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Biological Modeling Specialty Section (BMSS)

| President’s Letter | Membership | Officers | Documents | Awards | Events |
| Newsletter | Photo Gallery | Links |

Welcome to the website of the Biological Modeling Specialty Section (BMSS) of the Society of Toxicology (USA). The BMSS was established in 2000 (History).

Its mission/objective is to:

    1. Serve as the focal point for interaction of members of the Society of Toxicology interested in “BIOLOGICAL MODELING” toxicology.
    2. Develop, propose, and conduct programs and educational activities that emphasize the latest development in “BIOLOGICAL MODELING” toxicology.
    3. Relate those developments to the activities of the Society of Toxicology and stimulate new growth in “BIOLOGICAL MODELING” toxicology as it relates to the science of toxicology.
    4. Act as a resource to the Society in the area of the Section’s interest.

If you have any comments, suggestions, or other feedback about this website or any activities of the Specialty Section, please contact any of the officers. Become a BMSS member.

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Membership Information

To become a BMSS member, you must be a member in good standing of the Society of Toxicology. To become an SOT member, you can join online.

If you are already a member of the SOT, you can become a BMSS member at any time. The cost of BMSS membership is $20 per year. Postdoctoral and Student SOT members receive one free membership in the Specialty Section of their choice. Additional student memberships in Specialty Sections are $15 per year per section. For more information regarding SOT or Specialty Section memberships, please contact SOT Headquarters directly.

 

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Officers 2018–2019

Officer Roles and Responsibilities

Officer Affiliation
President
Jeffrey William Fisher US FDA-NCTR, Jefferson, AR
Vice President
Brad Reisfeld Colorado State University, Fort Collins, CO
Vice President-Elect
Miyoung Yoon ToxStrategies Inc, Durham, NC
Secretary-Treasurer
Tammie Covington HJF / USAFSAM,
WPAFB, OH
Past President-Councilor
Jeffery M. Gearhart Henry M Jackson Foundation for the Advancement of Military Medicine Inc, Oxford, OH
Councilor
Anne Elizabeth Loccisano Exponent Inc, Alexandria, VA
Councilor
Alicia Paini Joint Research Centre, Ispra
Postdoctoral Representative
Miao Li Kansas State University, Manhattan, KS
Student Representative
Axelle Marchand Université de Montréal, Montréal, PQ, Canada

To email the Biological Modeling Specialty Section Leadership, please send an email to SOTHQ@toxicology.org.

Past Officers:






 

 

SOT members’access to the Specialty Section Online Directory through ToXchange

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Chapter Documents

Bylaws (Current)



Annual Reports: 2016–2017 ; 2015–2016 ; 2014–2015 ; 2013–2014 ; 2012–2013 ; 2011–2012 ; 2010–2011 ; 2009–2010 ; 2008–2009 ; 2007 ; 2002 ; 2001

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Awards

2018 Perry J. Gehring Biological Modeling Endowment Award

    Dr. Yi-Hsien Cheng, Kansas State University, “A general physiologically based pharmacokinetic model for gold nanoparticles of different sizes with multiple administration routes in rats”.

2018 Andersen-Clewell Trainee Award Fund (shared with the Risk Assessment Specialty Fund)

    Dr. Yi-Hsien Cheng, Kansas State University, Probabilistic risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling.

2018 Trainee Award (made possible by a generous donation from Melvin E. Andersen)

    Dr. Miao Li, Kansa State University, “Application of Population Physiologically Based Pharmacokinetic Model for Penicillin G in Dairy Cows to Facilitate Food Safety Assessment”.

Biological Modeling Best Paper Award for Publication Year 2018

    Bois FY, Ochoa JGD, Gajewska M, Kovarich S, Mauch K, Paini A, Pery A, Benito JVS, Teng S, and Worth A. Multistage modeling approaches for assessing cosmetic ingredients safety. Toxicology 392 (2017) 130-139.
    Worley RR, Yang X, Fisher J. Physiologically based pharmacokinetic modeling of human exposure to perfluorooctanoic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations. Toxicology and Applied Pharmacology 330 (2017), 9-21.

Honorable Mention

    M Andersen, M Black, J Campbell, S Pendse, H Clewell III, L Pottenger, J Bus, D Dodd, D Kemp, and P McMullen. Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver. Toxicology and Applied Pharmacology 332 (2017), 149-158.
    S Borghoff, C Ring, M Banton, and T Leavens. Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u?globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes. Journal of Applied Toxicology 27 (2017), 621-640.
    S Ramoju, D Mattison, B Milton, D McGough, N Shilnikova, H Clewell, M Yoon, M Taylor, D Krewski, and M Andersen. The application of PBPK models in estimating human brain tissue manganese concentrations. Neurotoxicology 58 (2017), 226-237.
    C Ring, R Pearce, R Setzer, B Wetmore and J Wambaugh. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. Environment International 106 (2017), 105-118.
    C Ruark, G Song, M Yoon, M Verner, M Andersen, H Clewell III, and M Longnecker. Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause. Environment International 99 (2017) 245-254.
    J Smith, Z carver, T Weber and C Timchalk. Predicting transport of 3,5,6-trichloro-2-pyridinol into saliva using a combination experimental and computational approach. Toxicological Sciences 157(2) (2017), 438-450.
    T Zurlinden and B Reisfeld. Characterizing the effects of race/ethnicity on acetaminophen pharmacokinetics using physiologically based pharmacokinetic modeling. Eur J Drug Metab Pharmacokinet 42 (2017), 143-153.

Award Title Perry J. Gehring Biological Modeling Endowment Award 
Award Description The Biological Modeling Specialty Section (BMSS) will present the Perry J. Gehring Biological Modeling Award at the BMSS Business Meeting and Reception during the SOT Annual Meeting. This award is made possible by the Perry J. Gehring Biological Modeling Award Fund of the SOT Endowment, and it will consist of a plaque and a cash award.

Research areas of interest include all aspects of biologically based modeling and simulation; they may include, but are not limited to: modeling of complex biological systems, biological insights gained through model development and application, model validation, and mathematical/statistical/computational approaches to biological modeling.

Eligibility: The competition is open to all current graduate and postdoctoral students whose abstract have been accepted by the SOT for presentation at the upcoming Annual Meeting. Students who are not SOT members must have a major advisor who is a Full or Associate SOT member. Applicants will be considered for all BMSS awards for which graduate students and postdoctoral fellows are eligible.

Application Package: The package should be submitted to Miyoung Yoon, as a single PDF file containing the following three items:

1. A copy of the abstract.
2. A 3-5 page summary of the study with no more than 2 figures, discussing the rationale and scope of the study, significance of findings, and potential impact of the work on advancing toxicological science and biological modeling.
3. A letter of support from his/her major advisor, describing the student’s contributions (both in time and effort) to the overall study and modeling-specific tasks.

 
Deadline December 31 
Applicable Documents  
 
Award Title Best Paper Award 
Award Description The Biological Modeling Specialty Section (BMSS) will give a “Best Paper Award” for the authors of the best biologically based computational modeling paper published in peer-reviewed literature (in hard copy or online) in 2017. The award will be presented at the BMSS Business Meeting Reception at the Society of Toxicology Annual Meeting.

Process: The Best Paper Award Committee will be composed of BMSS member volunteers and led by the BMSS Vice President. The Committee will search Medline and other databases to identify candidate papers. Each candidate paper will be judged on the basis of innovation, quality of modeling, quality of the manuscript, impact on the field, utility in toxicology/risk assessment, and other criteria. At least one of the authors on the paper must be a SOT member.

BMSS members are also encouraged to nominate papers for competition by sending a PDF of the published paper, or its abstract and complete citation, via email to Brad Reisfeld.

 
Deadline December 31 
Applicable Documents  
 
Award Title Andersen-Clewell Trainee Award 
Award Description This award is given jointly by the Risk Assessment Specialty Section (RASS) and the Biological Modeling Specialty Section (BMSS). A copy of the research abstract submitted to SOT relating to the application of biological modeling to risk assessment, a brief synopsis of the project (3-5 pages) indicating the relevance of the modeling to risk assessment, and a letter of support from the candidate's major advisor should be sent to the contact below as a single PDF file. The Award Recipient will be selected based on the scientific quality of the abstract, the scientific quality and significance of the research project overall, the significance of the findings, and demonstrating excellence in health risk assessment. Applicants will be considered for all BMSS awards for which graduate students or postdoctoral fellows are eligible.

Eligibility: Graduate students or postdoctoral fellows who are SOT members.

Contact: Miyoung Yoon Recipient Receives: Achievement plaque to the graduate student or postdoctoral fellow, certificate to their advisor, and $1,500 check.

This award is made possible by the Andersen-Clewell Award Fund of the SOT Endowment.

 
Deadline December 31 
Applicable Documents  
 
Award Title Best Trainee Abstract Award 
Award Description The Biological Modeling Specialty Section (BMSS) will present the BMSS Best Trainee Abstract Award to the lead author of the best biologically-based computational modeling abstract at the BMSS Business Meeting and Reception during the SOT Annual Meeting. An achievement plaque will be presented to the lead author of the winning abstract.

Any student or postdoctoral abstract submitted to SOT for the annual meeting which indicates a biologically-based computational modeling focus or impact is eligible for this award. After acceptance of the abstract by the SOT Program Committee, please send a copy of the abstract to the contacts below (BMSS officers).

Eligibility: All student or postdoctoral SOT abstracts, both poster and platform presentations, that have been accepted by the SOT for presentation at the upcoming Annual Meeting are eligible.

Process: The Best Abstract Award Committee will be composed of BMSS member volunteers and led by the BMSS Vice President. Beside the nominated abstracts, the Committee will also search the submitted abstracts to identify eligible abstracts. Each candidate abstract will be judged based on innovation, quality of modeling, potential or realized impact on the field, utility in toxicology/risk assessment, and other criteria deemed important to the Committee.

BMSS members are also encouraged to nominate abstracts for competition by sending a copy of the submitted abstract via email to Miyoung Yoon.

 
Deadline December 31 
Applicable Documents  
 


2017 Awards
2015 Awards
2014 Awards
2013 Awards
2012 Awards
2011 Awards
2010 Awards
2009 Awards
2008 Awards
2007 Awards
2006 Awards
2003 Awards
2002 Awards

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Events

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Past Webinars

Topic: Quantitative Systems Toxicology as a Tool for Explaining and Predicting Drug-Related Organ Toxicity

Date: Wednesday, April 11, 2018

Time: 11:00 AM EDT

Presentation Slides:

Quantitative Systems Toxicology as a Tool for Explaining and Predicting Drug-Related Organ Toxicity

Webinar recording.


Topic: BMSS Webinar Series: A Liver-centric Multiscale Modeling Framework for Xenobiotics

Date: Wednesday, December 13, 2017

Time: 3:00 PM to 4:30 PM (EST)

Presentation Slides:

A Liver-centric Multiscale Modeling Framework for Xenobiotics

Webinar recording.


Topic: BMSS Webinar Series: An introduction to PK-Sim: the open source platform for PBPK

Date: Tuesday, October 24, 2017

Time: 11:00 am Eastern Daylight Time

Presentation Slides:

An Intorduction to PK-Sim®

There was no recording for this Webinar.


Topic: BMSS Webinar Series: TRA Vitro—Vivo

Date: Friday, September 15, 2017

Time: 11:00 AM Eastern Daylight Time (New York, GMT-04:00)

Presentation Slides:

TRA Vitro—Vivo

Webinar recording.


Topic: BMSS Webinar Series: Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models from acslX to Berkeley Madonna, MATLAB, and R language.

Date: Friday, July 21, 2017

Time: 11:00 AM Eastern Daylight Time (New York, GMT-04:00)

Presentation Slides:

Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models

Webinar recording.


Topic: BMSS Webinar Series: Application of Physiologically-Based Pharmacokinetic Modeling to Explore the Role of Kidney 2 Transporters in Renal Reabsorption of Perfluorooctanoic Acid in the Rat

Date: Tuesday, October 25, 2016

Time: 11:00 AM Eastern Daylight Time (New York, GMT–04:00)

No Slides Available
No Recording Available


Topic: BMSS Webinar Series: PharmML-Exchange Format for Models Used in Quantitative System Pharmacology and Pharmacometrics

Date: Friday, July 22, 2016

Time: 11:00 AM Eastern Daylight Time (New York, GMT–04:00)

Presentation Slides:

PharmML—Exchange Format for Models Used in QSP and PMx

Webinar recording.


Topic: BMSS Webinar Series: Saying I do to the QSAR/PBPK marriage in GastroPlus to predict chemical exposure for safety evaluation

Date: June 16, 2016

Presentation Slides:

Saying “I do” to the QSAR/PBPK marriage in GastroPlus™ to predict chemical exposure for safety evaluation

Validation of the GastroPlusTM Software Tool and Applications

Webinar recording.


Topic: Biological Modeling Webinar Series: Developing PBPK Models in MATLAB and SimBiology

Date: Friday, March 4, 2016

DCM Example

Presentation Slides*:

SimBiology for PBPK and Mechanistic Modeling

Translating PBPK Model Code from acslX™ to MATLAB®

Webinar recording*.

  • *Webinar presentations and recording have been removed at the presenter’s request.

Topic: BMSS Webinar Series: Understanding Dermal Drug Disposition Using TCAT—A Novel PBPK Model

Date: Thursday, February 16, 2017

Time: 11:00 AM Eastern Standard Time (New York, GMT–04:00)

Presentation Slides:

Understanding Dermal Drug Disposition Using TCAT—A Novel PBPK Model

Webinar recording.


Topic: Biological Modeling Webinar Series

Date: February 4, 2016

Presentation Slides:

George Loizou: A Free to use PBPK Modelling Platform

Drs. Paul Hinderliter & Christopher Ruark: PBPK Modeling Modeling in the R Project Project for Statistical Computing

R. Woodrow Setzer: Dynamic Modeling Using MCSim and R

Webinar recording.

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Newsletter

Newsletter Volume 5, No. 1

Newsletter Volume 4, No. 2

Newsletter Volume 4, No. 1

Newsletter Volume 3, No. 2

Newsletter Volume 3, No. 1

Newsletter Volume 2, No. 3

Newsletter Volume 2, No. 2

Newsletter Volume 2, No. 1

Newsletter Volume 1, No. 2

Newsletter Volume 1, No. 1

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Photo Gallery

BMSS Activities at the 2018 SOT Annual Meeting

Lunch and Learn:

BMSS Activities at the 2018 SOT Annual Meeting
BMSS Activities at the 2017 SOT Annual Meeting

BMSS Activities at the 2013 SOT Annual Meeting

BMSS Activities at the 2007 SOT Annual Meeting

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Links

Society of Toxicology

Aegis Technologies—Makers of modeling software acslXtreme®

Leadscope—Leadscope develops and markets a chemofinformatics application that provides seamless access to research data. It incorporates chemically based data mining, visualization and advanced informatics techniques (prediction tools,scaffold generators, etc.). The platform, coupled with our content

Lhasa Limited—Lhasa Limited develops database system and computer programs that is used to predict toxicity and metabolic fate of chemicals and provide chemical toxicity information management tools.

PLETHUM—Population Lifecourse Exposure-To-Health-Effects Model (PLETHEM) is a modeling platformed developed by us with funding from the American Chemistry Council and under a Memorandum of Understanding with EPA-NCCT.

Simulations-Plus—Simulations Plus, Inc. is the leading developer of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) and Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemical, cosmetic, herbicide, and food ingredient industries today. Our software allows pharmaceutical scientists to predict certain key potential endpoints and dynamics, in silico, thereby reducing research & development costs and helping clients make better projects decisions… sooner.

US EPA—Free downloadable copy of EPI Suite v3.11 software for estimation of physical & chemical properties (e.g., Kow, Henry’s Law constant, etc.)

US EPA—Free downloadable copy of Benchmark Dose software (BMDS)

Berkeley Madonna—Software of modeling and analysis of dynamic systems. It is a general purpose differential equation solver that is relatively inexpensive and runs on both Windows and Mac OS. It is currently used by academic and commercial institutions for constructing mathematical models for research and teaching.

The Mathworks—Makers of software MATLAB®

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