Program Overview

The 2020 Preliminary Program PDF pdf icon is available for viewing and downloading now as an additional planning tool.

This page is meant to provide a quick glimpse at the schedule of sessions and events that will occur during the 2020 SOT Annual Meeting and ToxExpo. As information becomes available and activities are finalized, they will be added to this page. Full details and information on the sessions and events listed on this page are available as part of the Online Planner on the “Program Details” web page. A printable PDF of the Program Overview will be available in February 2020.

SOT Regional Chapter, Special Interest Group and Specialty Section meetings, luncheons, receptions, mentoring events, and officer meetings occur at various times throughout the week. Use the “Session or Activity Type” filter in the Online Planner to view desired events.

Key:

IAT Innovations in Applied Toxicology   ITS Innovations in Toxicological Sciences


  

Saturday, March 14

5:15 PM to 7:30 PM


7:30 PM to 8:30 PM

Committee on Diversity Initiatives (CDI) Reunion


Sunday, March 15

7:00 AM to 7:45 AM

CONTINUING EDUCATION SUNRISE MINI-COURSES (Ticket Required)

  • SR01: Advances in CRISPR-Cas9 Tools and Applications for Toxicologists
  • SR02: Qualifying Biomarkers and Navigating the US FDA Predictive Toxicology Roadmap to Improve Decision-Making in Toxicology and Drug Safety Assessment

8:00 AM to 5:00 PM


8:15 AM to 12:00 NOON

CONTINUING EDUCATION MORNING COURSES (Ticket Required)

  • AM03: Developing Therapeutics for Ocular Indications: A 20/20 View
  • AM04: Introduction to Open-Access Computational Toxicology Tools
  • AM05: Lung Function: It’s Not Just Breathing
  • AM06: Modern Modeling Strategies to Address Uncertainty and Variability in Dose-Response Assessment
  • AM07: The Basics of In Vitro Xenobiotic Metabolism and Drug-Drug Interaction Investigations: Applicability to All Xenobiotics
  • AM08: Timing Is Everything: Developmental Exposure Alters the Path of Immune Cell Maturation and Function

1:15 PM to 5:00 PM

CONTINUING EDUCATION AFTERNOON COURSES (Ticket Required)

  • PM09: AAV Vectors on the Move: Safety Assessment and Advancing Sciences in Gene Therapy Second-Generation Products
  • PM10: An Introduction to New Approach Methodologies (NAMs) and Understanding Their Potential to Support Regulatory Decisions
  • PM11: Gateway Technologies to Tomorrow’s Metal Toxicological Research
  • PM12: Harnessing the T Cell for Cancer Immunotherapy: A Course on T Cell Redirection
  • PM13: In Vitro Approaches to Assess the Toxicity of Inhaled Substances
  • PM14: The Male Reproductive Tract: Development, Toxicology, and Pathology

4:45 PM to 5:15 PM

Awards Ceremony Music featuring Gregg Young


5:15 PM to 6:30 PM

Awards Ceremony


6:30 PM to 7:30 PM

Welcome Reception


7:00 PM to 8:00 PM

25-Year (Or More) Member Reception (By Invitation Only)


7:30 PM to 9:00 PM

Student/Postdoctoral Scholar Mixer (Free Ticket Required)


Monday, March 16

6:15 AM to 7:45 AM

SOT Mentoring Breakfast (Ticket Required)


8:00 AM to 10:45 AM

SYMPOSIUM SESSIONS

  • Can We Predict and Manage Immune-Related Adverse Events Associated with Cancer Immunotherapy?
  • Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS): Current In Vivo Approaches and Application to Human Health Risk Assessment
  • Lysosome/Autophagy Dysregulation in Toxicity and Disease ITS
  • New Data and Tools for Understanding Chemical Distribution In Vitro

WORKSHOP SESSIONS

  • Applicability Domains and Future of Nonanimal Tests for Skin Sensitization
  • Known Unknowns: Challenges and Approaches for Handling Chemical, Hazard, and Regulatory Uncertainty in Medical Device Safety Assessments
  • Oligodendrocytes/Schwann Cells: Major Targets in Neurotoxicity and Neurological Diseases
  • Toxicological Exposure and Risk Assessment of Emissions from 3D Printers

9:00 AM to 4:30 PM

ToxExpo Exhibits Hall, including the SOT Pavilion


9:30 AM to 3:00 PM

Research Funding Insights Room


11:00 AM to 12:20 PM

ROUNDTABLE SESSION

  • Mechanistic Read-Across of Chemical Toxicants Based on Big Data ITS

INFORMATIONAL SESSIONS

  • Individual-, Community-, and Population-Level Environmental-Associated Attributes of Disparate Health Outcomes in Vulnerable Populations
  • The Epidemic of Chronic Kidney Disease of Unknown Etiology in Agricultural Communities

11:00 AM to 12:30 PM

WORKSHOP SESSIONS

  • Aircraft Cabin Fume Events: Is There a Toxicological Explanation?
  • Globally Harmonized Guidance for Dose-Response Analysis and Derivation of Health-Based Guidance Values for Chemicals in Food—Part I: What’s New?
  • Impacts on Human Health of Sunscreen Active Ingredients Used to Filter Ultraviolet Light

11:30 AM to 12:45 PM

IN VITRO TOXICOLOGY LECTURE AND LUNCHEON FOR STUDENTS (Ticket Required)

Computational Intelligence: Building “Smart Models” for Toxicology in the Era of Big Data
Lecturer: Thomas B. Knudsen, US EPA/CCTE, Research Triangle Park, NC.
Supported by: An Educational Grant from the Colgate-Palmolive Company


1:00 PM to 2:00 PM

PLENARY SESSION

Precisely Practicing Medicine from 700 Trillion Points of Data
Speaker: Atul Butte, University of California San Francisco, San Francisco, CA.

Dr. Butte is a pioneer in the analysis of big data, using these data to gain new insights into diseases and their treatment. The promises of precision medicine are dependent on the appropriate analysis of large datasets. Dr. Butte will tell us about his group’s efforts to organize and gain insight from health records, leading to better therapeutic choices. He also will describe new methods for teaching intelligence, both real and artificial, for better medical practice.”

— George P. Daston
Scientific Program Committee Chair


2:15 PM to 3:00 PM

Trainee Discussion with Plenary Session Speaker Atul Butte (Ticket Required; Limited Seating)


3:00 PM to 4:30 PM

SYMPOSIUM SESSIONS

  • Evolving Technologies for Determination of Biotherapeutic Specificity
  • Genome Editing in Drug Discovery: Using the Cas9 Protein to Explore Target-Mediated Toxicity

WORKSHOP SESSIONS

  • Bringing Advances in Risk Science into Regulatory Decisions: Applying Data-Driven Uncertainty Analysis
  • Globally Harmonized Guidance for Dose-Response Analysis and Derivation of Health-Based Guidance Values for Chemicals in Food—Part II: Intuitive Demonstrations
  • Single Cell Applications in Mechanistic Toxicology ITS
  • The More, the Better? Single Biomarkers, Panels, and/or Composite Biomarkers to Characterize Organ Injury
  • Variety Is the Life of Spice: The Clinical Toxicology of Synthetic Cannabinoids

4:45 PM to 6:00 PM

SOT/EUROTOX DEBATE

Individual Toxicity Is the Future of Risk Assessment
SOT Debater: Syril D. Pettit, HESI, Washington, DC.
EUROTOX Debater: Alan R. Boobis, Imperial College London, London, United Kingdom.


Tuesday, March 17

6:00 AM to 7:00 AM

Past Presidents' 5K Fun Run/Walk


8:00 AM to 10:45 AM

SOCIETY OF TOXICOLOGY AND JAPANESE SOCIETY OF TOXICOLOGY SYMPOSIUM

Oxidative Stress in Multiple Manifestations of Toxicity
JSOT Speakers: Yoshito Kumagai, University of Tsukuba, Tsukuba, Japan; and Yoshiro Saito, Tohoku University, Sendai, Japan.
SOT Speakers: Alicia R. Timme-Laragy, University of Massachusetts Amherst, Amherst, MA; and Dean P. Jones, Emory University School of Medicine, Atlanta, GA.

SYMPOSIUM SESSIONS

  • Cellular Recovery and Resilience: A New Perspective on Toxicity Testing
  • Cyanide as a Chemical Threat: Finding Better Antidotes IAT
  • Electronic Cigarettes and Cardiovascular Toxicity: New Friend or Old Foe?
  • Environmental Exposure and Health Effects of Organophosphate Esters
  • Quantitative and Translational Systems Toxicology: Improving Drug Safety from Preclinical to Clinical Outcomes ITS

WORKSHOP SESSIONS

  • Human-Relevant Carcinogenicity Testing: Tools for Cancer Assessment in 2020 and Beyond
  • Using Human Genetics to Aid in Safety Assessment of Therapeutics

9:00 AM to 4:30 PM

ToxExpo Exhibits Hall, including the SOT Pavilion


9:30 AM to 3:30 PM

Blood Drive


9:30 AM to 4:30 PM

Research Funding Insights Room


11:00 AM to 12:20 PM

INFORMATIONAL SESSIONS

  • Communicating Risk in a (Mis)information-Rich World
  • Current Status and Knowledge Gaps in the Use of Zebrafish in Risk Assessment

EDUCATION-CAREER DEVELOPMENT SESSION

  • From Surviving to Thriving: A First Biology Course—Use of a CURE to Teach about Poisons

11:00 AM to 12:30 PM

SYMPOSIUM SESSION

  • Targeted Protein Degraders: Considerations for Nonclinical Safety Assessment of a New Pharmaceutical Modality

12:00 NOON to 1:00 PM

Postdoctoral Assembly Luncheon (Ticket Required)


1:30 PM to 2:50 PM

Career Exploration through Speed Informational Interviews (Ticket Required; Limited Seating)


1:30 PM to 4:15 PM

SYMPOSIUM SESSIONS

  • Environmental Carcinogenesis: Effect of Carcinogen Exposure on the Genome and Health Risks
  • Epigenetic Mechanisms of Metal-Induced Cancer Stem Cell–Like Property and Carcinogenesis
  • Immune Cell Polarization in Toxicology and Therapeutic Approaches
  • Organ to Silicon Chip: Emerging In Vitro and In Silico Tools for Evaluation of Cardiotoxicity
  • TaRGET II Consortium: Elucidating Epigenetic Responses to the Environment across Target and Surrogate Tissues

WORKSHOP SESSIONS

  • Genetic Mutations of Manganese Transporters: Clinical Presentation and Neurotoxicity
  • Mechanisms and Multiple Exposures: Methods to Tackle Toxicology’s Most Difficult Challenges Using Systematic Review Frameworks

4:45 PM to 6:15 PM

SOT Annual Business Meeting


7:30 PM to 9:00 PM

Tox ShowDown


Wednesday, March 18

8:00 AM to 10:45 AM

SYMPOSIUM SESSIONS

  • Immunosuppressive and Anti-inflammatory Activity of Cannabis and Cannabinoids: Adverse or Therapeutic?
  • Resolution of Inflammation in Chemical Toxicity/Tissue Injury: What’s Emerging?
  • Single Cell Technologies: A Potentially Transformative Tool for Toxicology ITS

WORKSHOP SESSIONS

  • Applying Modern Toxicology to Dietary Supplements with Ancient Roots: Botanical Safety in the 21st Century
  • Automation and Machine-Learning Techniques to Leverage Resources When Conducting a Systematic Review
  • In Vitro Microphysiological Systems: Developing Tools to Evaluate Immunotoxicity of Drug Candidates
  • Sex, Lungs, and Air Pollution

REGIONAL INTEREST SESSION

  • Protecting Public Health and the Environment during Wildfire Recovery

9:00 AM to 4:30 PM

ToxExpo Exhibits Hall, including the SOT Pavilion


9:30 AM to 3:30 PM

Blood Drive


9:30 AM to 4:30 PM

Research Funding Insights Room


11:00 AM to 12:00 Noon

EUROTOX BO HOLMSTEDT MEMORIAL AWARD LECTURE

Understanding Three Fundamental Quantitative Principles Is a Prerequisite for Improving Toxicological Science and Risk Assessment
Lecturer: Wout Slob, Rijksinstituut voor Volksgezondheid en Milieu (RIVM), Bilthoven, Netherlands.


11:00 AM to 12:20 PM

INFORMATIONAL SESSION

  • Novel Uses of Analytical Platforms for Efficacy/Safety Biomarker Selection to Improve De-risking of Therapeutics

EDUCATION-CAREER DEVELOPMENT SESSION

  • Next-Generation Toxicologist Training through Innovative Summer Internships

12:30 PM to 1:30 PM

PLENARY KEYNOTE MEDICAL RESEARCH COUNCIL (MRC) LECTURE

Lecturer: Dame Amanda Fisher, MRC London Institute of Medical Sciences, London, United Kingdom.


1:30 PM to 4:15 PM

SYMPOSIUM SESSION

  • Human Stem Cell–Derived Test Systems as Alternative Approaches for Developmental Neurotoxicity (DNT) Evaluation: Research and Regulatory Perspectives

WORKSHOP SESSIONS

  • Improving Our Understanding of Toxicant Metabolism and Cytochrome P450s Using Novel Knockout Models and High-Throughput Methods
  • New Frontiers in Dynamic Toxicology
  • Parental Cannabis Exposure and Long-Term Neurobehavioral Deficits in Offspring

2:00 PM to 3:00 PM

Trainee Discussion with Medical Research Council (MRC) Lecturer Dame Amanda Fisher (Ticket Required; Limited Seating)


Thursday, March 19

8:30 AM to 11:15 AM

SYMPOSIUM SESSIONS

  • Application of RISK21 Framework in Regulatory-Based Decision-Making: From Business Decisions to Prioritization to Risk Assessment
  • Chemical Probes in Toxicology: From Defining Exposures to Identifying Novel Toxicity and Druggable Targets
  • Express Yourself (or Not . . .): The Nonclinical Safety of Oligonucleotide Therapeutics
  • Identifying and Modeling Gene-Environment Interactions in Neurological Diseases Associated with Metal Exposure: Challenges and Recent Advances
  • Protecting the Force: Examining the Hazards of Military Service from the Bench and the Battlefield

WORKSHOP SESSIONS

  • Cannabidiol Science, Safety, and Societal Impacts: Where Do We Stand? IAT
  • Have In Vitro Teratogenicity Assessments Come of Age in the Pharmaceutical Industry?
  • Immune-Mediated Adverse Drug Reactions: State-of-the-Art Learnings from Preclinical and Clinical Drug Development IAT