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Biological Modeling Specialty Section (BMSS)

| President’s Letter | Membership | Officers | Documents | Awards | Events |
| Newsletter | Photo Gallery | Links |

Welcome to the website of the Biological Modeling Specialty Section (BMSS) of the Society of Toxicology (USA). The BMSS was established in 2000 (History).

Its mission/objective is to:

    1. Serve as the focal point for interaction of members of the Society of Toxicology interested in “BIOLOGICAL MODELING” toxicology.
    2. Develop, propose, and conduct programs and educational activities that emphasize the latest development in “BIOLOGICAL MODELING” toxicology.
    3. Relate those developments to the activities of the Society of Toxicology and stimulate new growth in “BIOLOGICAL MODELING” toxicology as it relates to the science of toxicology.
    4. Act as a resource to the Society in the area of the Section’s interest.

If you have any comments, suggestions, or other feedback about this website or any activities of the Specialty Section, please contact any of the officers. Become a BMSS member.

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Membership Information

To become a BMSS member, you must be a member in good standing of the Society of Toxicology. To become an SOT member, you can join online.

If you are already a member of the SOT, you can become a BMSS member at any time. The cost of BMSS membership is $20 per year. Postdoctoral and Student SOT members receive one free membership in the Specialty Section of their choice. Additional student memberships in Specialty Sections are $15 per year per section. For more information regarding SOT or Specialty Section memberships, please contact SOT Headquarters directly.

 

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Officers 2017–2018

Officer Roles and Responsibilities

Officer Affiliation
President
Jeffery M. Gearhart Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Oxford, OH
Vice President
Jeffrey W. Fisher US FDA/NCTR, Jefferson, AR
Vice President-Elect
Brad Reisfeld Colorado State University, Wellington, CO
Secretary/Treasurer
Martin B. Phillips ScitoVation, Durham, NC
Past President
Eva D. McLanahan Agency for Toxic Substances and Disease Registry, Atlanta, GA
Councilor
Anne Elizabeth Loccisano Exponent Inc, Alexandria, VA
Councilor
Andy Nong Health Canada, Ottawa, ON, Canada
Postdoctoral Representative
Miao Li Kansas State University, ICCM, Department of Anatomy and Physiology, Manhattan, KS
Student Representative
Axelle Marchand Université de Montréal, Environmental and Occupational Health, Montréal, PQ, Canada

Past Officers:

 






 

 

SOT members’access to the Specialty Section Online Directory through ToXchange

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Chapter Documents

Bylaws (Current)



Annual Reports: 2015–2016 ; 2014–2015 ; 2013–2014 ; 2012–2013 ; 2011–2012 ; 2010–2011 ; 2009–2010 ; 2008–2009 ; 2007 ; 2002 ; 2001

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Awards

2017 Perry J. Gehring Biological Modeling Endowment Award

    Marie-Emilie Willemin, US FDA, Characterization of the modes of action of thiocyanate on the thyroid hormones levels using a mechanistic dose-response model

2017 Trainee Award (made possible by a generous donation from Mevlin E. Andersen)

    Jeremy Leonard, US EPA, Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding

Student Travel Support

    Anteneh Assefa Desalegn, EU JRC, A Physiologically Based Pharmacokinetic Modeling of 5nm Cerium Oxide Nanoparticles in Intravenously Infused Rats

Biological Modeling Best Paper Award for Publication Year 2016

    Sluka JP, Fu X, Swat M, Belmonte JM, Cosmanescu A, Clendenon SG, Wambaugh, JF, and Glazier, JA. (2016)
    A Liver–Centric Multiscale Modeling Framework for Xenobiotics.
    PLoS ONE 11(9): e0162428. doi:10.1371/journal.pone.0162428.

Award Title Perry J. Gehring Biological Modeling Endowment Award 
Award Description The Biological Modeling Specialty Section (BMSS) will present the Perry J. Gehring Biological Modeling Award at the BMSS Business Meeting and Reception during the Annual Meeting. This award is made possible by the Perry J. Gehring Biological Modeling Award Fund of the SOT Endowment, and it will consist of a plaque and a cash award.

Research areas of interest include all aspects of biologically based modeling and simulation; they may include, but are not limited to: modeling of complex biological systems, biological insights gained through model development and application, model validation, and mathematical/statistical/computational approaches to biological modeling.

Eligibility: The competition is open to all current graduate and postdoctoral students whose abstract have been accepted by the SOT for presentation at the upcoming Annual Meeting. Students who are not SOT members must have a major advisor who is a Full or Associate SOT member. Applicants will be considered for all BMSS awards for which graduate students and postdoctoral fellows are eligible.

Application Package: The package should be submitted to Eva McLanahan, Jeff Gearhart, and Jeff Fisher, as a single PDF file containing the following three items:

1. A copy of the abstract.
2. A 3-5 page summary of the study with no more than 2 figures, discussing the rationale and scope of the study, significance of findings, and potential impact of the work on advancing toxicological science and biological modeling.
3. A letter of support from his/her major advisor, describing the student’s contributions (both in time and effort) to the overall study and modeling-specific tasks.

 
Deadline December 31 
Applicable Documents  
 
Award Title Best Paper Award 
Award Description The Biological Modeling Specialty Section (BMSS) will give a “Best Paper Award” for the authors of the best biologically based computational modeling paper published in peer-reviewed literature (in hard copy or online) in 2017. The award will be presented at the BMSS Business Meeting Reception at the Society of Toxicology Annual Meeting.

Process: The Best Paper Award Committee will be composed of BMSS member volunteers and led by the BMSS Vice President. The Committee will search Medline and other databases to identify candidate papers. Each candidate paper will be judged on the basis of innovation, quality of modeling, quality of the manuscript, impact on the field, utility in toxicology/risk assessment, and other criteria. At least one of the authors on the paper must be a SOT member.

BMSS members are also encouraged to nominate papers for competition by sending a PDF of the published paper, or its abstract and complete citation, via email to Jeff Gearhart.

 
Deadline December 31 
Applicable Documents  
 
Award Title Trainee Award 
Award Description The Biological Modeling Specialty Section (BMSS) will present the Trainee Award at the BMSS Business Meeting and Reception during the Annual Meeting, and it will consist of a cash award and plaque.

This award is made possible by a generous donation from Dr. Melvin E. Andersen.

Applicants Research areas of interest include all aspects of biologically based modeling and simulation; they may include, but are not limited to: modeling of complex biological systems, biological insights gained through model development and application, model validation, and mathematical/statistical/computational approaches to biological modeling.

Eligibility: The competition is open to all current graduate and postdoctoral students whose abstract have been accepted by the SOT for presentation at the upcoming Annual Meeting. Students who are not SOT members must have a major advisor who is a Full or Associate SOT member. Applicants will be considered for all BMSS awards for which graduate students and postdoctoral fellows are eligible.

Application Package: The package should be submitted to Eva McLanahan, Jeff Gearhart, and Jeff Fisher, as a single PDF file containing the following three items:

1. A copy of the abstract.
2. A 3-5 page summary of the study with no more than 2 figures, discussing the rationale and scope of the study, significance of findings, and potential impact of the work on advancing toxicological science and biological modeling.
3. A letter of support from his/her major advisor, describing the student’s contributions (both in time and effort) to the overall study and modeling-specific tasks.
 
Deadline December 31 
Applicable Documents  
 
Award Title Andersen-Clewell Trainee Award 
Award Description This award is given jointly by the Risk Assessment Specialty Section and the Biological Modeling Specialty Section. A copy of the research abstract submitted to SOT relating to the application of biological modeling to risk assessment, a brief synopsis of the project (3-5 pages) indicating the relevance of the modeling to risk assessment, and a letter of support from the candidate's major advisor should be sent to the contact below as a single PDF file. The Award Recipient will be selected based on the scientific quality of the abstract, the scientific quality and significance of the research project overall, the significance of the findings, and demonstrating excellence in health risk assessment. Applicants will be considered for all RASS awards for which graduate students or postdoctoral fellows are eligible.

Eligibility: Graduate students or postdoctoral fellows who are SOT members.

Contact: Gary Minsavage Recipient Receives: Achievement plaque to the graduate student or postdoctoral fellow, certificate to their advisor, and $1,500 check.

This award is made possible by the Andersen-Clewell Award Fund of the SOT Endowment.

 
Deadline December 31 
Applicable Documents  
 


2015 Awards
2014 Awards
2013 Awards
2012 Awards
2011 Awards
2010 Awards
2009 Awards
2008 Awards
2007 Awards
2006 Awards
2003 Awards
2002 Awards

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Events

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Past Webinars

Topic: BMSS Webinar Series: A Liver-centric Multiscale Modeling Framework for Xenobiotics

Date: Wednesday, December 13, 2017

Time: 3:00 PM to 4:30 PM (EST)

Presentation Slides:

A Liver-centric Multiscale Modeling Framework for Xenobiotics

Webinar recording.


Topic: BMSS Webinar Series: An introduction to PK-Sim: the open source platform for PBPK

Date: Tuesday, October 24, 2017

Time: 11:00 am Eastern Daylight Time

Presentation Slides:

An Intorduction to PK-Sim®

There was no recording for this Webinar.


Topic: BMSS Webinar Series: TRA Vitro—Vivo

Date: Friday, September 15, 2017

Time: 11:00 AM Eastern Daylight Time (New York, GMT-04:00)

Presentation Slides:

TRA Vitro—Vivo

Webinar recording.


Topic: BMSS Webinar Series: Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models from acslX to Berkeley Madonna, MATLAB, and R language.

Date: Friday, July 21, 2017

Time: 11:00 AM Eastern Daylight Time (New York, GMT-04:00)

Presentation Slides:

Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models

Webinar recording.


Topic: BMSS Webinar Series: Application of Physiologically-Based Pharmacokinetic Modeling to Explore the Role of Kidney 2 Transporters in Renal Reabsorption of Perfluorooctanoic Acid in the Rat

Date: Tuesday, October 25, 2016

Time: 11:00 AM Eastern Daylight Time (New York, GMT–04:00)

No Slides Available
No Recording Available


Topic: BMSS Webinar Series: PharmML-Exchange Format for Models Used in Quantitative System Pharmacology and Pharmacometrics

Date: Friday, July 22, 2016

Time: 11:00 AM Eastern Daylight Time (New York, GMT–04:00)

Presentation Slides:

PharmML—Exchange Format for Models Used in QSP and PMx

Webinar recording.


Topic: BMSS Webinar Series: Saying I do to the QSAR/PBPK marriage in GastroPlus to predict chemical exposure for safety evaluation

Date: June 16, 2016

Presentation Slides:

Saying “I do” to the QSAR/PBPK marriage in GastroPlus™ to predict chemical exposure for safety evaluation

Validation of the GastroPlusTM Software Tool and Applications

Webinar recording.


Topic: Biological Modeling Webinar Series: Developing PBPK Models in MATLAB and SimBiology

Date: Friday, March 4, 2016

DCM Example

Presentation Slides*:

SimBiology for PBPK and Mechanistic Modeling

Translating PBPK Model Code from acslX™ to MATLAB®

Webinar recording*.

  • *Webinar presentations and recording have been removed at the presenter’s request.

Topic: BMSS Webinar Series: Understanding Dermal Drug Disposition Using TCAT—A Novel PBPK Model

Date: Thursday, February 16, 2017

Time: 11:00 AM Eastern Standard Time (New York, GMT–04:00)

Presentation Slides:

Understanding Dermal Drug Disposition Using TCAT—A Novel PBPK Model

Webinar recording.


Topic: Biological Modeling Webinar Series

Date: February 4, 2016

Presentation Slides:

George Loizou: A Free to use PBPK Modelling Platform

Drs. Paul Hinderliter & Christopher Ruark: PBPK Modeling Modeling in the R Project Project for Statistical Computing

R. Woodrow Setzer: Dynamic Modeling Using MCSim and R

Webinar recording.

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Newsletter

Newsletter Volume 5, No. 1

Newsletter Volume 4, No. 2

Newsletter Volume 4, No. 1

Newsletter Volume 3, No. 2

Newsletter Volume 3, No. 1

Newsletter Volume 2, No. 3

Newsletter Volume 2, No. 2

Newsletter Volume 2, No. 1

Newsletter Volume 1, No. 2

Newsletter Volume 1, No. 1

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Photo Gallery

 

BMSS Activities at the 2015 SOT Annual Meeting

Lunch and Learn:

BMSS Activities at the 2013 SOT Annual Meeting

BMSS Activities at the 2007 SOT Annual Meeting

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Links

Society of Toxicology

Aegis Technologies—Makers of modeling software acslXtreme®

Entelos—Entelos is a life sciences company improving human health through predictive biosimulation. Using in silico disease models and a virtual patient approach, Entelos identifies and validates targets, develops biomarkers, improves the success rates of clinical trials, and helps bring therapeutics to market faster.

Leadscope—Leadscope develops and markets a chemofinformatics application that provides seamless access to research data. It incorporates chemically based data mining, visualization and advanced informatics techniques (prediction tools,scaffold generators, etc.). The platform, coupled with our content

Lhasa Limited—Lhasa Limited develops database system and computer programs that is used to predict toxicity and metabolic fate of chemicals and provide chemical toxicity information management tools.

Pharsight—Pharsight facilitates strategic decision making in drug development. Pharsight software improves the value and availability of preclinical and clinical program data for PK/PD modeling, analysis, drug attribute visualization, reporting and trial simulation. Strategic consulting based on quantitative, predictive models builds the foundation of knowledge to strengthen the quality, visibility, and value of critical drug development decisions.

Simulations-Plus—Simulations Plus, Inc. is the leading developer of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemical, cosmetic, herbicide, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions… sooner.

US EPA—Free downloadable copy of EPI Suite v3.11 software for estimation of physical & chemical properties (e.g., Kow, Henry’s Law constant, etc.)

US EPA—Free downloadable copy of Benchmark Dose software (BMDS)

US EPA—Council of Regulatory Environmental Modeling (CREM) links page – this is a page of general links that are useful for the environmental modeling community that is not limited to physiological modeling, but includes fate and transport, etc.

Biological Simulators, Inc.—Makers of modeling software QCP (Quantitative Circulatory Physiology) that is used to study the dynamics and complexity of integrative human physiology

Berkeley Madonna—Software of modeling and analysis of dynamic systems. It is a general purpose differential equation solver that is relatively inexpensive and runs on both Windows and Mac OS. It is currently used by academic and commercial institutions for constructing mathematical models for research and teaching.

The Mathworks—Makers of software MATLAB®

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