Events

Upcoming Events

Integrating Machine Learning and Quantitative Structure Activity Relationships Modeling Approaches to Develop AI-assisted Interactive Physiologically Based Pharmacokinetic Modeling Web Dashboard

Wednesday, December 13, 2023
3:00 PM to 4:30 PM (US EST, UTC -5)
Hosted by: The SOT Risk Assessment and Biological Modeling Specialty Sections and the SOT American Association of Chinese in Toxicology Special Interest Group

Registration required for this free webinar.

Register Now

Physiologically based pharmacokinetic (PBPK) and quantitative structure-activity relationship (QSAR) models are useful tools in the assessment of pharmacokinetics/toxicokinetics, toxicities, and health risks of environmental chemicals, drugs, and nanoparticles in animals and humans. Machine learning and artificial intelligence (AI) approaches have greatly advanced many scientific disciplines, including toxicology and risk assessment. This webinar will introduce representative applications of machine learning and AI approaches in different areas of toxicological sciences, including prediction of absorption, distribution, metabolism, and excretion (ADME) properties of drugs, QSAR modeling for toxicity prediction of environmental chemicals, PBPK model development for nanoparticles, and toxicological databases relevant to these applications. We will conclude with a summary of the current progress and share our perspectives on the challenges and future directions in the field of biological modeling in toxicology and risk assessment.

Speakers:

  • Zhoumeng Lin, PhD, Associate Professor, Department of Environmental and Global Health, University of Florida
  • Wei-Chun Chou, PhD, Research Assistant Professor, Department of Environmental and Global Health, University of Florida

Registration required for this free webinar.

Register Now

 



Past Events

Wednesday, November 8, 2023: A Connectivity Mapping (CMap) Based Assessment of Butylated Hydroxytoluene (BHT) for Endocrine Disruption (ED)

Hosted by: SOT Risk Assessment Specialty Section

Speaker:
Nadira DeAbrew, PhD, Group Scientist, Procter & Gamble

Wednesday, October 11, 2023: In Silico Tools for Prediction and Mechanistic Interpretation of Systemic and Topical Toxicity

Hosted by: The SOT Risk Assessment

Speakers:
Alexander Tropsha, PhD, K.H. Lee Distinguished Professor, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

Wednesday, September 20, 2023: Mixture Toxicity in the 21st Century: Assessment Methods Presentations

Hosted by: The SOT Risk Assessment and Mixtures Specialty Sections

Speakers:
Kristin Eccles, PhD
Paul S. Price, PhD

Thursday, August 3, 2023: Risk Assessment Syllabus: Basics of Exposure Assessment

Hosted by: SOT Risk Assessment Specialty Section

Speakers:
Nicolle Tulve, PhD, US EPA
Dan Vallero, PhD, US EPA

Moderator:
Linda Birnbaum, PhD, DABT, ATS, NIEHS, Retired

Panelists:
Paul Price, PhD, Risk Sciences International
Sharada Balakrishnan, MSc, PhD, DABT, California EPA-DTSC
Ruthann Rudel, MS, Silent Spring Institute

Thursday, May 25, 2023: An Introduction to Chemical Exposure Estimation

Hosted by: Exposure and Risk Assessment Specialty Sections

Speaker:
Jon Arnot, PhD, Arnot Research and Consulting Inc.

Wednesday, May 10, 2023: Improving the Technical Quality of New Approach Methodologies (NAMs) and Nanotoxicity Methods

Hosted by: SOT Risk Assessment Specialty Section

Speakers:
Elijah Petersen, PhD, National Institute of Standards and Technology

Wednesday, April 19, 2023: Engineering Complex Systems for Predictive Toxicology in the Animal-free Zone

Hosted by: Risk Assessment Specialty Section

Speakers:
Chad Deisenroth, PhD, US EPA
Thomas B. Knudsen, PhD, US EPA

Monday, February 6, 2023: Silicone Wristbands: Personal Exposure Monitors to Help Support Research on the Exposome

Co-Hosted by: SOT Risk Assessment Specialty Section, SOT Exposure Specialty Section, and The International Society of Exposure Science

Speaker:
Heather M. Stapleton, PhD, Ronie-Richele Garcia-Johnson Distinguished Professor of Environmental Health, Nicholas School of the Environment, Duke University

Wednesday, January 11, 2023: Mixture Assessment Factors—Motivations, Derivations and Uses

Hosted by: SOT Risk Assessment Specialty Section and Mixtures Specialty Section

Speaker:
Andreas Kortenkamp, PhD, Brunel University London, Centre for Pollution Research and Policy

Wednesday, December 14, 2022: Generic Pharmacokinetic Models for Mother-to-Offspring Transfer of Chemicals

Jointly Sponsored Webinar with the Biological Modeling Specialty Section

Speaker: Dustin F. Kapraun, PhD, US EPA

Tuesday, November 15, 2022: Evaluations of Epidemiology and Human Studies for Risk Assessment

Hosted by: SOT Risk Assessment Specialty Section (RASS)

Speakers:
Rachel Shaffer, PhD, US EPA
Rebecca Nachman, PhD, US EPA

Moderator:
Ronald Hines, PhD, ATS, Yale University School of Public Health

Panelists:
Daniel Krewski, PhD, University of Ottawa
Raghavendhran Avanasi, PhD, Syngenta Crop Protection LLC

This was the third of a webinar series on similar topics; the first was held in June 2021, and the second was held in June 2022.

Wednesday, October 12, 2022: A Community-Integrated Geographic Information System Study of Air Pollution Exposure Impacts in Colfax, Louisiana

Speakers:
Jennifer Richmond-Bryant, PhD
Associate Professor of the Practice, Department of Forestry and Environmental Resources and the Center for Geospatial Analytics, North Carolina State University, Raleigh, North Carolina

Margaret Reams, PhD
Professor and Joseph D. Martinez Professor of Environmental Sciences, Department of Environmental Sciences, College of the Coast and Environment, Louisiana State University (LSU), and Leader, Community Engagement Core, LSU Superfund Research Center, Baton Rouge, Louisiana

Wednesday, September 14, 2022: Combined Effects of Chemical Mixtures Are Predictable for the Whole Transcriptome—a Proof of Concept Toxicogenomic Study With Zebrafish Embryos

Jointly Sponsored Webinar with the Mixtures Specialty Section 

Speaker: Wibke Busch, PhD, Group leader iTox—integrative toxicology, Helmholtz-Centre for Environmental Research – UFZ, Leipzig

A Population-based Human In Vitro Approach to Quantify Inter-individual Variability in Responses to Chemical Mixtures

Speaker: Lucie Ford, Doctoral student, Interdisciplinary Faculty of Toxicology, Texas A&M University

Tuesday, June 7, 2022: Animal Toxicology in Risk Assessment—Study Design and Evaluation Considerations

Speaker: Margaret Pratt, PhD, Toxicologist, ORD, USEPA, Washington, DC

Facilitator/Moderator: George Daston, PhD, Victor Mills Society Research Fellow, Proctor & Gamble Co., Mason, OH

Panelists:
John Lipscomb, PhD, Toxicologist, CTEH, North Little Rock, AR
Elaina Kenyon, PhD, Research Toxicologist, ORD, USEPA, Durham, NC
Elaine Faustman, PhD, Professor, University of Washington

Wednesday, May 11, 2022: Establishing Scientific Confidence in New Approach Methodologies (NAMs): Eye Irritation Testing and Beyond

Jointly Sponsored Webinar with the In Vitro and Alternative Methods Specialty Section (IVAM)

Speakers:
Hans A. Raabe, MS, VP and Chief Operating Officer, Institute for in Vitro Sciences (IIVS)
Amy J. Clippinger, President, PETA Science Consortium International e.V. (PSCI)

Wednesday, April 13, 2022: Climate Change and Vulnerable Populations: Complementary Approaches for Assessing Extreme Heat and Health

Jointly Sponsored Webinar with the Exposure Specialty Section (ESS) and International Society for Exposure Science (ISES)

Speakers:
Dr. Madeleine Scammel, PhD
Dr. Gregory Wellenius, PhD

Wednesday, February 9, 2022: Natural Product Health Risk Assessment: Weaknesses and Potential Improvements

Speaker: James T. MacGregor, PhD, DABT

Wednesday, January 12, 2022: A Novel Framework to Form Sufficiently Similar Mixtures

Jointly Sponsored Webinar with the Mixtures Specialty Section (MSS)

Speaker: Brianna N. Rivera, BS

Wednesday, December 8, 2021: Opportunities and Challenges Related to Saturation of Toxicokinetic (TK) Processes: Implications for Risk Assessment

Speaker: Michelle Embry, PhD

Wednesday, November 10, 2021: Updates to the Cramer et al. Decision Tree and the Threshold of Toxicological Concern: The Expanded Decision Tree and Its Use in Safety Assessments

Speaker: Szabina Stice, PhD

Wednesday, October 13, 2021: The Environmental Health Language Collaborative: Using Harmonized Language to Address Environmental Health Challenges

Speakers:
Stephanie Holmgren, MSLS, MBA
Michelle Angrish, PhD
Stephen Edwards, PhD

Wednesday, September 8, 2021: The Missing Link: Ex Vivo E-Cigarette Toxicity Modeling

Speaker: Jacklyn “Skye” Kelty, PhD

Wednesday, June 9, 2021: RASS Webinar: Syllabus - Introduction to Human Health Risk Assessment

Speakers: Laura Carlson, PhD and George Woodall, PhD

Panelists: Jessica Hawes, PhD, David M. Reif, PhD, and Daniele Wikoff, PhD

Wednesday, May 12, 2021: Rapid Development of Physiologically Based Pharmacokinetic (PBPK) Models for Human Health Risk Assessment: Application of Diverse Approaches to Estimating Metabolism

Speaker: Lisa M. Sweeney, PhD

Wednesday, April 14, 2021: Improving Read-Across for Toxicological Data Gap Filling by Characterising, Assessing and Reducing Uncertainties

Speakers: Terry W. Shultz, PhD and Mark T.D. Cronin, PhD

Wednesday, February 10, 2021: Composite Scores, Social Embodiment and Risk of CVD: Evidence from the UK Biobank Cohort

Jointly Sponsored Webinar with the Exposure Specialty Section (ExpoSS) and International Society for Exposure Science (ISES)

Speaker: Marc Chadeau-Hyam, PhD

Webinar January 13, 2021: Characterization of Developmental Toxicity and Adverse Outcome Pathways (AOPs) for Emerging PFAS — Individual Compounds and Mixtures

Joint Risk Assessment Specialty Section (RASS) Webinar with the Mixtures Specialty Section (MixSS)

Speakers: L. Earl Gray Jr., PhD and Justin M. Conley, PhD

Webinar December 9, 2020: Assessing the Impact of Multi-route Co-exposures on Human Variability in Toxicokinetics of Drinking Water Contaminants in Binary and Quaternary Mixtures

Joint Risk Assessment Specialty Section (RASS) Webinar with the Biological Modeling Specialty Section (BMSS)

Speakers: Mathieu Valcke, PhD; and Sami Haddad, PhD

Webinar November 11, 2020: Risk Assessment Specialty Section (RASS) with the Mechanisms Specialty Section (MSS)

Webinar October 14, 2020: The COVID-19 Vulnerability Index (PVI) Dashboard: Monitoring County-level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Webinar September 9, 2020: Organizing Mechanism-related Information on Chemical Interactions Using a Framework based on the Aggregate Exposure and Adverse Outcome Pathways

Webinar May 13, 2020: Mechanistic and Pharmacokinetic Consideration to Aid in Determining Causality: Frontiesr for Data Integration

Webinar April 16, 2020: Computational Methods in Next-generation Risk Assessment of Consumer Products

Webinar February 12, 2020: Challenges and Opportunities in Assessing Health Risk from Unconventional Oil and Gas Development

Webinar January 8, 2020: Rapid Hazard Identification of Environmental Chemicals and Mixtures

Webinar December 11, 2019: Dose-Response Modeling for Risk Assessment—BMDS 3.2 and Bayesian Model Averaging

Webinar November 13, 2019: Chemical Carcinogenicity Revisited in Three Parts

Webinar October 9, 2019: Comparison of Various Approaches to AOP Quantification

Webinar September 11, 2019: A Novel Empirical Strategy using Human Biomonitoring Data to Estimate Regulatory Guideline Values

Webinar May 9, 2019: EuroMix: An assessment of mixture toxicity using in vitro analyses of liver steatosis to develop an adverse outcome pathway based strategy

Webinar April 10, 2019: Causal Modeling with Applications in Clinical and Policy Studies
Information-based Causal Modeling (IBCM) and Applications

Webinar February 13, 2019: Epidemiology and Risk Assessment—Bridging the Gap

Webinar January 9, 2019: Use of Chemometrics and Multivariate Statistical Analysis to Determine Toxic Constituents Within Various Crude Oils

Temporal Trends of Cumulative Risks from Six Phthalates in Biomonitoring Data

Webinar December 12, 2018: In Vitro to in Vivo Extrapolation (IVIVE) to Support New Approach Methodologies (NAMs)-based Safety Assessment: A Tiered Approach with a Focus on the Consideration of Kinetics and Metabolism

Webinar November 14, 2018: A Mechanistic Approach for Source-to-Outcome Risk Assessment Across Human Health and Ecological Endpoints Using the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks

Webinar October 10, 2018: U.S. EPA Strategic Plan to Promote the Development and Implementation of Alternative Test Methods

  • Webinar Recording (Unavailable)

Webinar September 12, 2018: The Key Characteristics Approach to Evaluating Mechanistic Data in Hazard Identification and Risk Assessment

  • Webinar Recording (Unavailable)

Webinar May 9, 2018: Overview of an Uncertainty Analysis Tool to Increase Transparency and Communication of Uncertainty in Chemical Risk Assessment

  • Webinar Recording (Unavailable)

Webinar April 11, 2018: Use of the "Exposome" in the Convergence of Toxicology and Epidemiology: A Primer on—Omic Technologies for Achieving Health Impact

  • Webinar Recording (Unavailable)

Webinar February 14, 2018: Exposure Assessment for Chemical and Non-chemical Exposures for Urban Epidemiology

  • Webinar Recording (Unavailable)

Webinar January 10, 2018: Assessing the Health Impact of Diverse Mixtures in the Environment

Webinar December 13, 2017: A Liver-centric Multiscale Modeling Framework for Xenobiotics

  • Webinar Recording (Unavailable)

Webinar November 8, 2017: Systematic Review: Concept and Tool Development with Application to Assessment Processes of the National Toxicology Program (NTP) and the Integrated Risk Information System (IRIS)

Systematic Review Methods to Support Transparency and Consistency in Environmental Health Decision Making

  • Webinar Recording (Unavailable)

Webinar October 11, 2017: A Source to Outcome Approach for Inhalation Risk Assessment

  • Webinar Recording (Unavailable)

Webinar September 13, 2017: Mixing Hazardous Agents in a Mouse Model: Noise with Lead and Cadmium

Complex Mixtures of Anti-Androgens at Concentrations below Individual Chemical Effect Levels Produce Reproductive Tract Malformations in the Male Rat

  • Webinar Recording (Unavailable)

Webinar May 10, 2017: Putting Exposure Back in Risk Assessment (Or: The Dose Makes the Poison)

  • Webinar Recording (Unavailable)

Webinar April 12, 2017: Crowdsourcing Scientific Perspectives with SciPinion™: Hexavalent Chromium as a Case Study

  • Webinar Recording (Unavailable)

Webinar February 8, 2017: How Can Mechanistic Data from Systems Approaches Improve our Understanding of Carcinogenic Risk for Mixtures?

  • Webinar Recording (Unavailable)

Webinar January 11, 2017: German Environmental Survey and Environmental Specimen Bank and the Use of Human Biomonitoring Data for Risk Assessment

  • Webinar Recording (Unavailable)

Webinar December 14, 2016: Aggregate Exposure Pathway (AEP): An Organizational Approach for Advancing Exposure Science Research and Applications

  • Webinar Recording (Unavailable)

Webinar November 9, 2016: Improving Causal Inference in Cumulative Risk Assessment Using Directed Acyclic Graphs

  • Webinar Recording (Unavailable)

Webinar October 12, 2016: Overview of TSCA Reform and Introduction to Key Provisions in the New
Lautenberg Law

  • Webinar Recording (Unavailable)

Webinar September 14, 2016: Incorporating Non-Chemical Stressors into Cumulative Risk Assessment (CRA)

Webinar May 11, 2016: Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

  • Webinar Recording (Unavailable)

Webinar April 13, 2016: Studying Biology to Understand Risk: Dosimetry Models and Quantitative Adverse Outcome Pathways

  • Webinar Recording (Unavailable)

Webinar February 10, 2016: Characterization of Murine Hepatocarcinogenesis Induced by the Nitrification Inhibitor Nitrapyrin: Mode of Action, Human Relevance Framework and Risk Assessment Implications

  • Webinar Recording (Unavailable)

Webinar January 13, 2016: Health Effects of Mixtures: Comparing Approaches in Epidemiology and Toxicology (with a discussion of the July 2015 NIEHS Workshop entitled “Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology Studies”)

  • Webinar Recording (Unavailable)

Webinar December 9, 2015: Highly fluorinated chemicals: A Legal and Technical Challenge

Webinar November 18, 2015: Framework for Human Health Risk Assessment of Noncancer Effects Resulting from Short-Duration and Intermittent Exposures to Chemicals

  • Webinar Recording (Unavailable)

Webinar October 14, 2015: The Integration of LNT and Hormesis for Cancer Risk Assessment Optimizes Public Health Protection

Webinar September 9, 2015: Mechanisms of Action for Arsenic in Cardiovascular Toxicity and Implications for Risk Assessment

  • Webinar Recording (Unavailable)

Webinar June 10, 2015: Quantitative Evidence Integration to Facilitate the Use of Tox21 Data for Rapid Risk Screening

  • Webinar Recording (Unavailable)

Webinar April 8, 2015: Adverse Outcome Pathways

  • Webinar Recording (Unavailable)

Webinar February 11, 2015: CHAMACOS: Lessons from the Fields

Webinar January 14, 2015: Systematic Reviews, Risk of Bias and Evidence Evaluation for Characterization of Environmental Chemicals

Instruments for Assessing Risk of Bias and Other Methodological Criteria of Published Animal Studies: A Systematic Review

  • Webinar Recording (Unavailable)

Webinar December 10, 2014: Improving Reproducibility in Toxicology

  • Webinar Recording (Unavailable)

Webinar November 12, 2014: Introduction to Decision Analysis and Value of Information Analysis for Toxicology and Environmental Science

Webinar October 8, 2014: Every Breath You Take: Exposure Science and the Virtual Respiratory System

  • Webinar Recording (Unavailable)

Webinar September 10, 2014: Toxicology for Breast Cancer Prevention

Webinar June 11, 2014: Environmental Decisions in the Face of Uncertainty

  • Webinar Recording (Unavailable)

Webinar May 14, 2014: Cancer Clusters in the USA: What Do the Last Twenty Years of State and Federal Investigations Tell Us?

  • Webinar Recording (Unavailable)

Webinar January 8, 2014: Environment-wide Association Studies (EWAS) to Connect Multiple Personal Exposures to Health

  • Webinar Recording (Unavailable)

Webinar December 11, 2013: Providing the Missing Link: the Exposure Ontology (ExO), High Throughput Human Exposure Forecasts for Environmental Chemical Risk

Webinar November 13, 2013: Approaches to Dose-response Analysis for Compounds with Endogenous Production: Two Case Studies Critical Issues for Formaldehyde Cancer Risk Assessment (Swenberg Presentation and Starr Presentation) and Derivation of Methanol RfD and RfC—Accounting for Background Blood Levels

Webinar September 11, 2013: International Experience in Addressing Combined Exposures: Increasing the Efficiency of Assessment

  • Webinar Recording (Unavailable)

Webinar June 12, 2013: Cumulative Risk Assessment: Approaches and Case Study

  • Webinar Recording (Unavailable)

Webinar May 8, 2013: Evidence for the Existence of Nonmonotonic Dose-Response: Does It or Doesn’t It?

Are Nonmonotonic Dose Response Curves (NMDRCs) Common after Estrogen or Androgen Signaling Pathway Disruption: Fact or Falderal?

Webinar April 10, 2013: Interface of Health Effects Caused by the CardioMetabolic Syndrome and Exposures to Air Pollutant Mixtures

Webinar February 13, 2013: Roundtable Panel Discussion: Should Journals Require the Release of Supporting Data As a Condition for Publication?

  • Webinar Recording (Unavailable)

Webinar January 9, 2013: Mode of Action Research, Multispecies Pharmokinetic Modeling, and Risk Assessment for the Carcinogenesis of Hexavalent Chromium in the Small Intestine

Webinar December 12, 2012: Deming and Statistical Strategies to Make Observational Studies More Reliable

  • Webinar Recording (Unavailable)

Webinar October 10, 2012: Alternative Methods for the Evaluation of Bioavailability of Arsenic in Mining Soils

Webinar September 12, 2012: A More Efficient and Effective Testing and Assessment Paradigm for Chemical Risk Management

Webinar June 13, 2012: Identification and Characterization of Adverse Effects in 21st Century Toxicology and Risk Assessment

Webinar April 25, 2012: Introduction to the New WHO/IPCS Guidelines for Immunotoxicity Risk Assessment for Chemicals

Immunotoxicity Risk Assessment

  • Webinar Recording (Unavailable)

Webinar February 8, 2012: Challenges in the Application Of Quantitative Approaches in Risk Assessment: A Case Study with Di-(2-Ethylhexyl)Phthalate

  • Webinar Recording (Unavailable)

Webinar January 11, 2012: Comprehensive Environmental Assessment of Nanomaterials:
A Meta-Assessment Approach

  • Webinar Recording (Unavailable)

Webinar December 14, 2011: Studies with Diesel Exhaust Particulate: Implications for the Potential Human Health Hazards of Nanoparticles

  • Webinar Recording (Unavailable)

Webinar November 9, 2011: Risk from Multiple Chemicals in Polluted Communities

Webinar October 12, 2011: Estimating the Economic Value of Improved Information for Health Risk Assessment

Webinar June 8, 2011: Linear Low-Dose Extrapolation for Noncancer Health Effects Is the Exception, Not the Rule

  • Webinar Recording (Unavailable)

Webinar May 11, 2011: The Maximum Cumulative Ratio (MCR): A Tool That Uses Both Exposure and Toxicity Data to Determine When Cumulative Assessments Are Most Necessary

Webinar April 13, 2011: OSTP Scientific Integrity Guidance Memo—December 17, 2010

Webinar February 9, 2011: Development of a Quantitative Model Incorporating Key Events in a Hepatotoxic MOA to Predict Tumor Incidence

Webinar January 12, 2011: NexGen Risk Assessment Framework

Teleconference December 8, 2010: Selected Silver Book Highlights and Update on Related Activities

Teleconference November 10, 2010: The Use of PBPK Modeling to Reduce Uncertainty in Risk Assessment: Example of Manganese

Teleconference October 13, 2010: An Integrated Evaluation Strategy for Making Regulatory Decisions: Moving from Data Requirements to Knowledge Requirements

Teleconference September 8, 2010: Improving Prognostic Science for Risk Assessment: Developing Better Biomarkers for Key Clinical Diseases

Teleconference June 30, 2010: Developments and Good Practice in Mode of Action/Human Relevance Anaylsis

Teleconference June 9, 2010: Analyzing Genomic Dose-Response Information to Inform Key Events in a Mode of Action for Carcinogenicity: An Example with Arsenic

Teleconference May 12, 2010: Opportunities for Progress in the Applications of Mechanistic Information in Risk Assessment

Rescheduled Teleconference February 10 presented on April 14, 2010: Key Events Dose-Response Analysis. Part 2: Application to Nutrients, Pathogenic Microorganisms, and Food Allergens

Teleconference January 13, 2010: Key Events Dose-Response Analysis. Part 1: Conceptual Framework and Application to Chemicals

Teleconference December 9, 2009: Biomonitoring Equivalents: Derivation Guidelines and Lessons Learned

Teleconference June 10, 2009: Models in Environmental Regulatory Decision-Making—Report of the Committee on Models in the Regulatory Decision Process

Teleconference May 13, 2009: Science and Decisions: Advancing Risk Assessment—Joseph Rodricks and Jonathan Levy

Teleconference April 8, 2009: Approaches for Evaluating the Relevance of Multiroute Exposures in Establishing Guideline Values for Drinking Water Contaminants—Kannan Krishnan and Richard Carrier

Teleconference March 11, 2009: Hormesis: What It Means for Toxicology, the Environment, and Public Health

Getting the Dose-Response Wrong: Why Hormesis Became Marginalized and the Threshold Model Accepted

The Road to Linearity: Why Linearity at Low-Doses Became the Basis for Carcinogen Risk Assessment

Teleconference February 11, 2009: Predicting Pharmacokinetics in Humans: The Bottom-Up Approach

Teleconference January 14, 2009: State of the Science Workshop: Low Dose-Response Extrapolation for Environmental Health Risk Assessment

Teleconference November 12, 2008: Pb NAAQS Human Health Risk Assessment—Overview of Design and Implementation

Teleconference October 8, 2008: Betraying Paracelsus, Ignoring Newton: A Flaw in the Nanotoxicology Paradigm

Teleconference September 10, 2008: Mutagenic MOA Carcinogens: How Hign Is the Burden of Proof?

Teleconference June 11, 2008: The Hamner Institutes Programs Related to Implementing Recommendations from “Toxicity Testing in the 21st Century: A Vision and a Strategy”

Teleconference May 14, 2008: Incorporating Gene-Environment Information into Kinetic Models: Lessons Learned and Future Challenges

Design and Dose Selection for Chronic Rodent Studies

Integration of Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling of Arsenic to Inform the Risk Assessment Process

Toxicity Testing in the 21st Centry—Mel Andersen and Dan Krewski

Updated Principles for Risk Analysis—Nancy Beck

Integrating Life Stage Susceptibility into Immuntoxicity and Microbial Risk Assessment—Robert W. Luebke

The Unc Atmospheric Simulation Chamber Toxicology System–Effects of Chemical Transformations in Complex Mixtures—Harvey Jeffries, Kenneth G. Sexton, Seth Ebersviller, Kim de Bruijne, Erin Potts, Liz Naess—32 mb, 2–5 minutes to download)

Model Averaging: Beyond Model Uncertainty in Risk Analysis—Matthew W. Wheeler

Developing Tumor-Associated Somatic Mutations As Biomarkers of Cancer Risk—Barbara Parsons

Benchmark Dose Evaluations for Acute Inhalation Exposures to Human Toxicants—G.V. Alexeeff, K. K. Deng, R. L. Broadwin, A. G. Salmon

Framework for Inorganic Metals Risk Assessment—Anne Fairbrother, Randy Wentsel, Bill Wood, Keith Sappington, and Pam Noyes Office of Research and Development

The Application of Genomic Dose-Response Data in Risk Assessment—Harvey Clewell and Rusty Thomas CIIT Centers for Health Research

Use of Developmental Neurotoxicity Data in Risk Assessment at EPA: Current Status and Future Efforts—Kathleen Raffaele and William Mundy

A Biologically-Based Model for Low-Dose Extrapolation of Cancer Risk from Ionizing Radiation—Doug Crawford-Brown

Dosimetry Can Change Mechanistic Models: The Challenge of Scrutinizing the Source before Gathering and Analyzing the Data—Owen R. Moss

Dose-Response Modeling for EPA’s Organophosphate Cumulative Risk Assessment: Combining Information from Several Datasets to Estimate Relative Potency Factors—R. Woodrow Setzer

Dose-Response Modeling: Past, Present, and Future—Rory B. Conolly

Intentional Human Dosing Studies for EPA: SOT Briefing

Dose-Response Modeling: Past, Present, and Future II—Rory B. Conolly and Rusty Thomas

HESI Project Committee on Dose-Dependent Transitions in Mechanisms of Toxicity Teleconference: Part 1 of 3

HESI Project Committee on Dose-Dependent Transitions in Mechanisms of Toxicity Teleconference: Part 2 of 3

HESI Project Committee on Dose-Dependent Transitions in Mechanisms of Toxicity Teleconference: Part 3 of 3

Identifying Research Needs for Risk Assessment of US Food Supply Security—Bruce Hope

RASS Annual Business Meeting and Reception

RASS Reception HESI Panel

RASS Panel Discussion Questions

Assessing the Real Risk in Complex Diseases—Michael N. Liebman