chemical-Induced Biological-Response Pathways and Associated Toxicity. Sreenivasa Ramaiahgari1, Scott Auerbach1, Trey Saddler1, Nisha Sipes1, Michael DeVito1, Pierre Bushel2, Alex Merrick1, Paules Richard1, Stephen Ferguson1. 1NIEHS/NTP, Durham, NC, The United States of America 2NIEHS, Durham, NC, The United States of America.
The Cross-Laboratory Testing and Evaluation of Two Liver Microphysiological Systems. Courtney Sakolish1, Yizhong Liu1, Celeste Reese2, Richard DeBiasio2, Felipe Lee-Montiel3, Caleb Lee3, Lawrence Vernetti2, Lansing Taylor2, Kevin Healy3, Ivan Rusyn1. 1Texas A&M University, College Station, TX, The United States of America 2University of Pittsburgh, Pittsburgh, PA, The United States of America 3University of California Berkeley, Berkeley, CA, The United States of America.
In Vitro Model for the Prediction of Respiratory Sensitization. Aline Chary1,2, Charlotte Stoffels1, Tommaso Serchi1, Sébastien Cambier1, Elisa Moschini1, Servane Contal1, Jennifer Hennen2, Janine Ezendam3, Brunhilde Blömeke2, Arno Gutleb1. 1Luxembourg Institute of Science and Technology, Belvaux, Luxembourg 2University Trier, Trier, Germany 3Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Aryl Hydrocarbon Receptor (AhR) Signaling Regulates the Inflammatory Potential of Dendritic Epidermal T Cells. Katja Merches, Charlotte Esser, Kathrin Hochrath, Nadine Teichweyde. IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Cadmium Telluride Quantum Dots Exposure Causes Functional Impairments in Monocyte-Derived Dendritic Cells and Alters CD4+ T Cells Differentiation. Tingting Wei, Tianshu Wu, Meng Tang. Southeast University, Nanjing, Jiangsu, China.
Docosahexaenoic Acid as a Prophylactic Treatment for Chronic Particle-Exposed Balb/c Mice. Paige Fletcher1, Ray Hamilton1, James Pestka2, Andrij Holian1. 1University of Montana, Missoula, MT, The United States of America 2Michigan State University, East Lansing, MI, The United States of America.
Lung Function and Immune Effects in Resident Lung Macrophages following Prenatal Exposure to Sodium Arsenite. Kristal Rychlik, Emily Illingworth, Sarah Attreed, Han Zhang, Jeffrey Loube, Wayne Mitzner, Fenna Sillé. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, The United States of America.
Protective Effect of Resveratrol on the Integrity of Alveolar and Intestinal Epithelial Barrier in Staphylococcal Enterotoxin B–Induced Acute Lung Injury. Hasan Alghetaa, Amira Mohammed, Mitzi Nagarkatti, Prakash Nagarkatti. University of South Carolina School of Medicine, Columbia, SC, The United States of America.
Comprehensive Analysis for Immunological Characteristics of Patients with Malignant Mesothelioma and Diffuse Pleural Thickening. Yasumitsu Nishimura1, Suni Lee1, Naoko Kumagai-Takei1, Hidenori Matsuzaki2, Kei Yoshitome1, Kenzo Okamoto3, Takumi Kishimoto4, Takemi Otsuki1. 1Kawasaki Medical School, Kurashiki, Japan 2Prefectural University of Hiroshima, Shobara, Japan 3Hokkaido Chuo Rosai Hospital, Iwamizawa, Japan 4Okayama Rosai Hospital, Okayama, Japan.
The Sex-Specific Effects of Arsenic on Immune Function, Infectious Disease Risk, and Vaccine Outcomes. Fenna Sillé, Sarah Attreed, Kristal Rychlik, Emily Illingworth, Chloe Kashiwagi, Ashley Fink, Han Zhang, Ian Sanchez, Tyrone Howard, Christopher Heaney, Sabra Klein. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, The United States of America.
Developmental Exposure to Manganese Causes Cognitive Deficits in Rats: Protective Effect of Nutrient Metal Mixture Supplementation. Chand Basha Davuljigari, Srinivasulu Reddy, Rajarami Reddy. Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
The Emerging Dark Side of Nuclear Factor Erythroid 2-related Factor 2 in Chemical Carcinogenesis: Taking Arsenic as an Example. Ruirui Wu1, Ru Sun1, Xiafang Wu1, Huihui Wang1, Jingqi Fu1, Jingbo Pi2, Yuanyuan Xu1. 1China Medical University, Shenyang, Liaoning, China 2China Medical University School of Public Health, Shenyang, Liaoning, China.
Heavy Metal Contamination of Drinking Water Sources and Hepato-renal Toxicities among Residents of a Crude Oil–Contaminated Area in Bayelsa State, Nigeria. Chinyere Usoro1, Caroline Thomas2, Augusta Nsonwu-Anyanwu1. 1University of Calabar, Calabar, Cross River, Nigeria 2Federal Medical Centre, Yenogoa, Bayelsa State, Nigeria.
Determination of Lead (Pb) Exposure on Infants Living around Pb Mining Area in Kabwe, Zambia. Haruya Toyomaki1, John Yabe2, Shouta Nakayama1, Yared Yohannes1,3, Kaampwe Muzandu2, Hazuki Mizukawa4, Yoshinori Ikenaka1,5, Hokuto Nakata1, Takeshi Kuritani6, Mitsuhiro Nakagawa6, Mayumi Ishizuka1. 1Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan 2The University of Zambia, Lusaka, Central, Zambia 3College of Natural and Computational Science, University of Gondar, Gondar, Begemder, Ethiopia 4Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan 5School of Environmental Sciences and Development, North-West University South Africa, Potchefstroom, North West, South Africa 6Graduate School of Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Prenatal Exposure to Toxic Metals Modulates Global and Specific DNA Methylation and Expression of Repair Genes. Nereida Montes-Castro1, Isabel Alvarado-Cruz1, Luisa Torres-Sánchez2, Israel García-Aguiar1, Angel Barrera-Hernández1, Consuelo Escamilla-Núñez2, Luz Maria Del Razo-Jiménez 1, Betzabet Quintanilla Vega1. 1Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico 2National Institute of Public Health, Cuernavaca, Morelos, Mexico.
PL04: Risk and Safety Evaluation
Evaluating Mechanistic Data in Hazard Assessment: Integration of Key Characteristics and Mode of Action. Bette Meek. University of Ottawa, Ottawa, Ontario, Canada.
A New Method to Evaluate Toxicological Data Reliability in Food Safety Risk Assessments. Qian Bian1, Ping Yu1, Jun Wu1, Zhongming Lyn1, Yan Song2, Lei Zhang2, Zhaoping Liu2. 1Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 2China National Center for Food Safety Risk Assessment, Beijing, China.
Development of New Risk Assessment Guideline of Food Contact Materials Based on the TTC Concept in Food Safety Commission of Japan. Atsushi Ono1, Masahiro Nakamoto2, Naofumi Iizuka2, Makiko Isozaki2. 1Okayama University, Okayama, Japan 2Food Safety Commission of Japan, Tokyo, Japan.
Establishment of a Reference Chemical Database to Evaluate In Vitro and In Silico Approaches to Assess Respiratory Sensitization to Facilitate Development of IATA. Kristie Sullivan1, Nancy Baker2, Stella Cochrane3, Steven Enoch4, Janine Ezendam5, Grace Patlewicz6, Ramya Rajagopal3, Erwin Roggen7, Raja Settivari8, Katherina Sewald9. 1Physicians Committee for Responsible Medicine, Washington, DC, The United States of America 2Leidos, Research Triangle Park, NC, The United States of America 3Unilever Safety and Environmental Assurance Centre, Bedford, United Kingdom 4Liverpool John Moores University, Liverpool, United Kingdom 5RIVM, Bilthoven, The Netherlands 6US EPA/NCCT, Research Triangle Park, NC, The United States of America 73RsMC ApS, Lyngby, Denmark 8Corteva Agriscience, Newark, DE, The United States of America 9Fraunhofer ITEM, Hannover, Germany.
The Research of Health Risk Factors in the Field of Occupational Health and Environmental Toxicology in Laboratory Workplaces. Nalinee Sripaung, Areepit Promrat, Satit Namwicha. Bureau of Occupational and Environmental Diseases, Department of Disease Control, Ministry of Public Health, Muang District, Nonthaburi, Thailand.
Do the REACH Derived No-Effect Levels Extend the Landscape of Occupational Exposure Guidance Values? Linda Schenk1,2, Gunnar Johanson1. 1Karolinska Institutet, Stockholm, Sweden 2KTH - Royal Institute of Technology, Stockholm, Sweden.
PL05: Computational Toxicology
How to Choose the Right Cancer Cell Line for Your Research: A Transcriptomes-Guided Approach. Xin Shao, Yang Hu, Jie Liao, Xuechun Chen, Yunru Yu, Lingqi Yu, Xiaoyan Lu, Ni Ai, Yi Wang, Xiaohui Fan. Zhejiang University College of Pharmaceutical Sciences, Hangzhou, Zhejiang, China.
Fit-for-Purpose Use of High-Throughput Toxicokinetics for Predicting Potential Human Health Risk. Nisha Sipes. NIEHS, Research Triangle Park, NC, The United States of America.
In Vivo Toxicity Prediction Modeling with Tox21 Data to Aid Regulatory Sciences. Ruili Huang. NIH/NCATS, Rockville, MD, The United States of America.
A Case Study in Quantitative Generalized Read-Across (GenRA) Predictions Using Acute Oral Toxicity. George Helman1,2, Imran Shah2, Grace Patlewicz2. 1Oak Ridge Institute for Science and Education, Oak Ridge, TN, The United States of America 2US EPA/NCCT, Research Triangle Park, NC, The United States of America.
Using (Q)SAR Models to Inform Drug Safety Assessment. Naomi Kruhlak, Marlene Kim, Christopher Ellis, Lidiya Stavitskaya. US FDA/CDER, Silver Spring, MD, The United States of America.
Reproducibility of Computational Toxicology: The Prerequisite for Regulatory Applications. Huixiao Hong. US FDA/NCTR, Jefferson, AR, The United States of America.
Neurological Risks of Inhaled Incidental Particulates and Engineered Nanomaterials. Krishnan Sriram, Amy Jefferson, Gary Lin, Samuel Stone, Aliakbar Afshari, Walter McKinney, James Antonini, Michael Wolfarth, Dale Porter. NIOSH, Morgantown, WV, The United States of America.
Mitochondrial Respiration and Metal Bioaccumulation in Zebrafish Developmental Stages (Danio rerio) Evaluating Three Functionalized Groups of CdTe Quantum Dot Nanoparticles. Suanne Bosch, Tarryn Botha, Victor Wepener. Water Research Group, Potchefstroom, South Africa.
Development of Physiologically Relevant In Vitro Models for Assessment of Nanoparticle-Induced Physicochemical Property–Dependent Cytotoxicity of Human Lung Cells. Liying Rojanasakul1, Raymond Derk1, Jhy-Charm Soo1, Philip Demokritou2, Dilpreet Singh2, Tiffany Kornberg1,3, Todd Stueckle1, Yon Rojanasakul3, Jayme Coyle1. 1NIOSH, Morgantown, WV, The United States of America 2Harvard University, Boston, MA, The United States of America 3West Virginia University, Morgantown, WV, The United States of America.
Nano ZnO Exposure Alters In Vitro Lipidomic Profiles of Human Immune Cells. Mala Jayamanne1, Paul Wright2, Terence Turney3, Philip Marriott1. 1Monash University, Clayton, Melbourne, Victoria, Australia 2RMIT University, Bundoora, Melbourne, Victoria, Australia 3Monash University, Clayton, Melbourne, Victoria, Australia.
Silver Nanoparticles Promote Procoagulant Activity of Red Blood Cells: A Potential Risk of Thrombosis in Susceptible Population. Yiying Bian, Jin-Ho Chung, Byung Hoon Lee. Seoul National University, Seoul, The Republic of Korea.
CdTe Quantum Dots Increase Microglial Polarization in Mice and Trigger Damage to Hippocampal Neurons. Keyu He, Tianshu Wu, Meng Tang. Southeast University, Nanjing, Jiangsu, China.
K-variant BCHE and Pesticide Exposure: Interactive Genome and Parkinson’s Disease. Mohamed Mosaad Salama1, Thomas Roesler2, Ali Shalash3, Urlich Müller4, Astrid Dempfle5, Gregor Kuhlenbäumer5, Gunter Hoeglinger2, ENND Consortium1. 1Mansoura University, Mansoura, Egypt 2Technical University of Munich, Munich, Germany 3Ain Shams University, Cairo, Egypt 4Justus Liebig University Giessen, Giessen, Germany 5Kiel University, Kiel, Germany.
THC Treatment Improved Neuronal Functions by Decreasing HIV gp120-Mediated Neurotoxicity. Amira Mohammed, Hasan Alghetaa, Prakash Nagarkatti, Mitzi Nagarkatti. University of South Carolina School of Medicine, Columbia, SC, The United States of America.
Manganese-Mycobacterium tuberculosis Interactions: Central and Peripheral Effects. Nick Filipov, Kaori Sakamoto, Tuhina Gupta, Ryan Mote, Robert Hogan, Davis Reardon. University of Georgia, Athens, GA, The United States of America.
Function of LncRNA NR_030777 in Affecting Cell Proliferation and Apoptosis and Protection of Motor Function by Regulating Zfp326/Cpne5 in Nerve Cell Damage Induced by Paraquat. Hongyu Yang1, Qingxia Lin1, Nengzhou Chen1, Zhousong Luo1, Jing Li1, Fuli Zheng1, Qunwei Zhang2, Siying Wu1, Huangyuan Li1. 1Fujian Medical University, Fuzhou, Fujian, China 2University of Louisville, Louisville, KY, The United States of America.
Effect of Silver Nanoparticles on Neural Differentiation in Human iPS Cells. Yasunari Kanda, Shigeru Yamada. National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Effect of MLL Modified H3K4me3 on Aluminum Induced Cognitive Impairment—Both Population and Animal Epigenetic Studies. Qiao Niu. Shanxi Medical University, Taiyuan, Shanxi, China.
PL08: Reproductive and Developmental Toxicology
Determination of Epigenetic Modifications in Fetal Brain Exposed to Methylmercury during Development. Hisaka Kurita, Manami Hatano, Suzuna Go, Kana Matsumoto, Masatoshi Inden, Isao Hozumi. Gifu Pharmaceutical University, Gifu, Japan.
Exposure to Low Doses of 3-Methylcholanthrene Impacts on the Oocyte Integrity without Causing Systemic Cytotoxicity. Eric Rhon Calderón, Rocío Galarza, Alicia Faletti. CEFYBO-CONICET, School of Medicine, University of Buenos Aires, CABA, Argentina.
Downregulation of SDF1/CXCR4 Signaling Mediates Ethanol-Induced Craniofacial Anomalies and Cranial Nerve Defects in Zebrafish Embryos by Disrupting Neural Crest Cell–Placode Interaction. Huadong Fan, Fuqiang Yuan, Jie Liu, Shao-yu Chen. University of Louisville Health Sciences Center, Louisville, KY, The United States of America.
Teratogen Assay Using Gene Expression Profiles of Developmental Regulators in Morphogenetic Aggregates of Human Embryonic Stem Cells. Yusuke Marikawa, Hong-Ru Chen, Vernadeth Alarcon. University of Hawaii John A. Burns School of Medicine, Honolulu, HI, The United States of America.
3- to 7-Ring Polycyclic Aromatic Hydrocarbons Are the Main Inducers of the In Vitro Prenatal Developmental Toxicity Observed with Some Petroleum Substances. Lenny Kamelia1, Laura de Haan1, Hans Ketelslegers2, Ivonne Rietjens1, Peter Boogaard1,3. 1Wageningen University and Research, Wageningen, Gelderland, The Netherlands 2European Petroleum Refiners Association, Brussels, Belgium 3Shell International BV, The Hague, The Netherlands.
Gestational and Lactational Exposure to the Di(2-Ethylhexyl) Phthalate (DEHP) Increases Mammary Gland Weight in Adult Female Rats Potentially by the Peroxisome Proliferator-Activated Receptor (PPAR) Pathway Activation. Bélinda Crobeddu1, Elise Kolasa1, Bernard Robaire2, Isabelle Plante1. 1INRS - Institut Armand-Frappier, Laval, Quebec, Canada 2McGill University, Montréal, Quebec, Canada.