Events

Upcoming Events

Carcinogenomics—Assessing the Tumorigenic Potential of Chemicals Through Genomic Biomarkers to Reduce the Reliance on the Rodent Cancer Bioassay

Webinar

Registration is required for this free webinar.

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As part of the safety assessment for new agrochemicals and pharmaceuticals, the rodent cancer bioassay has been a long-required study for regulatory assessment of carcinogenic hazard and risk. There is growing recognition across broad sectors of the scientific community that the use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceuticals through a weight-of-evidence approach. The goal of this research is to construct and qualify liver transcriptomic biomarkers of key molecular initiating events (MIE) in short-term rat studies that inform on liver tumorigenic risk in the rodent cancer bioassay. This webinar describes a collaborative approach launched to develop and qualify biomarker gene expression panels that measure widely accepted molecular pathways linked to tumorigenesis and their activation levels to predict tumorigenic doses of chemicals from short-term exposures. Success from these efforts will facilitate the transition from current heavy reliance on conventional rodent cancer bioassays to more rapid animal-and-resource-sparing approaches for mechanism-based carcinogenicity evaluation, supporting internal and regulatory decision making.

Speakers:
Chris Corton, PhD, Research Toxicologist, US EPA
Connie Mitchell, PhD, Senior Scientific Program Manager, HESI
Udayan Apte, PhD, Professor, University of Kansas Medical Center

Registration is required for this free webinar.

Register Now

Friday, February 23, 2024

10:00 AM to 11:00 AM
(US EST, UTC -5)


Past Events

Webinar

Weight of Evidence Approach to Assess the Human Carcinogenic Risk of Pharmaceuticals: Overview of The ICH S1B Addendum and Implementation

Hosted by: The SOT Women in Toxicology Special Interest Group and Carcinogenesis Specialty Section

Presenter(s): Alisa Vespa, PhD, Pharmaceutical Drugs Directorate, Health Canada Representative and Arianna Bassan, PhD, Principal Consultant, Innovatune


Webinar Recording
Presentation, Alisa Vespa, PhD
Presentation, Arianna Bassan, PhD

January 31, 2024

Webinar

2023 Carcinogenesis Specialty Section Webinar: Revised Approach for Carcinogenicity Hazard Classification: Potency and Mode of Action Considerations.

Presenter(s): Douglas C. Wolf, DVM, PhD and John Doe, PhD

Webinar Recording

March 6, 2023

Webinar

2022 Carcinogenesis Specialty Section Webinar: Do Per- and Poly-fluoroalkyl Substances (PFAS) Cause Cancer in Humans?

Presenter(s): Ella Atlas, PhD and Andrea Winquist, MD, PhD

Webinar Recording
Presentation, Ella Atlas, PhD
Presentation, Andrea Winquist, MD, PhD

May 24, 2022

Webinar

Integrating Computational Tools into Carcinogenicity Assessments

Presenter(s): Dr. Mark Cronin and Dr. Federica Madia

Webinar Recording
Presentation, Dr. Mark Cronin
Presentation, Dr. Federica Madia

December 14, 2021

Webinar

Fundamentals and Frontiers in Carcinogenesis—4 part Webinar Series

Cancer Biomarkers—February 26, 2021
Webinar Recording
Intro Slides
Presentation, Dr. Jia Sheng Wang

New Tools for Carcinogenicity Assessment—February 19, 2021
Webinar Recording
Intro Slides
Presentation, Dr. Meek Presentation

Cancer Risk Assessment—February 12, 2021
Webinar Recording
Intro Slides
Presentation, Dr. Meek Presentation

Molecular Mechanism of Chemical Carcinogenesis—February 5, 2021
Webinar Recording
Intro Slides
Presentation, Dr. Apte Presentation

February 5–26, 2021

Webinar

Part 2—Modernization of Cancer Risk Assessment



February 2020