This page provides an overview of the Annual Meeting schedule of sessions and events. As information becomes available and activities are finalized, they will be added to this page.

For the most up-to-date and detailed information, use the Online Planner.

Key:

CE Continuing Education Courses

E Events

EC Education-Career Development Sessions

IS Informational Sessions

R Roundtable Sessions

RI Regional Interest Sessions

S Symposium Sessions

TE ToxExpo

W Workshop Sessions

IAT Innovations in Applied Toxicology

ITS Innovations in Toxicological Sciences

  • Saturday SAT MAR 26 2021
  • Sunday SUN MAR 27 2022
  • Monday MON MAR 28 2022
  • Tuesday TUE MAR 29 2021
  • Wednesday WED MAR 30 2022
  • Thursday THU MAR 31 2022
Saturday, March 26, 5:15 PM to 7:30 PM

E

Undergraduate Diversity Program

Undergraduate students who receive an Undergraduate Diversity Program Student Travel Award participate in this program.

Learn More

Sunday, March 27, 7:15 AM to 7:45 AM

E

SOT Undergraduate Research Award Welcome

Invited: SURA Recipients and FUTURE members

FUTURE will welcome and recognize the students who have received the SOT Undergraduate Research Award (SURA) before they attend the Undergraduate Education Program.

Sunday, March 27, 8:00 AM to 5:00 PM

E

Undergraduate Education Program

All undergraduate students attending the SOT Annual Meeting and ToxExpo are invited to register for the complimentary Undergraduate Education Program. Capacity for the program may be limited.

Learn More

Sunday, March 27, 8:15 AM to 12:00 Noon

CE

Continuing Education Courses

The following courses are occurring concurrently and require an additional fee and ticket to attend:

AM01: Animal-Free Safety Assessment of Consumer Products and Ingredients: A Primer

AM02: Conceptual Models in Immunotoxicology: Leveraging Biological Knowledge, Alternative Approaches, and Computational Strategies for the Future of Risk Assessment

AM03: Evidence Map, Scoping Review, Rapid Systematic Review, and Systematic Review—And How to Conduct Them

AM04: How Advances in Exposure Science and Toxicology Are Changing Assessments of the Effects of Chemical Mixtures on Human Health

AM05: Importance of Sexual Maturity and Reproductive Senescence in Laboratory Animal Models

AM06: Safety Evaluation Strategies in Drug Discovery: From Target Assessment to Identification of Drug Candidates

Sunday, March 27, 1:15 PM to 5:00 PM

CE

Continuing Education Courses

The following courses are occurring concurrently and require an additional fee and ticket to attend:

PM07: Best Practices for Successfully Assessing Ototoxicity in Drug Development

PM08: Juvenile Toxicology Testing: Assessing Pediatric Safety

PM09: Leading-Edge Microbiome Methods for Toxicological Applications

PM10: Methodological Aspects of Vascular Toxicity

PM11: Next-Level Neurotoxicology: New Technologies to Advance Visualization of Spatial Molecular Alterations and Behavioral Phenotyping

PM12: Principles and Applications of Read-Across in Human Health Risk Assessment

Sunday, March 27, 5:15 PM to 6:30 PM

E

Awards Ceremony

Join SOT in honoring this year’s SOT Award recipients. Dozens of individuals will be recognized during this ceremony, and throughout the week, additional individuals will be honored with awards bestowed by the SOT Committees and Component Groups. More information on the 2022 SOT Award recipients will be available on the SOT and Annual Meeting websites in January 2022 and in the SOT Event App (launching February 2022).

Sunday, March 27, 7:00 PM to 8:00 PM

E

25-Year (or More) Member Reception

If you’ve been an SOT member for 25 years or more, come celebrate at this invitation-only event. Be sure to wear your anniversary pin in honor of your years of membership.

Monday, March 28, 6:15 AM to 7:45 AM

E

SOT Mentoring Breakfast

A separate registration is required to attend this event, designed for SOT members from graduate students through established career toxicologists. SOT recognizes that mentoring is important at all career stages and has implemented a year-round program for mentors and mentees to establish mentoring relationships online through the SOT Mentor Match Program. During the Mentoring Breakfast, the Education and Career Development Committee is providing an opportunity for mentees and mentors matched through this online program to meet in person during the SOT Annual Meeting. In addition, participants will learn from an engaging speaker about mentor and mentee best practices and the long-term benefits of mentoring relationships. SOT members who are interested in learning more about mentoring or being mentored through the SOT Mentor Match Program also are invited to attend and network with participants. Registration is limited and is accepted on a first-come, first-served basis..

Monday, March 28, 8:00 AM to 9:00 AM
Atul J. Butte
Atul J. Butte
University of California San Francisco, San Francisco, CA.

Opening Plenary Session: Precisely Practicing Medicine from 700 Trillion Points of Data

Dr. Butte’s lab at the University of California San Francisco builds and applies tools that convert trillions of points of molecular, clinical, and epidemiological data—measured by researchers and clinicians over the past decade and now commonly termed “big data”—into diagnostics, therapeutics, and new insights into disease.

There is an urgent need to take what we have learned in our new data-driven era of medicine and use it to create a new system of precision medicine, delivering the best, safest, cost-effective preventative or therapeutic intervention at the right time, for the right patients. Dr. Butte’s lab at the University of California San Francisco builds and applies tools that convert trillions of points of molecular, clinical, and epidemiological data—measured by researchers and clinicians over the past decade and now commonly termed “big data”—into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a computer scientist and pediatrician, will highlight his center’s recent work on integrating electronic health records data across the entire University of California and how analytics on this “real-world data” can lead to new evidence for drug efficacy, new savings from better medication choices, and new methods to teach intelligence—real and artificial—to more precisely practice medicine.

Monday, March 28, 9:00 AM to 4:30 PM

TE

ToxExpo Exhibits

The three-day ToxExpo features companies and organizations that support toxicologists and the toxicology community, including research organizations, government agencies, laboratory suppliers, drug developers, consulting firms, and academic institutions.

Learn More

Monday, March 28, 9:15 AM to 12:00 Noon

S

Symposium Sessions

Cardiovascular Effects of Environmental Metals: New Preclinical and Clinical Insights ITS

How to Maximize the Value of Electronic Data via Analytics and Exchange to Create Knowledge: Case Studies across the Pharmaceutical Industry and Regulatory Sectors

The Microbiome in Toxicity and Disease: A Yin and Yang Duality for the Host throughout the Life Span ITS

New Approach Methods for Functional Developmental Neurotoxicity

Novel Approaches to Finding Better Antidotes for Cyanide Toxicity

W

Workshop Sessions

A Holistic View of the Impacts of Climate Change

Leveraging Physiologically Based Pharmacokinetic (PBPK) Modeling for Refining Safety Assessment of Food, Drugs, and Chemicals under Data-Rich and Data-Poor Conditions

EC

Education-Career Development Session

Double Feature: Improving SciComm Skills through Creative Storytelling and Novel Presentation Delivery, Plus an SOT 2022 Three-Minute Thesis (3MT)

Monday, March 28, 12:30 PM to 1:30 PM
Ryan Feldman
Emily Kiernan
Kyle Suen

American Academy of Clinical Toxicology Symposium: Clinical Care Conundrums

As part of the SOT Strategic Plan to maximize the Society’s prominence within the scientific community and foster new relationships with other societies, SOT is happy to announce its collaboration with the American Academy of Clinical Toxicology (AACT), in the form of a pilot Symposium in 2022. In addition, SOT will be selecting two speakers from the 2022 SOT Annual Meeting to present their work at the AACT Annual Meeting, the North American Congress of Clinical Toxicology, in San Francisco in September 2022. Please join us in welcoming AACT speakers to San Diego!

Moderator:
Ryan Feldman
Wisconsin Poison Center, Milwaukee, WI.
Panelists:
Emily Kiernan
Emory University School of Medicine, Atlanta, GA.
Kyle Suen
Emory University School of Medicine, Atlanta, GA.

A construction worker on a hog farm walks into the bathroom. He later is found unresponsive on the ground. Was it drugs? I mean, it’s probably drugs. But wait, could it be something else? The coworker who found him smelled something funny coming from a hole in the bathroom floor. A graduate student, punished to work long hours sequencing DNA by gel, collapses. Is it from sheer exhaustion or a toxic inhalational exposure? And someone please call OSHA; another worker from that same hog farm collapses and his skin appears gray. He was working on experimenting with which bait hogs liked to eat to assist others trying to control the wild pig population. Come watch the panelists get stumped trying to determine the possible culprit compound for these patient presentations. There also will be lively discussion regarding the diagnosis and management of these exposures.

Monday, March 28, 1:45 PM to 4:30 PM

S

Symposium Sessions

All for One and One for All: One Environmental Health in Toxicology

It Takes Guts: Exploring New Models and Modalities for Gastrointestinal Toxicity

W

Workshop Sessions

Bad Breath: Noninvasive Investigation into the Exhaled Biomarkers for Toxicological Research

This Is Your Brain on Mixtures: Neurodevelopmental Effects of Combined Exposures

Up to the Task? Quantitative Evaluation Criteria for Physiologically Based Pharmacokinetic (PBPK) Models

RI

Regional Interest Session

DDT Dump Site Off Southern California: Seafloor Survey, Ecological Impact, and Human Health

EC

Education-Career Development Session

Publishing Educational Toxicology Exercises in CourseSource: A Step-by-Step Workshop for Preparing Your Manuscript

Monday, March 28, 4:30 PM to 5:30 PM

E

Undergraduate Educator Network Meeting

The Undergraduate Educator Network Meeting is for all faculty involved in the teaching of toxicology to undergraduates, trainees thinking about teaching, and for those interested in including toxicology at the under¬graduate level. Learn about initiatives for undergraduate faculty, provide your input, network with your colleagues, and discuss shared interests.

Monday, March 28, 4:45 PM to 6:15 PM
Craig Rowlands
Thomas Hartung

SOT/EUROTOX Debate: Is There a Role for Artificial Intelligence and Machine Learning in Risk Decisions?

Each year, the SOT Annual Meeting includes a debate in which leading toxicologists advocate opposing sides of an issue of significant toxicological importance. The debate continues a tradition that originated in the early 1990s.

Chair(s):
Dori R. Germolec
NIEHS/NTP.
Thomas Weiser
F. Hoffmann-La Roche AG, Switzerland.
SOT Debater:
Craig Rowlands
UL LLC, Northbrook, IL.
EUROTOX Debater:
Thomas Hartung
Johns Hopkins University Bloomberg School of Health, Baltimore, MD.

This year, the debaters will address the proposition: Is there a role for artificial intelligence (AI) and machine learning (ML) in risk decisions? The debaters will discuss the principles and limitations of these tools for decision-making. Specific questions to be addressed include: Can recent developments in AI and ML be applied in toxicology as they are being applied in precision medicine and other fields? Are current algorithms inherent to AI and ML sufficiently refined for the design of safer products? Are these applications sufficiently robust to identify toxic “signatures,” providing information for safety and risk assessment? Are they sufficiently reliable to predict toxicity and can they account for genetic and other toxicodynamic variability? Are they able to predict risk associated with exposures to mixtures? Can they predict the potential toxicity of new compounds or relate chemical structure or activity to risk? How can we tell if the results of AI and ML are accurate and defensible? In addition to inclusion as a Featured Session at this meeting, this debate will again take place (with the debaters taking the reverse positions) in Maastricht, Netherlands, during the XVIth International Congress of Toxicology, September 18–22, 2022.

Tuesday, March 29, 8:00 AM to 10:45 AM
Yasumitsu Nishimura
Christopher A. Reilly
Etsushi Kuroda
Alison C. P. Elder

Society of Toxicology and Japanese Society of Toxicology Symposium: Molecular Secrets Inside and Outside Respiratory Toxicity of Particles and Fibers

This Symposium provides the latest scientific findings about cellular and molecular mechanisms for the toxic effects of fine/ultrafine particles, wood/biomass smoke PM, and asbestos fibers as a session jointly organized by SOT and the Japanese Society of Toxicology (JSOT).

Yasumitsu Nishimura
Kawasaki Medical School, Kurashiki, Japan.
Christopher A. Reilly
University of Utah, Salt Lake City, UT.
Etsushi Kuroda
Hyogo College of Medicine, Nishinomiya, Japan.
Alison C. P. Elder
University of Rochester School of Medicine and Dentistry, Rochester, NY.

Respiratory toxicity of particles and fibers is a global issue that has been associated with progress of civilization and continues to harm human health. This Symposium provides the latest scientific findings about cellular and molecular mechanisms for the toxic effects of fine/ultrafine particles, wood/biomass smoke PM, and asbestos fibers as a session jointly organized by SOT and the Japanese Society of Toxicology (JSOT). Impact of inhalation exposure to those particles and fibers causes various kinds of events not only inside but also outside respiratory system, which includes intracellular and intercellular machineries related to cell death and inflammation and extends to the immune as well as the neuronal system. The Symposium will contribute to more understanding of the diseases caused by those toxicities.

Tuesday, March 29, 8:00 AM to 10:45 AM

S

Symposium Session

Safe and Sustainable Plastics: Navigating Health Impacts with Innovations

W

Workshop Sessions

Building the Toolbox: Three-Dimensional Tissue Constructs as Problem Solvers

Human Neural Tube Defects: Basic Embryology to Predictive Toxicology

Let’s Talk About Sex—Through the Lenses of a Toxicologist!

Mode of Action, Adverse Outcome Pathways, and Key Characteristics (KCs): Proposed Steps Forward and Mid-Course Corrections

Technological Advancements and Strategic Approaches in Developmental and Reproductive Toxicity Assessments

Transforming Safety Biomarker Development and Translation through Predictive Safety Testing, Big Data, and Artificial Intelligence: Industry, Academia, and Regulatory Perspectives

IS

Informational Session

Honor Thy Stakeholders: How Toxicologists Can Better Incorporate Stakeholders into Research, Communication, and Translation

Tuesday, March 29, 9:00 AM to 4:30 PM

TE

ToxExpo Exhibits

The three-day ToxExpo features companies and organizations that support toxicologists and the toxicology community, including research organizations, government agencies, laboratory suppliers, drug developers, consulting firms, and academic institutions.

Learn More

Tuesday, March 29, 11:00 AM to 12:20 PM

R

Roundtable Sessions

Cross-Species Extrapolation: Opportunities in a 21st-Century Regulatory Nonanimal Testing World

Harmonization of Approaches for the Biological Safety Assessment of Medical Devices and Pharmaceutical Packaging: Implications for Drug-Device Combination Products

Tg.rasH2 Positive Controls: Added Value or No Longer Necessary?

Tuesday, March 29, 12:00 Noon to 1:00 PM

E

Postdoctoral Assembly Luncheon

This ticketed event encourages networking and engagement among postdoctoral scholars. Stop in when you can to enjoy a buffet lunch with your fellow postdocs as well as SOT Council members. There is a short program at 12:30 pm to recognize the Best Postdoctoral Publication Award recipients and the Postdoctoral Assembly Officers and announce the raffle winners.

Tuesday, March 29, 12:30 PM to 1:30 PM

E

Undergraduate Student Meeting

Invited: Undergraduate Students and Invited Guests

An informal session for all undergraduate students attending the SOT Annual Meeting will be hosted by the Faculty United for Toxicology Undergraduate Recruitment and Education (FUTURE) Committee. SOT undergraduate travel awardees will participate in this event. Peer into your toxicology future by connecting with your peers and graduate students with common interests in the science of safety and in career opportunities in the field. This session will include opportunities for networking with toxicology graduate students along with free lunch for all participants.

Tuesday, March 29, 1:00 PM to 2:30 PM
Jeffrey M. Peters
Kristine Willett
Matthew J. Campen

Toxicological Sciences Featured Session: Publishing in Toxicological Sciences: From Submission to Peer Review, Publication, and Beyond

This session will familiarize attendees with the importance of Toxicological Sciences as the official journal of SOT, illustrate approaches to develop an impactful manuscript for submission to the journal, and describe the peer-review process, including best practices for responding to peer reviewers’ comments.

Chair(s):
Jeffrey M. Peters
Pennsylvania State University.
Panelists:
Jeffrey M. Peters
Pennsylvania State University, University Park, PA.
Kristine Willett
University of Mississippi, University, MS.
Matthew J. Campen
University of New Mexico, Albuquerque, NM.

Attendees also will have an opportunity to interact with the editorial team of Toxicological Sciences in a discussion session. While this session is primarily geared toward manuscript authors, peer reviewers and readers of Toxicological Sciences also will benefit from participating.

Tuesday, March 29, 1:00 PM to 2:30 PM

S

Symposium Sessions

Deep Learning and Graph Algorithms: New Approaches in Computational Toxicology

Developmental Origins of Inflammatory and Immune Diseases: Identifying the Effects of In Utero Stress on Immunological Competency

W

Workshop Sessions

Addressing the Toxicology of Newly Decriminalized Drugs

Advances in CRISPR-Based Molecular and Computational Methods for Assessing Mechanistic Underpinnings of Toxicity and Gene-Environment Interactions

Tuesday, March 29, 1:30 PM to 2:50 PM

E

Career Exploration through Speed Informational Interviews

This limited-seating and ticketed event is designed for graduate students and postdocs who want to gain insight in the different career sectors in toxicology. Groups of trainees will rotate through a series of eight-minute discussions with career representatives from academia, government, and industry.

Tuesday, March 29, 3:00 PM to 4:00 PM
Rick Woychik
Rick Woychik
NIEHS/NTP, Research Triangle Park, NC.

Meet the Director: A Conversation with Rick Woychik

This important session will provide an informal venue for attendees to have a candid and open discussion with Rick Woychik, PhD, the Director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP).

The 60-minute session will begin with a brief summary of the leadership values that Dr. Woychik brings to the position, and the remainder of the session will be devoted to a question-and-answer format concerning scientific directions and priorities for NIEHS, including funding priorities and outlooks and training opportunities.

Tuesday, March 29, 3:00 PM to 4:30 PM

S

Symposium Session

Disparities in Environmental Chemical Exposure and Health Risks

W

Workshop Sessions

Application of Next-Generation Risk Assessment Principles for Decision-Making

Safety Challenges and Development Strategies Unique to Biotechnology-Derived Products across Industries

Translating Lead Toxicology: Engaging Stakeholders and Communities

Tuesday, March 29, 4:45 PM to 6:15 PM

E

SOT Annual Business Meeting

SOT members are invited and encouraged to attend the Annual Business Meeting. The agenda includes a financial summary and a review of the 2019–2022 accomplishments.

Wednesday, March 30, 8:00 AM to 10:45 AM

S

Symposium Sessions

Applications of Single Cell Profiling Methods to Enhance Mechanistic Understanding of Toxicological Responses

Cadmium and the Developmental Origins of Disease: The Implication of Early-Life Exposures on Health Later in Life

Computational Toxicology Workflows for Prioritization and Safety Assessment of Environmentally Relevant Chemicals IAT

W

Workshop Sessions

Assay Gaps in the Developmental Neurotoxicity (DNT) New Approach Methodologies (NAMs) Battery for Human Health Risk Assessment

Communicating Science in an Age of Misinformation and Mistrust

How Can We Break Down the Silos of Epidemiology, Biological Mode of Action (MoA), and Statistical Modeling in Cancer Risk Assessment?

Wednesday, March 30, 9:00 AM to 4:30 PM

TE

ToxExpo Exhibits

The three-day ToxExpo features companies and organizations that support toxicologists and the toxicology community, including research organizations, government agencies, laboratory suppliers, drug developers, consulting firms, and academic institutions.

Learn More

Wednesday, March 30, 2022, 11:00 AM to 12:00 Noon
Shana Sturla
Shana Sturla
ETH Zurich, Switzerland.

EUROTOX Bo Holmstedt Memorial Award Lecture: Context Matters: Next-Generation Insights on the Chemistry of DNA Damage and Mutation

Cancer risk is impacted by exposures to chemicals from the environment, diet, and drugs, together with defects or deficiencies in DNA damage tolerance pathways.

Research of the past decades provides a basis for understanding how DNA oxidation, alkylation, and instability, balanced by DNA damage tolerance and repair, drive mutagenesis. Nevertheless, our ability to predict individual susceptibility to chemical mutagens or the etiology of individual cancers remains limited in part because there exists a mismatch between our low-resolution understanding of the dynamic process of DNA damage formation and removal on a genome-wide level versus our sophisticated single-base genome-wide picture of mutational landscapes of human cancers. Very recently, several strategies have emerged for base-resolution genome-wide mapping of DNA damage, including chemical probe– and ligation-based strategies. We have mapped DNA damage in mammalian cells and gained new insight on how damage profiles are governed by chemical sources and cellular repair proficiency, and, finally, related chemical exposures with in vitro mutation signatures. This research involves applying a combination of strategies for evaluating damage regions in the human genome based on DNA damage–tailored chemical probes and bioanalysis methods, including single nucleotide mapping of damage in whole genomes, and in vitro strategies to determine the impact of enzymatic deficiencies on mutation signatures. Elucidation of DNA damage and repair from chemical exposure to DNA alkylating drugs, diet-derived reactive nitrogen species, and reactive oxygen species will be presented. Chemical structure and sequence-specific chemical probe–based strategies for tracking DNA damage overcomes previous limitations to understanding the distribution of DNA damage formation and repair and its genome-wide impact on the accumulation of mutations. Furthermore, it provides information concerning the relationship between DNA repair enzyme function and mutation signatures that could lead to new approaches for quantifying risk on the basis of early biomarkers and characterization of causative factors of individual cancers.

Wednesday, March 30, 11:00 AM to 12:20 PM

R

Roundtable Sessions

Are Animal Studies Still the “Gold Standard” for Validating New Approach Methods?

Challenges with the TSCA Risk Evaluation Assessments of Occupational Exposures, Worker Health and Safety, and Risk

IS

Informational Session

Safer Chemical Tools and Practices: Successes in Advancing Safer Chemical Selection on a Global Scale

Wednesday, March 30, 12:30 PM to 1:30 PM
Kathy Niakan
Kathy Niakan
University of Cambridge, United Kingdom.

Plenary Keynote Medical Research Council (MRC) Lecture: Genetic Approaches to Study Early Lineage Specification in Human Embryos

We are using CRISPR/Cas9-mediated genome editing, TRIM-Away protein depletion, dominant negative mutations, and small molecules to dissect the function of genes during human embryogenesis. These methods have enabled us to uncover that the first lineage specification event in human embryos is the initiation of a placental program.

During preimplantation development, human embryos are composed of pluripotent embryonic cells, which eventually form the fetus, and extra-embryonic cells, which contribute to the placenta and yolk sac. The central question we address is: What are the molecular mechanisms that regulate these early cell fate choices in human embryos? We are using CRISPR/Cas9-mediated genome editing, TRIM-Away protein depletion, dominant negative mutations, and small molecules to dissect the function of genes during human embryogenesis. These methods have enabled us to uncover that the first lineage specification event in human embryos is the initiation of a placental program. Our work has also uncovered a high frequency of unintended on-target mutations following genome editing in human primary cells. By integrating signaling insights from human blastocysts, we have defined human embryonic stem cell culture conditions that more closely recapitulate the embryonic niche. The molecular basis of these early cell lineage decisions is of fundamental importance and has wide-reaching clinical implications for infertility, miscarriages, developmental disorders, and therapeutic applications of stem cells.

Wednesday, March 30, 1:30 PM to 4:15 PM

S

Symposium Sessions

Competitive Displacement of Physiologic Metals as a Mechanism of Toxicity

Role and Mechanisms of Persistent Epigenetic Alterations in Toxicological Responses

W

Workshop Sessions

Current Status and Future Outlook of Developmental Immunotoxicity Testing

Educating 21st-Century Toxicologists: Making In Vitro and In Silico Approaches Part of the Curriculum

Tools for Modernizing Ecological Risk Assessment

Use of Computational Methods for Addressing Occupational Safety: Opportunities to Support the 3Rs

IS

Informational Session

Making Your Data FAIR for Your Future Self and Others

Thursday, March 31, 8:30 AM to 11:15 AM

S

Symposium Sessions

Hypertensive Disorders of Pregnancy: Environmental Influences, Biomarkers, and Models

In Vitro Considerations for Predicting Retinal Toxicities

Lung Lipids in Xenobiotic-Induced Tissue Injury and Disease Pathogenesis

Optimizing the Design of Repeated-Dose Animal Studies to Inform Human Health Risk Assessment by Integrating Exposure, In Vitro and In Silico Data

PFAS Sum versus Some? The Science and Policy of Mixtures

State-of-the-Science on Thyroid Hormone Regulation and Disruption during Neurodevelopment

W

Workshop Session

The Use of Alternative Methods to Assess Chemical Toxicity and Risk in Military and Aerospace Exposure Scenarios

IS

Informational Session

How Does Your Study Measure Up? The Evolution of Study Quality Evaluations in Toxicology and Risk Assessment