CTTSS Events

Hosted by: The SOT Clinical and Translational Toxicology Specialty Section

Speaker(s):
• Hartmut Jaeschke, PhD, ATS, FAASLD, University Distinguished Professor, Chair of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center
• James Dear, PhD, FRCP, Professor, Personal Chair of Clinical Pharmacology, Deanery of Clinical Sciences, University of Edinburgh
• Nena Bowman, PharmD, DABAT, Managing Director and Adjunct Faculty, Tennessee Poison Center and Vanderbilt University Medical Center
• Shashi Ramaiah, DVM, PhD, DACVP, DABT, Vice President, Global Head of Discovery, Investigative and Translational Sciences, Pfizer

The goals of the Society of Toxicology are to provide a network of toxicologists responsible for establishing and securing public health standards and needs to prevent potential harm for current and future generations. One of the major challenges facing human toxicology research is bridging the gaps between scientific discovery and human health—as it is often hindered by limitations in model systems or applicable results. To meet the responsibilities of toxicologists to carry out studies connecting science to human medicine, the spectrum of translational toxicology research has since expanded to closely integrate research to human health. As a main pillar of translational research, clinical research and implementation has since evolved to encompass a wide range of applications in toxicology studies.

Join the Clinical and Translational Toxicology Specialty Section in exploring careers clinical toxicology, highlighting various applications of the specialty by current professionals in the field. This webinar aims to explore the current career possibilities in clinical toxicology while highlighting future prospects in incorporating translational methodologies into toxicology research practices. Through this session, panelists will target key elements of clinical translational toxicology through 1) highlighting their career trajectory in parallel with evolving research interests; 2) addressing the responsibilities and tasks of their respective positions; and 3) discussing current job prospects and strategies for finding the best fit in the field. Along with sharing narratives from current clinical and translational toxicologists, the objectives of this webinar will focus on how trainees and early career scientists can integrate clinical toxicology into their careers and help elucidate the role of clinical and translational toxicologists in an interdisciplinary framework. The webinar will consist of presentations from clinical and translational toxicologists from academia, industry, regulatory, and medical institutes; a discussion of current job prospects available and growing; and time for questions from the audience.

Webinar Recording

Dr. Bowman Slides

Dr. Jaeschke Slides

Dr. Ramaiah Slide

Speaker(s):
Hartmut Jaeschke, PhD, ATS
Jiri Aubrecht, PharmD, PhD
Laura P. James, MD

Acetaminophen (APAP) induced liver toxicity and liver failure remains a serious issue. APAP overdose, both intentional and unintentional, accounts for more than 50% of the overdose related acute liver failure cases in the United States annually. While the pathway for biological activation of APAP is well understood, the mechanisms, diagnosis, clinical presentations, and treatments are less well understood and more variable. A discussion of the basic mechanisms of cell death in mice and the translational application to human hepatocytes and humans in APAP toxicity will set the stage for the webinar. An understanding of these mechanisms may lead to potential new therapeutic targets. Next, liquid biopsies and their use in identifying mechanisms of APAP toxicity in humans, and the use of these various biomarkers for early diagnosis and predicting the potential outcome of APAP toxicity and acute liver failure, will be presented. Finally, a description of the clinical diagnosis of APAP overdose using protein adduct detection methods and applications as well as clinical treatment of liver toxicity will provide a translation of the mechanism to the bedside for patient care and impact. The webinar will end with a panel discussion to further integrate the information presented and encourage interactive learning.

Dr. Jaeschke Slides

Dr. Aubrecht Slides

Dr. James Slide