Past Award Recipients

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004

2018 Award Recipients

Perry J. Gehring Best Postdoctoral Fellow Abstract Award

Tara Raftery Catron, Advisor: Tamara L. Tal
US EPA, Research Triangle Park, NC, Exploring the Role of Host-Associated Microbiota as Mediators of Bisphenol Chemical Toxicity in Zebrafish.

Perry J. Gehring Best Graduate Student Abstract Award

Laura E. Ewing, Advisors: Igor Koturbash & Annie Lumen
University of Arkansas for Medical Sciences, Little Rock, AR
Dose-Response Effects of Dietary Methionine Intake on Radiation-Induced Toxicity: An Experimental and Computational Study.

Robert J. Rubin Student Travel Award*

Jalissa Nguyen Wynder, Advisor: William Ricke
University of Wisconsin-Madison, Madison, WI; ILSI North America, Washington, DC;
Evaluating the Applicability of Read-Across Tools and High-Throughput Screening Data for Food Relevant Chemicals.
*Joint award with Mechanisms Specialty Section

John Doull Award

Samantha C. Faber, Advisor: Shaun D. McCullough
University of North Carolina at Chapel Hill, Chapel Hill, NC.
Diesel Exhaust Particles Downregulate PI3K/Akt/mTOR Signaling and Mitochondrial Bioenergetics in a Novel Organotypic Model of the Airway Microenvironment.

Andersen Clewell Trainee Award**

Yi-Hsien Cheng, Advisor: Zhoumeng Lin
Kansas State University, Manhattan, KS.
Probabilistic Risk Assessment of Gold Nanoparticles by Integrating In Vitro and In Vivo Toxicity with Physiologically-Based Pharmacokinetic Modeling.
**Joint award with Biological Modeling Specialty Section

2017 BEST ABSTRACT AWARD WINNERS

Best Abstract
Broad Application of a Probabilistic Dose-Response Framework to Improve Chemical Risk Assessment.
W.A. Chiu1, Q. Ouyang¹, C. Dalaijamts¹, D. Axelrad², C. Dockins², and G. Paoli³.
¹Texas A&M University, College Station, TX; ²US EPA, Washington, DC; and ³Risk Sciences International, Ottawa, ON, Canada.

“TOP TEN” Abstracts

A Tool for Systematic Integration of Traditional and New Approach Methods for Prioritizing Chemical Lists.
R. Judson, A. Williams, C. Grulke, and R. Thomas.
US EPA, Research Triangle Park, NC.

Simulating Time Saved for Manual Screening of Literature for IRIS Assessments Using Text Analytics
M. Cawley, A. Varghese, H. Hubbard, and C. Henning.
ICF, Durham, NC. Sponsor: J. Wignall

Developmental and Reproductive Toxicology: Risk-Based Reference Values.
B. Gadagbui¹, A. Rak², A. Maier¹, and M. Dourson¹.
¹Risk Science Center, University of Cincinnati, Cincinnati, OH; and ²Noblis, Inc., Falls Church, VA.

Probabilistic Health Hazard Assessment of Cleaning Product Ingredients in All-Purpose Cleaners.
D. Dinh¹, Z. Wang¹, and B.W. Brooks¹,².
¹Baylor University, Waco, TX; and ²Institute of Biomedical Studies, Waco, TX.

Application of Quantitative Approaches to Assess Uncertainties in the Development of Toxicity Values: A Case Study Involving the Reference Dose (RfD) for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD).
D. Wikoff¹, P. Goodrum², L. Haws³, and R. Budinsky⁴.
¹ToxStrategies, Asheville, NC; ²Integral, Fayetteville,
NY; ³ToxStrategies, Austin, TX; and ⁴The Dow Chemical Company, Midland, MI.

The Future of Agrochemical Risk Assessment: Establishing a Platform for Early Estimation of Chronic Dietary Exposure for Agrochemicals.
Z. Zhang, P. Geurs, and Z. Yan.
Dow AgroSciences, Indianapolis, IN.

The Future of Agrochemical Risk Assessment: Framework for Conducting Chronic Risk Assessment with Enhanced Short-Term Toxicological Studies and Significantly Reduced Residue Trial Studies.
Z. Yan¹, K. Johnson², C. Terry¹, X. Wang1, L. Murphy², P. Geurs¹, Z. Zhang¹, and R. Rasoulpour¹.
¹Dow AgroSciences, Indianapolis, IN; and ²The Dow Chemical Company, Midland, MI.

Application of Collaborative Analysis Methods to Address Human Health Risk Assessment Decisions.
A. Maier, J. Patterson, and O. Ogbonnaya.
University of Cincinnati, Cincinnati, OH.

A General Physiologically-Based Pharmacokinetic Model for Gold Nanoparticles of Different Sizes with Multiple Administration Routes in Rats.
Y. Cheng¹, J.E. Riviere1, N.A. Monteiro-Riviere², W.G. Kreyling³, and Z. Lin¹.
¹Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, Kansas State University, Manhattan, KS; ²Nanotechnology Innovation Center of Kansas State (NICKS), Department of Anatomy and Physiology, Kansas State University, Manhattan, KS; and ³German Research Center for Environmental Health, Institute of Epidemiology², Munich, Germany

RASS Best Published Papers in Risk Assessment

Best Published Paper Advancing the Science of Risk Assessment Award (tie)

Katherine A. Phillips, John F. Wambaugh, Christopher M. Grulke, Kathie L. Dionisioc, and Kristin K. Isaacs. High-throughput screening of chemicals as functional substitutes using structure-based classification models. Green Chem., 2017, 19, 1063

Julia E. Rager, Scott S. Auerbach, Grace A. Chappell, Elizabeth Martin, Chad M. Thompson, and Rebecca C. Fry. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem. Res. Toxicol, published online on September 19, 2017.

Best Published Paper Demonstrating an Application of Risk Assessment Award

Richard A. Becker, David A. Dreier, Mary K. Manibusan, Louis A. (Tony) Cox, Ted W. Simon, and James S. Bus. How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? Regulatory Toxicology and Pharmacology 90 (2017) 185-196.

2017 Award Recipients

John Doull Award

Tanzir B. Mortuza¹, J. Pang¹, T.S. Osimitz², M.R. Creek³, B.S. Cummings¹, J.V. Bruckner¹, and C.A. White¹. ¹University of Georgia, Athens, GA; ²Science Strategies, LLC, Charlottesville, VA; and ³Valent, Dublin, CA. Age-dependent Toxicokinetics (TK) of Trans-Permethrin (TRANS) in Adult and Juvenile Sprague-Dawley (SD) Rats
Abstract # 2665 in Poster Session: Pesticides
Wednesday, March 15; 9:30 AM to 12:45 PM
Advisor: James V. Bruckner

Perry Gehring Postdoctoral Award

Fabian A. Grimm¹, W. Chiu¹, N.H. Hsieh¹, C. Dalaijamts¹, S. Burnett¹, B. Anson², A. Wright¹, F. Wright³, and I. Rusyn¹. ¹Texas A&M University, College Station, TX; ²Cellular Dynamics International, Madison, WI; and ³North Carolina State University, Raleigh, NC. Diversity in a dish: A population-based organotypic human in vitro model for cardiotoxicity testing.
Abstract #3223 in Poster Session: Emerging Technologies
Thursday, March 16; 8:30 AM to 11:45 AM
Advisor: Ivan Rusyn

Perry Gehring Student Award

Abhishek Venkatratnam University of North Carolina at Chapel Hill, Chapel Hill, NC. A population-wide study of metabolism and toxicodynamics of trichloroethylene using Collaborative Cross (CC) mouse panel provides critical insights into the mechanisms of inter-individual variability.
Abstract #2482 in Poster Session: Disposition/Pharmacokinetics
Wednesday, March 15; 9:30 AM to 12:45 PM
Advisor: Ivan Rusyn

Honorable Mention
Gopi Gadupudi¹, W.D. Klaren¹, A.K. Olivier², A.J. Klingelhutz¹, and L.W. Robertson¹. ¹University of Iowa, Iowa City, IA; and ²Mississippi State University, Mississippi State, MS. Diminished Phosphorylation of CREB Is a Key Event in the Dysregulation of Gluconeogenesis, Glycogenolysis, and Fatty Acid Oxidation in PCB126 Hepatotoxicity.
Abstract #2517 in Poster Session: Liver 1: Mechanisms and Translational Biomarkers
Wednesday, March 15; 9:30 AM to 12:45 PM
Advisor: Larry W. Robertson

Robert J. Rubin Student Travel Award

Yvonne Chang, D.A. Sampson, L.K. Siddens, C.V. Lohr, S.L. Massey, Simonich, and S.C. Tilton. Oregon State University, Corvallis, OR. PAHs Differentially Regulate Transcription in Human 3D Bronchial Epithelium Abstract #2779 in Poster Session: Alternatives to Mammalian Models II
Wednesday, March 15; 1:15 PM to 4:30 PM
Advisor: Susan C. Tilton

RASS Trainee Award Award

Joseph Cichocki¹, S. Furuya¹, I. Pogribny², W. Chiu¹, D. Threadgill¹, and I. Rusyn¹. ¹Texas A&M University, College Station, TX; and ²US FDA/NCTR, Jefferson, AR. Non-Alcoholic Fatty Liver Disease as a Modifier of Perchloroethylene-Induced Toxicity
Abstract #2512 in Poster Session: Liver 1: Mechanisms and Translational Biomarkers
Wednesday, March 15; 9:30 AM to 12:45 PM Advisor: Ivan Rusyn

2016 BEST ABSTRACT

Cross-Species Integration of Human Health and Ecological Endpoints Using the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Advance Risk Assessment.
D.E. Hines, S.W. Edwards, R.B. Conolly, and A.M. Jarabek. US EPA, Durham, NC.
Abstract #2827 in Poster Session: Risk Assessment Strategies and Applications, Wednesday Afternoon, March 15 1:15 PM to 4:30 PM

“TOP TEN” Abstracts

Linking High Resolution Mass Spectrometry Data with Exposure and Toxicity Forecasts to Advance High-Throughput Environmental Monitoring
Julia E. Rager¹, Mark J. Strynar², Shuang Liang¹, Rebecca McMahen¹, Ann M. Richard³, Christopher M. Grulke⁴, John F. Wambaugh³, Kristen K. Isaacs², Richard Judson³, Antony J. Williams³, Jon R. Sobus². ¹US EPA, ORISE, Research Triangle Park, NC; ²NERL, US EPA, Research Triangle Park, NC; ³NCCT, US EPA, Research Triangle Park, NC; ⁴Lockheed Martin, Research Triangle Park, NC. Abstract #3539 in Emerging Technologies, Thursday Morning, March 17

The Most Scientifically-Supported Approach for Assessing the Carcinogenicity of Oral Exposure to Hexavalent Chromium: Non-Linear, Non-Threshold versus Threshold Approaches
Joseph T. Haney. Toxicology Division, Texas Commission on Environmental Quality, Austin, TX. Abstract #1536 in Metal Toxicity, Monday Afternoon, March 14

Extrapolating Salivary Acinar Cell In Vitro Pesticide Transport to Whole Animals Using Computational Modeling
Charles Timchalk, Zana A. Carver, Thomas J. Weber, Jordan N. Smith. Pacific Northwest National Laboratory (PNNL), Richland, WA. Abstract #1129 in Biomonitoring, Monday Morning, March 14

An Approach to Skin Sensitization Quantitative Risk Assessment using a Bayesian Integrated Testing Strategy to Derive Potency
Cynthia Ryan¹, Joanna Jaworska², Petra Kern³, G. Frank Gerberick¹. ¹The Procter & Gamble Company, Mason, OH; ²The Procter & Gamble Company, Strombeek-Bever, Belgium; ³The Procter & Gamble Company, Beijing, China. Abstract #2195 in Alternative Models for Ocular and Skin Toxicity, Tuesday Afternoon, March 15

A Next Generation Benchmark Dose Computation System
Kan Shao¹, Andy Shapiro². ¹Department of Environmental Health, Indiana University, Bloomington, IN; ²Independent consultant, Durham, NC. Abstract #2165 in Risk Assessment 1, Tuesday Morning, March 15

An Evaluation of Transplacental Carcinogenesis for Human Health Risk Assessment
Brenda Foos¹, Michelle Mabson², John Rogers³, Bob Sonawane¹, Gary Ginsberg⁴. ¹US Environmental Protection Agency, Washington, DC; ²Oak Ridge Institute for Science and Education, Washington, DC; ³US Environmental Protection Agency, Research Triangle Park, NC; ⁴Connecticut Department of Health, Hartford, CT. Abstract #2717 in Risk Assessment 3, Wednesday Morning, March 16

Multimodal Screening of Functional and Structural Drug Toxicities Using Human Stem Cell-Derived Cardiomyocytes
Mathew Brock, Julia Heidmann, Ariel Kauss, Dinah Misner. Safety Assessment, Genentech, South San Francisco, CA. Abstract #1743 in Pluripotent Stem Cells in Cardiovascular Research, Monday, March 14 (3:20 pm)

A Case Study on the Utility of a Tiered Surrogate Approach in Quantitative Risk Assessment of 2,4,6-Trinitrophenol
Lucina E. Lizarraga¹, Q. Jay Zhao². ¹Oak Ridge Institute for Science and Education, Cincinnati, OH; ²U.S. EPA, National Center for Environmental Assessment, Cincinnati, OH. Abstract #2160 in Risk Assessment 1, Tuesday Morning, March 15

Developing An In Vitro Assay To Measure Key Signaling Events In Estrogen-initiated Pathways and Guide Risk Assessment
Michelle M. Miller, Daniel L. Doheny, Pergentino Balbuena, Susan M. Ross, Chad Deisenroth, Rebecca A. Clewell, The Hamner Institutes for Health Sciences, RTP, NC. Abstract #1867 in Endocrine Toxicology, Tuesday Morning, March 15

2016 Award Recipients

John Doull Award

Julia Tobacyk, Michele La Merrill, Shaoke Luo, and Alison H. Harrill. University of Arkansas, Little Rock, AS. The Role of Genetic Background on Adverse Health Effects due to Prenatal Exposure to Environmental Obesogen Tributyltin. Abstract # 2545 in Platform Session: Qualification of “New” DART Tools for Hazard Identification. Tuesday, March 15, 2:00 pm. Advisor: Alison Harrill

Perry Gehring Postdoctoral Award

Marjory Moreau and A. Nong. Health Canada, Ottawa, ON. Comparison of Hexabromocyclo-dodecane (HBCD) Biomonitoring Data and High Throughput Screening Dose-Responses Using Pharmacokinetic Modeling. Abstract # 3617 in Poster Session: Late Breaking 2. Thursday, March 17, 9:30 am to 12:45 pm. Advisor: Andy Nong

Perry Gehring Student Award

Brittany A. Weldon, Elaine M. Faustman, Günter OberdÖrster, Tomomi Workman, William C. Griffith Carsten Kneuer, Il Je Yu. University of Washington, Seattle, WA. A Framework for the Derivation of a Health-Based Occupational Exposure Limit for Silver Nanoparticle. Abstract # 1498 in Poster Session: Nanotoxicology: General. Monday, March 14, 1:15 pm to 4:30 pm. Advisor: Elaine M. Faustman

Robert J. Rubin Student Travel Award

Dana Lauterstein, Pamella Tijerina, Kevin Corbett, Terry Gordon, Catherine B Klein, Judith T Zelikoff. NYU School of Medicine Tuxedo, NY. E-cigarette Exposure Induces Neuro-alterations In Mice Exposed During Early Life. Abstract #1165 in Poster Session: Neurotoxicology—Developmental Neurotoxicity. Monday, March 14, 9:30 am to 12:45 pm.

Kristin M Bircsak, N. Memon, B.I. Weiberger, A.M. Vetrano, L.M. Aleksunes. Rutgers University, New Brunswick, NJ. Interindividual Regulation of the BCRP/ABCG2 Transporter in Human Term Placentas. Abstract #3235 in Poster Session: Reproductive Toxicology Wednesday, March 16, 1:15 pm to 4:30 pm

2016 BEST ABSTRACT

Innovative Strategies for Agrochemical Safety Assessments: Use of Toxicokinetic Data for Arylex™ and Rinskor™

Lynea Murphy¹, Sabitha Papineni², Manoj Aggarwal², Michael J. Bartels¹, Reza Rasoulpour²
¹The Dow Chemical Company, Midland, MI; ²Dow AgroSciences, Indianapolis, IN.
Abstract #2458 in Non-Pharmaceutical Safety Assessment, Tuesday Afternoon, March 15

“TOP TEN” Abstracts

Linking High Resolution Mass Spectrometry Data with Exposure and Toxicity Forecasts to Advance High-Throughput Environmental Monitoring
Julia E. Rager¹, Mark J. Strynar², Shuang Liang¹, Rebecca McMahen¹, Ann M. Richard³, Christopher M. Grulke⁴, John F. Wambaugh³, Kristen K. Isaacs², Richard Judson³, Antony J. Williams³, Jon R. Sobus². ¹US EPA, ORISE, Research Triangle Park, NC; ²NERL, US EPA, Research Triangle Park, NC; ³NCCT, US EPA, Research Triangle Park, NC; ⁴Lockheed Martin, Research Triangle Park, NC. Abstract #3539 in Emerging Technologies, Thursday Morning, March 17

The Most Scientifically-Supported Approach for Assessing the Carcinogenicity of Oral Exposure to Hexavalent Chromium: Non-Linear, Non-Threshold versus Threshold Approaches
Joseph T. Haney. Toxicology Division, Texas Commission on Environmental Quality, Austin, TX. Abstract #1536 in Metal Toxicity, Monday Afternoon, March 14

Extrapolating Salivary Acinar Cell In Vitro Pesticide Transport to Whole Animals Using Computational Modeling
Charles Timchalk, Zana A. Carver, Thomas J. Weber, Jordan N. Smith. Pacific Northwest National Laboratory (PNNL), Richland, WA. Abstract #1129 in Biomonitoring, Monday Morning, March 14

An Approach to Skin Sensitization Quantitative Risk Assessment using a Bayesian Integrated Testing Strategy to Derive Potency
Cynthia Ryan¹, Joanna Jaworska², Petra Kern³, G. Frank Gerberick¹. ¹The Procter & Gamble Company, Mason, OH; ²The Procter & Gamble Company, Strombeek-Bever, Belgium; ³The Procter & Gamble Company, Beijing, China. Abstract #2195 in Alternative Models for Ocular and Skin Toxicity, Tuesday Afternoon, March 15

A Next Generation Benchmark Dose Computation System
Kan Shao¹, Andy Shapiro². ¹Department of Environmental Health, Indiana University, Bloomington, IN; ²Independent consultant, Durham, NC. Abstract #2165 in Risk Assessment 1, Tuesday Morning, March 15

An Evaluation of Transplacental Carcinogenesis for Human Health Risk Assessment
Brenda Foos¹, Michelle Mabson², John Rogers³, Bob Sonawane¹, Gary Ginsberg⁴. ¹US Environmental Protection Agency, Washington, DC; ²Oak Ridge Institute for Science and Education, Washington, DC; ³US Environmental Protection Agency, Research Triangle Park, NC; ⁴Connecticut Department of Health, Hartford, CT. Abstract #2717 in Risk Assessment 3, Wednesday Morning, March 16

Multimodal Screening of Functional and Structural Drug Toxicities Using Human Stem Cell-Derived Cardiomyocytes
Mathew Brock, Julia Heidmann, Ariel Kauss, Dinah Misner. Safety Assessment, Genentech, South San Francisco, CA. Abstract #1743 in Pluripotent Stem Cells in Cardiovascular Research, Monday, March 14 (3:20 pm)

A Case Study on the Utility of a Tiered Surrogate Approach in Quantitative Risk Assessment of 2,4,6-Trinitrophenol
Lucina E. Lizarraga¹, Q. Jay Zhao². ¹Oak Ridge Institute for Science and Education, Cincinnati, OH; ²U.S. EPA, National Center for Environmental Assessment, Cincinnati, OH. Abstract #2160 in Risk Assessment 1, Tuesday Morning, March 15

Developing An In Vitro Assay To Measure Key Signaling Events In Estrogen-initiated Pathways and Guide Risk Assessment
Michelle M. Miller, Daniel L. Doheny, Pergentino Balbuena, Susan M. Ross, Chad Deisenroth, Rebecca A. Clewell, The Hamner Institutes for Health Sciences, RTP, NC. Abstract #1867 in Endocrine Toxicology, Tuesday Morning, March 15

Best Published Papers in 2015 Advancing the Science of Risk Assessment

OUTSTANDING PAPER (TIE)

Ivy Moffat, Nikolai L Chepelev, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K Buick, France Lemieux, Andrew Williams, Sabina Halappanavar, Amal I Malik, Mirjam Luijten, Jiri Aubrecht, Daniel R Hyduke, Albert J Fornace, Carol D Swartz, Leslie Recio, and Carole L Yauk. Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. (2015) Critical Reviews in Toxicology, vol. 45 (1) pp. 1–43

Richard A Becker, Gerald T Ankley, Stephen W Edwards, Sean W Kennedy, Igor Linkov, Bette Meek, Magdalini Sachana, Helmut Segner, Bart Van Der Burg, Daniel L Villeneuve, Haruna Watanabe, and Tara S Barton-Maclaren. Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence. 2015 Regulatory Toxicology and Pharmacology, vol. 72 (3) pp. 514–537

TOP TEN PAPERS

Elisabet Berggren, Patric Amcoff, Romualdo Benigni, Karen Blackburn, Edward Carney, Mark Cronin, Hubert Deluyker, Francoise Gautier, Richard S Judson, Georges E N Kass, Detlef Keller, Derek Knight, Werner Lilienblum, Catherine Mahony, Ivan Rusyn, Terry Schultz, Michael Schwarz, Gerrit Schüürmann, Andrew White, Julien Burton, Alfonso M Lostia, Sharon Munn, and Andrew Worth. Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making. Environ Health Perspect, 2015 vol. 123 (12) pp. 1232–1240.

Julie A Bourdon-Lacombe, Ivy D Moffat, Michelle Deveau, Mainul Husain, Scott Auerbach, Daniel Krewski, Russell S Thomas, Pierre R Bushel, Andrew Williams, and Carole L Yauk. Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. Regul Toxicol Pharmacol, 2015 vol. 72 (2) pp. 292–309.

Patience Browne, Richard S. Judson, Warren M. Casey, Nicole C. Kleinstreuer, and Russell S. Thomas Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model Environ Sci Technol 2015 Jul 21;49(14):8804–14

Hiroshi Kimura, Takashi Ikeda, Hidenari Nakayama, Yasuyuki Sakai, and Teruo Fujii. An on-chip small intestine-liver model for pharmacokinetic studies. J Lab Autom, 2015 vol. 20 (3) pp. 265–273.

Grace Patlewicz, Ted W Simon, J Craig Rowlands, Robert A Budinsky, and Richard A Becker. Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes. Regul Toxicol Pharmacol, 2015 vol. 71 (3) pp. 463–477.

Franco Scinicariello and Christopher Portier. A simple procedure for estimating pseudo risk ratios from exposure to non-carcinogenic chemical mixtures. Arch Toxicol, 2015 pp. 1–11.

Sheppard A Martin, Eva D McLanahan, Philip J Bushnell, E Sidney Hunter, and Hisham El-Masri. Species extrapolation of life-stage physiologically-based pharmacokinetic (PBPK) models to investigate the developmental toxicology of ethanol using in vitro to in vivo (IVIVE) methods. Toxicol Sci, 2015 vol. 143 (2) pp. 512–535.

C Terry, R J Rasoulpour, S Knowles, and R Billington. Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: a case study. Regul Toxicol Pharmacol, 2015 vol. 71 (2) pp. 301–317

Best Published Papers in 2015 Demonstrating an Application of Risk Assessment

OUTSTANDING PAPER

Scott M Arnold, Alistair Morriss, Joseph Velovitch, Daland Juberg, Carol J Burns, Michael Bartels, Manoj Aggarwal, Torka Poet, Sean Hays, and Paul Price Derivation of human Biomonitoring Guidance Values for chlorpyrifos using a physiologically based pharmacokinetic and pharmacodynamic model of cholinesterase inhibition. Regulatory Toxicology and Pharmacology, 2015 vol. 71 (2) pp. 235–243

TOP 10 PAPERS

Edward L Croom, Timothy J Shafer, Marina V Evans, William R Mundy, Chris R Eklund, Andrew F M Johnstone, Cina M Mack, and Rex A Pegram. Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity. Toxicol Appl Pharmacol, 2015 vol. 283 (1) pp. 9–19.

Haney J Jr. Use of dose-dependent absorption into target tissues to more accurately predict cancer risk at low oral doses of hexavalent chromium. Regul Toxicol Pharmacol. 2015 Feb;71(1):93–100.

Haney J Jr. Consideration of non-linear, non-threshold and threshold approaches for assessing the carcinogenicity of oral exposure to hexavalent chromium. Regul Toxicol Pharmacol, 2015 vol. 73 (3) pp. 834–852.

M José Gómez-Lechón, Laia Tolosa, and M Teresa Donato. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. J Appl Toxicol, 2015 Dec 22. doi: 10.1002/jat.3277.

Kevin McNally and George D Loizou. A probabilistic model of human variability in physiology for future application to dose reconstruction and QIVIVE. Front Pharmacol, 2015 vol. 6 (Pt 1) p. 213.

Rik Oldenkamp, Mark A J Huijbregts, and Ad M J Ragas. Uncertainty and variability in human exposure limits - a chemical-specific approach for ciprofloxacin and methotrexate. Crit Rev Toxicol, 2015 pp. 1–18.

M Trantallidi, C Dimitroulopoulou, P Wolkoff, S Kephalopoulos, and P Carrer. EPHECT III: Health risk assessment of exposure to household consumer products. Sci Total Environ, 2015 vol. 536 pp. 903–913.

John A Troutman, David L Rick, Sharon B Stuard, Jeffrey Fisher, and Michael J Bartels. Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment. Regul Toxicol Pharmacol, 2015 vol. 73 (2) pp. 530–543.

Valcke M, Haddad S. Assessing human variability in kinetics for exposures to multiple environmental chemicals: a physiologically based pharmacokinetic modeling case study with dichloromethane, benzene, toluene, ethylbenzene, and m-xylene. J Toxicol Environ Health A. 2015;78(7) pp 409–31

2015 Award Recipients

John Doull Award

Yongquan Lai, W. Bodnar, H. Hartwell and J.A. Swenberg. University of North Carolina, Chapel Hill, North Carolina. Formation of Endogenous and Exogenous DNA-Protein Crosslinks in Nonhuman Primates and Rats Following Inhalation Exposure to [13CD2]-Formaldehyde. Abstract #545 in Genetic Toxicology I. Monday, March 23 1:00–4:30 pm. Advisor: James Swenberg

Perry Gehring Postdoctoral Fellow Award

Marjory Moreau and A. Nong. Health Canada, Ottawa, ON. Comparison of phthalate biomonitoring and high throughput screening data using pharmacokinetic modeling. Abstract #742 in Biological Modeling. Monday, March 23 1:00–4:30 pm. Advisor: Andy Nong

Perry Gehring Student Award

Mylène Ratelle, J. Cote, M. Bouchard. Université de Montréal, Montreal, Canada. Time Course and Variability of biomarkers of exposure to pyrethroids in a Group of Agricultural Workers. Abstract #519 in Biomonitoring and Exposure Assessment. Monday, March 23 1:00–4:30 pm. Advisor: Michelle Bouchard

Robert J. Rubin Student Travel Award

WINNER
Mary Francis, M Mandal, C. Sun, H Choi, JD Laskin, DL Laskin. Rutgers University and Robert Wood Johnson Medical School, Piscataway, NJ. Tracking Inflammatory Macrophage Accumulation in the Lung during Ozone-induced Lung Injury in Mice. Abstract #1343 in Immunotoxicity II. Tuesday, March 24 1:00–4:30 pm.

RUNNER-UP
Page Smith, J. Fisher, A.A. Lumen. Colorado State University, Fort Collins, CO. A Computational Approach for a Quantitative and Mechanistic Understanding of Thiocyanate Kinetics and Dose-Response. Abstract #726 in Biological Modeling. Monday, March 23 1:00–4:30 pm.

2015 BEST ABSTRACTS (TIE)

Lisa G. McFadden, Alene T. McCoy, Sean Hays, Manoj Aggarwal, Michael J. Bartels, Richard Billington, Claire Terry. Developing a Framework for Integrating Toxicokinetics into Human Health Risk Assessment for Chemicals. Abstract #1891 in Risk Assessment III. Wednesday, March 25 9:00 am–12:30 pm.

Top Ten Abstracts

J. C. English, Kevin D. Cox. Oral Risk Assessment and Acceptable Drinking Water Levels for the Commonly Used Polyvinyl Chloride Plasticizer Acetyl Tributyl Citrate.

Jenny M. Pedersen, Joseph Shim, Edward LeCluyse, Jeffrey M. Macdonald, Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon. Liver Bioreactor As an In Vitro Metabolism System for Quantitative In Vitro to In Vivo Extrapolation.

Claire Terry, Richard Billington, Andrew Whyte. The concept of human exposure-based toxicity testing for agrochemicals.

Jeffrey W. Fisher, Teresa L. Leavens, Eva D. McLanahan, Paul M. Schlosser. Predicting Serum Thyroid Hormones Changes in the Bottle-Fed Infant Ingesting Dietary Iodine and the Environmental Contaminant Perchlorate.

John C. Lipscomb, Anna B. Lowit, Elaina M. Kenyon, Virginia C. Moser, Brenda P. Foos, Audrey Galizia, Michael Broder, Rita Schoeny. Data-Derived Extrapolation Factors: Improving the Quantitative Basis for Health Risk Assessment.

Michael Peterson, Gail Charnley, Thomas Lewandowski. Using PBPK Modeling to Evaluate the Concurrent Effects of Perchlorate, Other Goitrogens, and Iodine on Thyroid Status.

Trine Husøy, Andy Hart, Ralph Pirow, Wim C. Mennes, Detlef Wölfle, Paul A. Fowler, Ursula Gundert-Remy, Natalie Götz, Rudolf A. Woutersen, Davide Arcella, Anne Theobald, Cristina Croera, Anna Castoldi. EFSA’s Risk Assessments of Bisphenol A Using the Weight-of-Evidence Approach and an Improved Methodology on Uncertainty.

Heidi Hubbard, Cara Henning, Tao Hong, Daniel Vallero, Peter Egeghy. A High-Throughput Exposure Estimation Tool Incorporating ADME Processes.

Zhongyu (June) Yan, Sean C. Gehen, Radhakrishna Sura.Weight-of-Evidence Evaluation of 1,3-Dichloropropene Tumorigenesis Supports Application of a Threshold-Based Risk Assessment.

Rene Vinas, Amber Nagy, Prachi Pradeep, Stephen J. Merrill, Ron P. Brown, Peter L. Goering. Derivation of a Provisional Tolerable Intake for Intravenous Exposure to Silver Nanoparticles.

Best Published Papers in 2014 Advancing the Science of Risk Assessment

Outstanding Paper

Barbara A. Wetmore, Brittany Allen, Harvey J. Clewell, III, Timothy Parker, John F. Wambaugh, Lisa M. Almond, Mark A. Sochaski, and Russell S. Thomas (2014) Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing. Toxicological Sciences, 142(1):210-24.

Top Three Papers

G.E. Johnson, L.G. Soeteman-Hernandez, B.B.Gollapudi, O.G. Bodger, K.L. Dearfield, R.H. Heflich, J.G. Hixon, D.P. Lovell, J.T. MacGregor, L.H. Pottenger, C.M.Thompson, L. Abraham, V. Thybaud, J.Y. Tanir, E. Zeiger, J. van Benthem, and P.A.White (2014) Derivation of Point of Departure (PoD) Estimates in Genetic Toxicology Studies and Their Potential Applications in Risk Assessment. Environmental and Molecular Mutagenesis 55:609-623.

John F. Wambaugh, Anran Wang, Kathie L. Dionisio, Alicia Frame, Peter Egeghy, Richard Judson, and R. Woodrow Setzer (2014) High Throughput Heuristics for Prioritizing Human Exposure to Environmental Chemicals. Environmental Science & Technology 48, 12760-12767.

Best Published Papers in 2014 Demonstrating an Application of Risk Assessment

Outstanding Paper

Kevin McNally, Richard Cotton, Alex Hogg, George Loizou (2014) PopGen: A virtual human population generator. Toxicology 315:70-85.

Top Five Papers

Richard A. Becker, Sean M. Hays, Christopher R. Kirman, Lesa L. Aylward, and Kimberly Wise (2014) Interpreting Estrogen Screening Assays in the Context of Potency and Human Exposure Relative to Natural Exposures to Phytoestrogens. Birth Defects Research (Part B) 101:114-124.

Louis Anthony (Tony) Cox, Douglas Popken, M. Sue Marty, J. Craig Rowlands, Grace Patlewicz, Katy O. Goyak, Richard A. Becker(2014) Developing scientific confidence in HTS-derived prediction models: Lessons learned from an endocrine case study. Regulatory Toxicology and Pharmacology 69:443-450.

Corine J. Houtman, Jan Kroesbergen, Karin Lekkerkerker-Teunissen, Jan Peter van der Hoek (2014) Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data. Science of the Total Environment 496:54-62.

Nikolai L. Chepeleva, M. E. (Bette) Meek, Carole Lyn Yauka (2014) Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity. Journal of Applied Toxicology 34:1115-1121.

2014 Award Recipients

RASS Perry J. Gehring Best Graduate Student Abstract Award

Mia Johansson, G. Johanson, M. Öberg, and L. Schenk. Does Industry Take the Sensitive Subpopulation of Asthmatics into Account when Setting Derived No-Effect Levels under REACH? Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet. Abstract 643 Poster Board 551 in Regulation and Policy Poster Session. Monday, March 24, 1:00 pm–4:30 pm.

RASS Perry J. Gehring Best Postdoctoral Fellow Abstract Award

Rachel J. Church, J.E. McDuffie, M. Sonee, M. Otieno, P. B. Watkins, and A.H. Harrill Doxorubicin-Induced Glomerular Injury is Associated with Urinary MicroRNA Alterations in the Rat. The Hamner Institutes for Health Sciences. Abstract 106 Poster Board 150 in Biomarkers I Poster Session. Monday, March 24, 9:30 am–12:30 pm.

RASS Robert J. Rubin Student Travel Award

Mary Francis, M Mandal, H Choi, JD Laskin, and DL Laskin. Role of Spleen Monocytes (Mo) in Ozone-Induced Lung Inflammation and Injury. Rutgers University, Piscataway, NJ. Abstract 395 Poster Board 114 in Inflammation: Methods and Mechanisms. Monday, March 24 1:00 pm–4:30 pm.

RASS John Doull Award

Melanie Adler, EM Gottwald, AK Ajay, X Lu, M Hafner, A Subramanian, PK Sorger, and VS Vaidya. Cell-Based Approach to Predict Kidney Toxicity. Brigham and Women’s Hospital, Harvard Medical School. Abstract 2055, Poster Board 555, in Kidney Poster Session. Wednesday, March 26, 1:00 pm–4:30 pm.

RASS Overall Best Abstract

Harish Shankaran, and Justin G. Teeguarden. Improving Urine-Based Human Exposure Assessment of Short-Lived Chemicals Using Reverse Dosimetry and NHANES Physiological and Behavior Data: A Value-of-Information Approach for Bisphenol A. Pacific Northwest National Laboratory, AstraZenaca. Abstract 1517 Poster Board 133 in Biomarkers II Poster Session. Wednesday, March 26, 9:00 am–12:30 pm.

Top Ten Abstracts in Order of Presentation

April D. Lake, Susan D. Hester, Jie Liu, Jess Rowland, and Charles E. Wood. Mode of Action Profiles for Pesticide Compounds with Rodent Liver Tumor Outcomes. US Environmental Protection Agency. Abstract 65 in Enhancing Strategies for Pesticide Risk Assessment Platform Session. Monday, March 24, 9:15 am–12:00 noon.

Claire Terry, Lynea A. Murphy, Kinana Saffour, Alene T. McCoy, Manoj Aggarwal, Lisa G. McFadden, Reza J. Rasoulpour, David Rick, Michael Bartels, and Richard Billington. Integrating Toxicokinetics into the Human Health Risk Assessment Process for Agrochemicals: Halauxifen-methyl. Dow AgroSciences. Abstract 64 in Enhancing Strategies for Pesticide Risk Assessment Platform Session. Monday, March 24, 9:15 am–12:00 noon.
Paul S. Price, Torka Poet, Michael J. Bartels, and Daland R. Juberg. Using a Two-Dimension Monte Carlo Model to Develop Chemical Specific Adjustment Factors (CSAFs) for Chlorpyrifos and Chlorpyrifos Oxon. Dow Chemical Company. Abstract 61 in Enhancing Strategies for Pesticide Risk Assessment Platform Session. Monday, March 24, 9:15 am–12:00 noon.
Huali Wu, Miyoung Yoon, Matthew P. Longnecker, and Harvey J. Clewell. Can the Association between Serum Perfluorooctanoic Acid (PFOA) and Delayed Menarche Be Explained on the Basis of Physiology and Pharmacokinetics? The Hamner Institutes for Health Sciences. Abstract 91 Poster Board 126 in Biological Modeling Poster Session. Monday, March 24, 9:30 am–12:30 pm.
Marc-Andre Verner, Anne Loccisano, Miyoung Yoon, Huali Wu, Robin McDougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell, and Matthew P. Longnecker. The Association between Prenatal Exposure to Perfluoroalkyl Substances (PFAS) and Reduced Birth Weight: Is Glomerular Filtration Rate the Underlying Cause? Harvard Medical School, Karolinska Institutet. Abstract 89 Poster Board 124 in Biological Modeling Poster Session. Monday, March 24, 9:30 am–12:30 pm.
Michael Bartels, Torka S. Poet, Paul S. Price, J. A. Hotchkiss, Daland R. Juberg, and Sue Marty. Multi-Route PBPK/PD Model for Predictions of Chlorpyrifos Exposure and Effects in Humans and Rat. Dow Chemical. Abstract 82 Poster Board 117 in Biological Modeling Poster Session. Monday, March 24, 9:30 am–12:30 pm.
Deborah Proctor, Mina Suh, J. A. Tachovsky, Liz Abraham, Greg Hixon, Gregory Brorby, and Sharan Campleman. Cumulative Risk Assessment of Urban Air Toxics: A Pilot Study in San Antonio, Texas. Abstract 231 Poster Board 408 in Epidemiology Poster Session. Monday, March 24, 9:30 am–12:30 pm.
Lisa A. Bailey, Laura E. Kerper, and Barbara D. Beck. Health-Protective Manganese Guideline for Welding and Other Occupations. Gradient. Abstract 611 Poster Board 508 in Risk Assessment I Poster Session. Monday, March 24, 1:00 pm–4:30 pm.
Nolwenn Noisel, Michele Bouchard, and Gaetan Carrier. Deriving Algorithms for Matrix-to-Matrix Relations and Reverse Dosimetry of Selenium from Pooled Biomonitoring Data. Université de Montreal. Abstract 1558 Poster Board 209 in Exposure Assessment and Biomonitoring Poster Session. Wednesday, March 26, 9:00 am–12:30 pm.
Henghong Li, Daniel R. Hyduke, Carole L. Yauk, Jiri Aubrecht, and Albert Fornace. Integration of Genomic Biomarkers in Cancer Risk Assessment for Xenobiotics with Positive Findings in Chromosome Damage Assays. Georgetown University. Abstract 1938 Poster Board 348 in Genotoxicity Mechanisms Poster Session. Wednesday, March 26, 1:00 pm–4:30 pm.

Best Published Paper Demonstrating an Application of Risk Assessment

Alan F. Sasso, Paul M. Schlosser, Gregory L. Kedderis, Mary Beth Genter, John E. Snawder, Zheng Li, Susan Rieth, and John C. Lipscombll (2013). Application of an Updated Physiologically Based Pharmacokinetic Model for Chloroform to Evaluate CYP2E1-Mediated Renal Toxicity in Rats and Mice. Toxicological Sciences, 131(2), 360–374.

Remaining Top Ten Papers Demonstrating an Application of Risk Assessment

Susan Ritger Crowell, Arun K. Sharma, Shantu Amin, Jolen J. Soelberg, Natalie C. Sadler, Aaron T. Wright, William M. Baird, David E. Williams, and Richard A. Corley (2013). Impact of Pregnancy on the Pharmacokinetics of Dibenzo[def,p] chrysene in Mice. Toxicological Sciences, 135(1), 48–62.

Mark Pemberton, Lisa A. Bailey, and Lorenz R. Rhomberg (2013). Hypothesis-Based Weight-of-Evidence Evaluation of Methyl Methacrylate Olfactory Effects in Humans and Derivation of an Occupation Exposure Level. Regulatory Toxicology and Pharmacology, 66, 217–233.

Marije Strikwold, Bert Spenkelink, Ruud A. Woutersen, Ivonne M. C. M. Rietjens, and Ans Punt (2013). Combining In Vitro Embryotoxicity Data with Physiologically Based Kinetic (PBK) Modelling to Define In Vivo Dose-Response Curves for Developmental Toxicity of Phenol in Rat and Human. Arch Toxicol, 87, 1709–1723.

Justin G. Teeguarden, Conrad J. Housand, Jordan N. Smith, Paul M. Hinderliter, Rudy Gunawan, and Charles A. Timchalk (2013). A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans. Regulatory Toxicology and Pharmacology, 65, 12–28.

Wei Zhou, Chao Huang, Yan Li, Jinyou Duan, Yonghua Wang, and Ling Yang (2013). A Systematic Identification of Multiple Toxin-Target Interactions Based on Chemical, Genomic and Toxicological Data. Toxicology, 304, 173–184.

Xiaoxia Yang, Daniel R. Doerge, and Jeffrey W. Fisher (2013). Prediction and Evaluation of Route Dependent Dosimetry of BPA in Rats at Different Life Stages using a Physiologically Based Pharmacokinetic Model. Toxicology and Applied Pharmacology, 270, 45–59.

Lesa L. Aylward, Christopher R. Kirman, Rita Schoeny, Christopher J. Portier, and Sean M. Hays (2013). Evaluation of Biomonitoring Data from the CDC National Exposure Report in a Risk Assessment Context: Perspectives across Chemicals. Environmental Health Perspectives, 121 (3).

Samuel M. Cohen, Lora L. Arnold, Barbara D. Beck, Ari S. Lewis, and Michal Eldan (2013). Evaluation of the Carcinogenicity of Inorganic Arsenic. Critical Reviews in Toxicology, 43 (9), 711–752.

Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie, and Brian G. Lake (2013). Mode of Action and Human Relevance Analysis for Nuclear Receptor-Mediated Liver Toxicity: A Case Study with Phenobarbital As a Model Constitutive Androstane Receptor (CAR) Activator. Critical Reviews in Toxicology, 44 (1), 64–82.

Best Published Paper Advancing the Science of Risk Assessment

Mathieu Valcke, Kannan Krishnan (2013). Assessing the Impact of Child/Adult Differences in Hepatic First-Pass Effect on the Human Kinetic Adjustment Factor for Ingested Toxicants. Regulatory Toxicology and Pharmacology, 65, 126–134.

Remaining Top Five Papers Advancing the Science of Risk Assessment

Virunya S. Bhat, Susan D. Hester, Stephen Nesnow, and David A. Eastmond (2013). Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice. Toxicological Sciences, 136(1), 205–215.

Jonas Malmborg, and Bart A. Ploeger (2013). Predicting Human Exposure of Active Drug after Oral Prodrug Administration, Using a Joined In Vitro/In Silico-In Vivo Extrapolation and Physiologically-Based Pharmacokinetic Modeling Approach. Journal of Pharmacological and Toxicological Methods, 67, 203–213.

Kan Shao, Jeffrey S. Gift, and R. Woodrow Setzer (2013). Is the Assumption of Normality or Log-Normality for Continuous Response Data Critical for Benchmark Dose Estimation? Toxicology and Applied Pharmacology, 272, 767–779.

Sandhya Sukumaran, and Alastair Grant (2013). Differential Responses of Sexual and Asexual Artemia to Genotoxicity by a Reference Mutagen: Is the Comet Assay a Reliable Predictor of Population Level Responses? Ecotoxicology and Environmental Safety, 91, 110–116

2013 Award Recipients

John Doull Award

Rachel J. Church, D.M. Gatti, J.S. Eaddy, P.B. Watkins, D.W. Threadgill and A.H. Harrill. The Hamner – UNC Institute for Drug Safety Sciences, Jackson Laboratories and North Carolina State University. Identification of Genomic Regions Linked to Epigallochatechin Gallate Induced Liver Toxicity using the Diversity Outbred Stock. Abstract 183, Board 342 in Pharmacogenomics and Genetic Polymorphisms Poster Session, Monday, March 11, 9:30 am–12:30 pm.

Perry Gehring Postdoctoral Fellow Award

Merrie Mosedale, C. Lisa Kurtz, J. Scott Eaddy, Karissa Adkins, Hong Wu, Paul B. Watkins, and Alison Harrill. The Hamner Institutes for Health Sciences, Pfizer, Inc., and The University of North Carolina at Chapel Hill. Safety Assessment of a Novel Antibiotic Using a Mouse Population-Based Approach Predicts Risk of DILI in Humans Where Classical Models Fail. Abstract 716, Board 591 in Risk Assessment I: Advances in Approaches and Technologies Poster Session. Monday, March 11, 1:00–4:30 pm.

Perry Gehring Student Award

Virunya Bhat, Susan Hester, Steve Nesnow, and David Eastmond. UC Riverside and U. S. EPA. Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice. Abstract 1946, Board 536 in Risk Assessment II: Critical Considerations and Characterizations Poster Session. Wednesday, March 13, 9:00 am–12:30 pm.

Robert J. Rubin Student Travel Award

Xiao Pan, C. A. Whitten, M. Wu, C. Chan, C. G. Wilkerson, J. J. Pestka. Michigan State University, East Lansing, Michigan. Quantitative phosphoproteomic analysis of the dynamic signaling network mediating proinflammatory response in the spleen of mice under deoxynivalenol-induced ribotoxic stress. Abstract 2079, Board 138 in Immunotoxicity—Biochemical/Molecular Poster Session, Wednesday, March 13, 1:00–4:30 pm.

2013 BEST ABSTRACT

Robyn Prueitt, Julie Goodman, and Lorenz Rhomberg. Hypothesis-Based Weight-of-Evidence Evaluation of the Human Carcinogenicity of Toluene Diisocyanate. Abstract 1951, Board 541 in Risk Assessment II: Critical Considerations and Characterizations Poster Session. Wednesday, March 13, 9:00 am–12:30 pm.

Top Ten Abstracts

Christopher KirmanMark A Harris, Laurie C. Haws, Sean M. Hays, Deborah M. Proctor, Mina Suh, Chad M. Thompson. Using PBPK Modeling to Address Diurnal Variation and Age Differences in Hexavalent Chromium Toxicokinetics in Humans. Abstract 517, Monday, 1:00 pm.

Merrie Mosedale, Karissa Adkins, J. Scott Eaddy, Alison H. Harrill, C. Lisa Kurtz, Paul B. Watkins, Hong Wu. Safety Assessment of a Novel Antibiotic Using a Mouse Population-Based Approach Predicts Risk of DILI in Humans Where Classical Models Fail. Abstract 716, Monday, 1:00 pm.

Sesha Hanson-Drury, Justin G. Teeguarden. Systematic Review of BPA “Low Dose” Literature in the Context of Human Dosimetry Exposes a Need to Set Standards for Responsible Communication of Both Toxicity and Exposure Data. Abstract 1261, Tuesday, 1:00 pm.

Donatello Telesca, Justin G. Teeguarden, Andre Nel, Joel G. Pounds, Brian D. Thrall, Tian Xia, Haiyuan Zhang. Computational Dosimetry Driven Hazard Ranking of 25 Metal Oxide Nanomaterials Using Low- and High-Throughput In Vitro Toxicity Data. Abstract 1734, Wednesday, 9:00 am.

Joanne Wan, Jeffrey W. Card, Hanna Fikree, Lois Haughton, Valentia Lee-Brotherton, Bart Sangster. Evaluation of Tumor Pathology Concordance Between Epidemiological and Rodent Studies. Abstract 1943, Wednesday, 9:00 am.

Virunya S. Bhat, D. A. Eastmond, Susan Hester, S. Nesnow. Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice. Abstract 1946, Wednesday, 9:00 am.

Lynne T. Haber, B. Bhaskar Gollapudi, Matthew J. LeBaron, Mugimane G. Manjanatha, Martha M. Moore Nigel P. Moore, Barbara L. Parsons. Mode-of-Action Evaluation for Lung Tumors in Mice Exposed to Ethylene Oxide via Inhalation. Abstract 1969, Wednesday, 9:00 am.

Robinan Gentry, Pergentino Balbuena, Michael B. Black, Harvey J. Clewell, Alina Efremenko, Janice W. Yager. Advancements in Arsenic Research Suggest a Dose-Dependent Transition Concentration for Cancer Endpoints. Abstract 1979, Wednesday, 9:00 am.

Rachel E. Peters, Scott Clemow, Kyle James, Mark Richardson, Steven D. Siciliano. Assessment of Risks to the US Population Posed by Exposure to Gold and Ceramic Dental Restorations. Abstract 2220, Wednesday, 1:00 pm.

Best Published Papers in 2012 Advancing the Science of Risk Assessment

Outstanding Paper

Bars, R., I. Fegert, M. Gross, D. Lewis, L. Weltje, A. Weyers, J.R. Wheeler, Galay-Burgos, M. Risk assessment of endocrine active chemicals: identifying chemicals of regulatory concern. Regul Toxicol Pharmacol. 2012. 64(1):143-154.

Top Ten Papers

Creton S., Saghir S, Bartels M, Billington R, Bus J, et al. Use of toxicokinetics to support chemical evaluation: Informing high dose selection and study interpretation. Regul Toxicol Pharmacol. 2012. 62(2):241-247.

Gollapudi B, Johnson G, Hernandez L, Pottenger L, Dearfield K, et al. Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environ Mol Mutagen. 2012. 54(1).

Lock E, Abdo N, Huang R, Xia M, Kosyk O, et al. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci. 2012. 126(2):574-588.

Lavelle, KS, Schnatter A, Travis K, Swaen G, Pallapies D, et al. Framework for integrating human and animal data in chemical risk assessment. Regul Toxicol Pharmacol. 2012. 62(2):302-312.

Najita J, Catalano P. On Determining the BMD from Multiple Outcomes in Developmental Toxicity Studies when One Outcome is Intentionally Missing. Risk Anal. Dec 12, 2012. doi: 10.1111/j.1539-6924.2012.01939.x.

Roos V, Gunnarsson L, Fick J, Larsson D, Ruden C. Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Sci Total Environ. 2012. 421-422:102-110.

Selck H, Drouillard K, Eisenreich K, Koelmans A, Palmqvist A, et al. Explaining differences between bioaccumulation measurements in laboratory and field data through use of a probabilistic modeling approach. Integr Environ Assess Manag. 2012. 8(1):42-63.

Thomas R, Clewell H 3rd, Allen B, Yang L, Healy E, et al. Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study. Mutat Res. 2012. 746(2):135-143.

Thompson D, Beard D. Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment. J Pharm Sci. 2012. 101(1):424-435.

Best Published Papers in 2012 Demonstrating an Application of Risk Assessment

Outstanding Paper

Criswell KA, Cook JC, Wojcinski Z, Pegg D, Herman J, Wesche D, Giddings J, Brady J, Anderson T. Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance. Toxicol Sci. 2012.128(1):57-71.

Top Ten Papers

Bailey, LA, Prueitt R, Rhomberg L. Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen. Regul Toxicol Pharmacol. 2012. 62(2):278-291.

Bourdon JA, Williams A, Kuo B, Moffat I, White P, et al. Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure. Toxicology. 2012. 303C:83-93.

Hays S M, Pyatt DW, Kirman CR, Aylward LL. Biomonitoring Equivalents for benzene. Regul Toxicol Pharmacol. 2012. 62(1):62-73.

Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM. Physiologically-based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact. 2012. 200:45-64.

Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM. Genome-wide expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol. 2012. 259:13-26.

Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestine epithelia. Toxicol Appl Pharmacol. 2012. 262:124-138.

Schroeter J D, Dorman DC, Yoon M, Nong A, Taylor MD, et al. Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys. Toxicol Sci. 2012. 129(2):432-446.

Thomas R S, Himmelstein MW, Clewell HJ 3rd, Yang Y, Healy E, et al. Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene. Toxicol Sci. doi:10.1093/toxsci/kfs.314, Nov 3, 2012. 131(2):629-640.

Thompson CM, Proctor DM, Suh M, Haws LC, Hebert CD, Mann JF, Shertzer HG, Hixon G, Harris MA. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Tox Sci. 2012. 125(1):79-90.

2012 Award Recipients

RASS Perry J. Gehring Best Graduate Student Abstract Award

Student: Nick Heger
Title: Human Fetal Testis Xenografts Are Not Sensitive to Phthalate-Induced Endocrine Disruption
Authors: Heger, Nicholas, Hall, Susan J., Sandrof, Moses A., McDonnell, Elizabeth V., McDowell, Erin N., Martin, Kayla A., Hensley, Janan B., Gaido, Kevin W., Johnson, Kamin J., Boekelheide, Kim
Affiliation (First Author): Pathology and Laboratory Medicine, Brown University, Providence, RI, United States

RASS Perry J. Gehring Best Postdoctoral Fellow Abstract Award

Postdoc: Michelle DeSimone
Advisor: Jim Swenberg
Title: A Systems Genetics Approach to Investigating Cancer Susceptibility Due to Low-Dose Coexposures to Environmental Carcinogens
Authors: DeSimone, Michelle C., Cullen, John, Patisaul, Heather B., Threadgill, David W.
Affiliation (First Author): Genetics, North Carolina State University, Raleigh, NC, United States.

RASS Robert J. Rubin Student Travel Award

Student: Kelly Harris
Title: Benzo(a)pyrene Modulates Fluoranthene Cytotoxicity and Metabolism in HT-29 Colon Cells
Authors: Harris, Kelly L., Myers, Jeremy N., Ramesh, Aramandla
Affiliation (First Author): Biochemistry & Cancer Biology, Meharry Medical College, Nashville, TN, United States

RASS John Doull Award

Student: Alice Crane
Title: Effect of CYP2B6 Variants on Chlorpyrifos Metabolism: Implications for Human Risk
Authors: Crane, Alice L., Klein, Kathrin, Zanger, Ulrich M., Olson, James R.
Affiliation (First Author): University at Buffalo (SUNY), Buffalo, NY, United States

RASS Overall Best Abstract

Recipient: Harish Shankaran
Title: Pharmacokinetics-Enabled Reverse Dosimetry Improves the Accuracy of Bisphenol A (BPA) Exposure Assessment
Authors: Shankaran, Harish, Teeguarden, Justin G.
Affiliation (First Author): Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, United States

Top Ten Abstracts in Order of Presentation

Best Published Paper Demonstrating an Application of Risk Assessment

Belkebir E, Rousselle C, Duboudin C, Bodin L, Bonvallot N. 2011. Haber's rule duration adjustments should not be used systematically for risk assessment in public health decision-making. Toxicol Lett. 204(2–3):148–55.

Top Publications

Boogaard PJ, Hays SM, Aylward LL. 2011. Human biomonitoring as a pragmatic tool to support health risk management of chemicals—examples under the EU REACH programme. Regul Toxicol Pharmacol. 59(1):125–32.

Borgert CJ, Sargent EV, Casella G, Dietrich DR, McCarty LS, Golden RJ. 2011. The human relevant potency threshold: Reducing uncertainty by human calibration of cumulative risk assessments. Regul Toxicol Pharmacol. [Epub ahead of print]

Ciffroy P, Tanaka T, Johansson E, Brochot C. 2011. Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water. Environ Geochem Health.33(4):371–87.

Crump KS. 2011. Use of threshold and mode of action in risk assessment. Crit Rev Toxicol. 41(8):637–50.

Escher BI, Fenner K. 2011. Recent advances in environmental risk assessment of transformation products. Environ Sci Technol. 45(9):3835–47.

Judson RS, Kavlock RJ, Setzer RW, Hubal EA, Martin MT, Knudsen TB, Houck KA, Thomas RS, Wetmore BA, Dix DJ. 2011. Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment. Chem Res Toxicol. 24(4):451–62.

Rappaport SM. 2011. Implications of the exposome for exposure science. J Expo Sci Environ Epidemiol. 21(1):5–9.

Rhomberg LR, Goodman JE, Haber LT, Dourson M, Andersen ME, Klaunig JE, Meek B, Price PS, McClellan RO, Cohen SM. 2011. Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule. Crit Rev Toxicol. 41(1):1–19.

Ribonnet L, van der Heiden E, Nobels I, Chaumont A, Remacle AS, De Saeger S, Schneider YJ, Scippo ML, Blust R, Pussemier L, Larondelle Y. 2011. Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 28(9):1136–58.

Rowbotham AL, Gibson RM. 2011. Exposure-driven risk assessment: applying exposure-based waiving of toxicity tests under REACH. Food Chem Toxicol. 49(8):1661–73.

Stern AH, Korn LR. 2011. An approach for quantitatively balancing methylmercury risk and omega-3 benefit in fish consumption advisories. Environ Health Perspect. 119(8):1043–6.

Best Published Paper Advancing the Science of Risk Assessment

Thomas RS, Clewell HJ 3rd, Allen BC, Wesselkamper SC, Wang NC, Lambert JC, Hess-Wilson JK, Zhao QJ, Andersen ME. 2011. Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. Toxicol Sci. 120(1):194–205.

Top Publications

Burgess-Herbert SL, Euling SY. 2011. Use of comparative genomics approaches to characterize interspecies differences in response to environmental Nov 28. [Epub ahead of print].

Carmichael N, Bausen M, Boobis AR, Cohen SM, Embry M, Fruijtier-Pölloth C, Greim, H, Lewis R, Bette Meek ME, Mellor H, Vickers C, Doe J. 2011. Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview. Crit Rev Toxicol. 41(3):175–86.

Koster S, Boobis AR, Cubberley R, Hollnagel HM, Richling E, Wildemann T, Würtzen G, Galli CL. 2011. Application of the TTC concept to unknown substances found in analysis of foods. Food Chem Toxicol. 49(8):1643–60.

Lavelle KS, Robert Schnatter A, Travis KZ, Swaen GM, Pallapies D, Money C, Priem P, Vrijhof H. 2011. Framework for integrating human and animal data in chemical risk assessment. Regul Toxicol Pharmacol. [Epub ahead of print].

Mielke H, Anger LT, Schug M, Hengstler JG, Stahlmann R, Gundert-Remy U. 2011. A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing. Arch Toxicol. 85(6):555–63.

Price PS, Han X. 2011. Maximum cumulative ratio (MCR) as a tool for assessing the value of performing a cumulative risk assessment. Int J Environ Res Public Health. 8(6):2212–25.

Sappington KG, Bridges TS, Bradbury SP, Erickson RJ, Hendriks AJ, Lanno RP, Meador JP, Mount DR, Salazar MH, Spry DJ. 2011. Application of the tissue residue approach in ecological risk assessment. Integr Environ Assess Manag.7(1):116–40.

Thompson CM, Haws LC, Harris MA, Gatto NM, Proctor DM. Application of the U.S. EPA mode of action Framework for purposes of guiding future research: a case study involving the oral carcinogenicity of hexavalent chromium. Toxicol Sci. 2011 Jan;119(1):20–40.

2011 Award Recipients

RASS Perry J. Gehring Best Graduate Student Abstract Award

Student: Corrie Ellison
Advisor: James R. Olson
Title: Construction and validation of a human PBPK/PD model for dermal chlorpyrifos exposure utilizing human biomarker data
Authors: Corie A. Ellison¹, James B. Knaak¹, Robin McDougall², Pamela J. Lein ^3,4, Fayssal M. Farahat⁵, W. Kent Anger³, James R. Olson¹
Affiliation: ¹University at Buffalo, Buffalo, NY; ²University of Ontario Institute of Technology, Oshawa, Canada; ³Oregon Health & Science University, Portland, OR; ⁴UC Davis School of Veterinary Medicine, Davis, CA; ⁵Menoufia University, Shibin el Kom, Egypt

RASS Perry J. Gehring Best Postdoctoral Fellow Abstract Award

Postdoc: Ben Moeller
Advisor: Jim Swenberg
Title: Molecular Dosimetry of N2-hydroxymethyl-dG Adducts Following Formaldehyde Exposure to Non-Human Primates
Authors: Benjamin C. Moeller¹, Kun Lu², Melanie Doyle-Eisele³, Jacob McDonald³, Andrew Gigliotti³, James A. Swenberg^1,2
Affiliation: ¹Curriculum in Toxicology, University of North Carolina—Chapel Hill; ²Department of Environmental Sciences and Engineering, University of North Carolina—Chapel Hill; ³Lovelace Respiratory Research Institute, Albuquerque, NM

RASS Robert J. Rubin Student Travel Award

Student: P.K. Senthilkumar
Title: Telomere dysfunction and telomerase reactivation in human skin keratinocytes: a possible new mechanism of PCB carcinogenesis
Authors: P.K. Senthilkumar, A. Klingelhutz, L.W. Robertson, and G. Ludewig
Affiliation: Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA

RASS John Doull Award

Student: Mathieu Valcke
Advisor: Kannan Krishnan
Title: Evaluation of the impact of demography on the adequacy of the human kinetic adjustment factor (HKAF)
Authors: M. Valcke^1,2, K. Krishnan¹
Affiliation: ¹Santé environnementale et Santé au travail, Université de Montréal, Montréal, QC, Canada; ²Direction de la Santé environnementale et de la Toxicologie, Institut national de santé publique du Québec, Montréal, QC, Canada.

Overall Best Abstract

Case Study on Dose-Responses for Mutagenicity and Clastogenicity Induced by DNA-Reactive Chemicals

Lynn H. Pottenger¹, Martha M. Moore², Tong Zhou³, Errol Zeiger⁴

The Dow Chemical Company, Midland, MI, United States.
U.S. FDA/NCTR, Jefferson, AR, United States.
U.S. FDA/CVM, Rockville, MD, United States.
Errol Zeiger Consulting, Chapel Hill, NC, United States.

Session: March 7, 2011, 9:30 AM to 12:30 PM
Location: Exhibit Hall (Convention Center)
Poster Session Title: Genotoxicity
Abstract Final ID: 332 Poster Board -630

Best Published Paper Demonstrating an Application of Risk Assessment

Pouillot R, Delignette-Muller ML. 2010. Evaluating variability and uncertainty separately in microbial quantitative risk assessment using two R packages. International Journal of Food Microbiology 142(3):330–40.

Top Ten Publications

Andersen ME, Clewell HJ 3rd, Bermudez E, Dodd DE, Willson GA, Campbell JL, Thomas RS. 2010. Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. Toxicological Sciences 118(2):716–31.

Aylward LL, Kirman CR, Blount BC, Hays SM. 2010. Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)—application of steady-state PBPK model solutions. Regulatory Toxicology and Pharmacology 58(1):33–44.

Kumar A, Xagoraraki I. 2010. Human health risk assessment of pharmaceuticals in water: an uncertainty analysis for meprobamate, carbamazepine, and phenytoin. Regulatory Toxicology Pharmacology 57(2–3):146–56.

Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicological Sciences 116(2):441–51.

Magee B, Samuelian J, Haines K, Chappel M, Penn I, Chin D, Anders D, Hinz J. 2010. Screening-level population risk assessment of nasal tumors in the US due to naphthalene exposure. Regulatory Toxicology and Pharmacology 57(2–3):168–80.

Mörk AK, Johanson G. 2010. Chemical-specific adjustment factors for intraspecies variability of acetone toxicokinetics using a probabilistic approach. Toxicological Sciences 116(1):336–48.

Simon T, Aylward LL, Kirman CR, Rowlands JC, Budinsky RA. 2010. Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Toxicological Sciences 112(2):490–506.

Valdez-Flores C, Sielken RL Jr, Teta MJ. 2010. Quantitative cancer risk assessment based on NIOSH and UCC epidemiological data for workers exposed to ethylene oxide. Regulatory Toxicology and Pharmacology 56(3):312–20.

Yang JM, Salmon AG, Marty MA. 2010. Development of TEFs for PCB congeners by using an alternative biomarker—thyroid hormone levels. Regulatory Toxicology and Pharmacology 56(2):225–36.

Best Published Paper Advancing the Science of Risk Assessment

Louisse J, de Jong E, van de Sandt JJ, Blaauboer BJ, Woutersen RA, Piersma AH, Rietjens IM, Verwei M. 2010. The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man. Toxicological Sciences 118(2):470–84.

Top Ten Publications

Bercu JP, Jolly RA, Flagella KM, Baker TK, Romero P, Stevens JL. 2010. Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens. Regulatory Toxicology and Pharmacology 58(3):369–81.

Billington R, Lewis RW, Mehta JM, Dewhurst I. 2010. The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides. Critical Reviews in Toxicology 40(1):35–49.

Dellarco VL, Rowland J, May B. 2010. A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals. Critical Reviews in Toxicology 40(1):16–23.

Dorne JL. 2010. Metabolism, variability and risk assessment. Toxicology 268(3):156–64.

Ginsberg G, Foos B, Dzubow RB, Firestone M. 2010. Options for incorporating children’s inhaled dose into human health risk assessment. Inhalation Toxicology 22(8):627–47.

Hasegawa R, Hirata-Koizumi M, Dourson ML, Parker A, Sweeney LM, Nishikawa A, Yoshida M, Ono A, Hirose A. 2010. Proposal of new uncertainty factor application to derive tolerable daily intake. Regulatory Toxicology and Pharmacology 58(2):237–42.

Luke NS, Sams R 2nd, DeVito MJ, Conolly RB, El-Masri HA. 2010. Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. Toxicological Sciences 115(1):253–66.

Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. 2010. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological Sciences 117(2):348–58.

Teunis PF, Kasuga F, Fazil A, Ogden ID, Rotariu O, Strachan NJ. 2010. Dose-response modeling of Salmonella using outbreak data. International Journal of Food Microbiology 144(2):243–9.

Zhang Q, Bhattacharya S, Andersen ME, Conolly RB. 2010. Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. Journal of Toxicology and Environmental Health, Part B Critical Reviews 13(2–4):253–76.

2010 Award Recipients

2010 RASS Perry J. Gehring Best Student Abstract Award

ID 143 Poster Board—225. Distribution and Molecular Dose of Inhalation-derived and Endogenous Formaldehyde DNA Adducts Support Causation of Nasal Carcinoma, but not Leukemia
K. Lu 1; L. B. Collins1; H. Ru2; E. Bermudez3; J. A. Swenberg1

Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, United States.
Department of Statistics and Operation Research, University of North Carolina, Chapel Hill, NC, United States.
The Hamner Institutes for Health Sciences, Research Triangle Park, NC, United States.

2010 Perry J. Gehring Best Postdoctoral Fellow Abstract Award

ID 1384 Development of a Rat Gestation PBPK Model for PFOA/PFOS.
A. E. Loccisano1; Y. Tan2; M. E. Andersen1; H. J. Clewell1

The Hamner Institutes, RTP, NC, United States.
USEPA, RTP, NC, United States.

2010 RASS Best Overall Abstract Award

ID 2205 Nuclear Receptor (CAR/PXR) Humanized Mouse Models to Investigate Nongenotoxic Hepatocarcinogenesis
C. R. Elcombe1

CXR Biosciences Ltd, Dundee, United Kingdom.

Additional RASS Top 10 Best Abstracts

ID 247 Poster Board—548. Nine and Ten Chemical Haloacetic Acid Mixtures Exhibit Concentration-Dependent Departure from Dose Additivity
J. Simmons1; C. Dingus2; E. D. Wagner3; L. K. Teuschler4; G. E. Rice4; M. J. Plewa3

ORD/NHEERL, U.S. EPA, Research Triangle Park, NC, United States.
Batelle, Columbus, OH, United States.
Univ. of Illinois, Urbana, IL, United States.
ORD/NCEA, U.S. EPA, Cincinnati, OH, United States.

ID 250 Poster Board—603. In vitro-in vivo extrapolation of the human dose-response relationship for cellular perturbations by a binary mixture of toluene (TOL) and n-hexane (HEX)
K. Krishnan1; T. Peyret1

DSEST, Université de Montréal, Montréal, QC, Canada.

ID 37 The additivity to background argument for low-dose linearity—Is it viable?
K. S. Crump1

Mathematics and Statistics, Louisiana Tech University, Ruston, LA, United States.

ID 40 Noncancer Toxicity Potential at Low Doses: Background Processes Considered Statistically and Biologically
L. R. Rhomberg1

Gradient, Cambridge, MA, United States.

ID 542 High-Throughput Screening for Hazard and Risk of Environmental Contaminants
D. J. Dix1

U.S. EPA, Research Triangle Park, NC, United States.

ID 857 Poster Board— 505. Feasibility of the F1-extended-one generation reproduction toxicity study
L. Sheets1; I. Fegert2; S. Schneider2; B. van Ravenzwaay2; B. Stahl3; R. Lewis4; P. Botham4; T. Hanley5; R. Billington6; E. Carney7

Toxicology, Bayer CropScience, RTP, NC, United States.
Toxicology, BASF, Ludwigshafen, Germany.
Toxicology, Bayer CropScience, Sophia-Antipolis, France.
Toxicology, Syngenta, Raleigh, NC, United States.
Toxicology, Syngenta, Greensboro, NC, United States.
Toxicology, Dow AgroSciences, Abingdon, United Kingdom.
Toxicology, Dow Chemical, Midland, MI, United States.

ID 1351 Need for a New Approach to Genetic Toxicity Assessment: Lessons Learned and New Opportunities
J. T. MacGregor1

Toxicology Consulting Services, Arnold, MD, United States.

ID 1354 Beyond Positive or Negative: A Quantitative Approach for Interpreting Genotoxicity Data
B. Gollapudi1

Dow Chemical Company, Midland, MI, United States.

ID 1914 Poster Board—524. Evaluation of the magnitude of toxicokinetic inter-individual variability factor (IVF-TK): impact of subpopulations and chemical characteristics
M. Valcke1; K. Krishnan1

Sante environnementale et sante au travail, Universite de Montreal, Montreal, QC, Canada
Presented : Wednesday, March 10, 1:00-4:30, Exhibit Hall

ID 1939 Poster Board—601. Mode of Action For the Cancer Risk Assessment of Ingested Hexavalent Chromium: Identifying and Resolving Data Gaps
C. Thompson1; D. Proctor2; L. Haws2; M. A. Harris1

ToxStrategies, Inc., Katy, TX, United States.
ToxStrategies, Austin, TX, United States.

Outstanding Published Paper in 2009 for Advancing the Science of Risk Assessment

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW.

Mouse Population-Guided Resequencing Reveals that Variants in CD44 contribute to
Acetaminophen-Induced Liver Injury in Humans.

Genome Research. 2009 Sep;19(9):1507-15.

Outstanding Published Paper in 2009 Demonstrating an Application of Risk Assessment

DeSesso JM, Watson RE, Keen CL, Hazelden KP, Haws LC, Li AA.

Analysis and Integration of Developmental Neurotoxicity and Ancillary Data into Risk Assessment:
A Case Study of Dimethoate.

Journal of Toxicology and Environmental Health. 2009;72(2):94–109

Honorable Mention—Published Paper for Advancing the Science of Risk Assessment

Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals. Thomas RS, Bao W, Chu TM, Bessarabova M, Nikolskaya T, Nikolsky Y, Andersen ME, Wolfinger RD. Toxicol Sci. 2009 Dec;112(2):311–21.

Nonlinear cancer response at ultralow dose: A 40800-animal ED(001) tumor and biomarker study.
Bailey GS, Reddy AP, Pereira CB, Harttig U, Baird W, Spitsbergen JM, Hendricks JD, Orner GA, Williams DE, Swenberg JA. Chem Res Toxicol. 2009 Jul; 22(7):1264–76.

Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity. Taxvig C, Elleby A, Sonne-Hansen K, Bonefeld-Jørgensen EC, Vinggaard AM, Lykkesfeldt AE, Nellemann C Nutr Cancer. 2010;62(1):122–31.

Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamide.
Zeiger E, Recio L, Fennell TR, Haseman JK, Snyder RW, Friedman M. Toxicol Sci. 2009 Jan;107(1):247–57.

Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone.
Mörk AK, Jonsson F, Johanson G. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):423–32.

Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Simon T, Aylward LL, Kirman CR, Rowlands JC, Budinsky RA. Toxicol Sci. 2009 Dec;112(2):490–506.

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management.
Warheit DB, Reed KL, Sayes CM. Inhal Toxicol. 2009 Jul;21 Suppl 1:61–7.

Dose-response modeling of high-throughput screening data.
Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. J Biomol Screen. 2009 Dec;14(10):1216–27.

CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW. Toxicol Appl Pharmacol. 2009 May 15;237(1):119–26.

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.
Goetz AK, Dix DJ. Toxicol Appl Pharmacol. 2009 Jul 1;238(1):80–9.

Honorable Mention—Published Papers Demonstrating an Application of Risk Assessment

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans. Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Toxicol Sci. 2009 Feb;107(2):544-52.

Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice.
Sweeney LM, Kirman CR, Gargas ML, Dugard PH. Toxicology. 2009 Jun 16;260(1-3):77-83.

Development of a unit risk factor for 1,3-butadiene based on an updated carcinogenic toxicity assessment.
Grant RL, Haney J, Curry AL, Honeycutt M. Risk Anal. 2009 Dec;29(12):1726-42.

Using biomonitoring equivalents to interpret human biomonitoring data in a public health risk context.
Hays SM, Aylward LL. J Appl Toxicol. 2009 May;29(4):275-88.

Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?
Valberg PA, Bruch J, McCunney RJ. Regul Toxicol Pharmacol. 2009 Jun;54(1):72-83.

Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7).
Aylward LL, Hays SM, Gagné M, Krishnan K. Regul Toxicol Pharmacol. 2009 Dec;55(3):249-58.

Development of a quantitative microbial risk assessment for human salmonellosis through household consumption of fresh minced pork meat in Belgium. Bollaerts KE, Messens W, Delhalle L, Aerts M, Van der Stede Y, Dewulf J, Quoilin S, Maes D, Mintiens K, Grijspeerdt K. Risk Anal.
2009 Jun;29(6):820-40.

Establishing a point of departure for risk assessment using acute inhalation toxicology data.
Rusch GM, Bast CB, Cavender FL. Regul Toxicol Pharmacol. 2009 Aug;54(3):247-55.

Derivation of biomonitoring equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). Aylward LL, Hays SM, Gagné M, Krishnan K.
Regul Toxicol Pharmacol. 2009 Dec;55(3):259-67.

Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Cunningham VL, Binks SP, Olson MJ. Regul Toxicol Pharmacol. 2009 Feb;53(1):39-45.

2009 Award Recipients

2009 RASS Perry J. Gehring Best Student Abstract Award

#1472 An assessment of the impact of exposure route on the interindividual variability factor (IVF) for drinking water contaminants (DWCs)
M. Valcke1, 2; K. Krishnan1

Santé environnementale et santé au travail, Université de Montréal, Montréal, QC, Canada.
Institut national de santé publique du Québec, Montréal, QC, Canada.

2009 RASS Perry J. Gehring Best Postdoc Abstract Award

# 1097 Independent validation of gene expression-based hepatocarcinogenicity prediction models
S. Auerbach1; D. Mav2; R. Shah2; M. K. Vallant1; N. J. Walker1; G. A. Boorman1; R. D. Irwin1

NTP, NIEHS, Research Triangle Park, NC, USA.
SRA International. Inc., Research Triangle Park, NC, USA.

2009 Best Risk Assessment Abstract

# 440 Translating in vitro estrogenic assay results to ecological risk assessment
C. Mori1; S. Thakali1; A. Tarrant2; M. Sharma1; H. Yekel3; T. Verslycke1

Gradient Corporation, Cambridge, MA, USA.
Woods Hole Oceanographic Institution, Woods Hole, MA, USA.
Wyeth Pharmaceuticals, Malvern, PA, USA.

Poster Board 308
Location: Exhibit Hall
Time of Presentation: Mar 16 1:00 PM–1:00 PM
Category: Ecotoxicology, (Risk Assessment), (Safety Assessment: Pharmaceutical)

2009 Top 10 Risk Assessment Abstracts (Ordered by presentation date)

# 55 Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice
L. D. Burgoon1, 2, 5; Q. Ding1, 2, 3; A. N'jai1, 2, 3; E. Dere1, 2, 3; J. Rowlands4; R. A. Budinsky4; K. E. Stebbins4; T. R. Zacharewski1, 2, 3

Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, USA.
National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, USA.
Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
The Dow Chemical Company, Midland, MI, USA.
Toxicogenomic Informatics and Solutions, LLC, Lansing, MI, USA.

# 467 Assessing the Influence of Dietary Manganese Variability and Inhaled Exposure by Pharmacokinetic Modeling
A. Nong1; M. D. Taylor2; D. C. Dorman1, 3; M. E. Andersen1; H. J. Clewell1

The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA.
Afton Chemical Corporation, Richmond, VA, USA.
College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

# 477 Use of a physiologically based pharmacokinetic (PBPK) model to predict tissue disposition in pigs fed melamine.
J. L. Buur1; R. E. Baynes2; J. E. Riviere1

College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA.
Center for Chemical Toxicology and Pharmacokinetics, NCSU, Raleigh, NC, USA.

# 479 Age- and gender-structured distributions for physiological parameters: assessment of human variability in the exposure-internal-dose relationship for dichloromethane (DCM)
P. M. Schlosser1; A. Bale2; G. S. Cooper2

NCEA, U.S. EPA, RTP, NC, USA.
NCEA, U.S. EPA, Washington, DC, USA.

# 564 Evaluating Neurotoxicity of a Mixture of Five OP Pesticides Using a Composite Score
E. Nyirabahizi1; C. Gennings1; V. C. Moser2

Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.
Neurotoxicology Division, U.S. EPA-NHEERL, Research Triangle Park, NC, USA

# 719 Comparison of quantum dot biodistribution with blood flow-limited physiologically based pharmacokinetic model
H. A. Lee1; T. L. Leavens1; S. E. Mason1; N. A. Monteiro-Riviere1; J. E. Riviere1

Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC,

# 1201 Cryptosporidium exposure and recreational water contact in persons with HIV/AIDS in Baltimore, Maryland
C. C. McOliver1; E. K. Silbergeld1; T. K. Graczyk1

Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

# 1275 The relationship between the IC50, toxic threshold, and the magnitude of stimulatory response in biphasic (hormetic) dose-responses
M. A. Nascarella1, 2; E. J. Calabrese2

Gradient Corporation, Cambridge, MA, USA
Environmental Health Sceinces, University of Massachusetts Amherst, Amherst, MA, USA.

# 1473 Your results may vary: exploring the sensitivity of titanium dioxide risk estimates to different modeling assumptions
D. A. Dankovic1; E. D. Kuempel1; M. W. Wheeler1

Risk Evaluation Branch, CDC/NIOSH, Cincinnati, OH, USA.

2008 Award Recipients

2008 Best Publication Advancing the Science of Risk Assessment:

Andersen ME, Clewell HJ 3rd, Bermudez E, Willson GA, Thomas RS., 2008. Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. Toxicol Sci. 105(2):368-83.

Rest of Top 10 Publications in 2008 Advancing the Science of Risk Assessment:

Clewell HJ, Tan YM, Campbell JL, Andersen ME., 2008. Quantitative interpretation of human biomonitoring data. Toxicol Appl Pharmacol. 231(1):122-33.

Hays SM, Aylward LL, LaKind JS, Bartels MJ, Barton HA, Boogaard PJ, Brunk C, DiZio S, Dourson M, Goldstein DA, Lipscomb J, Kilpatrick ME, Krewski D, Krishnan K, Nordberg M, Okino M, Tan YM, Viau C, Yager JW., 2008. Guidelines for the derivation of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop. Regul Toxicol Pharmacol. 51(3 Suppl):S4-15.

Kostich MS, Lazorchak JM., 2008. Risks to aquatic organisms posed by human pharmaceutical use. Sci Total Environ. 389(2-3):329-39.

Leslie M. Shama and Robert K. D. Peterson., 2008. Assessing Risks of Plant-based Pharmaceuticals: I. Human Dietary Exposure. Hum Ecol Risk Assess. 14(1):179-193.

Moore MM, Heflich RH, Haber LT, Allen BC, Shipp AM, Kodell RL., 2008. Analysis of in vivo mutation data can inform cancer risk assessment. Regul Toxicol Pharmacol. 51(2):151-61.

Rice G, MacDonell M, Hertzberg RC, Teuschler L, Picel K, Butler J, Chang YS, Hartmann H., 2008. An approach for assessing human exposures to chemical mixtures in the environment. Toxicol Appl Pharmacol. 233(1):126-36.

Swenberg JA, Fryar-Tita E, Jeong YC, Boysen G, Starr T, Walker VE, Albertini RJ., 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol. 21(1):253-65.

Willhite CC, Ball GL, McLellan CJ., 2008. Derivation of a bisphenol A oral reference dose (RfD) and drinking-water equivalent concentration. J Toxicol Environ Health B Crit Rev. 11(2):69-146.

Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller M, Miller GG, Schwartz JM, Alexeeff G, Anderson H, Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, Foster PM, Germolec DR, Gray E, Hattis DB, Kyle AD, Luebke RW, Luster MI, Portier C, Rice DC, Solomon G, Vandenberg J, Zoeller RT., 2008. Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ Health Perspect. 116(11):1568-75.

Yoon M, Barton HA., 2008. Predicting maternal rat and pup exposures: how different are they? Toxicol Sci. 102(1):15-32.

2008 Best Publication Demonstrating an Application of Risk Assessment:

Ginsberg GL, Asgharian B, Kimbell JS, Ultman JS, Jarabek AM., 2008. Modeling approaches for estimating the dosimetry of inhaled toxicants in children. J Toxicol Environ Health 71(3):166-95.

Rest of Top 10 Publications in 2008 Demonstrating an Application of Risk Assessment:

Aylward LL, Lakind JS, Hays SM., 2008. Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context. J Toxicol Environ Health 71(22):1499-508.

Berman DW, Crump KS., 2008. A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type. Crit Rev Toxicol. 38 Suppl 1:49-73.

Bogen KT., 2008. An adjustment factor for mode-of-action uncertainty with dual-mode carcinogens: the case of naphthalene-induced nasal tumors in rats. Risk Anal. 28(4):1033-51.

Burgoon LD, Zacharewski TR., 2008. Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets. Toxicol Sci.104(2):412-8.

Burns FJ, Rossman T, Vega K, Uddin A, Vogt S, Lai B, Reeder RJ., 2008. Mechanism of selenium-induced inhibition of arsenic-enhanced UVR carcinogenesis in mice. Environ Health Perspect. 116(6):703-8.

Cullen AC, Corrales MA, Kramer CB, Faustman EM., 2008. The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach. Risk Anal. 28(4):877-90.

Lu Y, Rieth S, Lohitnavy M, Dennison J, El-Masri H, Barton HA, Bruckner J, Yang RS., 2008. Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane. Regul Toxicol Pharmacol. 50(2):249-60.

Schroeter JD, Kimbell JS, Gross EA, Willson GA, Dorman DC, Tan YM, Clewell HJ 3rd., 2008. Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal Toxicol. 20(3):227-43.

Zhang Q, Pi J, Woods CG, Jarabek AM, Clewell HJ, Andersen ME., 2009. Hormesis and adaptive cellular control systems. Dose Response 6(2):196-208.

2007 Award Recipients

2007 Overall Best Risk Assessment Abstract and Top Eleven

Best Risk Assessment Abstract:
#1482 “Visual Function Changes after Subchronic Toluene Inhalation in Long-Evans Rats” William Boyes, Laura Degn, Mark Bercegeay, Jean-Claude Mwanza, Charles Pinckney, Tracey Samsam, Andrew Geller, Philip Bushnell, USEPA

Best Graduate Student Abstract:
#623 “Cross-Species Association Mapping Identifies Genetic Risk Factors for Liver Toxicity” Alison I. Hege, University of North Carolina
Advisor: Ivan Rusyn

Best Postdoctoral Abstract:
#1606 “Characterization of Sensitivity of Risk Estimates to Uncertainties Associated with Biologically Based Modeling of Formaldehyde Carcinogenicity.”Yu-Ching Yang, CIIT Centers for Health Research
Advisor: Harvey Clewell

“Top Ten” Risk Assessment Abstracts:

#386 "Physiologically-motivated pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys and rats“, Cecilia Tan, CIIT Centers for Health Research

#399 "Improved physiological realism in PBPK modeling for variability analysis: A case study with ethanol“, Jeffry Schroeter, CIIT Centers for Health Research

#401 "Experimental and computational approaches to evaluate respiratory tract uptake and dosimetry of hexamethylene diisocyanate in rats“, Bahman Asgharian, CIIT Centers for Health Research

#781 “Interpretation of biomonitoring data for toluene: Use of PBPK modeling”, Lesa Aylward, Summit Toxicology

#1074 "Prediction of airflow and particle deposition in the human lung“, Kambiz Nazirdoust, CIIT Centers for Health Research

#1606 "Characterization of sensitivity of risk estimates to uncertainties associated with biologically based modeling of formaldehyde carcinogenicity“, Yu-Ching Yang, CIIT Centers for Health Research

#1684 "Physiologically-based pharmacokinetic (PBPK) modeling of inhaled manganese in rats“, Andy Nong, CIIT Centers for Health Research

#1690 "Bayesian physiologically based pharmacokinetic / pharmacodynamic (PBPK/PD) modeling of mixed route exposure of carbaryl." Harvey Clewell, CIIT Centers for Health Research

#1693 “Modeling the toxicokinetics of inhaled toluene in rats: The impact of feeding status, physical activity and strain." Elaina Kenyon, USEPA/NHEERL

#2002 "Nonlinear exposure-response relationships between ambient PM10 and daily mortality. " Teresa Bowers, Gradient Corp.

#2042 “Old principles in a new field: particokinetics affects size- and time-dependent toxicity of nano-silica in macrophages“, Justin Teeguarden PNL

2006 Award Recipients

2006 Best Published Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Yu, Xiaozhong; Griffith William C; Hanspers Kristina; Dillman James F; Ong Hansel; Vredevoogd Melinda A; Faustman Elaine M. 2006. A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences; Aug. 92 (2) p560–77.

Brandon, Esther F A; Oomen, Agnes G;Rompelberg, Cathy J M; Versantvoort, Carolien H M; van Engelen, Jacqueline G M; Sips, Adrienne J A M. 2006. Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment. Regulatory toxicology and pharmacology; Mar; 44 (2) p161–71.
Chiu, Weihsueh A; White, Paul. 2006. Steady-state solutions to PBPK models and their applications to risk assessment I: Route-to-route extrapolation of volatile chemicals. Risk analysis;Jun;26 (3) p769–80.
Goldbohm, R. Alexandra, Tielemans, Erik L.J.P., Heederik, Dick, Rubingh, Carina M., Dekkers, Susan, Willems, Marianne I. and Kroese, E. Dinant. 2006. Risk estimation for carcinogens based on epidemiological data: A structured approach, illustrated by an example on chromium. Regulatory Toxicology and Pharmacology. 44(3): 294–310.
Nong, A. McGarver, DG, Hines, RN., Krishnan, K. 2006. Modeling interchild differences in pharmacokinetics on the basis of subject specific data on physiology and hepatic CYP2E1 levels: A case study with toluene. Toxicology and Applied Pharmacology. 214:78–87.
Pery, Alexandre R R; Geffard Alain; Garric Jeanne. 2006. Mechanistic models to perform population risk assessment with the midge Chironomus riparius: application to heavy metals. Environmental science & technology; Oct 1;40 (19) p6026–31.
Rhomberg, L.R. And T.A. Lewandowski. 2006. Methods for identifying a default cross–species scaling factor. Human and Ecological Risk Assessment: 12: 1094–1127.
Sander P; Bergback B; Oberg T. 2006. Uncertain numbers and uncertainty in the selection of input distributions— Consequences for a probabilistic risk assessment of contaminated land. Risk Analysis. 26:(5):1363–1375.
Wu YP; Piegorsch WW (REPRINT); West RW; Tang DF; Petkewich MO; Pan W;2006. Multiplicity–adjusted inferences in risk assessment: Benchmark analysis with continuous response data. Environmental and Ecological Statistics;13:125 –141.

2006 Best Published Paper Demonstrating Application of Risk Assessment and Top Ten

Winner: Cox, Louis Anthony Tony;Sanders, Edward. 2006. Estimating preventable fractions of disease caused by a specified biological mechanism: PAHs in smoking lung cancers as an example. Risk Analysis. 26 (4) p881–92.

David, Raymond M;Clewell, Harvey J;Gentry, P Robinan;Covington, Tammie R;Morgott, David A;Marino, Dale J. 2006. Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations. Regulatory toxicology and pharmacology.45 (1) p55–65.
Dorman, David C;Struve, Melanie F;Clewell, Harvey J; Andersen, Melvin E.2006. Application of pharmacokinetic data to the risk assessment of inhaled manganese. Neurotoxicology;27 (5) p752–64.
Hack C Eric;Chiu Weihsueh A;Jay Zhao Q;Clewell Harvey J. 2006. Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. Regulatory toxicology and pharmacology. 46 (1) p63–83.
Hall, Jane R;Ashmore, Mike;Fawehinmi, Joseph;Jordan, Crawford;Lofts, Stephen;Shotbolt, Laura;Spurgeon, David J; Svendsen, Claus; Tipping, Edward. 2006. Developing a critical load approach for national risk assessments of atmospheric metal deposition. Environmental toxicology and chemistry.25 (3) p883–90.
Shao, Andrew and Hathcock, John N. 2006. Risk assessment for creatine monohydrate. Regulatory toxicology and pharmacology 45(3):242–251.
Sutter, Carrie Hayes, Rahman, Mostafizur and Sutter, Thomas R. 2006. Uncertainties related to the assignment of a toxic equivalency factor for 1,2,3,4,6,7,8,9–octachlorodibenzo–p–dioxin. Regulatory toxicology and pharmacology 44(3): 219–225.
Zartarian, VG; Xue, JP; Ozkaynak, H; Dang, W; Glen, G; Smith, L; Stallings, C. 2006. A probabilistic arsenic exposure assessment for children who contact CCA–treated playsets and decks, part I: Model methodology, variability results, and model evaluation. Risk Analysis. 26(2): 515–531.

2006 Overall Best Risk Assessment Abstract and Top Eleven

Winner: #901. Benchmark Dose Evaluation for Human Irritation. G.V. Alexeeff, K.K. Deng, R. Broadwin and A.G. Salmon. OEHHA, Cal/EPA.

#934. Assessment of Prenatal Development in PBDE Exposed Rats Sufficient or Marginal in Vitamin A. R. Ellis-Hutchings, G. Cherr and C. Keen. University of California Davis.

#882. Evaluation of the RD50 for determining acceptable levels of exposure to airborne sensory irritants. Y. Kuwabara, G.V. Alexeeff, R.L. Broadwin, and A.G. Salmon. OEHHA.

#792. Genetic Polymorphisms of Human N-acetyltransferase 2 Influence the Bioactivation of Aromatic and Heterocyclic Amines. Y. Zang, M.A. Doll, J. States and D.W. Hein. Pharmacology and Toxicology and Brown Cancer Center, University Louisville.

#51. Neighborhood environmental stress modifies the effect of lead on cognition: The Baltimore Memory Study. T. A. Glass, K. Bandeen-Roche, M. McAtee, and B.S. Schwatrz. Epidemiology, Johns Hopkins Bloomberg Scholl of Public Health.

#2382. Bayesian analysis of the inhalation pharmacokinetics of methyl tert-butyl ether (MTBE) and its metabolite tert-butanol in humans.A. Nong, L. Ernstgard, K. Krishnan and G. Johanson. Occupational and Environmental Health University de Montreal.

#2378. Improved Physiological Realism in PBPK Modeling for Variability Analysis: A Case Study with Ethanol. S. M. Hays and R.S. DeWoskin. Summit Toxicology.

#2339. Acute Hemodynamic and Hemolytic Effects of Intravenously Administered Ethylene Glycol in the Pig. R. Brown, D. Way-Cahen, A. Lucas, A. Steen, H. Baskar, J. Dux, and M. Stratmeyer. FDA/CDRH

#1641. Systems Biology Models For Integration Of Diverse Studies Of The Developing Neocortex After Exposure To Low Dose Radiation From External And Internal Sources. W. C. Griffith, N.M. DeFrank, J.M. Gohlke, E.J. Gribble, and E.M. Faustman. Environmental and Occupational Health Sciences, University of Washington.

#1633. The absorption and metabolism of inhaled benzo(a)pyrene in the isolated and perfused rat lung does not increase linearly with increasing exposures . P. Ewing, A. Ryrfeldt and P. Gerde. Environmental medicine. Karolinska Institute.

#1270. Using a PBPK Model to Explore Mechanisms of Observed Pharmocokinetic Differences of Phthalates across Life-Stages in Rats. R.A. Clewell, J. Kremer, M. Anderson and S. Borghoff. Environmental Sciences and Engineering. University of North Carolina at Chapel Hill.

#1256. Relation Of Urinary Metabolites Of Inorganic Arsenic With Transforming Growth Factor Alpha Concentration In Bladder Urothelial Cells From A Population Environmentally Exposed To Inorganic Arsenic. O.L. Valenzuela, D.R. Germolec, E.A. Garcia-Montalvo, L.C. Sanchez-Pena, A. Hernandez-Zavala, and L.M. Del Razo. Toxicology, Cinvstav, Mexico.

2006 Winner Best Graduate Student Abstract Award

#1207. Utilizing Human Cytochrome P450 Specific Content and Activity to Better Model Parathion and Chlorpyrifos Metabolism In Infants, Children, and Adults. R.J. Foxenberg, J.B. Knaak, B.P. McGarrigle, P.J., Kostyniak and J.R. Olson. Pharmacology and Toxicology, SUNY at Buffalo.

2006 Winner Best Postdoc Student Abstract Award

#646. Normal Gene Expression In Male And Female Sprague Dawley Rat Nasal Respiratory And Olfactory Epithelia. E. S. Roberts, N.V. Soucy, A.M. Bonner and D.C. Dorman. CIIT.

2005 Award Recipients

2005 Winner Best Risk Assessment Abstracts and Top Ten

Winner:# 2110. Improved Dosimetric Adjustment Factors for Interspecies Extrapolation of Inhaled, Poorly Soluble Particles. B. Asgharian; O. Price; A. Jarabek; F. Miller

#377. A Framework/Approach for Incorporating PBPK Modeling into Cumulative Risk Assessment of Chemical Mixtures. R. Yang; J. Dennison; J. Lipscomb

#381. Risk Assessment in Nephrotoxicology Sensitivity of Renal Tests. P. Potnis; A. Maier; T. Guidotti

#402. Incorporation of Trichloroacetic Acid Plasma Binding in Human and Mouse in Trichloroethylene Risk Assessment. D. Keys; M. Lumpkin; J. Bruckner; J. Fisher

#404. Monte Carlo Analysis of Sources of Variability in Chloroform-induced Hepatic Cytolethality and Regenerative Proliferation in B6c3f1 Mice. Y. Tan; R. Conolly

#349. An integrated QSAR-PBPK model for simulating pharmacokinetics of chemicals in mixtures. K. Price; K. Krishnan

#847. A Harmonized PBPK Model for Trichloroethylene Risk Assessment . T. Covington; H. Clewell; J. Fisher; D. Keys; C. Hack; J. Zhao

#866. Validation of a Human Physiologically-Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data. P. Hinderliter; K. Thrall; R. Corley; L. Bloemen; B. Matthew

#1096. Assessment of neurotoxicity using zebrafish as a model organism. N. Roy; C. Ton; Y. Lin; C. Parng

#1304. A Mechanistic Model of Lifetime Cancer Risk for Inhalation Exposures to Reactive Gases. J. Kimbell; D. Kalisak; R. Conolly; F. Miller; A. Jarabek

#1934. Evaluation of Systemic Toxicity in Mixtures of Trichloroethylene (TCE), Heptachlor (HEPT), and Di(2-ethylhexyl)phthalate (DEHP) Assessed in a 5x5x5 Design. J. Simmons; S. Yeatts; J. Zhao; C. Gennings; A. McDonald; R. MacPhail

2005 Winner Best Student Risk Assessment Abstract

Rat Kidney injury molecule-1 (rKim–1) ELISA: A sensitive assay for early detection of kidney tubular injury in preclinical toxicity studies. V. Vaidya; T. Ichimura; J. Bonventre, Harvard Medical School, Brigham and Women’s Hospital. (Abstract 197)

Awards for Best Published Papers in Risk Assessment

2005 Best Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Simmons, J. E., Evans,M. V., and Boyes, W. K. (2005). Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. J Toxicol. Environ. Health A 68(11–12), 927–950.

Allen, B., Zeiger, E., Lawrence, G., Friedman, M., and Shipp, A. (2005). Dose-response modeling of in vivo genotoxicity data for use in risk assessment: some approaches illustrated by an analysis of acrylamide. Regul. Toxicol. Pharmacol 41(1), 6–27.
Beliveau, M., Lipscomb, J., Tardif, R., and Krishnan, K. (2005). Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals. Chem. Res. Toxicol. 18(3), 475–485.
Bosgra, S., Bos, P. M., Vermeire, T. G., Luit, R. J., and Slob, W. (2005). Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate. Regul. Toxicol. Pharmacol 43(1), 104–113.
Clewell, H. J., Gentry, P. R., Kester, J. E., and Andersen, M. E. (2005). Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene. Crit Rev. Toxicol. 35(5), 413–433.
Clewell, H. J., and Crump, K. S. (2005). Quantitative estimates of risk for noncancer endpoints. Risk Anal. 25(2), 285–289.
Corley, R. A., Grant, D. M., Farris, E., Weitz, K. K., Soelberg, J. J., Thrall, K. D., and Poet, T. S. (2005). Determination of age and gender differences in biochemical processes affecting the disposition of 2-butoxyethanol and its metabolites in mice and rats to improve PBPK modeling. Toxicol. Lett. 156(1), 127–161.
Jarabek, A. M., Asgharian, B., and Miller, F. J. (2005). Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP). Inhal. Toxicol. 17(7–8), 317–334.
Preston, R. J. (2005). Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints. Environ. Mol. Mutagen. 45(2–3), 214–221.
Simmons, J. E., Evans, M. V., and Boyes, W. K. (2005). Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. J Toxicol. Environ. Health A 68(11–12), 927–950.
Slob, W., Moerbeek, M., Rauniomaa, E., and Piersma, A. H. (2005). A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints. Toxicol. Sci 84(1), 167–185.

2005 Best Paper Demonstrating the Application of Risk Assessment and Top Ten:

Winner: Walker, N. J., Crockett, P. W., Nyska, A., Brix, A. E., Jokinen, M. P., Sells, D. M., Hailey, J. R., Easterling, M., Haseman, J. K., Yin, M., Wyde, M. E., Bucher, J. R., and Portier, C. J. (2005). Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113(1), 43–48.

Axelrad DA et al. (2005). Risk assessment for benefits analysis: framework for analysis of a thyroid-disrupting chemical. J Toxicol Environ Health 68(11–12), 837–855.
Collins, J. F., Salmon, A. G., Brown, J. P., Marty, M. A., and Alexeeff, G. V. (2005). Development of a chronic inhalation reference level for respirable crystalline silica. Regul. Toxicol. Pharmacol 43(3), 292–300.
Dennison, J. E., Bigelow, P. L., Mumtaz, M. M., Andersen, M. E., Dobrev, I. D., and Yang, R. S. (2005). Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling. J Occup. Environ. Hyg. 2(3), 127–135.
Fukushima, S., Kinoshita, A., Puatanachokchai, R., Kushida, M., Wanibuchi, H., and Morimura, K. (2005). Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 26(11), 1835–1845.
Jeffrey, A. M., and Williams, G. M. (2005). Risk assessment of DNA-reactive carcinogens in food. Toxicol. Appl. Pharmacol 207(2 Suppl), 628–635.
Kirman, C. R., Sweeney, L. M., Corley, R., and Gargas, M. L. (2005). Using physiologically-based pharmacokinetic modeling to address nonlinear kinetics and changes in rodent physiology and metabolism due to aging and adaptation in deriving reference values for propylene glycol methyl ether and propylene glycol methyl ether acetate. Risk Anal.
Kirman, C. R., Gargas, M. L., Marsh, G. M., Strother, D. E., Klaunig, J. E., Collins, J. J., and Deskin, R. (2005). Cancer dose-response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity. Regul. Toxicol. Pharmacol 43(1), 85–103.
Mielke, H., Gundert, A., Abraham, K., and Gundert-Remy, U. (2005). Acute inhalative exposure assessment: derivation of guideline levels with special regard to sensitive subpopulations and time scaling. Toxicology 214(3), 256–267.
Schwarz, M., and Appel, K. E. (2005). Carcinogenic risks of dioxin: mechanistic considerations. Regul. Toxicol. Pharmacol 43(1), 19–34.
Teeguarden, J. G., Deisinger, P. J., Poet, T. S., English, J. C., Faber, W. D., Barton, H. A., Corley, R. A., and Clewell, H. J., III (2005). Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid. Toxicol. Sci 85(1), 429–446.
Walker, N. J., Crockett, P. W., Nyska, A., Brix, A. E., Jokinen, M. P., Sells, D. M., Hailey, J. R., Easterling, M., Haseman, J. K., Yin, M., Wyde, M. E., Bucher, J. R., and Portier, C. J. (2005). Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 113(1), 43–48.

2004 Award Recipients

2004 Winner Best Risk Assessment Abstract

Winner: Approaches for Converting Adult Dose to Children of Various Age Groups: Relevance for the Risk Assessment of Environmental Chemicals by B. Gohore and K. Krishnan (Abstract 1770)

2004 Winner Best Student Abstract Award

Impaired Signal Trafficking Failed On-Demand Liver Tissue Repair Upon Hepatotoxic Challenge in Type 2 Diabetes by A.V. Sawant, J.R. Latendresse, and H.M. Mehendale. (Abstract 512)

2004 Best Published Paper Demonstrating Application of Risk Assessment and Top Ten

Winner: Kirman CR, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini RJ and Gargas ML (2004) Addressing nonlinearity in the exposure-response relationships for a genotoxic carcinogen: cancer potency estimates for ethylene oxide. Risk Analysis 24: 1165–1183.

Babich MA, Chen SB, Greene MA, Kiss CT, Porter WK, Smith TP, Wind ML, Zamula WW. (2004). Risk assessment of oral exposure to diisononyl phthalate from children’s products. Regul. Toxicol. Pharmacol. 40(2): 151–67.
Booze TF, Reinhardt TE, Quiring SJ and Ottmar RD. (2004). A screening level assessment of the health risks of chronic smoke exposure for wildland firefighters. Journal of Occupational and Environmental Hygiene 1: 296–305.
Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J and Miller FJ. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: dose response predictions from biologically-motivated computational modeling of as combined rodent and human dataset. Toxicological Sciences 82: 279–296.
Farrrow S. (2004). Using risk assessment, benefit-cost analysis, and real options to implement a precautionary principle. Risk Anal. 24(3): 727–35.
Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM. (2004). Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. Toxicol. Sci. 79(1): 28–37.
Renwick AG. (2004). Establishing the upper end of the range of adequate and safe intakes for amino acids: a toxicologist’s viewpoint. J. Nutr. 134(6 Suppl): 1617S–1624S.
Schoen A, Beck B, Sharma R and Dubé E. (2004) Arsenic toxicity at low doses: epidemiological and model of action considerations. Toxicology and Applied Pharmacology 198: 253–267.
Sweeney LM, Andersen ME and Gargas ML. (2004). Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically-based nasal dosimetry model. Toxicological Sciences 79: 394–403.
Tsuji JS, Benson Rj, Schoof RA, Hook GC. (2004). Health effect levels for risk assessment of childhood exposure to arsenic. Regul. Toxicol. Pharmacol. 39(2): 99–110.

2004 Best Published Paper Advancing the Science of Risk Assessment and Top Ten

Winner: Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker NJ, Martinez J, Portier CJ.(2004). Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta. Environ. Health Perspect. 112(12): 1217–

Ashani Y and Pistinner S. (2004). Estimation of the upper limit of human butrylchloinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model. Toxicological Sciences 77: 358–367.
Clark LH, Setzer RW and Barton HA. (2004) Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Analysis 24: 1697.
Calabrese EJ (2004). Hormesis: from marginalization to mainstream: a case for hormesis as the defaul dose-response model in risk assessment. Toxicol. Appl. Pharmacol. 197: 125–136.
Conolly RB and Lutz WK. (2004). Nonmonotonic dose response relationships: mechanics basis, kinetic modeling and implications for risk assessment. Toxicological Sciences 77: 153–157.
Dorne JL, Walton K, Renwick AG. (2004). Human variability in the renal elimination of foreign compounds and renal excretion–related uncertainty factors for risk assessment. Food Chem. Toxicol. 42(23): 275–98.
Englehardt JD (2004) Predictive Bayesian dose–response assessment for appraising absolute health risk from available information. Human and Ecological Risk Assessment 10: 69–78.
Gaylor DW and Aylward LL. (2004). An evaluation of benchmark dose methodology for noncancer continuous data health effects in animals due to exposed to dioxin. Regulatory Toxicology and Pharmacology 40: 9–17.
Gaylor DW, Lutz WK and Conolly RB. (2004). Statistical analysis of nonmonotonic dose-response relationships: research design and analysis of nasal cell proliferation in rats exposed to formaldehyde. Toxicological Sciences 77: 158–164.
Razzaghi M and Kodell R. (2004) Quantitative risk assessment for developmental neurotoxic effects. Risk Analysis 24: 1673.