Archive of Award Recipients

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    • 2020......Dr. Zhenzhen Shi, postdoctoral fellow at Emory University, mentored by Dr. Qiang Zhang. Development of a Virtual Population Model of Thyroid Hormone Regulation for Safety Assessment of Endocrine Disrupting Chemicals
    • 2020......Honesty Tohon, graduate student at University of Montreal, mentored by Dr. Sami Haddad. Estimation of Toluene Exposure in Air from BMA (S-benzylmercapturic acid) Urinary Measures Using a Reverse Dosimetry Approach Based on Physiologically Based Pharmacokinetic Modeling
    • 2019......Axelle Marchand, Université de Montréal
    • 2018......Dr. Yi-Hsien Cheng, Kansas State University, General Physiologically Based Pharmacokinetic Model for Gold Nanoparticles of Different Sizes with Multiple Administration Routes in Rats
    • 2017......Marie-Emilie Willemin, US FDA/NCTR, Characterization of the Modes of Action of Hiocyanate on the Thyroid Hormones Levels Using a Mechanistic Dose-response Model
    • 2016......Rachel Worley, CDC/ATSDR, University of Georgia
    • 2015......Jeremy Leonard, US EPA (Postdoc winner), Development of a Conceptual Module to Investigate Pharmacokinetic Influences when Evaluating Chemicals in Adverse Outcome Pathways"
    • 2015......Axelle Marchand, Université de Montréal (Student winner) Evaluation and Modeling of the Impact of Co-Exposures to Voc Mixtures on Urinary Biomarkers
    • 2014......Huali Wu, The Hamner Institutes for Health Sciences (Postdoc winner) Can the Association between Serum Perfluorooctanoic Acid (PFOA) and Delayed Menarche Be Explained on the Basis of Physiology and Pharmacokinetics?
    • 2013......Zhoumeng Lin, University of Georgia (Postdoc winner) Gestational and Lactational Physiologically-based Pharmacokinetic (PBPK) Models for the Herbicide Atrazine in Rats: Development and Optimization
    • 2012......Kathleen Holm, US EPA (Postdoc winner), Identifying the Sources of Uncertainty in the Process of Reconstructing Exposures to Carbaryl Using Exposure-to-Dose Modeling
    • 2010......M. Marc-André Verner of the Université du Québec à Montréal, Montréal QC, Canada, Unveiling Associations between Lactational Exposure to PCBs and Infant Neurodevelopment: Use of PBPK Modeling vs Traditional Exposure Metrics
    • 2010......Sheppard Martin of the University of Georgia, for his presentation Progress in Development of a PBPK Model for Aviation Fuels
    • 2009......M. Marc-André Verner of the Université du Québec à Montréal, Montréal, QC, Canada, A PBPK Modeling Tool to Predict Infant Internal Exposure to Persistent Organic Chemicals and Assess Critical Periods of Susceptibility
    • 2009......M. Marc-André Verner of the Université du Québec à Montréal, Montréal, QC, Canada, (Postdoc winner) A PBPK Modeling Tool to Predict Infant Internal Exposure to Persistent Organic Chemicals and Assess Critical Periods of Susceptibility
    • 2020......Qiran Chen, graduate student at Indiana University, mentored by Dr. Kan Shao. A Novel Dose-Response Framework with Quantitatively Integrated MOA Information
    • 2019......Wei-Chun Chou and Zhoumeng Lin. Bayesian, Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) to Characterize the Interspecies Uncertainty between Mice, Rats, Monkeys, and Humans: Development and Performance Verification. Environ Int. 2019.
    • 2018......Dr. Yi-Hsien Cheng, Kansas State University, Probabilistic Risk Assessment of Gold Nanoparticles by Integrating In Vitro and In Vivo Toxicity with Physiologically Based Pharmacokinetic Modeling
    • 2020......Kazi Tasneem, graduate student at Vanderbilt University. Toxicokinetic Model Predicts Cellular Exposure in Organon-Chip Microdevices
    • 2019......Dr.Longfei Chao
    • 2018......Dr. Miao Li, Kansa State University, Application of Population Physiologically Based Pharmacokinetic Model for Penicillin G in Dairy Cows to Facilitate Food Safety Assessment
    • 2017.....Jeremy Leonard, US EPA, Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding
    • 2020......Wei-Chun Chou and Zhoumeng Lin. Bayesian Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) to Characterize the Interspecies Uncertainty between Mice, Rats, Monkeys, and Humans: Development and Performance Verification. Environ Int. 2019.
    • 2020......Serena Manganelli, Alessandra Roncaglioni, Kamel Mansouri, Richard S. Judson, Emilio Benfenati, Alberto Manganaro, Patricia Ruiz. Development, Validation and Integration of In Silico Models to Identify Androgen Active Chemicals. Chemosphere. 2019.
    • 2019......Brandon N, Dionisio KL, Isaacs K, Tornero-Velez R, Kapraun D, Setzer RW, Price PS
    • 2018......Bois FY, Ochoa JGD, Gajewska M, Kovarich S., Mauch K., Paini A., Pery A., Benito JVS, Teng S, and Worth A. Multistage Modeling Aapproaches for Aassessing Ccosmetic IingredientsSsafety. Toxicology 392 (2017) 130–139.
    • 2018......Worley RR, Yang X., Fisher J., Physiologically Based Pharmacokinetic Modeling of Human Exposure to Perfluorooctanoic Acid Suggests Historical Non Drinking-Water Exposures Are Important for Predicting Current Serum Concentrations. Toxicology and Applied Pharmacology 330 (2017), 9–21.
    • 2017......Zhang Q., Kline D.E., Bhattacharya S., Crawford R.B., Conolly R.B., Thomas R.S., Andersen M.E., Kaminski N.E,. All-Or-None Suppression of B Cell Terminal Differentiation by Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. Toxicol Appl Pharmacol. 2013, 268(1): 17–26.
    • 2017......Sluka JP, Fu X, Swat M, Belmonte JM, Cosmanescu A, Clendenon SG, Wambaugh, JF, and Glazier, JA., A Liver–Centric Multiscale Modeling Framework for Xenobiotics. PLoS ONE 11(9): e0162428.
    • 2015......Yang Y,. Nadanaciva S,. Will Y,. Woodhead J.L,..Howell BA, Watkins PB.., Siler S.Q., MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics. Pharm Res. 2015, 32(6):1975–92.
    • 2014......Sluka JP, Fu X, Swat M, Belmonte JM, Cosmanescu A, Clendenon SG, Wambaugh, JF, and Glazier, JA., A Liver–Centric Multiscale Modeling Framework for Xenobiotics. PLoS ONE 11(9): e0162428.
    • 2013......Corley R.A., Kabilan S., Kuprat A.P., Carson J.P., Minard K.R., Jacob R.E., Timchalk C., Glenny R., Pipavath S, Cox .T, Wallis C.D., Larson R.F., Fanucchi MV, Postlethwait E.M., Einstein D.R., Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human. Toxicol Sci. 2012, 128(2):500–16.
    • 2012......Yinderliter P.M., Price P.S., Bartels M.J., Timchalk C., Poet T.S., Development of a Source-to-Outcome Model for Dietary Exposures to Insecticide Residues: An Example Using Chlorpyrifos. Regul Toxicol Pharmacol. 2011, 61(1):82–92.
    • 2011......Nicholas Luke, Reeder Sams, Michael DeVito, Rory Conolly, Hisham El-Masri, Development of Quantitative Model Incorporating Key Events in a Hepatotoxic Mode of Action to Predict Tumor Incidence
    • 2008......Zhang Q. and Andersen M.E., Dose Response Relationship in Anti-Stress Gene Regulatory Networks. PLoS Comput Biol. 2007, 3(3): e24.
Honorable Mention
    • 2020......Han A.A., Timchalk C., Carver Z.A., Weber T.J., Tyrrell K.J., Sontag R.L., Gibbins T., Chrisler W.B., Weitz K.K., Du D., Lin Y., Smith J.N. Physiologically Based Pharmacokinetic Modeling of Salivary Concentrations for Noninvasive Biomonitoring of 2,4-Dichlorophenoxyacetic Acid (2,4-D). Toxicol Sci. 2019.
    • 2020......Ring C.L., Arnot J.A., Bennett D.H., Egeghy P.P., Fantke P., Huang L., Isaacs K.K., Jolliet O., Phillips K.A., Price P.S., Shin H.M., Westgate J.N., Setzer R.W., Wambaugh J.F. Consensus Modeling of Median Chemical Intake for the US Population Based on Predictions of Exposure Pathways. Environ Sci Technol. 2019.
    • 2018......M. Andersen, M. Black, J. Campbell, S. Pendse, H. Clewell III, L. Pottenger, J. Bus, D. Dodd, D. Kemp, and P. McMullen, Combining Transcriptomics and Pbpk Modeling Indicates a Primary Role of Hypoxia and Altered Circadian Signaling in Dichloromethane Carcinogenicity in Mouse Lung and Liver. Toxicology and Applied Pharmacology 332 (2017), 149–158.
    • 2018......S. Borghoff, C. Ring, M. Banton, and T. Leavens, Physiologically Based Pharmacokinetic Model for Ethyl Tertiary‐Butyl Ether and Tertiary‐Butyl Alcohol in Rats: Contribution of Binding to α2u? Globulin in Male Rats and High‐Exposure Nonlinear Kinetics to Toxicity and Cancer Outcomes. Journal of Applied Toxicology 27 (2017), 621–640.
    • 2018......S. Ramoju, D., Mattison, B. Milton, D. McGough, N. Shilnikova, H. Clewell, M. Yoon, M Taylor, D. Krewski, and M. Andersen, C. Ring, R. Pearce, R. Setzer, B. Wetmore and J. Wambaugh, The Application of Pbpk Models in Estimating Human Brain Tissue Manganese Concentrations.Neurotoxicology 58 (2017), 226–237.
    • 2018......C. Ruark, G. Song, M. Yoon, M. Verner, M Andersen, H. Clewell III, and M Longnecker, Quantitative Bias Analysis for Epidemiological Associations of Perfluoroalkyl Substance Serum Concentrations and Early Onset of Menopause. Environment International 99 (2017) 245–254.

    • 2018......J. Smith, Z. carver, T. Weber and C. Timchalk, Predicting Transport of 3,5,6-Trichloro-2-Pyridinol into Saliva Using a Combination Experimental and ComputationalAproach. Toxicological Sciences 157(2) (2017), 438–450.
    • 2018......T. Zurlinden and B. Reisfeld, Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling Eur J Drug Metab Pharmacokinet 42 (2017), 143–153.
    • 2015......Bogen K.T., Mechanistic Models Fit to ED001 Data on >40,000 Trout Exposed to Dibenzo[A,L]pyrene Indicate Mutations Do Not Drive Increased Tumor Risk. Dose Response. 2014, 12(3):386–403.
    • 2015...... Wetmore B.A., Allen B., Clewell H.J. 3rd, Parker T., Wambaugh J.F., Almond L.M., Sochaski M.A., Thomas R.S., Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. Toxicol Sci. 2014, 142(1):210–24.
    • 2015...... Yoon M., Kedderis G.L., Yan G.Z., Clewell H.J. 3rd. Use of In Vitro Data in Developing a Physiologically Based Pharmacokinetic Model: Carbaryl as a Case Study. Toxicology. 2015, 332:52–66.
    • 2015...... Li Z., Sun B., Clewell R.A., Adeleye Y., Andersen M.E., Zhang Q., Dose-response modeling of Etoposide-induced DNA damage response. Toxicol Sci. 2014, 137(2):371-84.
    • 2014......Strikwold M., Spenkelink B., Woutersen R.A., Rietjens I.M., Punt A., Lumen A., Mattie D.R., and Fisher J.W.
    • 2013......Jones, Kleinstreuer, Verner
2017......Anteneh Assefa Desalegn, EU JRC, A Physiologically Based Pharmacokinetic Modeling of 5nm Cerium Oxide Nanoparticles in Intravenously Infused Rats
2011......Anne Loccisano, Development of Human Gestation and Lactation PBPK Models for Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate
2003......Micaela Reddy, Colorado State University (1st Place), Julia Gohlke, University of Washington (2nd Place)
2002......Claude Emond, A Physiological Pharmacokinetic Model Based on Tissue Lipid Content for Simulating Inhalation Pharmacokinetics of Highly Lipophilic Volatile Organic Chemicals