REACH, a European Union regulation established in 2006, requires the registration and ample toxicological testing of all chemicals manufactured and sold in the EU. The REACH Regulation places greater responsibility on industry to manage the risks from chemicals and to provide safety information on the substances. Manufacturers and importers are required to gather information on the properties of their chemical substances, which will allow their safe handling, and to register the information in a central database run by the European Chemicals Agency (ECHA) in Helsinki.