Archive of Award Recipients

• 2023......Xue Wu, PhD Student at the University of Florida. Mentor: Dr. Zhoumeng Lin.
  “Development of a Physiologically Based Pharmacokinetic PBPK Model for Flunixin in Cattle and Swine following Dermal Exposure”
• 2022......Yun Zhou, PhD Student at Indiana University Bloomington. Mentor: Dr. Kan Shao.
  “Quantitative Integration of Mode-of-Action Information in Dose-Response Modeling and POD Estimation: A Case Study of PCB 126”
• 2021......David Filipovic, PhD candidate at Michigan State University
  In Silico Modeling of Bisphenols: Pregnancy-Specific Physiologically Based Toxicokinetic Models for BPA and BPS ”
• 2020......Dr. Zhenzhen Shi, postdoctoral fellow at Emory University, mentored by Dr. Qiang Zhang. Development of a Virtual Population Model of Thyroid Hormone Regulation for Safety Assessment of Endocrine Disrupting Chemicals
• 2020......Honesty Tohon, graduate student at University of Montreal, mentored by Dr. Sami Haddad. Estimation of Toluene Exposure in Air from BMA (S-benzylmercapturic acid) Urinary Measures Using a Reverse Dosimetry Approach Based on Physiologically Based Pharmacokinetic Modeling
• 2019......Axelle Marchand, Université de Montréal
• 2018......Dr. Yi-Hsien Cheng, Kansas State University, General Physiologically Based Pharmacokinetic Model for Gold Nanoparticles of Different Sizes with Multiple Administration Routes in Rats
• 2017......Marie-Emilie Willemin, US FDA/NCTR, Characterization of the Modes of Action of Hiocyanate on the Thyroid Hormones Levels Using a Mechanistic Dose-response Model
• 2016......Rachel Worley, CDC/ATSDR, University of Georgia
• 2015......Jeremy Leonard, US EPA (Postdoc winner), Development of a Conceptual Module to Investigate Pharmacokinetic Influences when Evaluating Chemicals in Adverse Outcome Pathways"
• 2015......Axelle Marchand, Université de Montréal (Student winner) Evaluation and Modeling of the Impact of Co-Exposures to Voc Mixtures on Urinary Biomarkers

• 2014......Huali Wu, The Hamner Institutes for Health Sciences (Postdoc winner) Can the Association between Serum Perfluorooctanoic Acid (PFOA) and Delayed Menarche Be Explained on the Basis of Physiology and Pharmacokinetics?
• 2013......Zhoumeng Lin, University of Georgia (Postdoc winner) Gestational and Lactational Physiologically-based Pharmacokinetic (PBPK) Models for the Herbicide Atrazine in Rats: Development and Optimization
• 2012......Kathleen Holm, US EPA (Postdoc winner), Identifying the Sources of Uncertainty in the Process of Reconstructing Exposures to Carbaryl Using Exposure-to-Dose Modeling
• 2010......M. Marc-André Verner of the Université du Québec à Montréal, Montréal QC, Canada, Unveiling Associations between Lactational Exposure to PCBs and Infant Neurodevelopment: Use of PBPK Modeling vs Traditional Exposure Metrics
• 2010......Sheppard Martin of the University of Georgia, for his presentation Progress in Development of a PBPK Model for Aviation Fuels
• 2009......M. Marc-André Verner of the Université du Québec à Montréal, Montréal, QC, Canada, A PBPK Modeling Tool to Predict Infant Internal Exposure to Persistent Organic Chemicals and Assess Critical Periods of Susceptibility
• 2009......M. Marc-André Verner of the Université du Québec à Montréal, Montréal, QC, Canada, (Postdoc winner) A PBPK Modeling Tool to Predict Infant Internal Exposure to Persistent Organic Chemicals and Assess Critical Periods of Susceptibility

• 2023......Elise Hickman, Postdoctoral Fellow at the University of North Carolina at Chapel Hill. Mentor: Dr. Julia Rager.
  Interindividual Variability Assessments through Benchmark Dose-Response Modeling of Primary Human Bronchial Epithelial-Fibroblast Co-culture Responses to Acrolein ]
• 2022......Long Yuan, Postdoctoral Fellow at the University of Florida.
  Mentor: Dr Zhoumeng Lin.
  Development and Application of a Web-Based Interactive Physiologically Based Pharmacokinetic (Ipbpk) Model for Meloxicam in Broiler Chickens and Laying Hens [Poster #3998]
• 2021......Mahbubul Huq Riad, MD, Postdoctoral Research Fellow at Kansas State University “Development and Application of a Physiologically Based Pharmacokinetic Model to Predict Oxytetracycline Tissue Distribution and Withdrawal Intervals in Market-Age Sheep”
• 2020......Qiran Chen, graduate student at Indiana University, mentored by Dr. Kan Shao. A Novel Dose-Response Framework with Quantitatively Integrated MOA Information
• 2019......Wei-Chun Chou and Zhoumeng Lin. Bayesian, Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) to Characterize the Interspecies Uncertainty between Mice, Rats, Monkeys, and Humans: Development and Performance Verification. Environ Int. 2019.
• 2018......Dr. Yi-Hsien Cheng, Kansas State University, Probabilistic Risk Assessment of Gold Nanoparticles by Integrating In Vitro and In Vivo Toxicity with Physiologically Based Pharmacokinetic Modeling

Honorable Mention

• 2023......KAnna Kreutz, Postdoctoral Fellow at US EPA. Mentor: Dr. Barbara Wetmore In Vitro to In Vivo Extrapolation (Ivive) for Neurodevelopment: Toxicokinetics and in Vitro Point of Departure Evaluation of Putative Developmental Neurotoxicants

• 2023......Susana Proença, Postdoctoral Fellow at Wageningen University and Research, Netherlands. Mentor: Dr. Nynke Kramer. A Mechanistic and Probabilistic PBPK Model for Amiodarone for Quantitative In Vitro to In Vivo Extrapolation”
• 2022......Student: Yun Zhou, PhD Student at Indiana University Bloomington.
  Mentor: Dr. Kan Shao. Quantitative Integration of Mode-of-Action Information in Dose-Response Modeling and POD Estimation: A Case Study of PCB 126 Postdoc:Qiran Chen, Postdoctoral Fellow at the University of Florida.
  Mentor: Dr. Zhoumeng Lin.
  The Application of toxicogenomics and physiologically based pharmacokinetic (PBPK) modeling in human health risk assessment of perfluorooctane sulfonate (PFOS)
• 2021......Kiara Fairman, Postdoctoral Research Fellow at US FDA/NCTR
  Pregnancy PBPK Modeling of UGT Substrate Labetalol: An Application of Parameter Contribution Analysis to Guide Predictive Performance of Life Stage Models

• 2020......Kazi Tasneem, graduate student at Vanderbilt University. Toxicokinetic Model Predicts Cellular Exposure in Organon-Chip Microdevices
• 2019......Dr.Longfei Chao
• 2018......Dr. Miao Li, Kansa State University, Application of Population Physiologically Based Pharmacokinetic Model for Penicillin G in Dairy Cows to Facilitate Food Safety Assessment
• 2017.....Jeremy Leonard, US EPA, Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding

• 2023......Kapraun DF, Zurlinden TJ, Verner MA, Chiang C, Dzierlenga MW, Carlson LM, Schlosser PM, Lehmann GM. A Generic Pharmacokinetic Model for Quantifying Mother-to-Offspring Transfer of Lipophilic Persistent Environmental Chemicals. Toxicol Sci. 2022 Sep 24;189(2):155-174.
• 2022......Chou WC, Lin Z. Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values. Environ Health Perspect. 2021 Mar;129(3):37004.
• 2021......Chimeddulam Dalaijamts, Joseph A. Cichocki, Yu-Syuan Luo, Ivan Rusyn, Weihsueh A. Chiu. PBPK Modeling of Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Perchloroethylene in Mice. Toxicology and Applied Pharmacology 2020; 400: 408–422. doi: 10.1016/j.taap.2020.115069.
• 2020......Wei-Chun Chou and Zhoumeng Lin. Bayesian Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) to Characterize the Interspecies Uncertainty between Mice, Rats, Monkeys, and Humans: Development and Performance Verification. Environ Int. 2019.
• 2020......Serena Manganelli, Alessandra Roncaglioni, Kamel Mansouri, Richard S. Judson, Emilio Benfenati, Alberto Manganaro, Patricia Ruiz. Development, Validation and Integration of In Silico Models to Identify Androgen Active Chemicals. Chemosphere. 2019.
• 2019......Brandon N, Dionisio KL, Isaacs K, Tornero-Velez R, Kapraun D, Setzer RW, Price PS
• 2018......Bois FY, Ochoa JGD, Gajewska M, Kovarich S., Mauch K., Paini A., Pery A., Benito JVS, Teng S, and Worth A. Multistage Modeling Aapproaches for Aassessing Ccosmetic IingredientsSsafety. Toxicology 392 (2017) 130–139.
• 2018......Worley RR, Yang X., Fisher J., Physiologically Based Pharmacokinetic Modeling of Human Exposure to Perfluorooctanoic Acid Suggests Historical Non Drinking-Water Exposures Are Important for Predicting Current Serum Concentrations. Toxicology and Applied Pharmacology 330 (2017), 9–21.

• 2017......Zhang Q., Kline D.E., Bhattacharya S., Crawford R.B., Conolly R.B., Thomas R.S., Andersen M.E., Kaminski N.E,. All-Or-None Suppression of B Cell Terminal Differentiation by Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. Toxicol Appl Pharmacol. 2013, 268(1): 17–26.
• 2017......Sluka JP, Fu X, Swat M, Belmonte JM, Cosmanescu A, Clendenon SG, Wambaugh, JF, and Glazier, JA., A Liver–Centric Multiscale Modeling Framework for Xenobiotics. PLoS ONE 11(9): e0162428.
• 2015......Yang Y,. Nadanaciva S,. Will Y,. Woodhead J.L,..Howell BA, Watkins PB.., Siler S.Q., MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics. Pharm Res. 2015, 32(6):1975–92.
• 2014......Sluka JP, Fu X, Swat M, Belmonte JM, Cosmanescu A, Clendenon SG, Wambaugh, JF, and Glazier, JA., A Liver–Centric Multiscale Modeling Framework for Xenobiotics. PLoS ONE 11(9): e0162428.
• 2013......Corley R.A., Kabilan S., Kuprat A.P., Carson J.P., Minard K.R., Jacob R.E., Timchalk C., Glenny R., Pipavath S, Cox .T, Wallis C.D., Larson R.F., Fanucchi MV, Postlethwait E.M., Einstein D.R., Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human. Toxicol Sci. 2012, 128(2):500–16.
• 2012......Yinderliter P.M., Price P.S., Bartels M.J., Timchalk C., Poet T.S., Development of a Source-to-Outcome Model for Dietary Exposures to Insecticide Residues: An Example Using Chlorpyrifos. Regul Toxicol Pharmacol. 2011, 61(1):82–92.
• 2011......Nicholas Luke, Reeder Sams, Michael DeVito, Rory Conolly, Hisham El-Masri, Development of Quantitative Model Incorporating Key Events in a Hepatotoxic Mode of Action to Predict Tumor Incidence
• 2008......Zhang Q. and Andersen M.E., Dose Response Relationship in Anti-Stress Gene Regulatory Networks. PLoS Comput Biol. 2007, 3(3): e24.

Honorable Mention

• 2023......Kapraun DF, Sfeir M, Pearce RG, Davidson-Fritz SE, Lumen A, Dallmann A, Judson RS, Wambaugh JF. Evaluation of a rapid, generic human gestational dose model. Reprod Toxicol. 2022 Oct;113:172-188.
• 2023......Borba JVB, Alves VM, Braga RC, Korn DR, Overdahl K, Silva AC, Hall SUS, Overdahl E, Kleinstreuer N, Strickland J, Allen D, Andrade CH, Muratov EN, Tropsha A. STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity. Environ Health Perspect. 2022 Feb;130(2):27012.
• 2022......Mansouri et al. CATMoS: Collaborative Acute Toxicity Modeling Suite. Environ Health Perspect. 2021 Apr;129(4):47013. doi: 10.1289/EHP8495. Epub 2021 Apr 30. Erratum in: Environ Health Perspect. 2021 Jul;129(7):79001.
• 2022......LBernstein AS, Kapraun DF, Schlosser PM. A Model Template Approach for Rapid Evaluation and Application of Physiologically Based Pharmacokinetic Models for Use in Human Health Risk Assessments: A Case Study on Per- and Polyfluoroalkyl Substances. Toxicol Sci. 2021 Aug 3;182(2):215-228.
• Cheng YH, He C, Riviere JE, Monteiro-Riviere NA, Lin Z. Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach. ACS Nano. 2020; 14(3):3075–3095.
• 2021......Cheng YH, He C, Riviere JE, Monteiro-Riviere NA, Lin Z. Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach. ACS Nano. 2020; 14(3):3075–3095.
• 2020......Han A.A., Timchalk C., Carver Z.A., Weber T.J., Tyrrell K.J., Sontag R.L., Gibbins T., Chrisler W.B., Weitz K.K., Du D., Lin Y., Smith J.N. Physiologically Based Pharmacokinetic Modeling of Salivary Concentrations for Noninvasive Biomonitoring of 2,4-Dichlorophenoxyacetic Acid (2,4-D). Toxicol Sci. 2019.
• 2020......Ring C.L., Arnot J.A., Bennett D.H., Egeghy P.P., Fantke P., Huang L., Isaacs K.K., Jolliet O., Phillips K.A., Price P.S., Shin H.M., Westgate J.N., Setzer R.W., Wambaugh J.F. Consensus Modeling of Median Chemical Intake for the US Population Based on Predictions of Exposure Pathways. Environ Sci Technol. 2019.
• 2018......M. Andersen, M. Black, J. Campbell, S. Pendse, H. Clewell III, L. Pottenger, J. Bus, D. Dodd, D. Kemp, and P. McMullen, Combining Transcriptomics and Pbpk Modeling Indicates a Primary Role of Hypoxia and Altered Circadian Signaling in Dichloromethane Carcinogenicity in Mouse Lung and Liver. Toxicology and Applied Pharmacology 332 (2017), 149–158.

• 2018......S. Borghoff, C. Ring, M. Banton, and T. Leavens, Physiologically Based Pharmacokinetic Model for Ethyl Tertiary‐Butyl Ether and Tertiary‐Butyl Alcohol in Rats: Contribution of Binding to α2u? Globulin in Male Rats and High‐Exposure Nonlinear Kinetics to Toxicity and Cancer Outcomes. Journal of Applied Toxicology 27 (2017), 621–640.
• 2018......S. Ramoju, D., Mattison, B. Milton, D. McGough, N. Shilnikova, H. Clewell, M. Yoon, M Taylor, D. Krewski, and M. Andersen, C. Ring, R. Pearce, R. Setzer, B. Wetmore and J. Wambaugh, The Application of Pbpk Models in Estimating Human Brain Tissue Manganese Concentrations.Neurotoxicology 58 (2017), 226–237.
• 2018......C. Ruark, G. Song, M. Yoon, M. Verner, M Andersen, H. Clewell III, and M Longnecker, Quantitative Bias Analysis for Epidemiological Associations of Perfluoroalkyl Substance Serum Concentrations and Early Onset of Menopause. Environment International 99 (2017) 245–254.
• 2018......J. Smith, Z. carver, T. Weber and C. Timchalk, Predicting Transport of 3,5,6-Trichloro-2-Pyridinol into Saliva Using a Combination Experimental and ComputationalAproach. Toxicological Sciences 157(2) (2017), 438–450.
• 2018......T. Zurlinden and B. Reisfeld, Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling Eur J Drug Metab Pharmacokinet 42 (2017), 143–153.
• 2015......Bogen K.T., Mechanistic Models Fit to ED001 Data on >40,000 Trout Exposed to Dibenzo[A,L]pyrene Indicate Mutations Do Not Drive Increased Tumor Risk. Dose Response. 2014, 12(3):386–403.
• 2015...... Wetmore B.A., Allen B., Clewell H.J. 3rd, Parker T., Wambaugh J.F., Almond L.M., Sochaski M.A., Thomas R.S., Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. Toxicol Sci. 2014, 142(1):210–24.
• 2015...... Yoon M., Kedderis G.L., Yan G.Z., Clewell H.J. 3rd. Use of In Vitro Data in Developing a Physiologically Based Pharmacokinetic Model: Carbaryl as a Case Study. Toxicology. 2015, 332:52–66.
• 2015...... Li Z., Sun B., Clewell R.A., Adeleye Y., Andersen M.E., Zhang Q., Dose-response modeling of Etoposide-induced DNA damage response. Toxicol Sci. 2014, 137(2):371-84.
• 2014......Strikwold M., Spenkelink B., Woutersen R.A., Rietjens I.M., Punt A., Lumen A., Mattie D.R., and Fisher J.W.
• 2013......Jones, Kleinstreuer, Verner

2017......Anteneh Assefa Desalegn, EU JRC, A Physiologically Based Pharmacokinetic Modeling of 5nm Cerium Oxide Nanoparticles in Intravenously Infused Rats

2011......Anne Loccisano, Development of Human Gestation and Lactation PBPK Models for Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate

2003......Micaela Reddy, Colorado State University (1st Place), Julia Gohlke, University of Washington (2nd Place)
2002......Claude Emond, A Physiological Pharmacokinetic Model Based on Tissue Lipid Content for Simulating Inhalation Pharmacokinetics of Highly Lipophilic Volatile Organic Chemicals