Announcements

IRSS Launches a New E-Journal Club:

The main aim of this E-journal Club is to discuss and facilitate the review of a specific research study/article and stimulate discussions for implications/relevance to inhalation toxicology.

Overall Time Duration: 45 mins and 15 mins for discussions

Aims

The journal clubs will meet quarterly for approximately 30–45 mins or one hour to review current research articles relevant to IRSS-SOT. Research findings will be presented and discussed.

The general purpose of this E-journal club is to facilitate the review of a specific research study/article and to discuss implications/relevance of the study to inhalation toxicology.

Objectives

  • Providing insight on hot/timely published papers in the area of inhalation toxicology relevant to basic/translational/clinical research
  • Introducing new/emerging concept (or even older concept/paradigm) in inhalation toxicology
  • Keeping abreast and share of new knowledge
  • Discuss methodologies and interpret results
  • Questions and discussion points to stimulate a journal club discussion
  • Bringing a forum for junior and senior researchers to share ideas, and
  • Foster new collaborations

Schedule ~30–45 mins or one hour (quarterly)

Plans/Format

  • Select articles via the members of the IRSS or solicit articles from members of IRSS
  • Identify the first and senior authors of the paper as a featured discussant
  • Distribute the notification via SOT headquarter
  • Post a copy of the research article (only the reference) for journal club discussion
  • Identify a facilitator for discussion
  • Hold the journal club

Overall, the webinar (~45 mins duration) will highlight and present the findings on using exposomics to assess cumulative risks and understanding the cause of disease, role of exposome and exposomics and their interplay in life-course health and disease with emphasis on inhalation toxicology.

The webinar is unique and will serve as a forum for novel approaches related to inhalation toxicology, foster integration of other scientific disciplines and specialties, promote integration and transformation of exposure science in toxicology, understand toxicological impacts on public health, and initiate discussion on environmental health issues for policy regulation.

A broad range of society members will be benefited from this newly launched E-journal club.

Chairs:

  • Irfan Rahman, PhD, Professor, University of Rochester, Rochester, NY
  • Matthew Campen, PhD, Professor, University of New Mexico, Albuquerque, NM

Panelists/Moderators:


Proposed Events

Gender Differences in Murine Pulmonary Responses Elicited by Cellulose Nanocrystals
Shvedova AA1,2, Kisin ER3, Yanamala N3, Farcas MT3, Menas AL3, Williams A4, Fournier PM5, Reynolds JS6, Gutkin DW7, Star A5, Reiner RS8, Halappanavar S4, Kagan VE. Part Fibre Toxicol. 2016 Jun 8;13(1):28. doi: 10.1186/s12989-016-0140-x.

This article will have pros and cons of the study:

  • Pro: Anna Shvedova
  • Con: Jo’Anne Shatkin

Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain
Patchin ES, Anderson DS, Silva RM, Uyeminami DL, Scott GM, Guo T, Van Winkle LS, and Pinkerton KE. Environ Health Perspect. 124:1870–1875; 2016.


Upcoming Events

IRSS Webinar: Novel applications for a noninvasive sampling method of the nasal mucosa in inhalation toxicology

Tuesday, October 23, 2018 EDT 12 Noon (Overall time duration: 45 minute presentation;15 minute discussion)

Register **Registration for this event is required.**

Event number: 739 978 018


Speakers:
Meghan Rebuli, PhD and Ilona Jaspers, PhD
University of North Carolina, Chapel Hill, NC

Chair:

  • Irfan Rahman, PhD
    Professor, University of Rochester, Rochester, NY
    Irfan_Rahman@urmc.rochester.edu
  • Matthew J Campen, PhD, MSPH
    Regents' Professor of Pharmaceutical Sciences Chair,
    Environmental Health Signature Program KL2 Program Director University of New Mexico, Albuquerque, NM
    MCampen@salud.unm.edu

The webinar entitled, “Non-invasive Nasal Mucosa Sampling Technique: Uses in Toxicology,” presents and demonstrates the non-invasive nasal mucosa sampling technique described in Rebuli et al (2017) Novel applications for a non-invasive sampling method of the nasal mucosa. Am J Physiol Lung Cell Mol Physiol. doi: 10.1152/ajplung. 00476.2016. This method was specifically designed to collect concentrated and replicable samples from the nasal mucosa and improve on the current gold standard, nasal lavage. This method because of its quick and non-invasive nature is easily adaptable to epidemiological studies as a biomarker collection technique, field studies because of its stable capture of proteins, and in the clinic in a variety of populations. This webinar will allow us to share this technique with others in the field of respiratory toxicology and potentially facilitate new translational research.

The second part of the webinar will describe current research using the technique and innovative ways to utilize the technique to answer research questions.  Examples include detection of low abundance cytokines and chemokines, detection of viral particles, and analysis of nasal microbiome, protease activity, and proteomics.

A broad range of society members will benefit from this webinar.

Audio Conference Information:

To receive a call back, provide your phone number when you join the event, or call the number below and enter the access code.
Call-in toll-free number (US/Canada): 1.866.469.3239
Call-in toll number (US/Canada): 1.650.429.3300
Show all global call-in numbers
Show toll-free dialing restrictions
Access code: 739 978 018

 


Past Events

IRSS Webinar: 3D Organ-on-Chip Framework and Translational Research by Environmental Exposures in Inhalation Toxicology

Thursday, June 21, 2018 at 12:00 Noon

Speaker: Kambez H. Benam, Assistant Professor, University of Colorado, Aurora, CO

Chair: Irfan Rahman, PhD, Professor, University of Rochester, Rochester, New York; and Matthew J Campen, PhD, MSPH, Regents' Professor of Pharmaceutical Sciences Chair, Environmental Health Signature Program KL2 Program Director University of New Mexico, Albuquerque, NM

Speaker: Kambez H. Benam, PhD, Professor, Rollins School of Public Health, Emory University, Atlanta, Georgia

No Recording Available for this Webinar

Development of new therapeutics for pulmonary disorders, and advancement in our understanding of inhalational toxico-pathology have been significantly hindered by challenges to study organ-level complexities of human lung in vitro. Moreover, clinical relevance of widely used animal models of respiratory diseases such as chronic obstructive pulmonary disease (COPD), which poses a huge public health burden, is questionable. Here, we applied a tissue microengineering approach to create a human lung "Small Airway-on-a-Chip" that supports full differentiation of a pseudostratified mucociliary bronchiolar epithelium from normal or diseased donors underlined by a functional microvascular endothelium.

IRSS: Adverse Outcome Pathway Framework in Inhalation and Respiratory Toxicology

Tuesday, February 6, 2018 at 12:00 Noon

Speaker: Sabina Halappanavar, PhD Research Scientist, Genomics and Nanotoxicology Laboratory Mechanistic Studies Division, Health Canada

IRSS: E-Journal Club

Monday, October 16, 2017, 11:00 AM

Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans.
Miller DB, Ghio AJ, Karoly ED, Bell LN, Snow SJ, Madden MC, Soukup J, Cascio WE, Gilmour MI, Kodavanti UP.
Am J Respir Crit Care Med. 2016 Jun 15;193(12):1382–1391. doi: 10.1164/rccm.201508-1599OC

Speaker: Urmila Kodavanti

Moderators: Andrea De Vizcaya-Ruiz, PhD; and Irfan Rahman, PhD

Recording | Presentation Slides

IRSS Webinar: Exposomes and Exposomics in Inhalation Toxicology

Tuesday, February 14, 2017, 2:00 PM EST

Chair: Irfan Rahman, PhD, Professor, University of Rochester, Rochester, New York
Co-Chairs/Moderators: Dean Jones, PhD, Professor, Emory University, Atlanta, Georgia; and Gunter Oberdorster, PhD, Professor, University of Rochester, Rochester, New York

Speaker: Gary W. Miller, PhD, Professor, Rollins School of Public Health, Emory University, Atlanta, Georgia

Webinar Recording | Presentation Slides

Exposome is defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to health (CDC). The exposome encompasses life-course environmental exposures (including lifestyle factors) from the prenatal period onwards. It is the cumulative measure of environmental influences and associated biological responses throughout the lifespan, including exposures from the environment, diet, behavior, and endogenous processes. This webinar will provide the state-of-the-art approaches as well as the recent developments on exposomes and exposomics in inhalation toxicological sciences. Further, it will provide the information on the role of the exposome and genome (exposomics) and their interplay in life-course health and disease by integrating inhalation toxicology.